Ovarian dysfunction: androgen excess

E4_ODANDRO

ovarian disease: A disease involving the ovary.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule only females	313377
2. Check conditions None	313377
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E28.1# Hospital discharge: ICD-9 — 2561 Cause of death: ICD-10 — E28.1# Cause of death: ICD-9 — 2561 2 out of 7 registries used, show all original rules.	65
4. Check minimum number of events None	65
5. Include endpoints None	65
6. Filter based on genotype QC (FinnGen only)	56

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E28
Name in latin: Hypersecretio androgenorum

NAME	E4_ODANDRO
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E281
HD_ICD_9	2561
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E281
COD_ICD_9	2561
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Ovarian dysfunction: androgen excess based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Ovarian dysfunction: androgen excess, drug-induced

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	356	356	-
Only index persons	343	343	-
Unadjusted period prevalence (%)
Whole population	0.01	0.01	-
Only index persons	0.01	0.01	-
Median age at first event (years)
Whole population	-	29.95	-
Only index persons	-	29.61	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	56	56	-
Unadjusted period prevalence (%)	0.02	0.02	-
Median age at first event (years)	30.65	30.65	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
60: Matched controls
600

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E28.1

ICD-10 Finland

Ovarian dysfunction: Androgen excess

+∞

68.4

E28.2

ICD-10 Finland

Polycystic ovarian syndrome

476.6

29.5

G03DB01

ATC

dydrogesterone; oral

11.5

21.1

A10BA02

ATC

metformin; oral

9.3

17.2

N97.0

ICD-10 Finland

Female infertility associated with anovulation

30.4

12.4

G03HB01

ATC

cyproterone and estrogen; oral

5.6

10.0

L68.0

ICD-10 Finland

Hirsutism

44.0

9.4

2561A

ICD-9 Finland

Ovarian dysfunction, Other ovarian hyperfunction

+∞

8.5

E, ,

ICD-9 Finland

+∞

7.4

O80.0

ICD-10 Finland

Spontaneous vertex delivery

0.1

6.9

260

N91.1

ICD-10 Finland

Secondary amenorrhoea

26.0

6.9

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023530) 17-Hydroxyprogesterone [Moles/volume] in Serum or Plasma

