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Disorders of phosphorus metabolism and phosphatases

DOID EFO Endpoint Browser PheWeb

E4_PHOS_MET

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E83.3
  • Hospital discharge: ICD-9 — 2753
  • Cause of death: ICD-10 — E83.3
  • Cause of death: ICD-9 — 2753
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — E83.3

3 out of 7 registries used, show all original rules.

190

4. Check minimum number of events

None

190

5. Include endpoints

None

190

6. Filter based on genotype QC (FinnGen only)

184

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E83
Name in latin
Perturbationes metabolismi phosphori

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 908 443 459
Only index persons 819 399 420
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 54.06 52.80 55.17
Only index persons 54.59 53.52 55.61

-FinnGen-

Key figures

All Female Male
Number of individuals 184 96 88
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 53.84 50.34 57.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
190
Matched controls
1900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
+∞
205.4
158
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
94.1
55.0
59
9
A11CC03
ATC
alfacalcidol; systemic
78.8
47.3
52
9
V03AG01
ATC
sodium cellulose phosphate; systemic
513.5
43.0
41
*
E87.6
ICD-10 Finland
Hypokalaemia
91.8
39.9
43
6
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.1
31.6
44
61
E83.4
ICD-10 Finland
Disorders of magnesium metabolism
+∞
28.9
27
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
13.0
28.2
29
26
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
+∞
27.8
26
*
E83.30
ICD-10 Finland
Acid phosphatase deficiency
+∞
26.7
25
*
E83.51
ICD-10 Finland
Hypocalcemia
149.7
25.3
26
*
A12AA04
ATC
calcium carbonate; oral
65.2
24.8
28
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.5
23.1
90
318
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.4
23.1
100
382
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.7
20.7
32
49
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.8
19.5
41
86
D64.9
ICD-10 Finland
Anaemia, unspecified
5.4
17.6
40
90
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
55.5
17.4
20
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.2
17.1
40
92
M05BX04
ATC
denosumab; parenteral
7.6
17.1
26
39
JN3AD
NOMESCO Finland
Abdominal CT examination
4.6
16.7
48
131
E83.50
ICD-10 Finland
Hypercalcemia
87.0
14.8
16
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
14.5
51
161
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
14.2
49
152
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.8
13.4
34
83
AA1AD
NOMESCO Finland
CT of head and brain
3.3
13.4
71
291
N17.9
ICD-10 Finland
Acute renal failure, unspecified
12.9
12.7
22
19
C03CA01
ATC
furosemide; systemic
3.2
12.4
64
257
R4190
NOMESCO Finland
Nutritional therapy
5.4
12.3
26
54
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.3
12.1
26
55
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.6
11.8
46
154
WZC00
NOMESCO Finland
Treatment plan or consultation
2.9
11.7
95
489
TPH07
NOMESCO Finland
Cathetrisation of artery
4.2
11.6
34
93
M05BA04
ATC
alendronic acid; oral
5.2
11.3
25
54
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
11.1
57
226
ZX120
NOMESCO Finland
Intravenous
4.4
11.1
30
77
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.4
10.8
29
74
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.0
10.6
34
99
H02AB09
ATC
hydrocortisone; systemic
13.1
10.6
18
15
B05XA09
ATC
sodium phosphate; parenteral
+∞
10.5
10
*
2753A
ICD-9 Finland
Disorders of mineral metabolism, Disorders of phosphorus metabolism[HYPOPHOSPHATHAEMIA FAMILIARIS]
+∞
10.5
10
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.9
10.3
34
101
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
10.2
108
624
SBB10
NOMESCO Finland
Dental impressions
3.7
10.0
35
108
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
10.0
59
252
N06AX11
ATC
mirtazapine; oral
2.7
9.9
83
425
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.1
9.8
22
48
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.4
9.8
40
137
R50.9
ICD-10 Finland
Fever, unspecified
3.2
9.8
48
184
321
Kela drug reimbursment
Paricalcitol and cinacalcet
58.0
9.8
11
*
WX002
NOMESCO Finland
Sedation and analgesia
3.1
9.7
49
191
A02BC02
ATC
pantoprazole; systemic
2.9
9.6
143
968
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.6
65
298
E86
ICD-10 Finland
Volume depletion
31.8
9.5
12
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.2
9.3
20
42
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
16.7
9.2
14
9
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
8.8
82
437
L04AX01
ATC
azathioprine; systemic
7.6
8.8
20
29
H02AB06
ATC
prednisolone; systemic
2.5
8.8
101
594
H05BX01
ATC
cinacalcet; oral
52.5
8.8
10
*
E21.2
ICD-10 Finland
Other hyperparathyroidism
52.5
8.8
10
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
17.3
8.7
13
8
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
11.5
8.5
15
14
E83.9
ICD-10 Finland
Disorder of mineral metabolism, unspecified
+∞
8.4
8
*
R4110
NOMESCO Finland
Physiotherapy
2.6
8.4
70
353
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
8.3
54
240
KA1AE
NOMESCO Finland
Kidney ultrasound examination
9.6
8.2
16
18
L04AD02
ATC
tacrolimus; systemic
18.2
8.2
12
7
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
35.0
8.2
10
*
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
23.2
8.1
11
5
127
Kela drug reimbursment
Transplant complication
13.8
8.0
13
10
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
6.4
7.9
20
34
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
7.9
29
92
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.5
7.9
65
324
UJF32
NOMESCO Finland
Coloscopy
2.6
7.9
60
288
A28
ICPC
Limited function/disability NOS
3.0
7.8
39
150
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
7.2
7.8
18
27
N02AX02
ATC
tramadol; systemic, rectal
2.4
7.8
91
531
R11
ICD-10 Finland
Nausea and vomiting
3.5
7.8
29
93
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.7
7.7
17
24
K70.0
ICD-10 Finland
Alcoholic fatty liver
83.2
7.5
8
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.7
7.4
18
29
A03FA01
ATC
metoclopramide; systemic, rectal
2.6
7.4
52
240
A12AA06
ATC
calcium lactate gluconate; oral
+∞
7.3
7
*
E83.8
ICD-10 Finland
Other disorders of mineral metabolism
+∞
7.3
7
*
Z94.0
ICD-10 Finland
Kidney transplant status
21.0
7.2
10
5
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.0
7.1
35
133
Z2446
NOMESCO Finland
Social worker
3.5
7.0
26
83
N18.8
ICD-10 Finland
Other chronic renal failure
14.5
7.0
11
8
XF600
NOMESCO Finland
Bloodpressure measurement
3.9
7.0
21
58
WX892
NOMESCO Finland
Monitored bed care
3.9
7.0
21
58
M13.9
ICD-10 Finland
Arthritis, unspecified
3.8
6.9
22
63
A04
ICPC
Weakness/tiredness general
2.9
6.9
37
148
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.9
6.9
37
148
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
41.6
6.8
8
*
B05DB
ATC
Hypertonic solutions
41.6
6.8
8
*
V03AE01
ATC
polystyrene sulfonate; oral
41.6
6.8
8
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
41.6
6.8
8
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.3
6.8
18
45
EBA15
NOMESCO Finland
Extraction of multiple teeth
6.3
6.8
17
29
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
23.5
6.7
9
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
6.7
29
102
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
6.6
94
586
ZXE00
NOMESCO Finland
One hour or less
2.2
6.6
84
501
C07AB02
ATC
metoprolol; systemic
2.8
6.6
38
158
205
Kela drug reimbursment
Chronic hypertension
2.5
6.5
46
212
Z3226
NOMESCO Finland
Physiotherapist
2.5
6.5
46
212
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.4
6.5
16
27
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
6.4
28
99
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.8
6.4
12
13
TK800
NOMESCO Finland
Hemodialysis
11.6
6.4
11
10
WW500
NOMESCO Finland
Blood transfusion
5.4
6.4
18
36
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.6
6.4
22
67
137
Kela drug reimbursment
Uraemia requiring dialysis
18.8
6.3
9
5
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
6.3
26
89
A11CC02
ATC
dihydrotachysterol; oral
+∞
6.3
6
*
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
+∞
6.3
6
*
26510
ICD-8 Finland
Vitamin D deficiency, Rickets, late effect
+∞
6.3
6
*
E55.0
ICD-10 Finland
Rickets, active
+∞
6.3
6
*
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
27.7
6.3
8
*
B05DA
ATC
Isotonic solutions
27.7
6.3
8
*
N30.0
ICD-10 Finland
Acute cystitis
2.7
6.3
36
149
Z31.5
ICD-10 Finland
Genetic counselling
3.6
6.2
21
63
N05BA04
ATC
oxazepam; oral
2.3
6.2
55
281
M54.5
ICD-10 Finland
Low back pain
2.2
6.1
78
462
R53
ICD-10 Finland
Malaise and fatigue
2.3
6.1
58
305
N02AA05
ATC
oxycodone; systemic
2.6
6.0
39
171
N05CD07
ATC
temazepam; oral
3.4
6.0
23
75

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Other disorder of phosphorus metabolism
E83.39 (2000501534)
Hypokalaemia
E87.6 (45537991)
Disorders of phosphorus metabolism and phosphatases
E83.3 (45542777)
Hypo-osmolality and hyponatraemia
E87.1 (45542779)
Disorders of magnesium metabolism
E83.4 (45595835)
Acid phosphatase deficiency
E83.30 (2000501533)
Hypocalcemia
E83.51 (2000501538)
Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
54067-4 (3051552)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Mental and behavioural disorders due to use of alcohol, Harmful use
F10.1 (45595844)
Thorax X-ray examination
GD1AA (2001303617)
Chronic disorders of vitamin D metabolism
123 (2001600122)
Phosphate [Moles/volume] in Serum or Plasma
14879-1 (3003458)
Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
2157-6 (3007220)
Norovirus RNA [Presence] in Stool by NAA with probe detection
7974-9 (3008909)
Glucose [Presence] in Urine by Test strip
25428-4 (3009261)
Magnesium [Moles/volume] in Serum or Plasma
2601-3 (3012095)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Prealbumin [Mass/volume] in Serum or Plasma
14338-8 (3013742)
Lactate [Moles/volume] in Serum or Plasma
2524-7 (3014111)
pH of Serum or Plasma
2753-2 (3018418)
Troponin T.cardiac [Mass/volume] in Serum or Plasma
6598-7 (3019800)
Urea [Moles/volume] in Serum or Plasma
22664-7 (3020779)
Nitrite [Presence] in Urine by Test strip
5802-4 (3021601)
Bacteria identified in Blood by Culture
600-7 (3023368)
Reticulocytes [#/volume] in Blood
14196-0 (3023520)
Bacteria identified in Urine by Culture
630-4 (3026008)
Ketones [Presence] in Urine by Test strip
2514-8 (3035350)
Urinalysis macro (dipstick) panel - Urine
24357-6 (3037467)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
47598-8 (3048816)
Endocrinology
46 (38004485)
CBC W Ordered Manual Differential panel - Blood
57782-5 (40760892)
25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
68438-1 (40771025)
Inpatient Hospital
21 (8717)
Outpatient Hospital
22 (8756)
Inpatient Visit
IP (9201)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
Internal Medicine
11 (38004456)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
Emergency Room and Inpatient Visit
ERIP (262)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
potassium chloride; oral
A12BA01 (21600877)
Calcium [Moles/volume] in Serum or Plasma
2000-8 (3015377)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
Outpatient Visit
OP (9202)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
CBC panel - Blood by Automated count
58410-2 (40761511)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Urinalysis microscopic panel [#/volume] - Urine by Automated count
50554-5 (3029287)
MCH [Entitic mass]
28539-5 (3035941)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Platelets [#/volume] in Blood
26515-7 (3007461)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
INR in Blood by Coagulation assay
34714-6 (3032080)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
Emergency Room Visit
ER (9203)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Basophils [#/volume] in Blood
26444-0 (3006315)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
Upper gastrointestinal surgery
106 (44777669)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
calcium (different salts in combination); oral
A12AA20 (21600872)
Erythrocytes [#/volume] in Urine
30391-7 (3002582)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
General Practice
1 (38004446)
Parathyrin.intact [Mass/volume] in Serum or Plasma
2731-8 (3000067)
Ferritin [Mass/volume] in Serum or Plasma
2276-4 (3001122)
Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1920-8 (3013721)
Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
2324-2 (3026910)
Emergency Medicine
93 (38004510)
Laboratory Visit
OMOP4822461 (32036)
Normoblasts [#/volume] in Blood
715-3 (3021589)
Bacteria [#/volume] in Urine by Automated count
51480-2 (3031040)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
Amylase [Enzymatic activity/volume] in Serum or Plasma
1798-8 (3016771)
furosemide; oral, parenteral
C03CA01 (21601518)
Iron/Transferrin [Ratio] in Serum or Plasma
60517-0 (40763571)
Transferrin [Mass/volume] in Serum or Plasma
3034-6 (3004789)
Reticulocytes/Erythrocytes in Blood
4679-7 (3027945)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Pharmacy visit
OMOP4822462 (581458)
Iron [Moles/volume] in Serum or Plasma
14798-3 (3022948)
Case Management Agency
251B00000X (38004193)
alfacalcidol; oral, parenteral
A11CC03 (21600818)
Essential (primary) hypertension
I10 (45591453)
pantoprazole; oral, parenteral
A02BC02 (21600097)
Bacteria [Presence] in Urine
87829-8 (36304419)
Supplier / Service Provider
OMOP5117446 (33004)
Thyrotropin [Units/volume] in Serum or Plasma
3016-3 (3009201)
paracetamol; oral, parenteral, rectal
N02BE01 (21604344)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
156
192
40.82
140.48
17.9
7.0
0.87
1.06
mmol/l
8.08
151
180
99
99
19.79
96.41
10.1
4.3
115.91
73.69
ng/l
2.31
89
86
170
777
12.29
36.50
27.8
7.7
1.21
1.21
mmol/l
0.11
154
677
128
453
6.59
36.14
17.9
4.0
7.40
7.40
ph
0.26
112
330
80
220
5.55
29.05
6.0
2.4
22.90
24.17
%
0.32
75
206
86
257
5.29
28.19
6.4
2.3
12.61
14.17
umol/l
1.07
80
241
81
233
5.32
27.73
6.5
2.3
2.14
2.34
g/l
1.85
75
217
127
531
5.20
27.05
5.0
3.1
2.34
2.36
mmol/l
0.82
122
486
105
403
4.59
24.36
6.9
4.4
—
—
—
0
0
64
175
5.01
22.76
11.4
7.9
7.38
7.38
ph
0.23
42
90
62
169
4.96
22.07
11.4
8.0
1.30
1.65
mmol/l
0.24
56
146
62
170
4.93
21.90
6.2
2.7
0.20
0.22
g/l
0.71
57
162
57
163
4.57
18.84
14.9
8.6
—
—
—
0
0
41
89
5.60
18.79
2.4
1.7
—
—
—
0
0
25
32
8.84
18.74
6.0
1.7
7.42
7.42
ph
0.03
25
32
96
403
3.79
18.44
4.0
2.5
3.16
2.95
mg/l
0.25
87
353
34
65
6.15
17.77
1.6
2.6
1.44
1.34
g/l
0.18
28
60
53
150
4.51
17.66
3.6
4.3
62.16
67.28
e9/l
0.51
39
117
28
22
14.71
16.80
9.6
1.8
10.49
4.95
pmol/l
2.20
28
22
114
572
3.48
15.93
10.8
8.3
—
—
—
0
0
15
0
+∞
15.85
1.5
0.0
—
—
—
0
0
90
396
3.42
15.48
5.1
3.1
357.68
342.13
umol/l
0.60
80
359
61
215
3.71
14.76
11.0
9.3
104.52
104.29
mmol/l
0.15
61
215
126
696
3.41
14.58
22.0
10.6
1.24
1.19
inr
0.50
112
567
73
292
3.44
14.48
4.0
2.8
2.47
2.45
mmol/l
0.43
65
259
24
40
6.72
14.24
1.7
1.4
207.24
272.02
ug/g
0.66
18
23
136
811
3.38
13.37
13.0
7.4
2.83
2.96
%
0.24
129
769
136
813
3.37
13.27
13.4
7.6
9.04
8.73
%
0.60
129
775
22
18
13.65
12.99
2.4
1.3
95.05
118.06
pmol/l
1.17
22
18
145
909
3.51
12.89
13.2
7.5
0.20
0.19
e9/l
0.14
130
801
142
881
3.42
12.81
13.2
7.3
0.04
0.04
e9/l
0.08
126
763
16
5
34.70
12.79
2.1
1.6
2001.87
1684.00
ml
—
16
5
135
815
3.27
12.72
12.4
7.4
58.22
56.36
%
1.03
128
787
137
836
3.29
12.63
13.2
7.4
25.12
28.55
%
2.92
129
801
134
811
3.21
12.46
13.2
7.5
0.64
0.68
%
0.41
127
765
23
42
6.09
12.45
3.3
3.4
56.54
178.80
mg/l
0.41
17
36
23
42
6.09
12.45
3.3
3.4
50.98
36.72
mg/l
0.59
17
37
150
973
3.57
12.33
19.4
11.3
4.07
3.93
e9/l
0.34
136
858
140
881
3.24
11.92
13.4
7.2
0.61
0.56
e9/l
1.90
124
763
89
439
2.93
11.88
4.6
2.5
—
—
—
0
0
141
896
3.22
11.70
13.4
7.3
1.74
1.84
e9/l
0.74
124
801
22
24
10.21
11.36
4.9
2.3
—
—
—
0
0
90
455
2.86
11.36
2.8
1.7
18.74
20.83
nmol/l
0.63
83
384
40
125
3.79
11.32
13.3
3.3
1.22
1.23
mmol/l
0.11
40
108
138
877
3.10
11.24
14.7
7.0
11.49
11.44
umol/l
0.02
131
832
97
522
2.75
10.69
3.6
2.5
—
—
—
0
0
95
507
2.75
10.63
4.3
2.3
58.59
68.60
u/l
0.51
89
468
20
39
5.61
10.08
3.5
3.1
1.06
1.96
ratio
—
10
22
19
20
10.42
10.03
4.5
1.5
4.76
4.92
kpa
0.32
19
20
19
20
10.42
10.03
4.5
1.5
9.32
8.35
kpa
0.62
19
20
50
194
3.14
10.02
9.8
4.1
7.77
8.95
umol/l
0.16
43
172
122
758
2.70
9.80
6.9
3.0
279.17
111.55
ug/l
1.81
115
710
56
235
2.96
9.76
3.2
2.9
29.63
29.35
s
0.16
56
229
86
461
2.58
9.23
6.5
3.1
0.46
0.34
e6/l
0.25
74
342
44
167
3.13
9.09
9.8
7.6
7.42
7.42
ph
0.02
26
89
97
556
2.52
8.96
4.9
3.1
7.17
8.09
mmol/l
1.16
87
475
77
398
2.57
8.84
2.2
1.5
2.96
2.45
g/l
1.13
48
240
53
228
2.84
8.74
2.9
2.1
—
—
—
0
0
93
533
2.46
8.47
7.0
3.2
134.50
44.54
e6/l
0.53
82
416
12
7
18.17
8.18
41.3
47.7
7.13
6.96
ug/l
—
12
7
52
229
2.75
8.15
2.0
1.6
1571.46
1205.72
nmol/l
0.58
41
177
19
29
7.16
8.12
3.4
3.7
—
—
—
0
0
39
148
3.06
8.00
5.8
5.0
1.03
0.82
%
0.34
19
48
111
704
2.39
7.87
3.5
1.9
95.25
99.61
pmol/l
0.48
78
365
117
762
2.39
7.77
3.8
2.8
—
—
estimate
—
0
0
41
164
2.91
7.65
10.3
7.7
0.51
0.60
mmol/l
0.06
36
143
100
612
2.34
7.63
8.1
3.9
99.53
73.71
e6/l
0.20
85
434
21
55
4.17
7.48
4.5
5.1
300.13
302.83
mg/l
0.01
15
29
77
427
2.35
7.32
1.5
1.4
0.50
1.74
u/ml
1.34
17
109
47
207
2.69
7.30
1.3
1.3
—
—
—
0
0
17
27
6.81
7.12
1.8
1.4
—
—
—
0
0
29
99
3.28
7.06
7.9
5.1
—
—
—
0
0
36
140
2.94
7.04
5.8
5.2
0.19
0.15
%
0.11
16
39
66
350
2.36
6.88
2.5
2.0
1.41
1.09
mg/l
0.39
44
271
27
91
3.29
6.70
8.4
8.3
1.97
1.42
%
0.62
27
91
12
12
10.58
6.63
3.8
2.5
92.08
127.19
ug/l
0.24
12
12
54
267
2.43
6.54
4.6
3.2
2.84
1.65
e6/l
0.37
31
137
17
42
4.35
6.51
5.5
3.0
1.45
2.29
index
0.39
11
28
40
172
2.68
6.46
2.5
1.6
—
—
—
0
0
63
338
2.29
6.32
2.3
2.1
—
—
—
0
0
115
786
2.17
6.26
23.9
11.9
0.00
0.00
e9/l
0.18
99
643
25
86
3.20
5.99
2.8
1.6
0.39
0.43
mg/l
0.09
15
35
25
87
3.16
5.88
1.8
1.2
—
—
—
0
0
52
269
2.28
5.61
1.8
1.8
527.09
443.16
pmol/l
0.72
45
234
18
52
3.72
5.61
1.7
1.5
101.80
143.89
au/ml
—
5
15
34
145
2.64
5.55
5.9
5.8
0.14
0.22
%
0.15
14
37
48
241
2.33
5.54
2.1
1.4
817.78
569.45
titre
—
9
55
22
74
3.23
5.46
2.1
1.5
—
—
—
0
0
18
53
3.65
5.46
2.1
1.4
214.46
221.07
u/ml
0.04
13
29
25
91
3.01
5.45
8.8
8.3
0.68
0.62
%
0.64
25
91
10
11
9.52
5.35
5.0
1.5
17.70
28.40
umol/l
—
10
11
122
884
2.06
5.32
6.3
3.2
41.41
0.00
estimate
0.49
34
187
42
203
2.37
5.27
2.6
1.6
—
—
—
0
0
121
878
2.04
5.21
6.3
3.2
0.00
0.00
estimate
-0.00
34
184
12
19
6.66
5.17
1.9
2.8
34.08
32.79
pg
0.42
12
19
143
1106
2.18
5.15
8.3
3.5
71.89
44.01
u/l
1.53
137
1046
81
513
2.01
5.11
14.6
6.5
—
—
—
0
0
100
683
1.98
5.07
5.2
3.0
6.46
6.18
ph
1.16
47
385
122
893
2.02
5.07
6.4
3.2
0.00
0.00
estimate
-0.00
34
183
33
145
2.54
5.06
5.7
4.8
0.79
0.64
%
0.16
14
44
50
272
2.14
4.70
2.5
1.7
—
—
—
0
0
15
36
4.43
4.63
2.7
17.6
60.71
63.18
%
0.14
15
36
86
572
1.92
4.59
6.1
3.1
25.85
30.34
ng/l
0.35
74
378
14
32
4.64
4.54
1.2
3.0
—
—
—
0
0
51
283
2.10
4.54
5.4
3.3
25.09
260.99
ng/l
2.14
38
204
39
196
2.25
4.44
1.9
1.5
—
—
—
0
0
21
79
2.86
4.32
4.2
1.9
0.00
9.30
estimate
—
7
27
15
46
3.45
4.29
1.5
1.5
—
—
—
0
0
12
26
4.85
4.13
5.5
2.7
5.90
4.22
e9/l
1.07
12
26
7
7
10.32
4.04
1.9
1.3
—
—
—
0
0
8
11
7.53
3.90
5.3
1.2
92.61
88.93
%
—
8
11
8
11
7.53
3.90
1.3
1.0
2.01
1.75
mmol/l
—
8
11
19
72
2.82
3.86
3.1
1.4
1.34
4.69
iu/ml
—
5
9
7
8
9.03
3.80
1.0
1.1
147.57
122.50
nmol/l
—
7
8
14
45
3.28
3.73
1.4
1.0
—
—
—
0
0
15
51
3.11
3.66
2.7
3.0
—
—
—
0
0
10
21
4.96
3.61
2.1
1.4
20.80
17.84
ng/l
—
10
21
6
6
10.27
3.52
1.0
1.3
—
—
—
0
0
6
6
10.27
3.52
1.0
1.0
—
—
—
0
0
10
23
4.53
3.36
1.0
1.1
—
—
—
0
0
23
104
2.38
3.31
3.0
2.5
4.29
7.28
ug/l
1.26
18
94
170
1492
2.32
3.29
7.8
4.9
1.81
1.91
mu/l
0.51
164
1378
41
238
1.92
3.15
2.8
2.6
139.55
96.64
ug/g
0.52
33
189
71
488
1.73
3.14
7.5
3.3
0.00
0.00
estimate
-0.00
29
177
72
498
1.72
3.11
4.6
3.2
79.58
46.56
mg/l
0.46
53
302
86
628
1.67
3.02
2.5
2.0
—
—
—
0
0
34
188
1.98
3.00
1.4
1.3
—
—
—
0
0
5
5
10.22
2.99
4.6
8.2
—
—
—
0
0
31
166
2.04
2.98
1.2
1.2
—
—
—
0
0
8
17
4.86
2.95
3.3
34.8
10.04
11.27
%
—
8
17
23
112
2.20
2.81
5.2
3.0
—
—
—
0
0
29
155
2.03
2.80
3.9
1.8
0.00
0.08
estimate
—
7
37
58
388
1.71
2.79
12.4
5.0
—
—
—
0
0
27
141
2.07
2.78
6.7
3.3
—
—
—
0
0
30
163
2.00
2.78
4.2
5.0
7.58
34.44
ug/l
0.49
25
128
6
10
6.15
2.72
1.0
1.1
265.83
294.70
mg/l
—
6
10
6
10
6.15
2.72
1.5
1.3
—
—
—
0
0
36
212
1.86
2.64
3.2
3.0
4.29
5.36
e9/l
0.44
28
189
12
44
2.84
2.60
5.9
2.8
66.25
57.43
%
1.25
12
44
11
37
3.09
2.53
1.2
2.8
8266.82
88.87
e6/l
0.58
11
31
8
21
3.93
2.49
1.3
1.1
—
—
—
0
0
25
133
2.01
2.45
1.8
1.5
—
—
—
0
0
70
507
1.60
2.43
6.2
3.6
20.61
7.76
mg/mmol
0.90
46
299
16
71
2.37
2.42
13.6
3.8
36.90
36.94
°c
0.21
16
71
5
8
6.38
2.38
4.2
1.0
2201.00
1048.50
u/ml
—
5
8
13
53
2.56
2.33
2.3
1.2
—
—
—
0
0
8
23
3.58
2.29
2.5
1.3
—
—
—
0
0
45
296
1.68
2.26
1.2
1.3
1.04
11.56
u/ml
2.27
17
115
16
76
2.21
2.09
1.1
1.1
—
—
—
0
0
5
10
5.10
2.08
1.0
1.0
—
—
—
0
0
6
15
4.09
2.05
1.3
4.1
—
—
—
0
0
181
1702
2.34
1.98
36.7
12.1
—
—
—
0
0
5
11
4.64
1.95
1.8
2.5
1010.80
567.64
mg
—
5
11
12
52
2.40
1.92
6.4
5.4
0.72
0.86
%
0.68
12
45
67
503
1.51
1.92
1.6
1.4
—
—
—
0
0
7
22
3.26
1.90
1.4
2.2
3.39
3.35
nmol/l
—
7
22
22
123
1.89
1.89
2.4
2.5
—
19.60
—
0
8
16
80
2.09
1.86
6.3
4.2
—
—
—
0
0
47
641
0.65
1.83
2.7
2.8
—
—
—
0
0
11
47
2.42
1.81
3.7
4.8
1.49
1.22
mmol/l
0.36
11
47
8
30
2.74
1.74
1.1
1.0
—
—
—
0
0
8
30
2.74
1.74
4.8
1.5
—
—
—
0
0
7
24
2.99
1.74
1.9
1.5
—
—
—
0
0
175
1630
1.93
1.68
43.2
14.1
26.54
23.03
mg/l
0.73
157
1292
65
498
1.46
1.65
5.1
2.6
0.00
0.01
estimate
0.50
27
151
5
14
3.64
1.62
1.0
1.0
—
—
—
0
0
5
14
3.64
1.62
1.2
1.1
—
—
—
0
0
8
32
2.56
1.61
1.1
1.1
—
—
—
0
0
16
86
1.94
1.55
8.7
6.8
24.40
24.82
mmol/l
0.17
16
81
5
15
3.39
1.53
3.0
2.4
0.32
0.57
e9/l
—
5
15
5
15
3.39
1.53
3.0
1.3
3.14
3.67
mg/l
—
5
15
24
149
1.70
1.50
2.0
1.4
—
—
—
0
0
5
16
3.18
1.44
1.2
1.1
—
—
—
0
0
82
671
1.39
1.41
6.3
3.0
0.00
0.01
estimate
0.50
31
159
6
23
2.66
1.38
1.0
1.3
11.65
20.85
ug/l
—
6
23
5
17
2.99
1.36
1.0
1.1
—
—
—
0
0
12
61
2.03
1.36
2.6
1.7
—
—
—
0
0
45
333
1.46
1.35
1.6
1.3
26.18
35.71
iu/ml
0.21
11
95
6
24
2.55
1.31
3.7
2.1
—
—
—
0
0
6
25
2.44
1.25
1.8
2.0
—
—
—
0
0
6
25
2.44
1.25
1.8
2.0
—
—
—
0
0
6
25
2.44
1.25
1.8
2.0
—
—
—
0
0
6
25
2.44
1.25
1.8
2.0
—
—
—
0
0
24
157
1.61
1.25
1.9
1.6
—
—
—
0
0
153
1405
1.46
1.24
48.0
18.0
14.29
13.55
%
6.10
153
1392
5
19
2.67
1.22
1.4
1.3
—
—
—
0
0
5
20
2.54
1.16
2.4
2.1
—
—
—
0
0
5
20
2.54
1.16
2.4
1.8
11.40
10.80
mmol/l
—
5
20
14
82
1.76
1.08
2.4
2.2
—
—
—
0
0
5
22
2.31
1.04
1.2
1.5
—
—
—
0
0
5
23
2.20
0.98
1.6
1.2
—
—
—
0
0
30
223
1.41
0.89
1.2
1.3
—
—
—
0
0
8
43
1.90
0.88
2.3
1.4
—
—
—
0
0
6
32
1.90
0.82
1.3
1.0
—
—
—
0
0
6
32
1.90
0.82
1.3
1.0
—
—
—
0
0
0
27
0.00
0.78
0.0
2.9
—
44.17
—
0
27
13
84
1.59
0.74
1.8
1.4
—
—
—
0
0
7
42
1.69
0.69
4.6
3.6
3.73
3.93
mmol/l
—
7
42
46
383
1.27
0.66
6.6
3.1
1.01
1.02
kg/l
2.10
32
239
13
88
1.51
0.62
1.8
1.3
—
—
—
0
0
13
90
1.48
0.57
1.8
1.3
—
—
—
0
0
13
90
1.48
0.57
1.8
1.3
—
—
—
0
0
13
91
1.46
0.54
1.8
1.3
—
—
—
0
0
22
172
1.32
0.51
2.3
1.9
—
—
—
0
0
10
69
1.47
0.45
1.3
1.3
—
—
—
0
0
160
1543
1.23
0.44
6.4
4.8
5.86
5.85
mmol/l
0.03
152
1430
17
216
0.77
0.43
1.6
1.6
—
—
—
0
0
14
110
1.29
0.32
1.3
1.3
—
—
—
0
0
183
1803
1.41
0.31
62.4
21.6
4.26
4.56
e12/l
7.60
183
1772
183
1803
1.41
0.31
62.4
21.7
7.14
6.50
e9/l
3.56
183
1771
183
1803
1.41
0.31
63.5
22.3
38.54
40.79
%
5.64
183
1790
183
1803
1.41
0.31
62.1
21.5
30.77
30.24
pg
3.10
183
1791
183
1803
1.41
0.31
63.1
21.8
128.86
136.85
g/l
6.87
183
1790
183
1802
1.42
0.31
62.2
21.6
92.37
90.66
fl
4.09
183
1790
183
1801
1.44
0.31
62.5
21.7
255.99
250.83
e9/l
0.43
183
1777
163
1593
1.16
0.26
6.0
4.6
1.45
1.47
mmol/l
0.30
153
1485
58
538
1.11
0.24
5.7
5.2
2.39
2.95
ug/l
0.30
51
482
163
1596
1.15
0.23
5.9
4.8
4.42
4.68
mmol/l
2.64
154
1499
0
11
0.00
0.21
0.0
1.6
—
1.17
—
0
11
0
12
0.00
0.21
0.0
1.6
—
104.42
—
0
12
0
12
0.00
0.21
0.0
1.6
—
3.89
—
0
12
153
1495
1.12
0.21
8.0
5.6
38.20
38.38
mmol/mol
0.07
148
1408
0
14
0.00
0.20
0.0
1.1
—
209.99
—
0
14
0
14
0.00
0.20
0.0
3.8
—
—
—
0
0
72
683
1.09
0.19
2.4
1.8
1.47
1.33
mmol/l
0.47
62
579
154
1516
1.08
0.13
5.2
4.0
1.32
1.26
mmol/l
0.52
146
1407
31
330
0.93
0.10
3.7
3.1
0.82
0.77
ug/l
0.17
19
217
5
47
1.07
0.09
2.8
1.2
0.80
0.92
g/l
—
5
47
6
55
1.09
0.09
1.5
1.4
—
233.33
—
0
27
9
88
1.02
0.07
1.1
1.1
—
—
—
0
0
163
1619
1.05
0.04
6.6
5.3
2.47
2.76
mmol/l
3.85
155
1508
15
147
1.02
0.00
5.7
1.8
6.25
6.06
ph
—
10
96
5
50
1.00
0.00
15.8
9.9
—
—
—
0
0
6
61
0.98
-0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
59.28
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
11.6
—
8.99
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.03
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint E4_PHOS_MET and mortality.

Females

Parameter HR [95% CI] p-value
E4_PHOS_MET 4.82 [3.0, 7.74] < 0.001
Birth year 0.995 [0.99, 1.0] 0.274

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 333 females with E4_PHOS_MET died.

Males

Parameter HR [95% CI] p-value
E4_PHOS_MET 3.918 [2.62, 5.86] < 0.001
Birth year 0.991 [0.98, 1.0] 0.048

During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 326 males with E4_PHOS_MET died.

Mortality risk

Mortality risk for people of age

years, who have E4_PHOS_MET.

N-year risk Females Males
1 0.415% 0.867%
5 2.335% 4.788%
10 6.908% 11.571%
15 13.29% 21.978%
20 22.891% 36.068%

Relationships between endpoints

↥

Index endpoint: E4_PHOS_MET – Disorders of phosphorus metabolism and phosphatases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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