Diseases of thymus

E4_THYMUSDIS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E32 Cause of death: ICD-10 — E32 2 out of 7 registries used, show all original rules.	81
4. Check minimum number of events None	81
5. Include endpoints E4_HYPERTHY E4_ABSCTHY E4_THYMUSDISNAS	100
6. Filter based on genotype QC (FinnGen only)	92

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E20-E35
Name in latin: Morbi thymi

NAME	E4_THYMUSDIS
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	E4_HYPERTHY\|E4_ABSCTHY\|E4_THYMUSDISNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E32
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E32
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Diseases of thymus based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	615	375	231
Only index persons	454	281	173
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	57.22	60.39	51.51
Only index persons	49.79	52.25	45.80

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	92	55	37
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.69	49.08	45.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
95: Matched controls
950

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E32.9

ICD-10 Finland

Disease of thymus, unspecified

+∞

48.1

E32.0

ICD-10 Finland

Persistent hyperplasia of thymus

+∞

24.0

F32.9

ICD-10 Finland

Depressive episode, unspecified

6.7

16.8

25499

ICD-8 Finland

Diseases of thymus gland

+∞

10.6

E32.8

ICD-10 Finland

Other diseases of thymus

+∞

8.5

2540A

ICD-9 Finland

Diseases of thymus gland, Persistent hyperplasia of thymus

+∞

7.4

D38.3

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Mediastinum

+∞

7.4

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

43.3

6.9

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.8

6.8

N02AX02

ATC

tramadol; systemic, rectal

3.0

6.5

264

GEC24

NOMESCO Finland

Thoracoscopic thymectomy

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023520) Reticulocytes [#/volume] in Blood

3.62

5.64

1.5

3.5

56.85

77.54

e9/l

2.50

(3023368) Bacteria identified in Blood by Culture

212

2.76

5.41

6.1

4.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.65

4.09

1.4

1.2

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

12.67

3.81

1.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

389

2.26

3.61

10.5

7.4

1.21

mmol/l

0.05

327

(3015235) Bicarbonate [Moles/volume] in Capillary blood

4.14

3.54

2.3

1.7

24.70

23.62

mmol/l

0.75

(3041096) Erythrocytes [Presence] in Urine by Automated

238

2.18

3.27

5.4

3.5

0.00

estimate

-0.00

(3002030) Lymphocytes/Leukocytes in Blood

399

2.16

3.27

6.8

6.5

26.59

27.70

0.32

380

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

198

2.22

3.24

3.5

2.2

—

(3035350) Ketones [Presence] in Urine by Test strip

430

2.17

3.20

5.2

4.0

0.00

17.46

estimate

0.49

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

319

2.11

3.15

5.2

3.9

0.00

0.03

estimate

0.49

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.94

3.14

1.5

1.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

356

2.11

3.14

2.8

2.6

79.17

76.74

nmol/l

0.27

319

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

311

2.10

3.12

5.2

3.8

61.16

35.86

ng/l

0.32

201

(3018010) Neutrophils/Leukocytes in Blood

394

2.12

3.12

6.7

6.4

57.58

57.95

0.08

375

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

348

2.09

3.09

2.5

2.1

96.02

96.49

pmol/l

0.03

189

(3021601) Nitrite [Presence] in Urine by Test strip

424

2.13

3.08

5.2

4.0

0.00

estimate

-0.00

(3044640) Blood type and Crossmatch panel - Blood

260

2.10

3.07

3.8

2.3

—

(3015736) pH of Urine

341

2.07

3.02

3.9

3.6

6.29

6.17

0.34

181

(3022096) Basophils/Leukocytes in Blood

391

2.05

2.91

6.8

6.7

0.75

0.68

0.28

367

(3006504) Eosinophils/Leukocytes in Blood

391

2.05

2.91

6.7

6.5

2.68

2.77

0.12

367

(3019977) pH of Arterial blood

2.51

2.87

8.9

9.2

7.42

7.43

0.06

(3019069) Monocytes/Leukocytes in Blood

393

2.04

2.85

6.8

6.7

9.10

8.54

0.69

372

(3009261) Glucose [Presence] in Urine by Test strip

435

2.03

2.75

5.3

4.0

0.00

estimate

-0.00

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.49

2.74

1.4

1.2

—

(42870588) Differential panel, method unspecified - Blood

280

1.98

2.65

4.7

6.0

—

(3013115) Eosinophils [#/volume] in Blood

439

2.00

2.63

6.7

0.18

0.19

e9/l

0.17

386

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.27

2.63

1.4

1.2

—

(40767503) Oxygen content in Capillary blood by calculation

4.63

2.52

1.7

2.1

16.74

15.79

—

(3019198) Lymphocytes [#/volume] in Blood

434

1.95

2.50

6.9

6.4

1.79

1.92

e9/l

0.42

386

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

6.52

2.40

1.4

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

363

1.87

2.33

4.2

2.8

—

estimate

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

4.85

2.31

1.0

1.8

—

(3018418) pH of Serum or Plasma

239

1.90

2.27

7.1

3.7

7.40

0.34

164

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

5.79

2.24

2.8

2.3

—

(3001604) Monocytes [#/volume] in Blood

424

1.86

2.23

6.7

6.3

0.60

0.58

e9/l

0.27

365

(3006315) Basophils [#/volume] in Blood

426

1.85

2.18

6.7

6.3

0.04

e9/l

0.20

367

(3032080) INR in Blood by Coagulation assay

342

1.82

2.13

15.8

11.6

1.16

1.24

inr

0.49

280

(3019060) Gas panel - Arterial blood

2.60

2.12

4.0

4.5

—

(3021901) Oxygen saturation in Capillary blood

3.69

2.10

2.9

1.6

91.16

90.77

—

(1616796) Gas panel - Central venous blood

3.69

2.10

3.3

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.70

2.09

1.4

1.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

5.21

2.09

8.0

2.6

2.04

3.08

nmol/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

245

1.84

2.07

3.0

3.3

930.22

1178.85

ng/l

0.38

198

(3028626) Oxygen [Partial pressure] in Capillary blood

3.26

2.06

2.9

1.7

9.22

8.04

kpa

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

115

2.06

2.03

12.7

7.3

103.00

104.57

mmol/l

0.68

115

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

3.69

1.87

1.0

1.3

—

(3026008) Bacteria identified in Urine by Culture

243

1.78

1.86

6.3

3.4

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

3.20

1.84

1.4

1.8

125.57

125.61

g/l

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.20

1.84

1.0

1.6

—

(3021960) Folate [Moles/volume] in Serum or Plasma

237

1.75

1.78

2.1

1.7

21.77

21.92

nmol/l

0.02

202

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

137

1.90

1.76

2.1

2.0

—

(3043409) Potassium [Moles/volume] in Arterial blood

3.06

1.76

5.4

3.8

3.81

4.04

mmol/l

—

(3022313) Gas panel - Capillary blood

2.60

1.70

7.2

3.7

—

(3042936) Bacteria identified in Isolate by Culture

123

1.91

1.68

2.6

1.9

—

(3025941) Bacteria identified in Stool by Culture

2.54

1.68

1.4

1.1

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

468

1.69

1.65

12.0

11.1

3.93

4.02

e9/l

0.11

411

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.36

1.64

5.0

2.5

1.62

1.51

0.07

(3021589) Normoblasts [#/volume] in Blood

343

1.66

1.62

13.6

12.0

0.01

e9/l

0.08

273

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

2.55

1.58

8.6

4.3

24.98

24.97

mmol/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.31

1.57

9.5

8.4

24.36

25.02

mmol/l

0.35

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

1.57

0.0

1.2

—

0.91

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

1.57

0.0

1.2

—

1.59

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

1.57

0.0

1.1

—

0.65

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.46

1.54

1.0

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.98

1.53

2.1

1.7

347.13

376.13

nmol/l

0.28

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.92

1.47

2.2

1.7

—

(3000991) Gas panel - Venous blood

2.06

1.41

15.8

9.2

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.71

1.39

1.0

1.5

—

(3003740) Influenza virus B Ag [Presence] in Specimen

3.04

1.37

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

3.04

1.37

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.89

1.35

2.1

1.8

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.13

1.33

13.7

10.9

0.54

0.67

1.00

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.21

1.33

5.4

2.5

0.54

0.62

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

609

1.66

1.30

6.0

4.4

14.23

11.49

mm/h

0.92

562

(3037756) Immunofixation for Serum or Plasma

2.87

1.30

1.2

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.87

1.30

1.0

1.3

—

(3018095) Leukocytes [#/volume] in Urine

303

1.55

1.25

5.0

4.3

40.48

43.54

e6/l

0.06

201

(3050129) First trimester maternal screen panel - Serum or Plasma

2.72

1.23

1.6

1.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.05

1.22

13.2

10.6

1.04

1.49

0.98

(4035726) Immunohistochemistry procedure

1.93

1.22

1.3

—

(3012544) pH of Venous blood

1.84

1.20

7.6

2.9

7.38

7.40

—

(3019150) Specific gravity of Urine by Refractometry

189

1.60

1.17

3.9

3.6

1.02

kg/l

0.20

111

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.58

1.16

1.0

1.8

—

(3020891) Body temperature

2.09

1.15

5.3

3.8

36.95

37.02

°c

—

(3002179) Metamyelocytes/Leukocytes in Blood

1.98

1.12

5.6

6.2

0.70

0.52

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

2.04

1.12

1.3

1.6

5.66

8.07

ug/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.03

1.11

2.0

2.2

—

(3025159) Blasts/Leukocytes in Blood

1.88

1.06

5.8

6.8

0.00

0.10

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.78

1.05

1.8

1.7

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.34

1.04

1.6

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

125

1.65

1.04

3.2

3.0

5.90

2.35

e6/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

101

1.70

1.01

1.8

1.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.99

0.0

1.3

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

648

1.55

0.98

36.8

19.9

13.92

13.69

0.60

643

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

280

1.46

0.95

4.5

3.2

—

(3000494) Fungus identified in Specimen by Culture

103

1.67

0.95

1.4

1.5

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.84

0.94

2.0

2.5

65.11

66.60

g/l

0.21

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

2.14

0.91

2.2

1.7

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.81

0.90

1.2

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.07

0.88

1.8

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

529

1.43

0.87

3.2

—

(3029937) Albumin [Presence] in Urine by Test strip

241

1.42

0.80

7.0

4.0

0.00

estimate

-0.00

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.24

0.77

1.2

1.1

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

2.24

0.77

5.4

2.6

2.68

3.44

g/l

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.24

0.77

1.6

5.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.67

0.75

4.1

3.8

1.23

mmol/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.05

0.74

2.4

2.8

0.00

g/l

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.97

0.71

1.2

1.5

—

(3007566) Smooth muscle Ab [Titer] in Serum

1.97

0.71

1.0

1.1

—

58.00

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.76

0.71

1.4

11.53

23.81

iu/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.76

0.71

1.3

1.0

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.90

0.69

1.4

1.3

—

(3034770) Mitochondria Ab [Titer] in Serum

1.90

0.69

1.0

1.1

—

(3012516) Albumin [Mass/volume] in Urine

248

1.37

0.67

3.0

3.2

67.48

53.96

mg/l

0.13

163

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

787

1.58

0.67

29.2

15.9

30.84

21.10

mg/l

1.47

642

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.57

0.63

3.7

2.9

26.67

30.35

u/l

0.32

(40768797) Stomach Pathology biopsy report

124

1.45

0.61

1.2

—

(3003694) ABO and Rh group [Type] in Blood

217

1.34

0.57

1.8

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.42

0.52

1.1

1.9

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.60

0.50

1.1

2.8

—

(40761511) CBC panel - Blood by Automated count

811

1.46

0.46

26.1

13.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

123

1.36

0.44

1.3

1.4

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.65

0.44

1.0

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.41

0.43

1.9

2.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

207

1.28

0.42

2.0

3.1

338.80

338.11

umol/l

0.01

180

(3002582) Erythrocytes [#/volume] in Urine

264

1.26

0.42

4.9

3.5

19.30

29.99

e6/l

0.59

197

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.41

0.0

2.5

—

32.38

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

134

1.33

0.40

3.6

2.9

0.42

0.77

e6/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.41

0.39

1.8

2.5

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

827

1.42

0.38

17.2

12.2

23.15

26.44

u/l

1.99

813

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

110

1.32

0.34

3.0

2.3

—

(3000492) Spirometry study

1.35

0.31

1.2

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

254

1.20

0.30

4.2

3.9

6.74

8.93

mg/mmol

0.20

162

(3002256) Pathology report gross observation

1.32

0.30

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.35

0.29

3.9

3.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

141

1.25

0.28

2.4

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.27

0.28

2.1

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

105

1.28

0.26

1.7

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

201

1.19

0.24

1.2

1.3

7.69

1.45

u/ml

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.37