+∞

5.27

2.6

0.0

6.28

—

nmol/l

—

(3022313) Gas panel - Capillary blood

7.03

3.28

5.7

3.8

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

8.94

2.80

1.0

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

160

2.41

2.75

2.1

3.0

17.06

17.56

ng/l

0.04

(3012516) Albumin [Mass/volume] in Urine

115

2.44

2.60

6.2

3.4

86.09

32.25

mg/l

0.52

(3020682) Albumin/Creatinine [Ratio] in Urine

117

2.39

2.49

7.3

4.2

11.14

5.99

mg/mmol

0.44

(4195642) Thrombophilia screening test

5.94

2.26

1.4

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.78

1.40

1.5

1.9

—

(3045424) Erythrocytes [Presence] in Urine

2.66

1.34

2.7

1.9

—

0.00

estimate

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

213

1.70

1.17

2.3

2.0

96.46

90.67

pmol/l

0.28

119

(40768797) Stomach Pathology biopsy report

1.99

1.14

1.2

1.3

—

(3019150) Specific gravity of Urine by Refractometry

125

1.76

1.12

3.4

3.7

1.02

kg/l

0.87

(3004588) Protein electrophoresis panel - Serum or Plasma

2.38

1.05

1.6

3.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

2.38

1.05

1.0

1.1

0.88

0.83

g/l

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

2.38

1.05

1.0

1.1

1.46

1.66

g/l

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.38

1.05

1.2

2.5

99.40

103.36

—

(3002256) Pathology report gross observation

1.89

1.01

1.1

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.07

1.01

1.6

1.4

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.99

0.92

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

503

2.12

0.87

5.3

4.1

6.47

5.55

mmol/l

2.58

466

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.04

0.87

1.7

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.75

0.82

1.4

2.0

—

(3023520) Reticulocytes [#/volume] in Blood

1.91

0.81

2.5

4.0

80.68

72.95

e9/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.81

0.0

2.4

—

1.31

—

(3026782) Osmolality of Urine

101

1.65

0.80

2.0

2.3

450.20

544.14

mosm/kgh2o

1.07

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.28

0.78

1.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.75

0.78

1.8

1.4

—

(40768804) Tissue Pathology biopsy report

240

1.50

0.76

2.2

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

139

1.54

0.72

1.7

1.9

—

(3027945) Reticulocytes/Erythrocytes in Blood

1.71

0.69

3.0

4.0

1.86

1.64

—

(3000494) Fungus identified in Specimen by Culture

1.70

0.66

1.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

1.70

0.66

2.0

1.8

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.61

0.0

3.0

—

6.52

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.61

0.0

4.3

—

23.80

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.61

0.0

2.4

—

25.16

—

(3001604) Monocytes [#/volume] in Blood

288

1.42

0.60

6.1

6.0

0.60

0.52

e9/l

1.19

258

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.59

0.0

2.4

—

0.64

—

(3025941) Bacteria identified in Stool by Culture

1.74

0.59

1.2

1.1

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

230

1.41

0.58

2.4

1.8

1.54

1.27

mmol/l

0.85

207

(3032080) INR in Blood by Coagulation assay

164

1.43

0.57

5.3

13.5

1.08

1.16

inr

0.34

135

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

155

1.44

0.57

2.3

2.5

74.55

57.35

u/l

0.26

140

(3006315) Basophils [#/volume] in Blood

291

1.39

0.55

6.1

6.0

0.05

0.04

e9/l

0.69

258

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.51

0.54

1.6

1.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

214

1.38

0.52

3.9

4.5

35.38

37.38

g/l

1.14

206

(3002582) Erythrocytes [#/volume] in Urine

176

1.39

0.52

2.6

2.7

11.45

29.63

e6/l

0.71

134

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

186

1.38

0.51

2.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

169

1.37

0.48

1.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

237

1.34

0.46

6.5

6.4

1.23

1.21

mmol/l

0.69

202

(40758558) Short blood count panel - Blood

159

0.69

0.46

2.7

6.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.52

0.45

1.6

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

447

0.74

0.42

3.8

4.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.38

0.42

4.5

5.7

1.02

1.03

mmol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

269

1.32

0.42

2.1

2.8

—

estimate

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

135

0.69

0.42

2.0

2.1

—

(3035933) Granulocytes/Leukocytes in Blood

0.00

0.42

0.0

2.6

—

60.53

—

(3020891) Body temperature

0.00

0.41

0.0

5.5

—

36.99

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

154

1.34

0.41

1.8

1.9

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.40

0.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

121

0.70

0.40

1.8

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.42

0.39

2.2

1.7

358.08

442.63

pmol/l

0.72

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.44

0.36

1.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.42

0.35

3.1

2.5

20.80

23.54

—

(3015736) pH of Urine

245

1.27

0.34

3.3

5.95

6.19

0.77

139

(42870588) Differential panel, method unspecified - Blood

178

1.28

0.32

7.7

5.8

—

(3000492) Spirometry study

1.33

0.32

1.9

1.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.28

0.31

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.36

0.30

2.0

2.6

0.48

0.97

e6/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.38

0.30

2.2

2.7

7.40

4.48

e6/l

—

(36660697) Celiac disease serology panel - Serum

1.33

0.29

1.5

1.1

—

(21494755) Public health laboratory ask at order entry panel

1.24

0.28

1.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

157

0.78

0.26

2.2

1.9

459.77

115.95

u/l

0.60

150

(36304419) Bacteria [Presence] in Urine

153

1.25

0.26

2.1

2.5

—

estimate

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

519

1.40

0.26

17.1

12.6

3.99

3.89

mmol/l

2.07

503

(3003694) ABO and Rh group [Type] in Blood

186

0.81

0.23

1.6

1.8

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.27

0.23

2.4

3.6

1.25

1.23

mmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

195

0.82

0.22

1.4

1.7

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

9.63

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

2.0

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(44806420) Estimation of glomerular filtration rate

