No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
171 |
4. Check minimum number of eventsNone |
171 |
5. Include endpointsNone |
171 |
6. Filter based on genotype QC (FinnGen only) |
151 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis acuta
Similar endpoints
↥List of similar endpoints to
Acute thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1138 | 842 | 289 |
| Only index persons | 1081 | 812 | 269 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.43 | 45.51 | 49.44 |
| Only index persons | 45.78 | 44.95 | 48.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 151 | 117 | 34 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | 47.74 | 46.58 | 51.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 157
- Matched controls
- 1570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
201.6
147
*
H03AA01
ATC
levothyroxine sodium; systemic
67.4
124.0
73
20
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
36.9
34
*
H03BB01
ATC
carbimazole; oral
183.9
29.8
30
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
73.5
27.1
30
5
104
Kela drug reimbursment
Thyroid insufficiency
112.8
26.6
28
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
12.0
26.4
29
29
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
21.3
20
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
19.1
18
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
17.0
16
*
BAA60
NOMESCO Finland
Total thyroidectomy
164.7
14.7
15
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
82.1
13.8
15
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
13.7
13
*
H02AB07
ATC
prednisone; oral
4.4
13.2
40
114
T86
ICPC
Hypothyroidism/myxoedema
70.4
11.8
13
*
C07AA05
ATC
propranolol; systemic
3.5
11.6
55
212
H02AB06
ATC
prednisolone; systemic
3.2
11.2
99
548
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
10.5
10
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
106.2
9.5
10
*
2450A
ICD-9 Finland
Thyroiditis, Acute thyroiditis
+∞
9.5
9
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
+∞
9.5
9
*
E03
ICD-10 Finland
Other hypothyroidism
94.9
8.5
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
8.0
77
422
J01FA06
ATC
roxithromycin; oral
2.4
7.0
79
461
E06.3
ICD-10 Finland
Autoimmune thyroiditis
41.9
6.8
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
6.6
84
513
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
63
6.86
19.68
1.3
1.2
225.69
76.81
u/ml
0.60
13
20
136
1041
3.29
6.52
8.9
2.8
15.66
14.46
pmol/l
4.93
130
948
58
340
2.12
4.65
2.8
2.4
298.90
329.28
umol/l
2.20
52
309
146
1260
3.27
3.85
10.2
3.8
1.71
1.84
mu/l
0.90
138
1161
128
1043
2.23
3.79
6.0
4.2
13.30
10.87
mm/h
1.26
122
963
53
329
1.92
3.47
3.4
2.2
2.75
2.69
mg/l
0.06
47
287
9
18
5.23
3.42
1.3
1.4
—
—
—
0
0
90
664
1.83
3.39
6.3
5.5
1.23
1.21
mmol/l
1.20
77
579
35
192
2.06
3.23
3.0
1.7
21.60
24.38
%
0.64
30
180
37
208
2.02
3.19
2.7
1.7
2.43
2.35
g/l
0.34
32
191
25
123
2.23
3.02
3.4
2.1
408.00
366.87
nmol/l
0.31
25
113
82
609
1.73
2.85
3.1
2.3
77.41
76.56
nmol/l
0.10
77
554
97
765
1.70
2.62
6.0
5.9
10.01
10.61
umol/l
0.43
91
729
67
479
1.70
2.62
4.1
2.9
32.52
29.53
u/l
0.52
62
451
76
564
1.67
2.57
2.2
1.9
103.01
94.48
pmol/l
0.67
40
278
61
430
1.68
2.49
2.7
2.4
53.62
63.98
u/l
0.51
55
406
17
78
2.32
2.41
1.4
1.5
—
—
—
0
0
6
14
4.41
2.17
1.3
1.1
—
—
—
0
0
68
507
1.60
2.17
3.3
3.9
44.21
34.23
ng/l
0.15
39
339
42
277
1.70
2.15
1.4
1.3
2.49
12.99
u/ml
2.19
12
112
9
33
2.83
1.96
2.7
2.7
—
—
—
0
0
62
462
1.57
1.94
2.5
3.1
2.35
2.36
mmol/l
0.36
54
426
47
338
1.56
1.68
1.4
1.3
0.65
1.78
u/ml
1.05
11
101
6
19
3.24
1.68
1.5
1.1
—
—
—
0
0
37
254
1.60
1.61
3.9
3.3
146.57
229.18
ng/l
0.21
23
188
95
798
1.48
1.59
11.4
10.4
3.88
4.08
e9/l
0.44
86
694
43
309
1.54
1.54
1.3
1.3
10.17
30.93
iu/ml
3.59
12
102
147
1372
2.12
1.51
5.5
4.6
1.45
1.55
mmol/l
2.54
139
1273
147
1375
2.08
1.45
5.6
4.8
4.68
4.75
mmol/l
0.35
138
1284
6
23
2.67
1.38
1.0
1.3
—
—
—
0
0
10
48
2.16
1.31
2.7
1.7
—
—
—
0
0
5
18
2.83
1.29
1.0
1.1
—
—
—
0
0
147
1389
1.92
1.17
6.5
5.4
2.81
2.76
mmol/l
0.27
137
1291
12
65
1.92
1.17
2.0
2.0
5.67
13.58
nmol/l
2.51
12
60
72
598
1.38
1.16
2.3
1.9
1.51
1.32
mmol/l
0.76
61
507
24
161
1.58
1.15
1.7
1.9
—
—
—
0
0
16
97
1.72
1.11
2.6
2.6
67.21
68.04
g/l
0.30
16
92
39
293
1.44
1.11
2.1
1.7
—
—
—
0
0
42
320
1.43
1.11
1.7
1.6
1.47
1.26
mg/l
0.10
31
261
137
1277
1.57
1.08
7.7
5.7
39.26
38.51
mmol/mol
0.43
129
1209
9
45
2.06
1.07
2.2
2.0
—
—
—
0
0
30
216
1.48
1.06
1.8
1.9
—
—
—
0
0
42
323
1.41
1.05
3.5
3.8
1.02
1.02
kg/l
0.17
31
212
139
1302
1.59
1.04
4.5
4.0
1.34
1.20
mmol/l
1.05
131
1206
5
22
2.31
1.04
2.8
1.3
—
—
—
0
0
5
22
2.31
1.04
1.0
1.2
—
—
—
0
0
51
407
1.37
1.03
4.5
3.7
1.94
8.80
mg/mmol
2.74
37
243
9
48
1.93
1.02
1.4
1.7
0.25
0.21
g/l
—
9
48
7
35
2.05
1.01
1.3
1.8
4.84
3.82
g/l
—
7
35
9
50
1.85
0.98
1.4
1.7
1.28
1.14
g/l
—
9
50
23
159
1.52
0.98
1.8
1.9
—
—
—
0
0
6
27
2.27
0.94
1.3
1.2
—
—
—
0
0
8
42
1.95
0.90
1.1
1.0
—
—
—
0
0
8
42
1.95
0.90
1.1
1.0
—
—
—
0
0
8
43
1.91
0.89
1.1
1.4
—
—
—
0
0
16
104
1.60
0.88
1.4
1.3
—
—
—
0
0
86
757
1.30
0.86
3.8
3.8
0.00
0.00
estimate
-0.00
12
167
6
31
1.97
0.85
1.0
1.9
—
—
—
0
0
144
1372
1.60
0.83
19.3
14.0
18.28
24.15
mg/l
1.75
128
1105
6
32
1.91
0.82
1.2
1.5
—
—
—
0
0
28
210
1.41
0.81
2.1
2.7
0.82
2.97
e6/l
1.83
16
88
6
34
1.79
0.77
1.2
1.2
—
—
—
0
0
140
1331
1.48
0.76
5.8
4.6
5.93
5.82
mmol/l
0.60
133
1233
7
39
1.83
0.73
1.1
1.1
—
4.23
—
0
6
7
39
1.83
0.73
1.0
1.4
—
—
—
0
0
5
27
1.88
0.69
1.0
1.5
—
—
—
0
0
149
1441
1.67
0.67
16.2
11.0
25.76
25.19
u/l
0.21
143
1402
5
28
1.81
0.66
1.8
1.5
—
—
—
0
0
45
377
1.27
0.63
3.7
3.2
765.67
1178.19
ng/l
0.80
38
319
26
202
1.34
0.62
1.7
1.7
1271.50
1322.81
nmol/l
0.12
20
155
5
30
1.69
0.62
1.0
1.6
—
—
—
0
0
6
35
1.74
0.58
2.2
1.5
—
—
—
0
0
6
36
1.69
0.57
1.2
1.1
5.07
0.33
u/ml
—
6
19
6
38
1.60
0.55
1.0
1.4
—
—
—
0
0
14
100
1.44
0.54
1.6
1.3
188.03
126.22
u/ml
0.36
14
94
16
118
1.40
0.52
1.9
2.2
3.70
3.34
mmol/l
0.55
11
94
82
747
1.20
0.52
3.8
3.8
0.00
0.00
estimate
-0.00
12
169
7
45
1.58
0.49
1.6
1.2
—
—
—
0
0
13
94
1.42
0.47
1.5
1.4
30.26
26.66
iu/l
0.16
13
83
83
763
1.19
0.46
3.9
3.9
0.00
0.02
estimate
0.50
12
162
148
1444
1.43
0.45
23.5
17.7
71.97
71.21
umol/l
0.21
148
1426
7
51
1.39
0.44
1.1
1.4
—
—
—
0
0
112
1177
0.83
0.43
25.8
18.2
331.88
331.82
g/l
0.02
112
1171
45
393
1.20
0.43
2.5
2.8
0.16
0.45
e6/l
1.09
31
275
8
56
1.45
0.43
1.4
1.2
—
2.52
—
0
5
5
32
1.58
0.42
1.4
2.6
3.64
4.19
umol/l
—
5
24
28
233
1.25
0.42
2.1
2.6
0.43
0.74
e6/l
0.97
16
109
8
58
1.40
0.42
1.4
1.4
—
—
—
0
0
11
79
1.42
0.42
1.1
1.1
—
—
—
0
0
63
571
1.17
0.40
3.5
3.6
0.00
0.01
estimate
—
9
139
31
263
1.22
0.40
1.9
1.8
422.62
443.90
pmol/l
0.23
26
231
5
35
1.44
0.39
1.6
1.2
—
—
—
0
0
19
152
1.28
0.39
2.3
2.3
3.49
3.16
ratio
0.54
14
132
35
303
1.20
0.37
1.5
1.5
—
—
—
0
0
71
658
1.14
0.32
2.6
2.5
—
—
estimate
—
0
0
5
75
0.66
0.26
3.0
1.8
—
—
—
0
0
9
74
1.23
0.25
1.9
2.7
1.30
1.41
%
—
9
74
12
96
1.27
0.25
2.3
2.9
135.17
129.97
g/l
0.44
12
91
0
11
0.00
0.21
0.0
1.1
—
1.20
—
0
6
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
1.50
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
17
146
1.18
0.20
3.9
3.0
—
—
—
0
0
22
194
1.16
0.20
3.5
4.2
17.50
22.60
%
1.06
11
92
21
185
1.16
0.19
2.0
2.2
—
—
—
0
0
89
924
0.92
0.18
3.2
3.5
—
—
—
0
0
7
59
1.20
0.18
1.4
1.4
—
—
—
0
0
5
67
0.74
0.17
1.0
1.7
—
—
—
0
0
8
71
1.13
0.16
1.1
1.3
—
—
—
0
0
34
314
1.11
0.16
2.2
2.1
—
—
—
0
0
9
82
1.10
0.15
6.4
5.2
24.86
25.00
mmol/l
—
9
82
7
90
0.77
0.15
3.6
2.0
—
—
—
0
0
20
180
1.13
0.14
4.8
5.9
104.50
104.40
mmol/l
0.03
20
180
5
45
1.11
0.10
1.6
1.9
—
—
—
0
0
5
45
1.11
0.10
1.6
1.8
—
—
—
0
0
10
87
1.16
0.09
6.7
7.7
24.45
24.97
mmol/l
—
10
82
5
62
0.80
0.08
3.4
2.0
23.54
24.44
mmol/l
—
5
62
18
166
1.10
0.08
1.9
2.1
—
—
—
0
0
8
74
1.09
0.07
6.3
7.2
24.00
24.19
mmol/l
—
8
74
10
111
0.89
0.06
3.0
2.0
—
—
—
0
0
44
425
1.05
0.06
3.3
3.4
0.00
0.01
estimate
—
8
133
40
411
0.96
0.03
3.5
3.6
0.00
0.00
estimate
-0.00
11
156
15
144
1.05
0.00
3.7
3.0
0.66
0.76
ug/l
—
9
94
15
148
1.01
0.00
6.2
7.2
13.44
12.14
kpa
0.37
15
143
15
145
1.04
0.00
7.7
7.6
—
—
—
0
0
15
148
1.01
0.00
6.2
7.2
5.04
5.18
kpa
0.29
15
143
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
56
0.89
-0.00
1.6
1.7
0.56
1.95
ug/l
—
5
50
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
302.37
—
0
8
0
7
0.00
-0.00
0.0
6.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
10.82
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
9.52
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
4.71
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
25.88
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITACU | 1.181 [0.92, 1.52] | 0.199 |
| Birth year | 0.999 [0.99, 1.01] | 0.739 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 742 females with E4_THYROIDITACU died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | No data |
| 5 | 0.776% | No data |
| 10 | 1.927% | No data |
| 15 | 3.803% | No data |
| 20 | 6.664% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITACU – Acute thyroiditis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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