0.24

2.8

2.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

163

1.21

0.24

1.1

1.3

25.63

36.78

iu/ml

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.33

0.23

1.4

1.8

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.33

0.23

1.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

1.26

0.23

1.6

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

164

1.20

0.22

2.7

2.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.26

0.22

2.9

2.2

—

(3028300) Cannabinoids [Presence] in Urine

1.20

0.22

1.6

1.7

—

(3027944) Amphetamines [Presence] in Urine

1.20

0.22

1.6

1.7

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

69.40

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.21

0.0

1.5

—

528.60

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.3

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.21

0.0

1.0

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

12.38

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.1

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.27

0.20

3.2

1.9

247.50

129.57

ng/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.24

0.20

2.0

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.24

0.20

1.3

2.6

3.12

5.15

ug/l

—

(1761868) Lipid panel - Serum or Plasma

329

0.87

0.20

3.1

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.20

0.0

1.0

—

3.00

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.20

0.0

1.6

—

(3022145) Colonoscopy Study observation

1.24

0.18

1.0

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

110

1.21

0.18

2.0

1.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

749

0.89

0.13

4.4

4.2

1.27

mmol/l

0.01

697

(40758558) Short blood count panel - Blood

243

1.10

0.10

15.3

7.5

—

(1002224) Polysomnography panel

1.07

0.09

1.2

1.0

—

(40761535) Cells panel - Urine sediment

1.10

0.09

3.2

3.6

—

(40761536) Microorganisms panel - Urine sediment

1.10

0.08

15.7

4.0

—

(36660697) Celiac disease serology panel - Serum

0.81

0.08

1.2

—

(40768804) Tissue Pathology biopsy report

325

1.07

0.07

1.8

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

169

1.08

0.05

1.7

1.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

790

0.93

0.04

5.6

2.60

2.77

mmol/l

0.72

737

(3030467) Casts [#/volume] in Urine by Automated count

231

1.05

0.03

5.4

3.1

0.10

0.40

e6/l

1.68

167

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

773

1.05

0.01

4.7

5.0

1.41

1.46

mmol/l

0.42

722

(40760892) CBC W Ordered Manual Differential panel - Blood

198

1.01

0.00

8.5

5.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

169

1.01

0.00

3.5

4.1

17.63

20.67

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

779

1.01

0.00

4.9

5.1

4.44

4.69

mmol/l

1.02

732

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

119

1.01

0.00

2.6

3.0

0.41

0.69

ug/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

336

1.02

0.00

1.6

2.0

1.39

1.45

mmol/l

0.09

287

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

94.57

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.6

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

206.80

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.4

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.0

2.4

—

0.37

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.0

—

6.98

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

1235.00

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.6

—

140.59

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(4146454) Self-monitoring of blood glucose

0.00

0.0

2.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

57.88

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.3

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

2.7

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.1

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(44806420) Estimation of glomerular filtration rate

0.00

0.0

1.7

—

(4062490) Immunoglobulin typing, IgG

0.00

0.0

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.97

0.00

5.1

6.1

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.4

—

26.62

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.4

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

11.12

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.3

—

(3010813) Leukocytes [#/volume] in Blood

852

1.10

-0.00

43.8

24.0

6.85

6.63

e9/l

0.44

838

(3000963) Hemoglobin [Mass/volume] in Blood

852

1.10

-0.00

43.9

24.0

128.83

135.27

g/l

2.81

847

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.0

—

15.17

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3026361) Erythrocytes [#/volume] in Blood

852

1.10

-0.00

43.6

23.9

4.29

4.50

e12/l

2.62

837

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

14.5

—

0.74

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

190

1.00

-0.00

1.6

1.4

1.74

2.63

g/l

1.92

113

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3007461) Platelets [#/volume] in Blood

851

1.11

-0.00

43.7

23.9

254.21

253.03

e9/l

0.05

841

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYMUSDIS and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_THYMUSDIS	2.212 [1.49, 3.28]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.041

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 234 females with E4_THYMUSDIS died.

Males

Parameter	HR [95% CI]	p-value
E4_THYMUSDIS	3.602 [1.75, 7.41]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 149 males with E4_THYMUSDIS died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYMUSDIS.

N-year risk	Females	Males
1	0.18%	0.795%
5	1.148%	4.018%
10	2.685%	9.576%
15	5.111%	17.15%
20	9.273%	29.089%

Relationships between endpoints

↥

Index endpoint: E4_THYMUSDIS – Diseases of thymus

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Diseases of thymus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints