Isolated growth hormone deficiency

E4_ISOLATED_GROWTH_HORMONE_DEFICIENCY

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E23.01
  • Cause of death: ICD-10 E23.01

2 out of 7 registries used, show all original rules.

270

4. Check minimum number of events

None

270

5. Include endpoints

None

270

6. Filter based on genotype QC (FinnGen only)

227

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 227 94 133
Unadjusted period prevalence (%) 0.05 0.03 0.06
Median age at first event (years) 10.59 11.70 9.80

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
256
Matched controls
2560
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H01AC01
ATC
somatropin; parenteral
655.0
307.7
235
43
101
Kela drug reimbursment
Anterior pituitary hypofunction
1164.1
307.7
210
10
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
307.7
255
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
129.7
223.0
115
16
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
20.0
135.0
145
157
E34.35
ICD-10 Finland
Abnormal growth retardation
19.4
96.1
86
65
301
Kela drug reimbursment
Growth hormone
27.5
86.7
63
30
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
22.2
84.6
68
41
E23.00
ICD-10 Finland
Panhypopituitarism
676.4
56.9
54
*
H03AA01
ATC
levothyroxine sodium; systemic
7.5
44.9
79
143
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
15.1
42.7
40
31
H02AB09
ATC
hydrocortisone; systemic
7.8
40.6
66
109
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
5.4
36.9
102
279
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
61.4
32.3
37
7
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.2
29.5
76
192
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.8
23.9
41
70
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
227.8
20.9
21
*
E34.31
ICD-10 Finland
Short stature, prenatal disorder
23.1
19.1
27
13
602
Kela drug reimbursment
Children's severe malnutrition
5.5
18.7
40
84
E34.30
ICD-10 Finland
Short stature NOS
18.3
18.3
28
17
E23.0
ICD-10 Finland
Hypopituitarism
+∞
16.9
16
*
Z31.5
ICD-10 Finland
Genetic counselling
4.0
16.7
55
163
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
16.7
113
527
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
170.0
15.7
16
*
Z3231
NOMESCO Finland
Registered nurse
2.9
15.2
145
803
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.0
14.7
87
372
E23.05
ICD-10 Finland
Lack of TSH
158.7
14.6
15
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
6.2
14.0
25
44
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.9
13.9
46
136
ZXD10
NOMESCO Finland
Scheduled procedure
2.7
13.9
132
720
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.7
13.7
49
153
E23.1
ICD-10 Finland
Drug-induced hypopituitarism
+∞
13.7
13
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.5
12.9
51
170
XCK00
NOMESCO Finland
Perimetry
10.1
12.3
24
26
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
14.3
12.2
20
15
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
24.2
11.7
16
7
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.6
11.1
28
67
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.7
11.1
79
366
Z3226
NOMESCO Finland
Physiotherapist
2.5
11.0
99
513
121
Kela drug reimbursment
Severe hypofunction of sexual glands
16.4
11.0
17
11
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
10.9
73
327
ZXE00
NOMESCO Finland
One hour or less
2.4
10.9
139
842
102
Kela drug reimbursment
Diabetes insipidus
62.7
10.7
12
*
F83
ICD-10 Finland
Mixed specific developmental disorders
3.7
10.6
36
108
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.0
10.5
32
89
G03DB01
ATC
dydrogesterone; oral
4.6
10.4
26
62
BF20A, ,
NOMESCO Finland
27.2
9.9
13
5
T99
ICPC
Endocr/metab/nutrit disease other
15.8
9.6
15
10
G03FB08
ATC
dydrogesterone and estrogen; systemic
15.8
9.6
15
10
E22.80
ICD-10 Finland
Central precocious puberty
18.4
9.5
14
8
L02AE02
ATC
leuprorelin; implant, parenteral
11.3
9.4
17
16
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
9.4
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
9.2
59
257
RD210, ,
NOMESCO Finland
3.2
9.0
38
131
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
9.0
64
294
XA800
NOMESCO Finland
Neuropsychological investigation
2.8
8.8
49
198
H53.4
ICD-10 Finland
Visual field defects
13.4
8.5
14
11
E23.03
ICD-10 Finland
Lack of ACTH
93.0
8.5
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.0
8.2
18
38
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
7.2
8.2
19
28
Z2446
NOMESCO Finland
Social worker
2.3
7.9
71
360
H47.2
ICD-10 Finland
Optic atrophy
15.7
7.8
12
8
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
7.8
77
407
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
19.1
7.7
11
6
Z2445
NOMESCO Finland
Psychologist
2.5
7.6
57
267
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.0
7.5
22
59
UKC02
NOMESCO Finland
Cystoscopy
3.8
7.5
23
64
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
7.5
102
612
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
+∞
7.3
7
*
TAB00
NOMESCO Finland
Lumbar puncture
3.3
7.3
28
91
R4190
NOMESCO Finland
Nutritional therapy
2.4
7.2
57
272
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
31.0
7.2
9
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.5
7.2
25
76
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
7.1
100
604
104
Kela drug reimbursment
Thyroid insufficiency
6.7
7.1
17
27
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
6.4
6.9
17
28
Y28
ICPC
Limited function/disability (Y)
23.2
6.7
9
*
WX1PA
NOMESCO Finland
Total body mineral density measurement with Dual energy X-ray absorptiometry (DXA)
10.4
6.6
12
12
R4110
NOMESCO Finland
Physiotherapy
2.0
6.5
92
553
ZXC86
NOMESCO Finland
Use of endoscopic device
71.6
6.5
7
*
E23.2
ICD-10 Finland
Diabetes insipidus
71.6
6.5
7
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
14.8
6.4
10
7
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.6
6.4
40
171
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
+∞
6.3
6
*
E23.08
ICD-10 Finland
Hypopituitarism
+∞
6.3
6
*
Q96.0
ICD-10 Finland
Karyotype 45,X
+∞
6.3
6
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.1
6.1
17
44
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
6.1
47
222
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.7
6.0
19
54

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
138
299
8.84
69.38
4.6
3.1
307.64
326.42
nmol/l
0.53
133
291
84
111
10.77
63.96
1.8
1.9
22.09
19.73
ng/l
0.58
84
111
99
222
6.64
45.65
3.3
2.4
4.26
5.15
u/l
0.76
59
129
92
213
6.18
40.52
3.2
2.5
7.00
9.67
iu/l
0.82
58
134
53
130
4.88
20.83
3.3
3.4
4.92
5.19
pmol/l
0.87
53
120
54
139
4.66
19.97
3.4
1.5
302.22
337.06
mu/l
0.42
54
131
197
1254
3.48
16.62
8.7
7.3
129.14
125.71
u/l
0.23
187
1191
110
520
2.96
15.67
13.1
14.3
1.33
1.33
mmol/l
0.12
104
494
100
469
2.86
14.20
6.2
5.1
7.38
7.39
ph
0.29
77
321
26
51
5.56
12.98
2.6
1.5
0.22
0.44
nmol/l
0.99
20
40
236
1827
4.73
11.91
7.5
4.4
1.90
1.96
mu/l
0.32
224
1742
66
284
2.78
10.66
4.6
4.1
23.24
21.45
%
0.42
66
279
102
555
2.39
10.02
4.1
3.5
2.40
2.40
mmol/l
0.16
97
517
119
700
2.31
9.69
10.0
10.8
38.13
38.28
g/l
0.12
114
680
164
1109
2.33
9.50
19.8
14.4
1.22
1.22
mmol/l
0.30
150
1036
184
1323
2.39
9.01
12.8
12.1
0.60
0.66
%
0.95
179
1284
59
262
2.63
8.83
3.6
5.6
0.22
0.21
g/l
0.64
59
257
187
1375
2.34
8.36
12.3
11.9
0.56
0.56
e9/l
0.07
149
1149
137
895
2.14
8.20
7.5
10.5
—
—
—
0
0
64
307
2.45
8.10
4.7
4.0
2.51
2.54
g/l
0.20
64
295
186
1374
2.29
8.08
12.3
11.9
0.04
0.04
e9/l
0.26
148
1147
153
1058
2.11
7.71
12.9
12.2
—
—
—
0
0
187
1403
2.23
7.54
12.5
11.9
2.28
2.24
e9/l
0.20
152
1205
188
1415
2.24
7.49
13.6
13.0
0.25
0.22
e9/l
0.91
158
1199
31
110
3.07
6.97
1.7
2.0
—
—
—
0
0
177
1332
2.07
6.63
14.7
14.0
0.00
0.00
e9/l
0.31
126
1017
16
26
6.49
6.58
1.0
1.0
—
—
—
0
0
189
1468
2.10
6.34
14.1
14.4
3.45
3.52
e9/l
0.17
155
1221
137
973
1.88
5.74
1.8
2.0
0.69
4.44
u/ml
3.28
20
159
34
153
2.41
4.85
11.0
18.8
7.41
7.41
ph
0.02
16
50
91
600
1.80
4.61
3.6
3.8
2.47
2.45
mg/l
0.05
83
547
13
28
4.83
4.43
6.1
2.7
—
—
—
0
0
240
2146
2.89
4.42
15.6
9.5
—
—
—
0
0
33
153
2.33
4.41
11.3
18.7
-0.58
0.12
mmol/l
0.45
28
131
16
51
3.28
4.28
13.3
10.3
7.38
7.39
ph
0.40
16
51
128
945
1.71
4.28
2.1
1.8
1.58
1.64
g/l
0.18
62
478
144
1100
1.71
4.22
4.9
4.0
92.96
64.02
ug/l
0.93
139
1065
30
136
2.37
4.22
7.9
7.6
0.00
0.13
%
1.25
13
47
29
131
2.37
4.11
6.9
7.4
0.45
0.74
%
0.49
11
50
14
43
3.39
3.97
7.5
4.5
3.03
3.29
e9/l
0.21
14
43
71
452
1.79
3.96
1.5
1.3
—
—
—
0
0
30
141
2.28
3.89
8.0
7.7
0.68
0.82
%
0.24
14
55
29
135
2.29
3.85
8.8
8.0
0.00
0.00
%
-0.00
12
41
79
530
1.71
3.64
15.1
13.5
—
—
—
0
0
13
36
3.75
3.55
14.9
12.9
5.03
4.82
kpa
0.52
13
36
13
36
3.75
3.55
14.9
12.9
1.29
2.50
mmol/l
—
7
21
13
36
3.75
3.55
14.9
11.8
9.52
9.52
kpa
0.00
13
36
8
13
6.31
3.53
1.0
1.3
—
—
nmol/l
—
0
0
6
6
10.20
3.51
4.5
3.8
8.50
12.33
%
—
6
6
6
6
10.20
3.51
4.5
3.8
32.67
26.17
%
—
6
6
55
337
1.80
3.45
8.0
8.3
1.45
1.39
%
0.25
50
326
44
251
1.91
3.45
13.0
14.2
105.48
105.10
mmol/l
0.14
44
251
7
10
7.16
3.38
1.3
1.1
—
—
—
0
0
14
48
3.03
3.35
16.1
8.9
—
—
—
0
0
150
1201
1.60
3.33
12.9
9.1
6.10
6.27
mmol/l
0.30
141
1131
13
39
3.46
3.27
6.5
2.3
29.09
36.56
mmol/l
0.49
13
39
36
198
1.95
3.14
2.0
2.1
2.42
2.42
mmol/l
0.01
28
166
19
81
2.45
3.07
3.2
5.3
9.32
8.17
%
0.40
19
81
19
81
2.45
3.07
3.2
5.3
71.53
67.88
%
0.34
19
81
234
2133
2.13
2.98
22.0
13.5
64.38
61.08
umol/l
0.59
225
2106
8
17
4.82
2.94
1.0
1.4
—
—
—
0
0
28
145
2.05
2.88
1.2
1.2
—
—
—
0
0
6
9
6.79
2.88
2.5
2.4
—
—
—
0
0
12
39
3.18
2.81
6.8
4.5
17.02
17.03
%
0.01
12
39
232
2117
2.02
2.81
29.1
20.0
13.23
13.11
%
1.08
232
2100
14
54
2.68
2.75
4.2
5.6
—
—
—
0
0
82
591
1.57
2.75
16.8
11.3
7.37
7.37
ph
0.09
65
409
6
10
6.11
2.71
5.2
3.2
175.00
192.70
e6/l
—
6
10
6
175
0.33
2.52
1.0
1.3
—
—
—
0
0
11
37
3.06
2.52
19.0
11.9
8.34
6.62
pmol/l
0.19
11
37
33
191
1.84
2.48
1.5
1.4
180.21
173.82
u/ml
—
9
63
83
613
1.52
2.46
21.6
15.5
24.45
24.86
mmol/l
0.63
83
613
5
8
6.35
2.38
1.2
1.5
194.16
46.26
mu/l
—
5
8
18
85
2.20
2.35
3.2
5.1
36.18
36.86
%
0.07
18
85
8
23
3.56
2.29
3.0
2.7
34.50
32.00
pg
—
8
23
45
293
1.65
2.26
5.1
4.6
9.30
8.81
g/l
0.35
45
280
48
318
1.63
2.26
2.5
2.0
—
—
—
0
0
79
589
1.49
2.21
16.8
11.2
0.86
1.20
mmol/l
0.32
62
483
71
518
1.51
2.20
2.2
1.6
102.70
96.88
pmol/l
0.63
33
265
43
630
0.62
2.18
2.2
2.3
—
—
—
0
0
66
478
1.51
2.11
7.2
3.7
534.31
602.81
mosm/kgh2o
1.84
60
424
17
83
2.12
2.06
2.2
5.0
600.75
501.02
e6/l
0.33
12
56
17
83
2.12
2.06
2.5
5.0
173.00
142.54
e6/l
0.44
12
57
73
545
1.47
2.01
14.7
10.7
23.53
23.66
mmol/l
0.17
73
545
16
77
2.15
2.01
2.1
5.3
28.50
26.88
%
0.19
16
77
19
98
2.01
2.01
2.2
5.4
8.14
3.92
e6/l
0.28
14
75
7
21
3.40
1.98
1.4
1.2
132.71
112.71
pmol/l
—
7
21
19
99
1.99
1.96
2.2
5.4
1206.07
201.92
e6/l
0.71
14
77
18
92
2.03
1.95
2.3
5.7
—
—
—
0
0
17
85
2.07
1.95
2.3
5.6
15.29
16.81
%
0.15
17
85
5
11
4.61
1.95
3.2
1.6
5.58
4.52
mmol/24h
—
5
11
5
11
4.61
1.95
1.0
2.4
1.46
1.37
nmol/l
—
5
11
13
58
2.31
1.94
2.4
3.2
46.35
23.01
u/ml
0.62
13
58
19
100
1.97
1.91
2.0
5.3
345.42
335.03
mg/l
0.06
19
100
20
108
1.92
1.87
6.7
2.9
48.51
55.30
%
0.96
20
108
39
260
1.59
1.80
4.6
6.4
62.77
65.41
e9/l
0.17
24
166
56
406
1.49
1.77
8.0
5.1
—
—
—
0
0
21
118
1.85
1.76
15.1
19.1
0.64
0.65
%
0.06
21
118
6
18
3.39
1.75
3.0
5.2
87.83
244.55
ug/l
—
6
18
16
82
2.01
1.73
2.2
5.2
0.33
0.32
e9/l
—
10
52
29
181
1.68
1.72
6.0
3.8
1.14
1.36
ug/l
0.58
29
157
5
13
3.90
1.72
1.4
1.2
—
—
—
0
0
5
13
3.90
1.72
1.2
1.6
7.12
8.24
umol/l
—
5
13
21
119
1.83
1.72
15.1
19.0
1.00
1.14
%
0.43
21
119
16
83
1.99
1.68
2.3
6.2
—
—
—
0
0
72
554
1.42
1.67
4.5
7.2
1.09
1.13
inr
0.47
58
451
10
41
2.50
1.66
3.4
1.2
300.00
365.29
mu/l
—
10
35
7
25
2.85
1.66
2.3
1.5
91.29
51.56
pmol/l
—
7
25
11
50
2.25
1.59
1.6
1.6
0.00
0.00
estimate
—
5
20
67
514
1.41
1.57
7.7
3.9
5.15
5.09
e6/l
0.02
62
459
18
101
1.84
1.53
2.7
2.0
0.53
0.69
ug/l
0.87
13
43
35
237
1.55
1.52
2.7
2.3
0.95
0.97
g/l
0.10
35
227
16
276
0.55
1.51
1.1
1.8
—
—
—
0
0
15
263
0.54
1.50
1.1
1.7
—
—
—
0
0
16
275
0.55
1.49
1.1
1.7
—
—
—
0
0
16
274
0.56
1.48
1.1
1.7
—
—
—
0
0
6
22
2.77
1.44
1.0
1.1
—
—
—
0
0
214
1990
1.46
1.43
29.8
16.2
3.92
3.95
mmol/l
0.56
209
1940
73
577
1.37
1.43
4.4
3.9
—
0.20
—
0
5
16
271
0.56
1.42
1.1
1.7
—
—
—
0
0
12
60
2.05
1.40
2.1
5.2
—
—
—
0
0
81
654
1.35
1.39
4.6
3.7
—
—
—
0
0
5
17
2.98
1.36
4.2
2.6
—
—
—
0
0
5
17
2.98
1.36
1.0
1.2
360.80
268.18
mg/l
—
5
17
38
272
1.47
1.29
6.6
4.2
13.54
7.42
mg/mmol
0.46
27
208
14
77
1.87
1.28
16.6
18.3
68.29
69.61
%
0.10
14
77
13
225
0.56
1.26
1.0
1.8
—
—
—
0
0
86
712
1.31
1.23
8.7
5.0
0.05
0.17
e6/l
2.05
66
525
156
1401
1.29
1.18
4.3
3.0
5.42
5.48
mmol/l
0.30
148
1298
8
39
2.08
1.16
3.3
15.6
—
—
—
0
0
11
58
1.94
1.14
2.2
3.9
0.75
0.66
e9/l
0.25
11
58
38
280
1.42
1.12
5.9
3.7
62.54
60.39
mg/l
0.03
31
213
19
120
1.63
1.12
16.5
18.9
95.42
95.36
%
0.01
19
120
62
496
1.33
1.12
15.3
9.7
—
—
—
0
0
5
21
2.41
1.09
2.4
2.7
411.00
1356.95
u/ml
—
5
21
40
300
1.40
1.08
8.7
8.9
4.50
6.19
umol/l
0.83
34
252
7
33
2.15
1.06
4.0
2.8
—
—
—
0
0
34
249
1.42
1.05
20.5
16.3
1.75
1.32
mmol/l
0.48
34
239
113
986
1.26
1.04
6.4
3.9
0.00
0.01
estimate
0.50
26
169
114
998
1.26
1.02
6.4
4.0
0.00
0.00
estimate
-0.00
26
162
62
503
1.31
1.01
2.4
4.0
131.81
105.12
ug/g
0.23
51
418
7
35
2.03
1.01
11.3
9.1
2.16
1.94
mg/l
—
7
27
59
476
1.31
1.00
6.5
3.0
0.00
0.01
estimate
0.80
23
146
10
54
1.89
0.98
1.4
1.4
—
—
—
0
0
0
30
0.00
0.98
0.0
1.3
—
15.43
—
0
7
0
30
0.00
0.98
0.0
1.3
—
30.33
—
0
9
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
0
32
0.00
0.95
0.0
1.0
—
—
—
0
0
7
37
1.92
0.94
1.9
1.8
—
—
—
0
0
225
2151
1.38
0.90
27.5
19.5
336.43
335.38
g/l
1.01
225
2141
34
257
1.37
0.89
2.1
2.3
—
—
—
0
0
25
179
1.44
0.88
6.4
10.6
22.60
22.94
s
0.17
25
174
56
457
1.29
0.88
6.3
3.9
0.00
0.00
estimate
-0.00
27
163
13
202
0.62
0.87
1.2
2.0
—
—
—
0
0
8
139
0.56
0.86
1.1
1.1
—
44.76
—
0
14
18
121
1.52
0.85
1.5
1.7
0.00
0.00
estimate
—
6
29
6
31
1.96
0.85
1.0
1.1
—
—
—
0
0
6
31
1.96
0.85
1.0
1.1
—
—
—
0
0
67
562
1.26
0.85
17.5
9.9
7.40
7.41
ph
0.78
59
457
57
469
1.28
0.84
6.2
4.4
3.07
1.23
e6/l
0.64
30
258
90
782
1.23
0.83
9.3
5.0
20.15
39.14
e6/l
0.85
73
596
8
46
1.76
0.83
52.4
51.5
6.08
6.49
ug/l
—
8
41
22
303
0.70
0.83
2.3
2.1
—
—
—
0
0
39
306
1.32
0.81
1.2
1.4
—
108.07
—
0
15
8
47
1.72
0.81
1.3
1.1
—
—
—
0
0
8
47
1.72
0.81
1.1
1.4
—
—
—
0
0
76
651
1.24
0.80
5.6
3.4
0.00
0.01
estimate
0.80
22
155
110
980
1.21
0.79
6.5
3.9
0.00
0.00
estimate
-0.00
27
175
0
26
0.00
0.79
0.0
1.2
—
1.65
—
0
20
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
43
345
1.30
0.77
3.0
2.9
14.44
46.49
ng/l
1.00
23
159
20
276
0.70
0.77
1.2
1.3
9.98
2.16
u/ml
0.67
14
219
6
34
1.78
0.77
1.7
1.4
—
—
—
0
0
9
54
1.69
0.75
3.8
5.0
2.58
5.19
u/ml
—
9
54
40
321
1.29
0.72
2.6
2.7
—
—
—
0
0
9
145
0.61
0.72
1.0
2.0
—
—
—
0
0
9
58
1.57
0.70
5.9
4.1
333.22
403.15
ug/l
—
9
53
18
248
0.71
0.69
1.1
1.3
3.39
2.57
u/ml
0.17
11
197
10
61
1.67
0.69
22.2
20.1
11.11
11.79
%
—
10
61
9
138
0.64
0.62
1.0
1.0
—
—
—
0
0
24
183
1.34
0.62
1.6
1.5
506.92
497.02
pmol/l
0.05
24
165
13
88
1.50
0.62
2.8
2.4
—
—
—
0
0
13
88
1.50
0.62
2.8
2.4
—
—
—
0
0
13
88
1.50
0.62
2.8
2.4
—
—
—
0
0
13
88
1.50
0.62
2.8
2.4
—
—
—
0
0
5
30
1.68
0.61
3.0
3.0
—
—
—
0
0
45
376
1.24
0.60
4.5
6.2
3.04
1.97
mg/l
0.45
35
283
0
22
0.00
0.59
0.0
2.6
—
—
—
0
0
0
23
0.00
0.58
0.0
13.4
—
815.48
—
0
23
74
652
1.19
0.58
4.9
3.2
—
0.14
—
0
7
19
251
0.74
0.58
1.2
1.3
5.45
6.60
u/ml
0.20
12
201
19
141
1.38
0.58
1.7
1.8
6.08
6.22
ph
0.24
12
92
64
729
0.84
0.57
2.3
2.1
—
—
—
0
0
6
37
1.64
0.56
4.2
2.1
1.92
1.68
mmol/l
—
6
37
100
908
1.17
0.55
11.3
6.1
14.70
37.57
e6/l
1.22
77
616
19
248
0.75
0.54
1.2
1.3
1.30
0.85
u/ml
0.47
11
189
27
215
1.29
0.53
2.1
1.9
—
—
—
0
0
9
63
1.44
0.53
2.0
2.4
—
—
—
0
0
46
536
0.83
0.52
3.8
2.3
—
—
—
0
0
6
40
1.51
0.52
1.0
1.1
—
—
—
0
0
11
75
1.49
0.51
2.2
2.0
—
—
—
0
0
13
93
1.42
0.49
2.3
1.3
1.24
1.19
g/l
0.23
13
87
16
120
1.36
0.47
6.2
3.2
0.10
0.10
e6/l
0.01
16
113
8
116
0.68
0.47
1.3
1.1
—
—
—
0
0
13
94
1.40
0.47
1.5
2.4
0.96
0.45
nmol/l
1.85
13
81
5
83
0.59
0.46
1.0
1.4
—
—
—
0
0
5
84
0.59
0.46
1.2
1.2
—
—
—
0
0
34
402
0.82
0.45
1.7
1.9
—
—
—
0
0
43
495
0.84
0.44
1.9
1.8
—
—
—
0
0
12
87
1.40
0.43
12.2
4.6
27.58
35.52
umol/l
1.27
12
87
18
141
1.30
0.41
11.1
4.1
—
—
—
0
0
7
104
0.66
0.40
1.4
1.2
—
—
—
0
0
7
105
0.66
0.40
1.4
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
274.22
—
0
18
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
57
510
1.15
0.38
2.5
1.8
—
—
—
0
0
11
146
0.74
0.37
2.5
1.9
—
—
—
0
0
15
118
1.29
0.34
15.6
13.6
0.44
0.60
%
1.74
15
118
6
46
1.31
0.33
1.2
1.0
—
—
—
0
0
11
83
1.34
0.32
1.1
1.3
—
—
—
0
0
47
420
1.15
0.32
13.4
7.2
—
—
—
0
0
12
92
1.32
0.32
2.4
1.3
0.23
0.22
g/l
0.07
12
87
128
1217
1.10
0.31
7.8
4.3
5.67
88.53
e6/l
—
6
15
31
355
0.86
0.31
1.6
1.7
—
—
—
0
0
12
93
1.30
0.30
2.0
3.4
12.20
8.25
index
—
5
61
16
195
0.81
0.30
2.8
1.4
—
—
—
0
0
65
705
0.90
0.29
1.8
1.6
—
—
—
0
0
8
66
1.22
0.27
1.0
1.1
—
—
—
0
0
50
456
1.12
0.26
3.8
3.2
1.02
1.02
kg/l
0.00
34
289
5
75
0.66
0.26
1.6
2.8
—
—
—
0
0
9
73
1.24
0.25
1.9
1.6
—
—
—
0
0
13
157
0.82
0.23
1.1
1.1
11.12
8.93
u/ml
—
8
110
5
41
1.22
0.22
1.6
1.3
120.71
7.85
u/ml
—
5
41
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
5.8
—
4.35
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
14
166
0.83
0.21
1.1
1.2
17.12
6.71
u/ml
—
9
121
13
154
0.84
0.19
1.1
1.1
0.07
1.56
u/ml
—
6
97
7
63
1.11
0.17
1.6
1.7
12.65
4.28
u/ml
—
7
63
5
69
0.72
0.17
1.0
1.5
4.27
22.49
u/ml
—
5
59
8
70
1.15
0.16
2.0
1.5
—
—
—
0
0
13
150
0.86
0.15
4.1
2.6
—
—
—
0
0
21
189
1.12
0.14
1.6
1.5
—
—
—
0
0
13
149
0.87
0.14
4.1
2.7
120.14
98.87
au/ml
—
7
68
19
211
0.89
0.13
1.3
1.6
—
—
—
0
0
18
161
1.13
0.13
1.7
1.4
—
—
—
0
0
88
851
1.05
0.12
5.8
3.6
6.34
6.29
ph
0.15
40
407
85
825
1.05
0.09
4.7
3.8
—
—
estimate
—
0
0
10
113
0.88
0.08
1.6
1.3
—
—
—
0
0
32
307
1.05
0.05
2.8
4.5
1146.69
1330.72
ng/l
0.08
16
181
13
138
0.94
0.02
2.1
2.1
—
—
—
0
0
12
127
0.94
0.01
1.3
1.1
—
—
—
0
0
41
403
1.02
0.01
6.7
2.7
—
—
—
0
0
217
2172
0.99
0.00
21.3
14.2
19.03
25.10
mg/l
2.96
174
1581
18
179
1.01
0.00
2.6
2.4
187.54
198.97
u/ml
0.09
13
83
15
147
1.02
0.00
1.2
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
7.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.0
—
0.50
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.00
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
15.70
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
11.0
—
98.83
—
0
6
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
75.48
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
76.80
—
0
5

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: E4_ISOLATED_GROWTH_HORMONE_DEFICIENCY – Isolated growth hormone deficiency

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).