Thyroid crisis or storm

E4_THYCRISIS

Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E05.5 Cause of death: ICD-10 — E05.5 2 out of 7 registries used, show all original rules.	91
4. Check minimum number of events None	91
5. Include endpoints None	91
6. Filter based on genotype QC (FinnGen only)	85

Control definitions (FinnGen only)

Control exclude: E4_THYROID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E05
Name in latin: Crisis thyreotoxica

NAME	E4_THYCRISIS
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E055
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E055
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Thyroid crisis or storm based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	550	428	119
Only index persons	515	401	114
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	50.42	49.11	55.48
Only index persons	49.42	47.76	55.28

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	85	67	18
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	49.20	48.15	53.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
89: Matched controls
890

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H03AA01

ATC

levothyroxine sodium; systemic

624.0

160.0

E05.5

ICD-10 Finland

Thyroid crisis or storm

+∞

120.1

H03BB01

ATC

carbimazole; oral

2304.1

96.1

E05.0

ICD-10 Finland

Thyrotoxicosis with diffuse goitre

+∞

96.0

E05.9

ICD-10 Finland

Thyrotoxicosis, unspecified

+∞

59.1

BAA60

NOMESCO Finland

Total thyroidectomy

+∞

49.7

104

Kela drug reimbursment

Thyroid insufficiency

831.5

48.1

E89.01

ICD-10 Finland

Postsurgical hypothyroidism

+∞

34.7

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

190.7

27.3

H06.2*E05.9

ICD-10 Finland

Dysthyroid exophthalmos

+∞

25.2

E03

ICD-10 Finland

Other hypothyroidism

192.4

16.0

E03.89

ICD-10 Finland

Other specified hypothyroidism

88.8

14.0

E05.2

ICD-10 Finland

Thyrotoxicosis with toxic multinodular goitre

+∞

13.9

E89.00

ICD-10 Finland

Postirradiation hypothyroidism

+∞

13.9

C07AA05

ATC

propranolol; systemic

5.3

13.4

124

H062, E050,

ICD-10 Finland

+∞

11.7

E05

ICD-10 Finland

Thyrotoxicosis [hyperthyroidism]

+∞

11.7

T86

ICPC

Hypothyroidism/myxoedema

+∞

10.6

BA1AE

NOMESCO Finland

Thyroiid ultrasound examination

55.7

8.9

T85

ICPC

Hyperthyroidism/thyrotoxicosis

+∞

7.4

E03.80

ICD-10 Finland

Hypothyroidism caused by autoimmune thyroiditis

+∞

7.4

Z03.80

ICD-10 Finland

Observation for other suspected diseases and conditions

15.4

7.1

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

75.0

6.5

H05.2

ICD-10 Finland

Exophthalmic conditions

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

6.24

10.66

1.5

1.2

328.76

49.43

u/ml

1.43

(42868691) Thyroxine (T4) free [Moles/volume] in Serum or Plasma by Dialysis

+∞

6.32

2.8

0.0

38.50

—

pmol/l

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

384

2.59

4.33

7.8

6.1

1.21

1.22

mmol/l

0.29

330

(3018418) pH of Serum or Plasma

242

2.39

3.91

4.0

3.7

7.41

7.40

0.37

168

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

5.43

3.47

1.0

1.2

—

16.52

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

330

2.18

3.19

4.1

3.7

35.88

36.13

g/l

0.11

316

(3019309) Folate [Moles/volume] in Red Blood Cells

105

2.45

3.00

1.4

1.7

893.63

1348.34

nmol/l

2.44

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

197

2.17

2.97

1.4

1.2

1.22

1.98

u/ml

—

(3019069) Monocytes/Leukocytes in Blood

372

1.96

2.44

8.0

5.4

8.17

8.19

0.01

355

(3002030) Lymphocytes/Leukocytes in Blood

382

1.96

2.43

8.2

5.4

25.88

27.35

0.37

369

(3007164) IgA [Mass/volume] in Serum or Plasma

181

1.99

2.28

1.5

1.3

2.10

2.17

g/l

0.13

111

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

332

1.88

2.22

2.0

1.9

99.35

95.71

pmol/l

0.21

160

(3006504) Eosinophils/Leukocytes in Blood

370

1.89

2.22

8.1

5.4

2.72

2.69

0.04

351

(3022096) Basophils/Leukocytes in Blood

370

1.89

2.22

8.2

5.4

0.72

0.67

0.26

345

(3013650) Neutrophils [#/volume] in Blood by Automated count

464

1.90

2.09

10.7

10.5

4.11

4.19

e9/l

0.08

406

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.83

2.08

1.2

1.1

—

(40758558) Short blood count panel - Blood

240

1.84

2.00

5.5

7.3

—

(42870588) Differential panel, method unspecified - Blood

250

1.82

1.96

7.9

5.3

—

(3018010) Neutrophils/Leukocytes in Blood

373

1.78

1.88

8.3

5.3

57.70

58.29

0.12

359

(3022145) Colonoscopy Study observation

2.16

1.83

1.4

1.2

—

(3027945) Reticulocytes/Erythrocytes in Blood

2.26

1.82

3.1

2.7

1.84

1.65

0.27

(3001604) Monocytes [#/volume] in Blood

407

1.75

1.76

8.0

5.9

0.58

0.55

e9/l

0.38

358

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.10

1.73

2.4

2.1

25.94

27.56

u/l

0.18

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

2.83

1.61

2.3

1.6

219.34

214.41

ug/l

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

151

1.81

1.56

1.2

1.4

53.03

9.86

u/ml

—

(3006315) Basophils [#/volume] in Blood

407

1.67

1.53

8.1

5.9

0.04

e9/l

0.08

356

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

136

1.82

1.51

6.0

3.0

50.21

75.91

ng/l

0.21

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.62

1.48

1.1

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.27

1.39

1.0

—

(4035726) Immunohistochemistry procedure

2.04

1.37

1.7

1.4

—

(36660697) Celiac disease serology panel - Serum

2.08

1.35

1.2

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.21

1.35

2.7

1.4

—

(3014051) Protein [Presence] in Urine by Test strip

248

1.60

1.27

2.4

3.2

—

0.00

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.50

1.26

1.2

2.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.50

1.26

1.2

2.2

—

(3023368) Bacteria identified in Blood by Culture

198

1.60

1.18

3.1

3.8

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

742

2.02

1.17

17.0

14.0

86.86

84.64

ml/min/173m2

0.38

685

(3037467) Urinalysis macro (dipstick) panel - Urine

549

1.59

1.13

4.1

4.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.46

1.10

1.2

—

(40768804) Tissue Pathology biopsy report

332

1.50

1.06

2.1

1.9

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.35

1.04

1.0

1.2

—

(3015736) pH of Urine

353

1.49

1.03

2.7

3.4

6.21

6.18

0.06

200

(3020891) Body temperature

0.00

0.99

0.0

4.2

—

37.02

—

(40768443) Skin Pathology biopsy report

2.31

0.95

1.0

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.14

0.91

2.5

1.8

—

(3021589) Normoblasts [#/volume] in Blood

350

1.44

0.90

12.6

12.1

0.00

e9/l

0.50

287

(3004588) Protein electrophoresis panel - Serum or Plasma

1.90

0.88

1.0

2.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.90

0.88

1.3

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.68

0.87

1.8

1.6

—

(40768793) Breast Pathology biopsy report

1.85

0.87

1.6

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

277

1.43

0.84

3.2

3.7

35.72

26.16

ng/l

0.33

188

(1002224) Polysomnography panel

1.77

0.83

1.0

1.1

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.80

0.0

1.2

—

2.18

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.80

0.0

1.3

—

22.11

—

(3035350) Ketones [Presence] in Urine by Test strip

435

1.40

0.80

3.1

3.9

0.00

estimate

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.74

0.77

2.3

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

180

1.46

0.76

1.7

1.6

1.25

1.45

mg/l

0.10

148

(3009261) Glucose [Presence] in Urine by Test strip

440

1.37

0.72

3.1

3.9

0.00

estimate

—

(3044640) Blood type and Crossmatch panel - Blood

266

1.38

0.70

2.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

174

1.43

0.69

1.4

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

432

1.36

0.69

3.1

3.9

0.00

estimate

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.83

0.67

1.0

1.5

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.60

0.0

1.3

—

(3000492) Spirometry study

1.54

0.58

1.3

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

722

1.49

0.57

6.4

6.0

38.17

38.67

mmol/mol

0.24

683

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.67

0.57

2.0

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

790

1.75

0.55

16.9

13.7

20.57

22.28

mg/l

0.18

634

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

154

1.39

0.55

1.8

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

193

1.33

0.51

1.9

2.0

—

(3013512) EKG study

243

1.29

0.46

3.6

3.5

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

449

1.26

0.45

5.6

4.3

6.46

6.55

mmol/l

0.15

427

(3000494) Fungus identified in Specimen by Culture

1.41

0.44

1.6

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.47

0.44

1.6

2.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

169

1.32

0.44

1.2

1.4

9.30

24.28

iu/ml

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.41

0.0

1.3

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.40

0.40

1.6

2.1

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.39

0.35

12.8

6.8

25.33

25.03

mmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

101

1.34

0.34

1.8

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

206

0.78

0.34

8.1

5.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

252

1.22

0.33

3.3

0.00

0.01

estimate

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.38

0.32

1.1

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

121

1.29

0.31

2.1

1.7

—

(3000991) Gas panel - Venous blood

1.27

0.30

11.9

6.4

—

(3045414) Leukocytes [Presence] in Urine

0.69

0.27

1.0

1.8

—

0.00

estimate

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.73

0.25

2.2

7.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.30

0.23

2.9

3.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

101

0.77

0.22

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

123

0.79

0.22

2.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.3

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.21

0.0

1.5

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.1

—

31.17

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.30

0.21

14.0

4.8

22.75

24.74

mmol/l

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.5

—

1.19

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.5

—

3.90

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.2

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.21

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.5

—

108.15

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.20

0.0

1.3

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.20

0.0

2.1

—

9.50

—

(40761536) Microorganisms panel - Urine sediment

1.12

0.16

3.9

3.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

376

1.12

0.15

2.6

—

estimate

—

(21494755) Public health laboratory ask at order entry panel

1.21

0.15

1.2

1.4

—

(3002256) Pathology report gross observation

105

0.84

0.14

1.3

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

228

0.90

0.11

2.6

2.8

0.59

0.41

e6/l

0.24

160

(3019832) Treponema pallidum Ab [Presence] in Serum

1.18

0.11

1.7

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

115

0.85

0.11

2.0

—

(3012516) Albumin [Mass/volume] in Urine

232

1.11

0.11

3.4

2.9

10.76

44.98

mg/l

1.67

146

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.12

0.10

2.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

343

1.08

0.09

3.5

3.6

0.00

estimate

—

(40768797) Stomach Pathology biopsy report

107

1.14

0.09

1.3

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

164

0.90

0.08

2.3

2.0

—

(3019150) Specific gravity of Urine by Refractometry

186

1.10

0.08

3.4

3.6

1.02

kg/l

0.00

119

(36304419) Bacteria [Presence] in Urine

214

0.92

0.08

2.7

2.8

—

estimate

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

355

1.07

0.07

2.0

1.9

1.33

1.32

mmol/l

0.03

299

(40761511) CBC panel - Blood by Automated count

806

1.22

0.07

17.1

12.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.04

0.07

2.2

1.6

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

673

0.93

0.07

26.3

17.4

13.42

13.62

0.88

663

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

141

0.91

0.06

1.7

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

238

1.07

0.05

4.0

3.5

1.61

8.89

mg/mmol

1.69

143

(3003694) ABO and Rh group [Type] in Blood

242

0.93

0.05

1.3

1.6

—

(3000850) Epithelial cells [#/volume] in Urine

171

0.92

0.05

2.6

5.40

6.04

e6/l

0.12

158

(1761868) Lipid panel - Serum or Plasma

322

0.94

0.05

2.8

3.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

552

0.94

0.05

3.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

271

0.94

0.04

2.7

3.0

—

(3029937) Albumin [Presence] in Urine by Test strip

229

0.95

0.03

3.3

3.8

0.00

estimate

—

(3026008) Bacteria identified in Urine by Culture

257

0.96

0.01

2.8

3.0

—

(3042936) Bacteria identified in Isolate by Culture

108

1.02

0.00

1.9

—

(3002582) Erythrocytes [#/volume] in Urine

255

0.97

0.00

2.7

3.1

52.27

44.93

e6/l

0.08

188

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.06

0.00

7.9

6.4

107.20

104.16

mmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

116

1.04

0.00

2.4

3.0

25.60

3.38

e6/l

—

(3018095) Leukocytes [#/volume] in Urine

296

1.02

0.00

3.0

4.0

29.64

67.55

e6/l

0.35

201

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.2

—

31.68

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.0

—

114.17

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

2.2

—

11.27

—

(3004451) EKG impression Narrative

0.00

0.0

1.7

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

2.3

—

71.50

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.4

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

3.67

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

257.14

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.7

—

2.00

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.0

—

218.27

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

4.7

—

0.83

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.0

—

7.32

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.8

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

7.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.98

-0.00

1.5

1.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

223.76

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3033306) Mononuclear cells/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

3.36

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3012565) Volume of 24 hour Urine

0.00

-0.00

0.0

4.2

—

2110.00

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.00

-0.00

2.2

1.6

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

6.5

—

577.38

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

45.12

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.91

-0.00

1.5

1.7

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

12.6

—

1038.80

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

3.2

—

10.84

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1378.20

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

-0.00

0.0

7.8

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

1.7

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYCRISIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYCRISIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_THYCRISIS – Thyroid crisis or storm

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Thyroid crisis or storm

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints