No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
203 |
4. Check minimum number of eventsNone |
203 |
5. Include endpointsNone |
203 |
6. Filter based on genotype QC (FinnGen only) |
184 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E83
- Name in latin
- Perturbationes metabolismi phosphori
Similar endpoints
↥List of similar endpoints to
Disorders of phosphorus metabolism and phosphatases
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 908 | 443 | 459 |
| Only index persons | 819 | 399 | 420 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 54.06 | 52.80 | 55.17 |
| Only index persons | 54.59 | 53.52 | 55.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 184 | 96 | 88 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 53.84 | 50.34 | 57.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 190
- Matched controls
- 1900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
+∞
205.4
158
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
94.1
55.0
59
9
A11CC03
ATC
alfacalcidol; systemic
78.8
47.3
52
9
V03AG01
ATC
sodium cellulose phosphate; systemic
513.5
43.0
41
*
E87.6
ICD-10 Finland
Hypokalaemia
91.8
39.9
43
6
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.1
31.6
44
61
E83.4
ICD-10 Finland
Disorders of magnesium metabolism
+∞
28.9
27
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
13.0
28.2
29
26
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
+∞
27.8
26
*
E83.30
ICD-10 Finland
Acid phosphatase deficiency
+∞
26.7
25
*
E83.51
ICD-10 Finland
Hypocalcemia
149.7
25.3
26
*
A12AA04
ATC
calcium carbonate; oral
65.2
24.8
28
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.5
23.1
90
318
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.4
23.1
100
382
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.7
20.7
32
49
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.8
19.5
41
86
D64.9
ICD-10 Finland
Anaemia, unspecified
5.4
17.6
40
90
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
55.5
17.4
20
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.2
17.1
40
92
M05BX04
ATC
denosumab; parenteral
7.6
17.1
26
39
JN3AD
NOMESCO Finland
Abdominal CT examination
4.6
16.7
48
131
E83.50
ICD-10 Finland
Hypercalcemia
87.0
14.8
16
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
14.5
51
161
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
14.2
49
152
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.8
13.4
34
83
AA1AD
NOMESCO Finland
CT of head and brain
3.3
13.4
71
291
N17.9
ICD-10 Finland
Acute renal failure, unspecified
12.9
12.7
22
19
C03CA01
ATC
furosemide; systemic
3.2
12.4
64
257
R4190
NOMESCO Finland
Nutritional therapy
5.4
12.3
26
54
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.3
12.1
26
55
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.6
11.8
46
154
WZC00
NOMESCO Finland
Treatment plan or consultation
2.9
11.7
95
489
TPH07
NOMESCO Finland
Cathetrisation of artery
4.2
11.6
34
93
M05BA04
ATC
alendronic acid; oral
5.2
11.3
25
54
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
11.1
57
226
ZX120
NOMESCO Finland
Intravenous
4.4
11.1
30
77
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.4
10.8
29
74
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.0
10.6
34
99
H02AB09
ATC
hydrocortisone; systemic
13.1
10.6
18
15
2753A
ICD-9 Finland
Disorders of mineral metabolism, Disorders of phosphorus metabolism[HYPOPHOSPHATHAEMIA FAMILIARIS]
+∞
10.5
10
*
B05XA09
ATC
sodium phosphate; parenteral
+∞
10.5
10
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.9
10.3
34
101
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
10.2
108
624
SBB10
NOMESCO Finland
Dental impressions
3.7
10.0
35
108
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
10.0
59
252
N06AX11
ATC
mirtazapine; oral
2.7
9.9
83
425
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.1
9.8
22
48
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.4
9.8
40
137
R50.9
ICD-10 Finland
Fever, unspecified
3.2
9.8
48
184
321
Kela drug reimbursment
Paricalcitol and cinacalcet
58.0
9.8
11
*
WX002
NOMESCO Finland
Sedation and analgesia
3.1
9.7
49
191
A02BC02
ATC
pantoprazole; systemic
2.9
9.6
143
968
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.6
65
298
E86
ICD-10 Finland
Volume depletion
31.8
9.5
12
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.2
9.3
20
42
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
16.7
9.2
14
9
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
8.8
82
437
L04AX01
ATC
azathioprine; systemic
7.6
8.8
20
29
H02AB06
ATC
prednisolone; systemic
2.5
8.8
101
594
E21.2
ICD-10 Finland
Other hyperparathyroidism
52.5
8.8
10
*
H05BX01
ATC
cinacalcet; oral
52.5
8.8
10
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
17.3
8.7
13
8
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
11.5
8.5
15
14
E83.9
ICD-10 Finland
Disorder of mineral metabolism, unspecified
+∞
8.4
8
*
R4110
NOMESCO Finland
Physiotherapy
2.6
8.4
70
353
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
8.3
54
240
KA1AE
NOMESCO Finland
Kidney ultrasound examination
9.6
8.2
16
18
L04AD02
ATC
tacrolimus; systemic
18.2
8.2
12
7
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
35.0
8.2
10
*
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
23.2
8.1
11
5
127
Kela drug reimbursment
Transplant complication
13.8
8.0
13
10
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
6.4
7.9
20
34
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
7.9
29
92
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.5
7.9
65
324
UJF32
NOMESCO Finland
Coloscopy
2.6
7.9
60
288
A28
ICPC
Limited function/disability NOS
3.0
7.8
39
150
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
7.2
7.8
18
27
N02AX02
ATC
tramadol; systemic, rectal
2.4
7.8
91
531
R11
ICD-10 Finland
Nausea and vomiting
3.5
7.8
29
93
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.7
7.7
17
24
K70.0
ICD-10 Finland
Alcoholic fatty liver
83.2
7.5
8
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.7
7.4
18
29
A03FA01
ATC
metoclopramide; systemic, rectal
2.6
7.4
52
240
E83.8
ICD-10 Finland
Other disorders of mineral metabolism
+∞
7.3
7
*
A12AA06
ATC
calcium lactate gluconate; oral
+∞
7.3
7
*
Z94.0
ICD-10 Finland
Kidney transplant status
21.0
7.2
10
5
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.0
7.1
35
133
Z2446
NOMESCO Finland
Social worker
3.5
7.0
26
83
N18.8
ICD-10 Finland
Other chronic renal failure
14.5
7.0
11
8
WX892
NOMESCO Finland
Monitored bed care
3.9
7.0
21
58
XF600
NOMESCO Finland
Bloodpressure measurement
3.9
7.0
21
58
M13.9
ICD-10 Finland
Arthritis, unspecified
3.8
6.9
22
63
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.9
6.9
37
148
A04
ICPC
Weakness/tiredness general
2.9
6.9
37
148
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
41.6
6.8
8
*
V03AE01
ATC
polystyrene sulfonate; oral
41.6
6.8
8
*
B05DB
ATC
Hypertonic solutions
41.6
6.8
8
*
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
41.6
6.8
8
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.3
6.8
18
45
EBA15
NOMESCO Finland
Extraction of multiple teeth
6.3
6.8
17
29
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
23.5
6.7
9
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
6.7
29
102
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
6.6
94
586
ZXE00
NOMESCO Finland
One hour or less
2.2
6.6
84
501
C07AB02
ATC
metoprolol; systemic
2.8
6.6
38
158
Z3226
NOMESCO Finland
Physiotherapist
2.5
6.5
46
212
205
Kela drug reimbursment
Chronic hypertension
2.5
6.5
46
212
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.4
6.5
16
27
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
6.4
28
99
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.8
6.4
12
13
TK800
NOMESCO Finland
Hemodialysis
11.6
6.4
11
10
WW500
NOMESCO Finland
Blood transfusion
5.4
6.4
18
36
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.6
6.4
22
67
137
Kela drug reimbursment
Uraemia requiring dialysis
18.8
6.3
9
5
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
6.3
26
89
E55.0
ICD-10 Finland
Rickets, active
+∞
6.3
6
*
26510
ICD-8 Finland
Vitamin D deficiency, Rickets, late effect
+∞
6.3
6
*
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
+∞
6.3
6
*
A11CC02
ATC
dihydrotachysterol; oral
+∞
6.3
6
*
B05DA
ATC
Isotonic solutions
27.7
6.3
8
*
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
27.7
6.3
8
*
N30.0
ICD-10 Finland
Acute cystitis
2.7
6.3
36
149
Z31.5
ICD-10 Finland
Genetic counselling
3.6
6.2
21
63
N05BA04
ATC
oxazepam; oral
2.3
6.2
55
281
M54.5
ICD-10 Finland
Low back pain
2.2
6.1
78
462
R53
ICD-10 Finland
Malaise and fatigue
2.3
6.1
58
305
N02AA05
ATC
oxycodone; systemic
2.6
6.0
39
171
N05CD07
ATC
temazepam; oral
3.4
6.0
23
75
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
156
192
40.82
140.48
17.9
7.0
0.87
1.06
mmol/l
8.08
151
180
99
99
19.79
96.41
10.1
4.3
115.91
73.69
ng/l
2.31
89
86
170
777
12.29
36.50
27.8
7.7
1.21
1.21
mmol/l
0.11
154
677
80
220
5.55
29.05
6.0
2.4
22.90
24.17
%
0.32
75
206
86
257
5.29
28.19
6.4
2.3
12.61
14.17
umol/l
1.07
80
241
81
233
5.32
27.73
6.5
2.3
2.14
2.34
g/l
1.85
75
217
127
531
5.20
27.05
5.0
3.1
2.34
2.36
mmol/l
0.82
122
486
62
169
4.96
22.07
11.4
8.0
1.30
1.65
mmol/l
0.24
56
146
62
170
4.93
21.90
6.2
2.7
0.20
0.22
g/l
0.71
57
162
44
103
5.26
18.52
2.7
1.7
—
—
—
0
0
96
403
3.79
18.44
4.0
2.5
3.16
2.95
mg/l
0.25
87
353
34
65
6.15
17.77
1.6
2.6
1.44
1.34
g/l
0.18
28
60
30
53
6.53
16.93
2.4
1.4
—
—
—
0
0
28
22
14.71
16.80
9.6
1.8
10.49
4.95
pmol/l
2.20
28
22
90
396
3.42
15.48
5.1
3.1
357.68
342.13
umol/l
0.60
80
359
61
215
3.71
14.76
11.0
9.3
104.52
104.29
mmol/l
0.15
61
215
73
292
3.44
14.48
4.0
2.8
2.47
2.45
mmol/l
0.43
65
259
24
40
6.72
14.24
1.7
1.4
207.24
272.02
ug/g
0.66
18
23
22
18
13.65
12.99
2.4
1.3
95.05
118.06
pmol/l
1.17
22
18
63
245
3.35
12.88
2.4
2.1
—
—
—
0
0
23
42
6.09
12.45
3.3
3.4
50.98
36.72
mg/l
0.59
17
37
23
42
6.09
12.45
3.3
3.4
56.54
178.80
mg/l
0.41
17
36
150
973
3.57
12.33
19.4
11.3
4.07
3.93
e9/l
0.34
136
858
39
113
4.08
12.32
8.0
4.8
2.65
1.73
mmol/l
0.97
28
95
90
455
2.86
11.36
2.8
1.7
18.74
20.83
nmol/l
0.63
83
384
40
125
3.79
11.32
13.3
3.3
1.22
1.23
mmol/l
0.11
40
108
138
877
3.10
11.24
14.7
7.0
11.49
11.44
umol/l
0.02
131
832
31
82
4.32
11.00
1.9
1.4
—
—
—
0
0
95
507
2.75
10.63
4.3
2.3
58.59
68.60
u/l
0.51
89
468
20
39
5.61
10.08
3.5
3.1
1.06
1.96
ratio
—
10
22
19
20
10.42
10.03
4.5
1.5
4.76
4.92
kpa
0.32
19
20
50
194
3.14
10.02
9.8
4.1
7.77
8.95
umol/l
0.16
43
172
122
758
2.70
9.80
6.9
3.0
279.17
111.55
ug/l
1.81
115
710
56
235
2.96
9.76
3.2
2.9
29.63
29.35
s
0.16
56
229
86
461
2.58
9.23
6.5
3.1
0.46
0.34
e6/l
0.25
74
342
29
86
3.80
8.76
2.3
1.8
—
—
—
0
0
20
45
4.85
8.59
9.9
8.7
432.80
623.50
iu/ml
—
5
6
48
199
2.89
8.45
3.7
2.2
1.97
1.47
%
1.77
35
176
46
188
2.91
8.30
2.3
2.0
—
—
—
0
0
52
229
2.75
8.15
2.0
1.6
1571.46
1205.72
nmol/l
0.58
41
177
20
48
4.54
7.95
2.0
1.8
—
—
—
0
0
111
704
2.39
7.87
3.5
1.9
95.25
99.61
pmol/l
0.48
78
365
117
762
2.39
7.77
3.8
2.8
—
—
estimate
—
0
0
43
176
2.87
7.70
2.4
2.0
—
—
—
0
0
41
164
2.91
7.65
10.3
7.7
0.51
0.60
mmol/l
0.06
36
143
75
405
2.41
7.63
3.2
2.5
—
—
—
0
0
160
1217
2.99
7.44
8.1
4.3
16.59
10.50
mm/h
3.41
155
1144
16
22
7.83
7.36
1.5
1.2
—
—
—
0
0
77
427
2.35
7.32
1.5
1.4
0.50
1.74
u/ml
1.34
17
109
34
126
3.07
7.24
5.1
2.6
49.80
71.38
ml/min/173m2
2.40
20
39
93
567
2.25
6.98
9.1
3.4
38.83
32.26
u/l
0.45
88
536
66
350
2.36
6.88
2.5
2.0
1.41
1.09
mg/l
0.39
44
271
27
91
3.29
6.70
8.4
8.3
1.97
1.42
%
0.62
27
91
12
12
10.58
6.63
3.8
2.5
92.08
127.19
ug/l
0.24
12
12
54
267
2.43
6.54
4.6
3.2
2.84
1.65
e6/l
0.37
31
137
17
42
4.35
6.51
5.5
3.0
1.45
2.29
index
0.39
11
28
37
154
2.74
6.36
5.9
2.9
—
—
—
0
0
18
48
4.04
6.25
1.3
2.2
—
—
—
0
0
19
54
3.80
6.06
2.2
2.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
40
4.28
6.03
5.9
6.0
0.34
0.29
iu/ml
—
8
24
25
86
3.20
5.99
2.8
1.6
0.39
0.43
mg/l
0.09
15
35
56
298
2.25
5.65
4.4
2.9
0.59
0.87
e6/l
0.43
35
168
52
269
2.28
5.61
1.8
1.8
527.09
443.16
pmol/l
0.72
45
234
18
52
3.72
5.61
1.7
1.5
101.80
143.89
au/ml
—
5
15
18
52
3.72
5.61
2.2
1.3
—
—
—
0
0
18
53
3.65
5.46
1.7
1.5
—
—
—
0
0
18
53
3.65
5.46
2.1
1.4
214.46
221.07
u/ml
0.04
13
29
25
91
3.01
5.45
8.8
8.3
0.68
0.62
%
0.64
25
91
15
30
5.34
5.38
1.4
1.1
—
—
—
0
0
15
30
5.34
5.38
1.4
1.1
—
—
—
0
0
122
884
2.06
5.32
6.3
3.2
41.41
0.00
estimate
0.49
34
187
121
878
2.04
5.21
6.3
3.2
0.00
0.00
estimate
-0.00
34
184
12
19
6.66
5.17
1.9
2.8
34.08
32.79
pg
0.42
12
19
143
1106
2.18
5.15
8.3
3.5
71.89
44.01
u/l
1.53
137
1046
122
893
2.02
5.07
6.4
3.2
0.00
0.00
estimate
-0.00
34
183
15
36
4.43
4.63
2.7
17.6
60.71
63.18
%
0.14
15
36
86
572
1.92
4.59
6.1
3.1
25.85
30.34
ng/l
0.35
74
378
51
283
2.10
4.54
5.4
3.3
25.09
260.99
ng/l
2.14
38
204
14
41
3.61
4.27
1.6
1.3
0.00
0.00
g/l
-0.00
14
41
10
17
6.14
4.19
1.1
2.7
—
—
—
0
0
68
429
1.91
4.18
3.7
2.9
3369.10
1122.57
ng/l
0.86
61
355
9
14
6.69
4.03
1.0
3.1
—
—
—
0
0
14
37
4.00
3.99
3.0
1.6
—
—
—
0
0
16
54
3.14
3.95
1.9
3.1
—
—
—
0
0
8
11
7.53
3.90
1.3
1.0
2.01
1.75
mmol/l
—
8
11
19
72
2.82
3.86
3.1
1.4
1.34
4.69
iu/ml
—
5
9
11
24
4.80
3.81
1.3
1.7
—
220.00
—
0
6
17
62
2.91
3.70
4.3
4.0
87.59
94.39
%
0.50
17
62
11
25
4.60
3.68
1.3
1.7
—
—
—
0
0
14
48
3.07
3.38
1.2
1.2
—
—
—
0
0
132
1064
1.79
3.34
3.6
3.2
—
—
—
0
0
23
104
2.38
3.31
3.0
2.5
4.29
7.28
ug/l
1.26
18
94
170
1492
2.32
3.29
7.8
4.9
1.81
1.91
mu/l
0.51
164
1378
8
15
5.52
3.22
1.0
1.0
—
—
—
0
0
9
20
4.67
3.15
1.2
1.2
—
—
—
0
0
172
1523
2.37
3.15
37.3
13.2
79.81
84.34
ml/min/173m2
1.25
166
1396
71
488
1.73
3.14
7.5
3.3
0.00
0.00
estimate
-0.00
29
177
8
16
5.17
3.08
8.5
1.7
90.25
108.63
%
—
8
16
6
8
7.70
3.07
1.0
1.6
—
—
—
0
0
6
8
7.70
3.07
1.0
1.1
—
—
—
0
0
6
8
7.70
3.07
1.0
1.1
—
—
—
0
0
5
5
10.22
2.99
1.0
1.0
—
—
—
0
0
30
163
2.00
2.78
4.2
5.0
7.58
34.44
ug/l
0.49
25
128
6
10
6.15
2.72
1.0
1.0
—
—
—
0
0
6
10
6.15
2.72
1.0
1.1
265.83
294.70
mg/l
—
6
10
5
7
7.30
2.56
8.2
3.0
0.90
1.57
%
—
5
7
11
37
3.09
2.53
1.2
2.8
8266.82
88.87
e6/l
0.58
11
31
11
37
3.09
2.53
2.3
1.4
—
—
—
0
0
11
37
3.09
2.53
3.8
1.2
—
—
—
0
0
9
26
3.58
2.51
2.4
1.6
—
—
—
0
0
7
16
4.50
2.50
1.0
2.2
—
—
—
0
0
70
507
1.60
2.43
6.2
3.6
20.61
7.76
mg/mmol
0.90
46
299
13
52
2.61
2.41
2.3
1.2
—
—
—
0
0
13
52
2.61
2.41
2.3
1.2
—
—
—
0
0
5
8
6.38
2.38
4.2
1.0
2201.00
1048.50
u/ml
—
5
8
5
8
6.38
2.38
1.4
1.0
—
—
—
0
0
45
296
1.68
2.26
1.2
1.3
1.04
11.56
u/ml
2.27
17
115
13
54
2.51
2.25
1.4
1.5
—
—
—
0
0
8
25
3.29
2.12
1.1
2.3
—
—
—
0
0
11
43
2.65
2.12
1.6
1.2
—
—
—
0
0
10
37
2.80
2.10
1.7
1.7
—
—
—
0
0
6
15
4.09
2.05
1.2
1.0
—
—
—
0
0
6
15
4.09
2.05
1.2
1.0
—
—
—
0
0
11
44
2.59
2.05
1.5
2.1
—
—
—
0
0
7
21
3.42
1.98
1.0
1.0
—
—
—
0
0
5
11
4.64
1.95
1.8
2.5
1010.80
567.64
mg
—
5
11
28
168
1.78
1.94
22.3
6.2
—
—
—
0
0
7
22
3.26
1.90
1.4
2.2
3.39
3.35
nmol/l
—
7
22
7
22
3.26
1.90
1.1
1.3
—
—
—
0
0
7
22
3.26
1.90
1.9
1.1
—
—
—
0
0
22
123
1.89
1.89
2.4
2.5
—
19.60
—
0
8
12
53
2.35
1.85
1.7
1.2
—
—
—
0
0
11
47
2.42
1.81
3.7
4.8
1.49
1.22
mmol/l
0.36
11
47
6
18
3.41
1.76
1.2
4.3
—
17.44
—
0
12
175
1630
1.93
1.68
43.2
14.1
26.54
23.03
mg/l
0.73
157
1292
6
19
3.23
1.67
1.7
1.8
—
—
—
0
0
6
19
3.23
1.67
1.3
1.3
—
—
—
0
0
65
498
1.46
1.65
5.1
2.6
0.00
0.01
estimate
0.50
27
151
5
14
3.64
1.62
1.0
1.0
—
—
—
0
0
5
14
3.64
1.62
1.2
1.1
—
—
—
0
0
6
20
3.06
1.59
1.3
1.3
—
—
—
0
0
6
20
3.06
1.59
1.3
1.3
—
—
—
0
0
16
86
1.94
1.55
8.7
6.8
24.40
24.82
mmol/l
0.17
16
81
5
15
3.39
1.53
3.0
1.3
3.14
3.67
mg/l
—
5
15
5
15
3.39
1.53
1.0
1.0
—
—
—
0
0
5
15
3.39
1.53
3.0
2.4
0.32
0.57
e9/l
—
5
15
9
40
2.31
1.42
1.6
2.0
—
—
—
0
0
82
671
1.39
1.41
6.3
3.0
0.00
0.01
estimate
0.50
31
159
9
41
2.25
1.39
1.7
1.3
—
—
—
0
0
6
23
2.66
1.38
1.0
1.3
11.65
20.85
ug/l
—
6
23
13
68
1.98
1.37
1.9
1.6
—
—
—
0
0
5
17
2.99
1.36
1.0
1.6
—
—
—
0
0
45
333
1.46
1.35
1.6
1.3
26.18
35.71
iu/ml
0.21
11
95
23
146
1.65
1.33
1.7
1.5
—
—
—
0
0
153
1405
1.46
1.24
48.0
18.0
14.29
13.55
%
6.10
153
1392
5
19
2.67
1.22
1.4
1.3
—
—
—
0
0
5
19
2.67
1.22
1.4
1.3
—
—
—
0
0
5
20
2.54
1.16
1.4
1.3
—
—
—
0
0
5
20
2.54
1.16
2.4
1.8
11.40
10.80
mmol/l
—
5
20
5
23
2.20
0.98
1.0
1.1
—
—
—
0
0
8
42
1.94
0.90
1.6
1.7
—
—
—
0
0
6
30
2.03
0.87
1.8
1.7
—
—
—
0
0
6
30
2.03
0.87
1.5
1.2
—
—
—
0
0
6
34
1.79
0.77
1.7
1.6
—
—
—
0
0
6
34
1.79
0.77
1.3
1.2
—
—
—
0
0
27
203
1.38
0.76
5.0
4.5
36.00
31.16
%
1.07
22
128
14
92
1.56
0.74
2.4
1.4
—
—
—
0
0
5
25
2.03
0.73
1.0
1.0
—
—
—
0
0
5
25
2.03
0.73
1.8
1.8
—
—
—
0
0
27
206
1.36
0.70
2.7
2.5
—
—
—
0
0
46
383
1.27
0.66
6.6
3.1
1.01
1.02
kg/l
2.10
32
239
5
29
1.74
0.64
1.4
1.6
—
—
—
0
0
42
350
1.26
0.60
2.0
1.7
—
—
—
0
0
24
185
1.34
0.60
2.7
2.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.7
—
48.95
—
0
23
6
39
1.56
0.53
1.0
1.6
—
—
—
0
0
160
1543
1.23
0.44
6.4
4.8
5.86
5.85
mmol/l
0.03
152
1430
0
17
0.00
0.41
0.0
4.4
—
20.12
—
0
17
14
109
1.31
0.34
1.1
1.1
—
—
—
0
0
183
1803
1.41
0.31
63.1
21.8
128.86
136.85
g/l
6.87
183
1790
183
1803
1.41
0.31
63.5
22.3
38.54
40.79
%
5.64
183
1790
183
1803
1.41
0.31
62.4
21.6
4.26
4.56
e12/l
7.60
183
1772
183
1802
1.42
0.31
62.2
21.6
92.37
90.66
fl
4.09
183
1790
183
1801
1.44
0.31
62.5
21.7
255.99
250.83
e9/l
0.43
183
1777
163
1593
1.16
0.26
6.0
4.6
1.45
1.47
mmol/l
0.30
153
1485
58
538
1.11
0.24
5.7
5.2
2.39
2.95
ug/l
0.30
51
482
163
1596
1.15
0.23
5.9
4.8
4.42
4.68
mmol/l
2.64
154
1499
0
12
0.00
0.21
0.0
1.4
—
12.75
—
0
12
153
1495
1.12
0.21
8.0
5.6
38.20
38.38
mmol/mol
0.07
148
1408
0
14
0.00
0.20
0.0
1.1
—
209.99
—
0
14
72
683
1.09
0.19
2.4
1.8
1.47
1.33
mmol/l
0.47
62
579
13
112
1.17
0.15
1.8
2.4
—
—
—
0
0
154
1516
1.08
0.13
5.2
4.0
1.32
1.26
mmol/l
0.52
146
1407
31
330
0.93
0.10
3.7
3.1
0.82
0.77
ug/l
0.17
19
217
5
47
1.07
0.09
2.8
1.2
0.80
0.92
g/l
—
5
47
6
55
1.09
0.09
1.5
1.4
—
233.33
—
0
27
42
437
0.95
0.07
5.0
4.5
22.94
21.24
%
0.31
21
218
163
1619
1.05
0.04
6.6
5.3
2.47
2.76
mmol/l
3.85
155
1508
23
235
0.98
0.00
1.7
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
0.23
—
0
8
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
127.33
—
0
6
9
99
0.90
-0.00
1.7
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
9
0.00
-0.00
0.0
2.2
—
144.89
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
1.33
—
0
7
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PHOS_MET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PHOS_MET | 4.82 [3.0, 7.74] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 333 females with E4_PHOS_MET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PHOS_MET | 3.918 [2.62, 5.86] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 326 males with E4_PHOS_MET died.
Mortality risk
Mortality risk for people of age
years, who have E4_PHOS_MET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.415% | 0.867% |
| 5 | 2.335% | 4.788% |
| 10 | 6.908% | 11.571% |
| 15 | 13.29% | 21.978% |
| 20 | 22.891% | 36.068% |
Relationships between endpoints
↥Index endpoint: E4_PHOS_MET – Disorders of phosphorus metabolism and phosphatases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data