0.00

0.21

0.0

2.2

—

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

2.8

—

59.72

—

(3029937) Albumin [Presence] in Urine by Test strip

166

1.21

0.21

3.1

3.9

0.00

0.01

estimate

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

4.5

—

0.00

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

4.5

—

0.00

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

235

1.19

0.21

3.5

0.00

0.05

estimate

—

(3035715) Granulocytes [#/volume] in Blood

0.00

0.20

0.0

2.7

—

5.23

—

(3012501) Base excess in Blood by calculation

0.00

0.20

0.0

1.8

—

3.54

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.20

0.0

1.8

—

4.85

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.20

0.0

1.8

—

9.99

—

(3026008) Bacteria identified in Urine by Culture

173

0.82

0.20

3.5

2.6

—

(3044640) Blood type and Crossmatch panel - Blood

187

1.19

0.19

1.8

1.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.77

0.17

3.5

1.9

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

522

1.34

0.16

16.8

12.5

139.04

139.68

mmol/l

0.99

510

(3021589) Normoblasts [#/volume] in Blood

259

1.15

0.15

6.1

9.6

0.00

e9/l

0.80

214

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.81

0.15

1.3

1.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

179

0.86

0.15

1.9

2.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

300

1.14

0.14

3.7

0.00

0.01

estimate

—

(3013512) EKG study

133

1.17

0.13

3.1

2.9

—

(3018095) Leukocytes [#/volume] in Urine

213

1.13

0.11

2.9

3.4

17.67

45.49

e6/l

0.68

143

(3030467) Casts [#/volume] in Urine by Automated count

154

1.14

0.11

2.2

2.6

0.21

0.27

e6/l

0.18

109

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

125

0.85

0.11

1.6

2.0

—

(3035350) Ketones [Presence] in Urine by Test strip

303

1.12

0.11

3.7

0.00

21.37

estimate

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

276

0.90

0.10

4.2

5.9

7.33

9.78

umol/l

1.82

258

(3022145) Colonoscopy Study observation

1.12

0.10

1.0

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

554

0.91

0.10

20.5

14.5

65.51

67.08

umol/l

0.39

547

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.05

0.09

2.0

4.7

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.08

0.09

2.0

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

539

1.24

0.08

15.1

13.1

19.50

18.78

mg/l

0.07

420

(40761536) Microorganisms panel - Urine sediment

0.79

0.08

2.2

3.5

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.86

0.08

2.8

2.4

5.00

4.29

umol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

111

0.88

0.06

1.7

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

161

0.91

0.06

2.8

4.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

184

1.05

0.00

3.1

3.0

0.00

0.05

estimate

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

334

1.04

0.00

6.4

9.7

4.75

3.85

e9/l

2.00

295

(3007164) IgA [Mass/volume] in Serum or Plasma

163

0.97

0.00

1.4

2.04

2.50

g/l

—

102

(3023368) Bacteria identified in Blood by Culture

105

1.06

0.00

3.0

3.6

—

(1761868) Lipid panel - Serum or Plasma

248

1.01

0.00

3.2

2.9

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

15.8

—

951.67

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

-0.00

0.0

1.2

—

44.02

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

-0.00

0.0

1.3

—

10.14

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

108.88

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.5

—

3.93

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.0

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.90

-0.00

1.3

1.5

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.5

—

1.18

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.5

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

65.40

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.5

—

106.50

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.00

-0.00

2.4

2.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

-0.00

0.0

1.1

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

18.2

—

1508.33

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.02

-0.00

2.2

2.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

2.6

—

10.80

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

4.2

—

41.00

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

-0.00

0.0

1.8

—

15.90

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

-0.00

0.0

8.0

—

3.98

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

-0.00

0.0

1.1

—

(44813793) Dust mix specific IgE antibody measurement

0.00

-0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

11.4

—

0.72

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

-0.00

0.0

1.8

—

1.72

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.6

—

(3012494) Peanut IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

0.38

—

(3008898) HLA-B27 [Presence]

1.00

-0.00

1.0

1.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

-0.00

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.4

—

91.56

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

2.4

—

57.22

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.3

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.4

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

-0.00

0.0

7.7

—

1.49

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ODANDRO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ODANDRO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_ODANDRO – Ovarian dysfunction: androgen excess

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Ovarian dysfunction: androgen excess

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints