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Drug-induced obesity

DOID EFO Endpoint Browser PheWeb

E4_OBESITYDRUG

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E66.1#
  • Cause of death: ICD-10 — E66.1#

2 out of 7 registries used, show all original rules.

374

4. Check minimum number of events

None

374

5. Include endpoints

None

374

6. Filter based on genotype QC (FinnGen only)

338

Control definitions (FinnGen only)

Control exclude
E4_OBESITY

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E66
Name in latin
Obesitas medicamento provocata

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1947 1310 630
Only index persons 1879 1276 603
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.04 0.05 0.02
Median age at first event (years)
Whole population 43.29 41.92 45.89
Only index persons 42.39 41.22 44.86

-FinnGen-

Key figures

All Female Male
Number of individuals 338 256 82
Unadjusted period prevalence (%) 0.08 0.09 0.04
Median age at first event (years) 46.58 44.03 54.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
350
Matched controls
3500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E66.01
ICD-10 Finland
Obesity due to excess calories
101.9
307.7
251
85
E66.1
ICD-10 Finland
Drug-induced obesity
+∞
307.7
350
*
E66.8
ICD-10 Finland
Other obesity
102.9
260.7
138
22
E66.00
ICD-10 Finland
Metabolic syndrome
47.2
161.7
99
29
E66.9
ICD-10 Finland
Obesity, unspecified
207.4
103.6
103
7
T82
ICPC
Obesity
17.3
88.1
79
58
A10BA02
ATC
metformin; oral
7.2
76.3
178
438
E66
ICD-10 Finland
Obesity
12.0
69.3
78
82
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
63.5
59
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
12.8
60.1
63
59
G47.3
ICD-10 Finland
Sleep apnoea
5.6
54.7
153
425
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
5.7
52.4
133
338
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
11.5
50.3
56
57
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
7.7
47.9
76
121
N05AX12
ATC
aripiprazole; systemic
9.0
45.7
62
82
103
Kela drug reimbursment
Diabetes, insulin-treated
5.0
45.3
138
403
E11
ICD-10 Finland
Type 2 diabetes mellitus
5.9
43.7
95
207
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
11.0
42.2
48
50
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.8
41.7
131
389
T90
ICPC
Diabetes non-insulin dependent
4.8
40.8
125
363
C03CA01
ATC
furosemide; systemic
4.5
37.9
124
377
A10BJ06
ATC
semaglutide; parenteral
9.5
35.1
44
52
QBJ30
NOMESCO Finland
Correction of abdominal apron
133.3
34.4
36
*
N05AH03
ATC
olanzapine; systemic
6.1
33.3
65
126
B01AB05
ATC
enoxaparin; parenteral
3.7
31.5
158
636
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.2
29.8
100
304
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
28.7
142
561
SPAT1262
SPAT
Handing over of treatment supplies
4.4
28.6
87
245
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
28.5
27
*
E66.0
ICD-10 Finland
Obesity due to excess calories
304.6
28.2
28
*
N05AH04
ATC
quetiapine; oral
3.7
27.8
124
457
A46
ICD-10 Finland
Erysipelas
4.5
27.7
80
216
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
4.3
27.6
85
241
310
Kela drug reimbursment
Orlistat, sibutramine and other major and expensive medicines used to treat obesity
105.1
27.1
29
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.6
26.5
73
190
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.7
26.2
110
387
N05AA02
ATC
levomepromazine; systemic
7.4
25.6
39
58
N06AB04
ATC
citalopram; systemic
3.5
25.4
120
455
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.5
24.5
52
108
205
Kela drug reimbursment
Chronic hypertension
3.7
23.5
95
324
N06AX16
ATC
venlafaxine; oral
3.4
22.3
100
364
RD210, ,
NOMESCO Finland
18.1
21.4
33
20
N02AX02
ATC
tramadol; systemic, rectal
2.9
21.4
184
966
SPAT1229
SPAT
Assessment of need for aid
5.6
21.3
43
85
N03AX16
ATC
[U] pregabalin
3.2
21.2
115
468
N03AX09
ATC
lamotrigine; oral
5.0
20.8
49
111
I10
ICD-10 Finland
Essential (primary) hypertension
2.9
20.5
213
1226
B03BA03
ATC
hydroxocobalamin; parenteral
6.4
20.5
36
62
N05AN01
ATC
lithium; oral
7.8
20.2
29
40
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
6.8
20.1
33
53
R5140
NOMESCO Finland
Monitoring the use of the aid
4.2
19.8
59
161
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
19.4
144
691
A10BJ02
ATC
liraglutide; parenteral
8.6
19.0
25
31
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
+∞
18.9
18
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.5
18.8
50
125
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.6
18.5
71
231
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
7.9
18.5
26
35
F20.9
ICD-10 Finland
Schizophrenia, unspecified
7.9
18.5
26
35
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.1
18.3
55
151
A10BB12
ATC
glimepiride; oral
6.0
17.8
33
60
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.6
17.4
66
213
N05BA01
ATC
diazepam; systemic, rectal
3.4
17.2
73
253
A10BH01
ATC
sitagliptin; oral
4.5
17.2
45
111
WX722
NOMESCO Finland
PEEP
8.0
17.2
24
32
N05AB03
ATC
perphenazine; systemic, rectal
6.5
17.1
29
48
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
17.1
183
1039
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
3.6
16.9
64
206
A10BK03
ATC
empagliflozin; oral
3.9
16.9
54
155
N06AX05
ATC
trazodone; oral
6.5
16.7
28
46
N05AX08
ATC
risperidone; systemic
4.1
16.6
50
137
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
3.6
16.6
63
203
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
12.5
16.4
29
25
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
7.2
16.4
25
37
A10AE04
ATC
insulin glargine; parenteral
3.9
16.3
52
149
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
16.2
106
469
B81
ICPC
Anaemia vit B12/folate deficiency
6.8
16.1
26
41
Z3226
NOMESCO Finland
Physiotherapist
2.9
16.0
93
386
N05CD07
ATC
temazepam; oral
3.8
15.8
52
152
N02BF02
ATC
pregabalin; oral
4.2
15.8
46
123
Z3231
NOMESCO Finland
Registered nurse
2.6
15.7
127
625
F31.8
ICD-10 Finland
Other bipolar affective disorders
6.8
15.6
25
39
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
4.4
15.5
42
106
N06AB03
ATC
fluoxetine; oral
3.2
15.4
70
252
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
6.0
15.3
28
50
OAB72, ,
SPAT
13.3
15.1
26
21
T83
ICPC
Overweight
7.2
15.0
23
34
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.1
14.9
44
119
A08AB01
ATC
orlistat; oral
156.3
14.6
15
*
A28
ICPC
Limited function/disability NOS
3.2
14.3
66
239
N05BA06
ATC
lorazepam; systemic, sublingual
4.5
14.3
37
90
B01AA03
ATC
warfarin; systemic
3.4
14.2
56
184
J01FF01
ATC
clindamycin; systemic
2.5
14.2
119
591
Z2446
NOMESCO Finland
Social worker
3.9
14.2
45
128
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.8
14.1
33
74
TLC00
NOMESCO Finland
Insertion of intrauterine device
3.6
14.0
50
154
N05BA04
ATC
oxazepam; oral
2.5
14.0
126
647
OAB72
NOMESCO Finland
Weight control and weight loss guidance
55.7
13.9
16
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
4.7
13.9
34
79
H03AA01
ATC
levothyroxine sodium; systemic
2.5
13.9
116
574
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.3
13.6
56
189
R4190
NOMESCO Finland
Nutritional therapy
5.2
13.6
29
60
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.3
13.3
36
91
SPAT1301
SPAT
No procedures
2.4
13.2
130
691
IGY02
NOMESCO Finland
Psychiatric monitoring contact
4.7
13.2
32
74
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
13.1
66
251
N06AX03
ATC
mianserin; oral
4.9
13.1
30
66
SPAT1310
SPAT
Counselling related to known health issue
2.4
13.1
141
780
M79.6
ICD-10 Finland
Pain in limb
2.3
12.8
191
1207
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
12.7
182
1132
A10AC01
ATC
insulin (human); parenteral
3.8
12.5
41
119
F61.0
ICD-10 Finland
Mixed personality disorders
11.1
12.4
23
22
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.9
12.4
39
110
N03AG01
ATC
valproic acid; systemic, rectal
3.8
12.4
40
115
M54.5
ICD-10 Finland
Low back pain
2.3
12.2
159
945
S97
ICPC
Chronic ulcer skin
4.3
12.2
33
83
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
4.6
12.2
30
70
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
10.6
12.2
23
23
A06AD11
ATC
lactulose; oral
3.2
12.1
54
191
A02BC02
ATC
pantoprazole; systemic
2.4
12.1
254
1834
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.6
11.8
83
375
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
11.8
60
229
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.6
11.7
29
68
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.3
11.7
47
156
M79.7
ICD-10 Finland
Fibromyalgia
4.7
11.7
28
64
I50.9
ICD-10 Finland
Heart failure, unspecified
3.6
11.6
41
125
ZXE20
NOMESCO Finland
More than three and less than five hours
2.9
11.6
60
231
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.4
11.6
30
73
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
11.5
57
214
A08AA10
ATC
sibutramine; oral
123.9
11.5
12
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
11.5
51
180
XG466
NOMESCO Finland
Sleep oxymetry
10.1
11.4
22
23
M54.4
ICD-10 Finland
Lumbago with sciatica
2.5
11.3
89
424
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
2.3
11.3
120
653
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
11.2
60
235
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.5
11.2
84
391
N02BE01
ATC
paracetamol; systemic, rectal
4.7
11.1
332
2788
A10BJ05
ATC
dulaglutide; parenteral
14.5
11.1
18
13
160
Kela drug reimbursment
exenatide
14.5
11.1
18
13
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.8
11.1
35
99
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
11.1
89
428
L17
ICPC
Foot/toe symptom/complaint
2.2
10.9
129
730
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.1
10.8
48
169
R4140
NOMESCO Finland
Psychotherapy
18.6
10.8
16
9
A08
ICPC
Swelling
4.2
10.8
30
77
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.9
10.8
54
204
P99
ICPC
Psychological disorders other
4.5
10.8
27
64
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
10.7
118
648
N05AF03
ATC
chlorprothixene; systemic
5.5
10.7
21
40
S89.9
ICD-10 Finland
Unspecified injury of lower leg
4.7
10.7
25
56
SPAT1307
SPAT
Psychosocial counselling and guidance
3.4
10.7
40
127
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
10.6
162
1011
RD112, ,
NOMESCO Finland
113.3
10.5
11
*
N05CF01
ATC
zopiclone; oral
2.2
10.5
128
733
C07AB07
ATC
bisoprolol; oral
2.1
10.4
158
983
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
10.4
161
1009
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.9
10.3
52
197
L28
ICPC
Limited function/disability (L)
2.5
10.3
73
330
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.4
10.2
39
125
N06AB10
ATC
escitalopram; oral
2.2
10.2
110
597
B01AB04
ATC
dalteparin; parenteral
4.6
10.2
25
58
A10BD07
ATC
metformin and sitagliptin; systemic
5.3
10.2
21
42
A10BH05
ATC
linagliptin; oral
4.9
10.2
23
50
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
10.5
10.1
19
19
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
10.5
10.1
19
19
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
10.1
83
401
L15
ICPC
Knee symptom/complaint
2.2
10.1
110
600
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.3
10.1
101
532
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
10.0
137
817
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.8
9.9
53
207
UJF32
NOMESCO Finland
Coloscopy
2.3
9.9
94
483
A10BK01
ATC
dapagliflozin; oral
3.8
9.9
31
87
F31
ICD-10 Finland
Bipolar affective disorder
10.0
9.9
19
20
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.6
9.9
34
102
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
5.5
9.7
19
36
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.3
9.7
39
129
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
9.7
125
727
N05AH02
ATC
clozapine; systemic
7.5
9.7
22
31
P06
ICPC
Sleep disturbance
2.5
9.6
71
326
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.7
9.6
58
242
J01DB01
ATC
cefalexin; oral
2.9
9.6
310
2553
N03AX12
ATC
[U] gabapentin; oral
2.4
9.5
73
342
WX110
NOMESCO Finland
Infiltration anesthesia
2.3
9.4
280
2206
R06.5
ICD-10 Finland
Mouth breathing
3.2
9.4
40
137
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.1
9.4
20
41
Z50.4
ICD-10 Finland
Psychotherapy, not elsewhere classified
22.4
9.4
13
6
2780A
ICD-9 Finland
Obesity and other hyperalimentation, Obesity
+∞
9.4
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
9.4
141
866
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.4
9.3
34
106
ZY010
NOMESCO Finland
Hospital outpatient
3.5
9.3
33
101
N02BF01
ATC
gabapentin; oral
2.8
9.2
51
203
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
9.2
41
145
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
9.4
9.1
18
20
A10BX04
ATC
[U] exenatide
37.7
9.1
11
*
S10
ICPC
Boil/carbuncle
3.4
9.0
33
103
L03
ICPC
Low back symptom/complaint
2.1
9.0
127
760
M54.8
ICD-10 Finland
Other dorsalgia
3.6
9.0
30
88
J01MA02
ATC
ciprofloxacin; systemic
2.0
9.0
133
810
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.9
9.0
45
170
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
8.8
52
214
N06AX11
ATC
mirtazapine; oral
2.0
8.8
142
890
N03AX11
ATC
topiramate; oral
4.4
8.8
22
52
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
4.6
8.7
21
48
J45
ICD-10 Finland
Asthma
2.7
8.7
52
215
SPAT1254
SPAT
Administration of medicine
2.6
8.7
54
228
EBA00
NOMESCO Finland
Extraction of tooth
2.0
8.7
147
936
R03AC02
ATC
salbutamol; inhalant
2.0
8.7
225
1658
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.7
8.6
50
204
J01MA12
ATC
levofloxacin; systemic
2.4
8.6
68
322
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.8
8.6
46
180
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
8.6
57
249
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
8.5
101
564
A10BJ01
ATC
exenatide; parenteral
28.3
8.5
11
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.1
8.5
38
134
C03AA03
ATC
hydrochlorothiazide; oral
3.3
8.5
33
107
K02.1
ICD-10 Finland
Caries of dentine
2.0
8.5
238
1795
ZXD05
NOMESCO Finland
Urgent procedure
2.0
8.5
126
765
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
8.4
42
158
P29
ICPC
Psychological sympt/compl other
2.7
8.4
47
188
WX290
NOMESCO Finland
Other blockage of nerve
1.9
8.4
202
1445
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
4.1
8.3
23
59
M04AA01
ATC
allopurinol; systemic
3.0
8.3
39
142
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.3
8.3
69
334
A08AA02
ATC
fenfluramine; oral
14.9
8.3
13
9
N06AB06
ATC
sertraline; oral
2.4
8.2
64
300
N06AX21
ATC
duloxetine; oral
2.5
8.2
59
267
H02AB09
ATC
hydrocortisone; systemic
4.9
8.2
18
38
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.2
8.2
22
55
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
8.2
105
604
N05AE04
ATC
ziprasidone; systemic
12.1
8.1
14
12
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
3.7
8.1
26
74
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
17.7
8.1
12
7
R60.0
ICD-10 Finland
Localized oedema
2.6
8.1
50
210
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
4.3
8.1
21
51
Z71.8
ICD-10 Finland
Other specified counselling
1.9
8.1
150
979
N04AA02
ATC
biperiden; systemic
7.5
8.1
18
25
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.0
8.0
131
819
Z2445
NOMESCO Finland
Psychologist
3.6
8.0
27
80
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.2
8.0
32
106
C03DA01
ATC
spironolactone; oral
2.8
7.9
43
169
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
7.9
63
298
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.0
7.9
23
61
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
4.0
7.9
23
61
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
4.2
7.9
21
52
C09AA05
ATC
ramipril; oral
2.3
7.9
71
355
IEV99
NOMESCO Finland
Other psychiatric network intervention
46.0
7.7
9
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
7.7
170
1169
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.5
7.7
52
228
C10AA01
ATC
simvastatin; oral
2.0
7.7
108
639
N05BA12
ATC
alprazolam; oral
2.6
7.6
46
191
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.8
7.6
23
63
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.4
7.5
27
83
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
7.5
44
180
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.0
7.5
103
604
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
6.2
7.5
19
32
188
Kela drug reimbursment
Psychosis requiring demanding treatment
13.8
7.4
12
9
3051, ,
Kela drug reimbursment
9.7
7.3
14
15
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.2
7.3
29
95
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.9
7.3
141
925
SGC10
NOMESCO Finland
Pulp capping
2.6
7.3
46
195
IAB12
NOMESCO Finland
Psychiatric psychosis consultation
+∞
7.3
7
*
RD140, ,
NOMESCO Finland
+∞
7.3
7
*
R50.9
ICD-10 Finland
Fever, unspecified
2.3
7.3
64
316
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.9
7.2
36
135
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.9
7.2
21
56
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.9
7.2
21
56
F31.31
ICD-10 Finland
Bipolar disorder depressive episode with somatic syndrome
20.5
7.2
10
5
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
7.1
184
1319
C08CA01
ATC
amlodipine; oral
1.9
7.1
112
687
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
7.2
7.1
16
23
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
3.2
7.1
28
92
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.7
7.0
38
149
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.3
7.0
58
279
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
4.1
7.0
19
48
K07
ICPC
Swollen ankles/oedema
4.1
7.0
19
48
R4190, ,
SPAT
14.1
6.9
11
8
SFA10
NOMESCO Finland
One-surface restoration
1.8
6.9
217
1646
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.9
6.9
20
53
N05AA01
ATC
chlorpromazine; systemic, rectal
8.5
6.9
14
17
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
8.5
6.9
14
17
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
11.2
6.8
12
11
D50.8
ICD-10 Finland
Other iron deficiency anaemias
11.2
6.8
12
11
N06AA09
ATC
amitriptyline; systemic
2.6
6.8
41
170
A10BD20
ATC
metformin and empagliflozin; oral
17.1
6.8
10
6
IGY99
NOMESCO Finland
Other psychiatric treatment contact
3.9
6.7
20
54
SPAT1312
SPAT
General health counselling
1.9
6.7
124
798
F32
ICD-10 Finland
Depressive episode
3.0
6.7
30
106
J01DA09
ATC
[U] cefadroxil
1.9
6.7
104
634
N02AA05
ATC
oxycodone; systemic
2.2
6.7
59
292
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.0
6.6
29
101
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
6.6
112
701
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.2
6.6
61
307
SPAT1263
SPAT
Sampling
1.8
6.6
154
1064
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
7.1
6.6
15
22
N05AD01
ATC
haloperidol; systemic
5.5
6.6
18
34
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.8
6.5
207
1563
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.5
155
1076
H02AB06
ATC
prednisolone; systemic
1.8
6.5
163
1150
K04.0
ICD-10 Finland
Pulpitis
2.4
6.5
48
220
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
6.5
104
640
A10AB05
ATC
insulin aspart; parenteral
2.8
6.4
32
120
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
71.1
6.4
7
*
J01CF05
ATC
flucloxacillin; systemic
2.8
6.4
33
126
N03AF01
ATC
carbamazepine; oral, rectal
3.3
6.4
24
76
JKA20
NOMESCO Finland
Cholecystectomy
6.8
6.4
15
23
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.4
85
490
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
5.7
6.4
17
31
SPAT1240
SPAT
Therapeutic discussion
2.2
6.4
55
269
S80.0
ICD-10 Finland
Contusion of knee
2.6
6.4
38
157
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
6.4
81
460
M48.0
ICD-10 Finland
Spinal stenosis
2.5
6.4
41
176
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
9.5
6.3
12
13
N06AX12
ATC
bupropion; oral
2.5
6.3
40
170
C09BA02
ATC
enalapril and diuretics; systemic
3.2
6.3
25
82
H02AB07
ATC
prednisone; oral
2.3
6.3
49
229
A10AE05
ATC
insulin detemir; parenteral
3.3
6.3
24
77
R60.9
ICD-10 Finland
Oedema, unspecified
3.3
6.3
24
77
SGA01
NOMESCO Finland
Emergency treatment
2.0
6.3
75
416
T81.9
ICD-10 Finland
Unspecified complication of procedure
7.2
6.3
14
20
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
7.2
6.3
14
20
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.5
6.2
21
62
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
3.5
6.2
21
62
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
5.9
6.2
16
28
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
5.9
6.2
16
28
D64.9
ICD-10 Finland
Anaemia, unspecified
2.6
6.2
35
141
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
6.1
48
225
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
2.4
6.1
45
205
A02BC05
ATC
esomeprazole; systemic
1.8
6.1
143
983
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
6.9
6.1
14
21
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
6.9
6.1
14
21
A10BX01
ATC
guar gum; oral
5.4
6.1
17
33
S18
ICPC
Laceration/cut
1.7
6.1
165
1183
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.3
6.1
48
226
K04.4
ICD-10 Finland
Acute apical periodontitis of pulpal origin
2.4
6.1
45
206
XCK10
NOMESCO Finland
Photography of fundus of eye
2.7
6.1
33
130
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.7
6.1
16
29
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
6.2
6.1
15
25

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
114
380
3.97
29.87
2.4
1.6
1230.72
1269.54
nmol/l
0.17
94
282
222
1195
3.35
26.34
6.4
4.9
35.05
36.64
g/l
4.54
212
1139
97
318
3.84
25.64
7.0
7.1
1.03
1.06
mmol/l
0.40
90
288
160
740
3.14
24.11
3.1
2.1
2.84
2.80
mg/l
0.08
144
643
212
1196
2.96
21.60
3.1
1.9
89.90
97.17
pmol/l
1.90
143
598
234
1401
3.02
21.20
3.7
2.4
68.14
76.95
nmol/l
5.59
221
1283
157
773
2.87
20.36
2.1
1.5
20.18
21.07
nmol/l
0.34
140
670
213
1239
2.84
19.90
9.2
6.2
1.21
1.22
mmol/l
0.41
203
1148
229
1388
2.88
19.68
10.2
7.0
1.22
1.22
mmol/l
0.05
211
1213
172
914
2.73
18.91
3.9
3.3
8.22
7.58
mmol/l
0.83
143
784
155
796
2.70
18.04
4.7
3.9
8.33
11.22
mg/mmol
0.31
100
467
170
916
2.66
17.93
3.0
2.5
110.82
63.95
u/l
0.32
159
859
101
421
2.97
17.43
3.3
2.6
2.53
2.34
g/l
2.14
88
396
138
684
2.68
17.05
5.8
4.3
—
—
—
0
0
150
779
2.62
16.81
4.1
3.4
32.92
65.20
mg/l
1.23
105
479
102
455
2.75
15.28
3.5
2.6
12.41
14.18
umol/l
1.82
94
427
248
1684
2.62
15.11
7.5
4.8
6.64
6.38
mmol/l
1.37
238
1563
193
1170
2.45
15.05
18.9
9.7
1.26
1.13
inr
2.24
165
968
115
549
2.63
15.02
2.6
1.6
394.84
34864745.14
pmol/l
0.72
101
479
67
244
3.16
14.43
2.3
2.5
0.21
0.23
g/l
1.19
62
228
175
1038
2.37
14.04
3.3
3.0
29.59
29.98
u/l
0.06
164
989
89
387
2.74
13.88
3.6
2.7
21.17
23.76
%
0.91
81
369
40
108
4.05
13.51
4.0
4.0
—
—
—
0
0
48
148
3.60
13.43
4.6
3.6
7.42
7.42
ph
0.17
40
123
79
330
2.80
13.25
2.1
1.6
—
—
—
0
0
134
732
2.35
12.72
2.3
2.7
349.32
315.03
umol/l
2.55
108
658
296
2275
2.95
12.71
9.8
7.6
83.68
76.47
u/l
2.03
280
2161
227
1557
2.30
12.32
5.7
6.1
9.78
10.41
umol/l
0.44
217
1483
235
1675
2.23
11.05
5.1
3.1
99.64
84.68
ug/l
0.52
219
1586
80
376
2.46
10.39
3.9
2.1
—
—
—
0
0
159
994
2.10
10.30
3.0
2.2
—
—
—
0
0
144
875
2.10
9.99
4.9
3.9
7.40
7.40
ph
0.20
104
619
71
321
2.52
9.99
2.3
1.8
360.68
406.02
nmol/l
0.99
66
310
330
2805
4.09
9.85
10.6
5.1
40.46
37.82
mmol/mol
5.84
322
2671
141
866
2.05
9.37
4.1
2.6
—
—
—
0
0
158
1017
2.01
9.17
3.6
3.3
2.34
2.36
mmol/l
1.18
144
931
157
1013
2.00
9.00
6.3
6.1
—
—
—
0
0
306
2536
2.64
8.73
6.8
4.7
14.49
14.52
pmol/l
0.08
294
2357
240
1810
2.04
8.63
15.5
9.7
4.29
3.92
e9/l
1.99
207
1565
70
338
2.34
8.45
11.0
6.9
104.44
104.19
mmol/l
0.16
70
338
40
148
2.92
8.25
2.1
1.4
0.22
0.25
mg/l
0.14
13
65
55
244
2.49
7.98
4.0
4.5
7.39
7.39
ph
0.08
27
145
54
239
2.49
7.87
4.1
4.4
2.31
1.48
mmol/l
0.85
49
206
331
2894
3.65
7.85
7.2
4.3
6.26
5.69
mmol/l
8.99
313
2702
21
53
4.15
7.73
2.6
2.3
10.90
6.63
pmol/l
0.73
21
53
56
259
2.38
7.41
11.9
9.6
1.59
0.84
mmol/l
0.61
48
215
50
222
2.46
7.22
3.3
4.0
7.37
7.34
ph
0.55
43
156
56
263
2.34
7.15
12.7
9.5
7.41
7.42
ph
0.28
31
160
116
724
1.90
6.97
1.7
1.7
1.15
1.00
mg/l
0.34
89
543
94
554
1.95
6.66
3.6
2.5
2.45
2.43
mmol/l
0.64
83
493
46
204
2.44
6.66
4.0
4.5
89.91
79.72
ng/l
0.29
39
185
12
12
10.31
6.58
2.0
3.2
—
—
—
0
0
55
266
2.27
6.55
2.1
3.3
1.68
1.85
%
0.74
44
239
199
1487
1.78
6.49
3.4
2.7
—
—
estimate
—
0
0
324
2860
2.79
6.35
5.2
3.8
1.56
1.20
mmol/l
12.01
302
2675
11
10
11.31
6.34
1.5
1.1
130.36
115.60
nmol/l
—
11
10
44
199
2.39
6.10
2.0
3.3
73.27
72.25
e9/l
0.09
35
140
211
1629
1.74
5.91
7.1
6.4
0.04
0.04
e9/l
0.04
175
1386
133
903
1.76
5.89
10.6
6.5
—
—
—
0
0
10
9
11.39
5.83
1.6
1.9
17.62
20.01
umol/l
—
10
9
210
1623
1.73
5.82
7.1
6.4
0.58
0.54
e9/l
1.64
175
1385
45
214
2.27
5.56
3.5
4.1
4.34
4.59
pmol/l
0.93
40
191
145
1029
1.70
5.37
4.3
3.3
466.53
29.39
ng/l
0.52
98
631
214
1689
1.69
5.25
9.1
6.8
0.18
0.18
e9/l
0.04
184
1468
36
160
2.39
5.19
10.1
6.6
25.79
24.78
mmol/l
0.80
36
160
36
160
2.39
5.19
15.3
9.3
0.70
0.66
%
0.15
36
160
190
1461
1.66
5.09
7.4
6.5
0.60
0.71
%
2.17
175
1367
211
1667
1.67
5.09
7.2
6.4
2.00
1.99
e9/l
0.04
183
1464
334
3052
3.06
5.01
7.0
5.1
2.64
2.80
mmol/l
2.77
317
2885
190
1466
1.65
4.99
7.3
6.4
2.68
2.85
%
0.56
175
1377
190
1466
1.65
4.99
7.4
6.6
8.27
8.46
%
0.44
173
1381
36
163
2.35
4.98
15.3
9.3
1.41
1.31
%
0.18
36
163
265
2234
1.77
4.93
4.8
3.1
57.37
38.00
u/l
1.73
254
2124
325
2939
2.48
4.83
8.4
5.5
1.78
1.80
mu/l
0.07
311
2762
20
68
3.06
4.79
4.5
1.7
7.40
7.42
ph
1.04
20
68
35
160
2.32
4.74
15.7
9.4
92.73
94.42
%
1.05
35
160
330
3011
2.68
4.70
6.0
4.5
1.30
1.53
mmol/l
23.15
312
2839
23
86
2.79
4.68
2.5
2.0
2.46
4.53
ug/l
0.26
18
78
176
1351
1.61
4.58
4.1
3.3
6.29
6.25
ph
0.17
103
768
51
278
1.98
4.44
3.4
2.2
30.10
32.73
u/l
0.22
39
235
330
3026
2.58
4.37
6.2
4.6
4.40
4.76
mmol/l
9.99
316
2865
191
1509
1.58
4.31
7.4
6.4
28.25
28.95
%
0.45
177
1440
73
452
1.78
4.28
2.9
2.9
5.99
2.91
e6/l
0.94
35
198
37
181
2.17
4.28
2.2
2.6
3.52
5.08
ug/l
0.82
30
162
42
217
2.06
4.23
13.0
8.9
—
—
—
0
0
63
375
1.83
4.21
1.6
1.4
—
—
—
0
0
131
959
1.58
4.03
3.8
3.1
86.48
112.12
e6/l
0.11
102
705
150
1136
1.56
3.97
4.4
3.7
75.43
70.31
e6/l
0.05
106
752
64
391
1.78
3.92
1.5
1.3
—
—
—
0
0
106
745
1.61
3.84
4.8
3.7
1.02
1.02
kg/l
0.47
68
482
183
1456
1.54
3.84
14.5
10.3
0.00
0.00
e9/l
0.56
141
1182
17
407
0.39
3.79
1.0
1.3
—
—
—
0
0
251
2152
1.59
3.68
5.9
4.2
—
2.71
—
0
5
186
1498
1.52
3.60
7.3
6.4
57.99
56.93
%
0.70
176
1435
114
829
1.56
3.53
3.4
2.9
0.26
0.34
e6/l
0.31
83
580
6
6
10.14
3.51
2.8
1.5
88.17
51.93
ng/l
—
6
6
7
10
7.12
3.38
5.7
2.0
—
—
—
0
0
124
927
1.52
3.36
1.5
1.3
0.73
1.93
u/ml
1.33
40
263
81
554
1.60
3.24
3.1
2.6
548.59
522.65
mosm/kgh2o
0.39
72
483
48
287
1.78
3.16
1.9
2.0
0.00
0.04
estimate
—
7
78
64
415
1.66
3.15
1.2
1.2
—
—
—
0
0
55
344
1.71
3.10
2.7
2.7
7.42
5.55
umol/l
0.40
44
294
29
148
2.05
3.05
3.6
4.4
25.03
23.92
mmol/l
1.08
29
148
60
392
1.64
2.87
2.0
1.9
—
—
—
0
0
27
138
2.04
2.84
2.7
2.2
—
—
—
0
0
329
3099
2.03
2.61
25.8
13.0
22.09
21.43
mg/l
0.15
311
2449
88
644
1.49
2.56
3.2
2.5
9.33
7.20
e6/l
0.52
82
585
17
75
2.33
2.55
7.9
3.9
3.82
3.90
mmol/l
0.28
17
75
119
925
1.43
2.53
4.8
3.8
0.00
0.00
estimate
0.50
34
350
198
1684
1.40
2.51
4.8
3.6
0.00
0.00
estimate
0.50
38
368
11
37
3.04
2.51
6.9
1.5
—
—
—
0
0
158
1295
1.40
2.48
2.0
1.9
1.71
1.33
mmol/l
3.81
132
1122
41
253
1.70
2.44
3.2
5.3
0.57
0.12
%
0.35
14
51
70
495
1.52
2.39
3.3
3.4
60.30
247.40
ng/l
1.65
46
332
10
34
3.00
2.30
1.1
1.7
—
—
—
0
0
11
40
2.81
2.29
1.2
1.6
—
—
—
0
0
198
1701
1.38
2.28
4.7
3.6
0.00
3.83
estimate
0.50
37
368
18
86
2.15
2.27
2.6
1.5
—
—
—
0
0
6
167
0.35
2.20
1.0
1.1
0.80
0.88
g/l
—
6
167
18
341
0.50
2.19
1.1
1.7
3.42
3.39
mmol/l
—
10
241
27
152
1.84
2.19
2.0
2.1
0.00
0.02
estimate
—
5
61
16
74
2.22
2.18
1.1
1.8
—
—
—
0
0
11
42
2.67
2.16
5.6
1.5
9.22
9.43
kpa
0.15
11
42
11
42
2.67
2.16
5.7
1.5
5.43
5.08
kpa
0.81
11
42
19
95
2.06
2.15
1.1
1.6
491.26
430.24
mg/l
0.27
19
90
39
248
1.64
2.09
3.4
4.9
0.09
0.14
%
0.20
11
56
198
1715
1.36
2.09
4.7
3.6
0.00
0.01
estimate
0.50
32
354
11
244
0.43
2.07
1.3
1.7
—
—
—
0
0
6
162
0.36
2.07
1.0
1.1
1.46
1.59
g/l
—
6
162
9
32
2.86
2.01
2.1
1.3
18.18
35.36
ng/l
—
9
32
54
375
1.52
2.01
3.2
3.0
4.34
5.62
e9/l
0.63
43
336
13
57
2.33
2.00
4.5
4.2
—
—
—
0
0
16
77
2.13
2.00
1.8
2.8
2.18
1.92
index
0.07
11
39
40
263
1.59
1.89
3.4
4.7
0.88
1.01
%
0.12
12
72
112
1350
0.75
1.74
3.4
2.8
—
—
—
0
0
35
228
1.59
1.73
3.2
2.2
9737.91
6660.52
u/l
0.19
12
105
7
26
2.73
1.59
1.6
2.0
—
—
—
0
0
6
20
3.03
1.58
1.5
1.1
—
—
—
0
0
7
27
2.62
1.52
2.1
2.1
9.74
11.26
%
—
7
27
25
155
1.66
1.51
2.0
1.7
—
—
—
0
0
36
247
1.51
1.45
3.4
4.7
0.92
0.65
%
0.28
13
60
5
16
3.15
1.44
1.0
1.5
—
—
—
0
0
16
88
1.86
1.44
1.1
1.4
247.75
333.43
ug/g
—
8
52
9
40
2.28
1.41
1.7
1.4
355.33
451.69
pmol/l
—
9
35
24
151
1.63
1.39
1.5
2.4
—
—
—
0
0
99
814
1.30
1.39
1.7
1.4
2.67
2.17
g/l
1.89
59
518
6
23
2.64
1.37
2.0
1.2
157.67
104.09
pmol/l
—
6
23
6
23
2.64
1.37
3.7
4.0
—
—
—
0
0
6
23
2.64
1.37
3.0
1.2
91.30
92.70
%
—
6
23
7
149
0.46
1.35
1.6
1.6
—
—
—
0
0
28
187
1.54
1.28
1.0
1.2
—
—
—
0
0
9
45
2.03
1.24
1.7
1.5
—
—
—
0
0
332
3215
1.64
1.22
22.9
11.6
—
—
—
0
0
5
19
2.65
1.22
1.2
1.7
62.40
76.89
umol/l
—
5
19
34
241
1.45
1.19
1.1
1.3
—
—
—
0
0
16
97
1.68
1.08
8.2
8.7
—
—
—
0
0
7
33
2.14
1.06
1.9
1.3
—
—
—
0
0
18
114
1.61
1.04
1.6
1.2
—
—
—
0
0
5
22
2.29
1.03
1.0
1.1
—
—
—
0
0
5
22
2.29
1.03
1.0
1.1
—
—
—
0
0
33
240
1.41
1.03
2.5
2.0
6.23
6.24
ph
0.02
20
152
32
232
1.42
1.02
3.8
2.5
0.16
0.16
e6/l
0.01
32
220
146
1297
1.22
1.01
5.0
3.5
0.00
0.01
estimate
0.69
31
308
14
85
1.67
0.95
1.1
2.1
10.97
10.87
mg/l
0.02
14
80
8
146
0.54
0.95
1.3
1.5
—
—
—
0
0
146
1311
1.19
0.88
2.2
2.0
—
—
—
0
0
36
275
1.34
0.86
1.7
1.3
22.12
23.32
iu/l
0.08
29
235
20
137
1.49
0.86
1.2
1.5
1.39
1.18
g/l
2.46
20
131
8
45
1.80
0.85
2.3
1.9
—
—
—
0
0
6
31
1.95
0.85
2.8
2.8
—
—
—
0
0
16
105
1.55
0.83
1.5
2.2
1.84
5.34
iu/l
—
9
41
43
536
0.77
0.82
1.3
1.5
—
—
—
0
0
27
199
1.39
0.81
1.1
1.1
—
145.00
titre
—
0
6
62
517
1.24
0.78
1.6
1.4
536.47
563.08
titre
0.03
17
117
83
721
1.20
0.71
1.4
1.3
16.12
28.35
iu/ml
1.78
25
216
38
304
1.28
0.68
1.2
1.3
179.48
155.67
u/ml
0.09
13
140
23
171
1.37
0.67
1.4
1.9
1.33
3.71
iu/ml
—
6
36
5
28
1.80
0.66
3.2
2.4
4.64
3.94
mmol/l
—
5
28
5
28
1.80
0.66
3.2
2.4
105.60
106.29
mmol/l
—
5
28
5
28
1.80
0.66
3.2
2.4
1.28
1.20
mmol/l
—
5
28
21
156
1.37
0.62
2.2
1.4
—
—
—
0
0
27
209
1.32
0.62
1.6
1.7
1.25
1.40
g/l
0.27
27
195
5
30
1.68
0.61
1.0
1.0
—
—
—
0
0
25
192
1.33
0.61
2.4
1.4
—
—
—
0
0
25
192
1.33
0.61
2.4
1.4
—
—
—
0
0
6
35
1.73
0.58
1.2
1.2
—
—
—
0
0
25
194
1.31
0.57
2.4
1.4
—
—
—
0
0
6
37
1.63
0.56
1.2
1.2
—
—
—
0
0
25
196
1.30
0.54
2.2
1.4
—
—
—
0
0
31
251
1.26
0.53
1.2
1.4
—
—
—
0
0
6
39
1.55
0.53
1.2
2.2
—
—
—
0
0
6
39
1.55
0.53
1.2
1.2
—
—
—
0
0
25
312
0.79
0.51
2.8
3.0
0.61
0.75
ug/l
0.67
17
189
14
101
1.40
0.50
1.3
1.3
—
—
—
0
0
18
136
1.34
0.50
3.6
1.6
—
—
—
0
0
7
46
1.53
0.48
1.3
1.2
—
—
—
0
0
7
46
1.53
0.48
1.1
1.2
—
—
—
0
0
14
102
1.39
0.48
1.0
1.1
—
—
—
0
0
5
81
0.61
0.46
2.0
2.4
—
—
—
0
0
89
978
0.88
0.46
3.9
2.9
0.00
0.01
estimate
0.99
27
296
23
184
1.27
0.44
2.3
1.4
—
—
—
0
0
75
677
1.14
0.41
1.3
1.3
1.92
8.96
u/ml
3.57
30
274
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
177.71
—
0
18
6
42
1.44
0.35
3.7
2.1
—
—
—
0
0
6
43
1.40
0.35
3.2
2.9
4.00
4.34
e9/l
—
6
43
56
503
1.13
0.34
2.5
2.2
192.81
89.65
ug/g
1.12
43
392
6
45
1.34
0.34
1.0
1.0
—
—
—
0
0
7
55
1.28
0.30
1.0
1.1
—
—
—
0
0
30
261
1.16
0.29
4.7
4.1
3.77
25.20
ug/l
0.72
24
215
96
1019
0.92
0.26
1.6
1.6
—
—
—
0
0
11
88
1.26
0.23
1.1
1.1
2.01
2.10
u/ml
—
6
52
11
88
1.26
0.23
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
3.6
—
0.61
—
0
11
0
10
0.00
0.21
0.0
1.5
—
21.80
—
0
10
0
10
0.00
0.21
0.0
2.3
—
4.39
—
0
10
0
12
0.00
0.21
0.0
1.1
—
57.40
—
0
12
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
27
301
0.89
0.19
1.8
1.4
—
—
—
0
0
6
51
1.18
0.19
1.0
1.1
—
—
—
0
0
84
799
1.07
0.18
5.3
4.5
—
—
—
0
0
7
63
1.11
0.17
3.0
2.8
60.14
58.20
%
—
7
63
83
869
0.94
0.16
2.1
2.0
—
—
—
0
0
16
182
0.87
0.15
1.1
1.1
—
—
—
0
0
53
561
0.93
0.14
2.0
1.8
—
—
—
0
0
40
374
1.08
0.13
1.6
1.3
—
—
—
0
0
5
44
1.14
0.10
1.6
1.3
—
—
—
0
0
5
46
1.09
0.09
1.4
1.6
—
—
—
0
0
5
46
1.09
0.09
1.4
1.6
—
—
—
0
0
5
46
1.09
0.09
1.4
1.6
—
—
—
0
0
5
46
1.09
0.09
1.4
1.6
—
—
—
0
0
340
3386
1.14
0.09
42.4
20.2
89.83
90.67
fl
2.75
340
3367
13
145
0.89
0.09
1.5
1.4
—
—
—
0
0
48
502
0.95
0.09
4.4
5.0
1.47
2.46
ug/l
0.82
40
441
15
165
0.91
0.09
1.7
1.3
236.75
252.84
miu/ml
—
7
82
340
3387
1.13
0.08
42.5
20.2
4.53
4.49
e12/l
1.02
335
3335
340
3387
1.13
0.08
43.6
20.5
40.28
40.36
%
0.11
340
3365
340
3387
1.13
0.08
42.3
20.1
29.58
30.23
pg
8.90
340
3367
8
75
1.07
0.07
1.3
1.1
—
—
—
0
0
8
75
1.07
0.07
1.3
1.1
—
—
—
0
0
33
314
1.06
0.07
1.2
1.2
—
—
—
0
0
9
105
0.85
0.06
1.1
1.3
—
—
—
0
0
340
3390
1.10
0.05
42.9
20.3
132.99
134.83
g/l
1.53
340
3369
36
349
1.04
0.03
1.5
1.4
—
—
—
0
0
19
181
1.05
0.03
1.2
1.1
—
—
—
0
0
25
258
0.97
0.02
4.4
3.4
—
—
—
0
0
47
462
1.02
0.01
2.1
1.6
—
—
—
0
0
10
101
0.99
0.00
1.3
1.1
—
—
—
0
0
13
129
1.01
0.00
2.7
1.8
—
—
—
0
0
13
131
0.99
0.00
1.5
1.3
—
—
—
0
0
73
732
1.00
0.00
2.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
7
70
1.00
-0.00
3.4
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
12.5
—
0.24
—
0
6
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
31.8
—
141.32
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
1.71
—
0
9
0
9
0.00
-0.00
0.0
1.3
—
1.77
—
0
9

Mortality – FinRegistry

↥

Association

Association between endpoint E4_OBESITYDRUG and mortality.

Females

Parameter HR [95% CI] p-value
E4_OBESITYDRUG 2.566 [2.01, 3.27] < 0.001
Birth year 0.997 [0.99, 1.01] 0.542

During the follow-up period (1.1.1998 — 31.12.2019), 125 out of 1189 females with E4_OBESITYDRUG died.

Males

Parameter HR [95% CI] p-value
E4_OBESITYDRUG 3.083 [2.32, 4.1] < 0.001
Birth year 0.989 [0.98, 1.0] 0.065

During the follow-up period (1.1.1998 — 31.12.2019), 123 out of 581 males with E4_OBESITYDRUG died.

Mortality risk

Mortality risk for people of age

years, who have E4_OBESITYDRUG.

N-year risk Females Males
1 0.326% 0.507%
5 1.67% 3.295%
10 4.356% 8.667%
15 8.38% 15.952%
20 13.586% 26.563%

Relationships between endpoints

↥

Index endpoint: E4_OBESITYDRUG – Drug-induced obesity

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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