No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
155 |
4. Check minimum number of eventsNone |
155 |
5. Include endpointsNone |
155 |
6. Filter based on genotype QC (FinnGen only) |
146 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Chronic thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1039 | 904 | 126 |
| Only index persons | 846 | 752 | 94 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.00 |
| Only index persons | 0.02 | 0.03 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 44.91 | 44.84 | 45.36 |
| Only index persons | 41.61 | 41.53 | 42.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 146 | 138 | 8 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.00 |
| Median age at first event (years) | 42.94 | 42.10 | 57.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 148
- Matched controls
- 1480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
329.7
240.6
125
24
104
Kela drug reimbursment
Thyroid insufficiency
840.8
89.2
79
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
88.7
76
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
445.3
60.0
56
*
24503
ICD-8 Finland
Thyroiditis, Chronica
+∞
54.6
49
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
52.2
47
*
H03BB01
ATC
carbimazole; oral
351.4
50.4
48
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
44.0
40
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
39.3
36
*
E03
ICD-10 Finland
Other hypothyroidism
194.3
31.0
31
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
25.8
24
*
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
24.7
23
*
T86
ICPC
Hypothyroidism/myxoedema
284.1
24.4
24
*
H062, E050,
ICD-10 Finland
+∞
23.6
22
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
142.1
23.3
24
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
22.5
21
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.3
11.9
85
425
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.3
11.5
21
38
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
10.5
10
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.1
9.8
100
591
2458X
ICD-9 Finland
Thyroiditis, Other and unspecified chronic thyroiditis
+∞
9.5
9
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
8.5
30
94
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
84.1
7.5
8
*
H05.2
ICD-10 Finland
Exophthalmic conditions
84.1
7.5
8
*
2504
FHL
Unilateral resection or enucleation
+∞
7.3
7
*
24502
ICD-8 Finland
Thyroiditis, Subchronica
+∞
7.3
7
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
7.3
7
*
ZXA10
NOMESCO Finland
Bilateral
2.8
7.2
45
199
WZC00
NOMESCO Finland
Treatment plan or consultation
2.5
6.9
70
391
E06.3
ICD-10 Finland
Autoimmune thyroiditis
42.0
6.8
8
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.5
6.7
26
86
XCK10
NOMESCO Finland
Photography of fundus of eye
3.6
6.6
24
76
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
19.0
6.3
9
5
C07AA05
ATC
propranolol; systemic
2.6
6.3
46
218
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
6.3
6
*
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
+∞
6.3
6
*
XCK00
NOMESCO Finland
Perimetry
4.0
6.3
19
53
H02AB07
ATC
prednisone; oral
3.1
6.1
29
109
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
40
18.37
54.05
4.3
1.7
4.31
4.29
pmol/l
0.05
43
35
104
667
2.88
8.10
6.9
5.3
1.22
1.22
mmol/l
0.48
93
572
96
632
2.48
6.43
3.5
2.4
82.47
79.17
nmol/l
0.54
87
575
77
465
2.37
6.20
2.8
3.0
2.34
2.37
mmol/l
1.26
67
427
21
67
3.49
5.73
1.8
1.2
433.50
71.87
u/ml
0.75
14
22
89
596
2.24
5.33
6.8
4.8
1.22
1.22
mmol/l
0.35
80
552
23
88
2.91
4.66
1.8
2.3
58.71
71.02
ng/l
0.74
17
73
48
264
2.21
4.56
2.8
2.4
2.44
2.46
mmol/l
0.51
40
234
102
748
2.17
4.54
9.2
9.5
3.98
3.97
e9/l
0.02
90
653
90
640
2.04
4.22
3.9
2.8
113.93
85.91
ug/l
0.63
84
585
55
336
2.01
3.88
2.4
2.2
2.53
2.77
mg/l
0.36
47
283
125
1022
2.44
3.88
9.9
7.1
77.72
76.34
u/l
0.20
120
955
6
5
12.42
3.79
1.0
1.0
—
—
—
0
0
11
28
4.16
3.36
1.0
1.3
—
—
—
0
0
10
24
4.39
3.26
1.2
1.2
—
—
—
0
0
10
24
4.39
3.26
1.2
1.2
—
—
—
0
0
12
36
3.53
3.10
1.6
2.3
26.32
26.00
mmol/l
0.12
12
36
21
95
2.41
3.07
2.9
2.6
0.30
0.27
e6/l
0.07
21
88
142
1293
3.42
2.93
25.3
16.4
139.44
139.80
mmol/l
0.95
142
1263
142
1293
3.42
2.93
25.1
16.5
3.96
3.94
mmol/l
0.31
142
1259
96
752
1.79
2.83
4.5
4.4
6.40
6.47
mmol/l
0.17
89
705
34
195
1.97
2.78
2.9
3.1
6.43
4.48
e6/l
0.25
22
83
118
995
1.92
2.60
6.3
4.3
15.40
11.88
mm/h
1.35
110
921
41
256
1.83
2.59
3.6
3.7
16.56
278.31
ng/l
1.29
32
196
5
7
7.34
2.57
1.2
1.3
46.00
48.51
u/l
—
5
7
34
202
1.89
2.50
1.9
1.9
11.88
12.71
umol/l
0.26
34
180
60
423
1.70
2.49
2.5
2.2
49.38
70.55
u/l
1.22
52
386
51
344
1.74
2.48
1.5
1.3
1.58
1.80
u/ml
0.06
14
90
18
86
2.24
2.34
1.2
1.6
—
—
—
0
0
55
384
1.69
2.34
3.7
3.0
1531.04
1090.75
ng/l
0.33
48
329
6
13
4.76
2.29
1.3
1.5
—
—
—
0
0
45
299
1.73
2.28
2.4
2.0
—
—
—
0
0
35
216
1.81
2.28
2.9
2.9
1.02
1.15
e6/l
0.13
22
103
77
591
1.63
2.24
2.5
2.0
94.28
95.46
pmol/l
0.07
44
278
79
611
1.63
2.23
2.9
2.5
—
—
estimate
—
0
0
25
140
1.95
2.18
1.6
1.9
27.45
28.57
u/l
0.12
20
120
16
75
2.27
2.18
7.2
6.4
95.13
94.12
%
0.49
16
75
39
254
1.73
2.11
1.6
1.8
428.88
24390713.44
pmol/l
0.50
25
205
35
222
1.76
2.07
2.2
1.8
—
—
—
0
0
31
194
1.76
1.92
1.9
1.9
2.49
2.36
g/l
0.56
31
172
18
94
2.04
1.90
1.6
1.4
—
—
—
0
0
29
179
1.77
1.88
1.8
1.7
29.34
29.63
s
0.14
29
171
90
738
1.56
1.85
6.7
5.5
10.13
10.14
umol/l
0.01
85
688
29
183
1.73
1.74
2.0
1.9
18.21
21.81
%
0.78
29
162
24
143
1.81
1.74
3.3
4.0
24.55
8.77
ug/l
0.34
19
113
135
1242
1.99
1.58
5.3
5.0
5.87
5.86
mmol/l
0.02
122
1129
59
458
1.48
1.48
3.2
3.1
—
—
—
0
0
7
28
2.57
1.47
1.4
1.6
—
—
—
0
0
142
1348
2.32
1.36
28.8
18.6
71.66
69.89
umol/l
0.67
142
1331
8
34
2.43
1.31
1.4
1.3
—
0.01
—
0
6
25
164
1.63
1.31
7.0
4.8
103.44
104.18
mmol/l
0.39
25
164
25
164
1.63
1.31
2.0
1.7
—
—
—
0
0
136
1268
1.89
1.31
23.4
14.3
22.67
20.96
mg/l
0.27
121
1024
9
44
2.11
1.29
2.0
1.7
—
—
—
0
0
132
1223
1.73
1.26
22.2
14.2
79.82
80.45
ml/min/173m2
0.13
124
1136
48
368
1.45
1.25
2.9
3.1
0.14
0.49
e6/l
1.64
37
259
10
49
2.12
1.25
2.0
2.0
—
—
—
0
0
8
37
2.23
1.23
1.3
1.2
—
—
—
0
0
5
19
2.69
1.22
1.2
1.1
142.00
119.89
%
—
5
19
5
20
2.55
1.16
1.4
1.1
—
—
—
0
0
5
21
2.43
1.10
3.8
4.0
24.56
99.41
u/ml
—
5
21
52
414
1.39
1.09
4.4
3.8
9.11
6.75
mg/mmol
0.21
35
237
49
387
1.40
1.07
1.9
1.6
21.71
22.28
nmol/l
0.07
40
324
34
251
1.46
1.07
2.2
1.6
—
—
—
0
0
13
75
1.80
1.06
1.8
1.5
—
—
—
0
0
9
46
2.02
1.06
1.9
1.8
—
—
—
0
0
19
125
1.60
1.00
3.0
3.6
—
—
—
0
0
98
872
1.37
0.99
4.0
2.9
43.78
39.53
u/l
0.29
93
817
0
30
0.00
0.98
0.0
2.0
—
—
—
0
0
19
126
1.58
0.97
2.3
1.8
—
—
—
0
0
91
803
1.35
0.96
3.4
3.1
—
—
—
0
0
28
206
1.44
0.90
1.9
1.7
1279.12
1318.76
nmol/l
0.07
17
148
86
758
1.32
0.89
4.6
4.1
0.00
10.75
estimate
0.50
11
151
6
30
2.04
0.88
1.3
1.6
—
—
—
0
0
34
261
1.39
0.87
1.4
1.3
9.86
9.08
u/ml
—
9
93
37
289
1.37
0.86
1.4
1.3
28.54
28.23
iu/ml
0.01
14
102
22
156
1.48
0.85
2.2
1.8
—
—
—
0
0
86
761
1.31
0.85
4.6
4.2
0.00
0.00
estimate
—
9
144
13
82
1.64
0.81
2.2
2.2
—
—
—
0
0
37
294
1.34
0.77
1.8
1.4
—
—
—
0
0
5
24
2.12
0.75
1.0
1.2
—
—
—
0
0
84
750
1.28
0.73
4.7
4.1
0.00
0.01
estimate
—
10
149
5
25
2.03
0.73
1.2
1.1
—
1.40
—
0
5
57
485
1.29
0.73
3.7
3.9
16.26
24.43
ng/l
1.57
36
336
7
40
1.79
0.72
1.9
1.9
110.14
100.62
%
—
7
40
142
1377
1.77
0.65
35.0
21.9
4.39
4.40
e12/l
0.05
137
1346
5
29
1.75
0.64
1.6
1.6
—
—
—
0
0
5
30
1.69
0.62
1.2
2.3
5.00
6.94
pmol/l
—
5
30
11
72
1.57
0.61
7.0
5.6
26.02
24.51
mmol/l
1.18
11
72
19
141
1.40
0.60
2.4
1.9
—
—
—
0
0
128
1221
1.36
0.58
6.9
6.1
39.41
38.81
mmol/mol
0.28
119
1142
6
38
1.60
0.55
1.0
1.3
—
—
—
0
0
18
135
1.38
0.54
3.0
4.7
218.17
255.46
u/l
1.01
18
127
15
110
1.40
0.51
5.2
2.4
58.71
63.23
ml/min/173m2
—
7
43
7
50
1.42
0.45
2.1
1.5
—
—
—
0
0
10
70
1.46
0.43
1.4
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
5
34
1.49
0.40
1.0
1.4
—
—
—
0
0
5
36
1.40
0.38
5.0
2.6
—
—
—
0
0
10
73
1.40
0.35
1.9
2.1
—
—
—
0
0
123
1269
0.82
0.34
5.6
4.9
4.64
4.78
mmol/l
0.90
113
1175
11
83
1.35
0.33
1.0
1.0
—
—
—
0
0
63
580
1.15
0.32
4.5
4.0
0.00
0.08
estimate
—
9
122
126
1295
0.82
0.31
6.5
5.7
2.71
2.75
mmol/l
0.23
117
1195
123
1266
0.83
0.30
5.4
4.8
1.60
1.59
mmol/l
0.07
112
1166
46
416
1.15
0.30
3.9
3.5
0.00
0.03
estimate
—
8
121
5
37
1.36
0.24
1.4
1.3
—
—
—
0
0
5
38
1.33
0.23
1.0
1.4
—
—
—
0
0
117
1202
0.87
0.22
4.6
4.1
1.16
1.21
mmol/l
0.59
106
1097
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
10
80
1.27
0.21
1.2
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
6
50
1.21
0.20
1.2
1.1
—
—
—
0
0
14
119
1.19
0.18
3.1
3.9
1.25
1.23
mmol/l
—
8
106
6
75
0.79
0.16
7.7
3.7
49.28
44.25
%
—
6
75
37
344
1.10
0.15
3.9
4.0
1.01
1.02
kg/l
0.86
30
217
5
45
1.11
0.10
2.8
2.7
14.40
38.62
u/ml
—
5
45
5
60
0.83
0.08
3.6
2.4
22.80
24.46
mmol/l
—
5
60
43
413
1.06
0.08
4.3
4.1
0.00
0.01
estimate
0.50
11
141
57
559
1.03
0.03
2.1
1.8
1.20
1.30
mmol/l
0.79
51
471
14
148
0.94
0.02
10.1
7.2
—
—
—
0
0
33
322
1.03
0.02
2.2
1.6
1.21
1.19
mg/l
0.02
28
258
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
108.60
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.30
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
593.44
—
0
9
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
-0.00
4.0
5.8
2.08
1.93
ug/l
—
6
50
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
-0.00
0.0
1.0
—
131.60
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
10.66
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITCHRON and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITCHRON – Chronic thyroiditis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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