Nondiabetic hypoglycaemic coma

E4_HYPOCOMA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E15
  • Hospital discharge: ICD-9 2510B
  • Cause of death: ICD-10 E15
  • Cause of death: ICD-9 2510B

2 out of 7 registries used, show all original rules.

175

4. Check minimum number of events

None

175

5. Include endpoints

None

175

6. Filter based on genotype QC (FinnGen only)

145

Control definitions (FinnGen only)

Control exclude
E4_GLUCOPANCREAS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E15-E16
Name in latin
Coma hypoglychaemicum non diabeticum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1177 513 627
Only index persons 618 283 335
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 46.88 50.02 44.06
Only index persons 34.95 33.91 35.83

-FinnGen-

Key figures

All Female Male
Number of individuals 145 69 76
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 25.18 25.86 24.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
146
Matched controls
1460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A10AA02, ,
ATC
122.1
182.3
105
30
A10AA01, ,
ATC
119.9
177.0
100
26
A10AB01
ATC
insulin (human); parenteral
110.8
174.5
101
29
A10AC01
ATC
insulin (human); parenteral
79.6
161.2
110
54
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
95.5
150.3
85
21
2510B
ICD-9 Finland
Other disorders of pancreatic internal secretion, Hypoglycaemic coma[COMA HYPOGLYCAEMICUM]
+∞
141.7
112
*
H04AA01
ATC
glucagon; nasal, parenteral
78.6
134.2
78
21
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
49.6
124.3
86
41
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
66.0
124.3
75
23
A10AB05
ATC
insulin aspart; parenteral
44.4
121.6
90
51
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
100.0
117.2
63
11
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
74.5
115.2
66
16
A10AB04
ATC
insulin lispro; parenteral
50.7
113.6
74
29
A10AE04
ATC
insulin glargine; parenteral
31.9
104.5
92
74
T89
ICPC
Diabetes insulin dependent
37.6
96.7
69
34
A10AE05
ATC
insulin detemir; parenteral
33.9
86.7
63
32
103
Kela drug reimbursment
Diabetes, insulin-treated
30.5
83.3
123
218
E10
ICD-10 Finland
Type 1 diabetes mellitus
40.2
69.3
45
16
A10AE06
ATC
insulin degludec; parenteral
29.6
69.2
51
26
215
Kela drug reimbursment
Diabetes, non-insulin-treated
16.6
66.7
102
179
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
131.6
37.9
39
*
E15
ICD-10 Finland
Nondiabetic hypoglycaemic coma
+∞
37.1
34
*
SPAT1262
SPAT
Handing over of treatment supplies
8.5
33.9
58
105
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
+∞
33.6
31
*
H3600, E103,
ICD-10 Finland
87.7
31.5
34
5
A10AD01
ATC
insulin (human); parenteral
52.6
28.2
33
8
XCK10
NOMESCO Finland
Photography of fundus of eye
9.7
28.2
38
51
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
44.7
24.1
29
8
H3603, E103,
ICD-10 Finland
99.9
23.5
25
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
142.4
23.3
24
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
95.1
22.4
24
*
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
31.1
21.4
28
11
177
Kela drug reimbursment
Insulin glargine 300 U / ml
23.8
20.5
29
15
OAB50, ,
SPAT
7.8
19.7
31
49
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
81.0
19.3
21
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
60.8
18.5
21
*
A10AA03, ,
ATC
36.6
17.6
22
7
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
4.6
16.9
55
169
H3601, E103,
ICD-10 Finland
34.7
16.6
21
7
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
43.3
15.8
19
5
H36.00
ICD-10 Finland
Diabetic background retinopathy
32.8
15.7
20
7
H36.01
ICD-10 Finland
Diabetic maculopathy
50.9
15.5
18
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
89.3
14.9
16
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
40.7
14.8
18
5
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
165.9
14.7
15
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
20.8
13.8
20
11
A10AD04
ATC
insulin lispro; parenteral
+∞
13.8
13
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
13.3
45
140
H43.1
ICD-10 Finland
Vitreous haemorrhage
35.6
12.9
16
5
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
141.7
12.6
13
*
CKC12
NOMESCO Finland
Photocoagulation of retina
11.2
12.3
23
24
171
Kela drug reimbursment
Degludekinsuliini
70.8
11.8
13
*
E16.19
ICD-10 Finland
Other specified hypoglycaemia
+∞
11.6
11
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
9.0
10.6
22
28
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
+∞
10.5
10
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.4
10.4
48
182
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
12.7
9.9
17
15
2507B
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]
106.7
9.5
10
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
+∞
9.5
9
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.9
9.2
22
51
C10AA05
ATC
atorvastatin; oral
2.9
9.2
65
313
A10AB06
ATC
insulin glulisine; parenteral
39.3
9.2
11
*
OAB50
NOMESCO Finland
Delivery of care equipment and instruction on their use
25.9
9.1
12
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.5
9.0
24
61
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
15.3
8.9
14
10
BEF00, ,
SPAT
29.5
8.6
11
*
CL2S4, ,
SPAT
13.9
8.6
14
11
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
5.1
8.4
19
42
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
11.8
8.0
14
13
C10AX09
ATC
ezetimibe; oral
3.4
7.9
34
121
C10AA01
ATC
simvastatin; oral
2.8
7.8
57
275
R11
ICD-10 Finland
Nausea and vomiting
4.2
7.7
22
59
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
26.6
7.7
10
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.3
7.4
17
26
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
16.8
7.4
11
7
25008
ICD-8 Finland
Diabetes mellitus, Complicatio alia definita
+∞
7.3
7
*
2503B
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI I]
+∞
7.3
7
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.9
7.2
12
10
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
10.1
6.9
13
14
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
11.8
6.9
12
11
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.3
6.8
29
102
WZC30
NOMESCO Finland
Teaching
3.1
6.8
34
132
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
23.8
6.8
9
*
V03AE01
ATC
polystyrene sulfonate; oral
23.8
6.8
9
*
C03CA01
ATC
furosemide; systemic
2.7
6.7
46
212
A11CC03
ATC
alfacalcidol; systemic
13.1
6.7
11
9
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
72.9
6.5
7
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
72.9
6.5
7
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
72.9
6.5
7
*
H3603, E113,
ICD-10 Finland
72.9
6.5
7
*
OAB42, ,
SPAT
3.2
6.4
28
100
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
19.0
6.3
9
5
B05DA
ATC
Isotonic solutions
28.0
6.3
8
*
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
+∞
6.3
6
*
E10.0
ICD-10 Finland
Type 1 diabetes mellitus, With coma
+∞
6.3
6
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.8
6.1
13
18

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
98
308
7.64
32.98
9.7
4.5
16.40
11.25
mg/mmol
0.36
78
215
93
313
6.43
27.91
8.2
3.6
59.50
72.03
mg/l
0.20
71
221
99
365
6.32
26.39
7.6
3.4
6.84
8.38
mmol/l
2.87
88
320
22
45
5.58
10.65
7.3
3.9
24.93
24.24
mmol/l
0.35
22
45
67
314
3.10
10.10
2.2
1.4
4.83
1.07
u/ml
0.55
25
79
19
22
9.75
9.64
2.9
2.1
104.82
125.32
ug/min
—
14
10
28
84
3.89
8.44
4.2
2.7
4.45
4.74
kpa
0.25
28
84
32
108
3.51
8.12
6.8
3.6
7.35
7.38
ph
1.95
23
66
84
1094
0.45
5.04
5.2
4.5
8.15
5.81
mmol/l
10.14
78
1028
12
22
5.84
4.71
3.4
3.0
1.13
1.52
mmol/l
1.61
12
22
41
210
2.32
4.62
2.2
1.6
465.41
466.66
pmol/l
0.01
32
181
15
38
4.28
4.45
2.4
18.4
1.28
1.68
%
1.35
15
33
17
58
3.19
4.17
2.6
2.4
1.69
1.61
%
0.06
17
58
22
88
2.77
4.11
1.2
1.3
186.44
131.64
u/ml
0.24
11
38
17
59
3.13
4.05
2.5
2.4
0.77
0.63
%
0.83
17
59
22
98
2.47
3.33
12.4
8.7
—
—
—
0
0
23
109
2.32
3.04
1.4
1.2
—
—
—
0
0
12
37
3.44
3.01
3.3
2.6
23.29
24.37
mmol/l
0.47
12
37
28
146
2.14
2.96
7.7
8.0
103.11
104.47
mmol/l
0.63
28
146
9
23
4.10
2.82
4.7
4.6
—
—
—
0
0
8
19
4.39
2.72
4.5
2.9
9.78
7.34
mmol/l
—
8
19
73
534
1.73
2.71
20.3
8.8
1.21
1.21
mmol/l
0.49
65
466
8
20
4.17
2.61
4.3
3.9
92.76
90.12
%
—
8
20
6
11
5.63
2.57
2.7
2.9
4.07
4.07
mmol/l
—
6
11
6
11
5.63
2.57
2.7
2.9
1.19
1.18
mmol/l
—
6
11
6
11
5.63
2.57
2.7
2.9
105.33
107.91
mmol/l
—
6
11
69
503
1.70
2.56
3.2
1.9
1.02
1.42
mmol/l
4.94
62
441
27
147
2.03
2.54
2.7
1.6
—
—
—
0
0
9
28
3.36
2.35
4.1
3.2
8.53
8.60
kpa
—
9
28
46
308
1.72
2.28
7.8
4.5
—
—
—
0
0
43
288
1.70
2.11
2.1
1.5
3.38
2.39
g/l
0.42
30
191
0
57
0.00
2.11
0.0
1.1
—
0.73
—
0
10
5
10
5.13
2.08
1.2
1.8
10.60
11.00
mmol/l
—
5
10
6
15
4.12
2.06
1.2
1.9
30.00
32.27
pg
—
6
15
41
278
1.66
1.91
3.8
2.8
—
—
—
0
0
69
532
1.56
1.89
19.2
11.9
0.00
0.00
e9/l
-0.00
59
435
7
23
3.14
1.82
9.1
6.3
—
—
—
0
0
8
29
2.86
1.82
2.6
21.3
1.27
1.21
mmol/l
—
8
24
6
18
3.43
1.76
5.0
4.6
14.23
16.26
%
—
6
18
7
27
2.67
1.53
17.3
6.0
16.71
10.44
pmol/l
—
7
27
100
863
1.50
1.47
6.3
4.1
15.25
14.81
pmol/l
0.83
91
808
7
29
2.48
1.41
2.3
1.4
—
—
—
0
0
61
481
1.46
1.41
9.2
11.1
1.13
1.18
inr
0.44
54
396
20
123
1.73
1.32
8.1
12.7
7.43
7.43
ph
0.00
13
69
20
123
1.73
1.32
8.1
12.7
2.29
1.32
mmol/l
0.30
14
101
18
108
1.76
1.29
2.1
4.5
1.00
0.71
%
—
8
34
9
168
0.51
1.29
1.2
1.3
—
—
—
0
0
27
183
1.58
1.25
3.9
2.3
—
—
—
0
0
26
368
0.64
1.22
3.4
4.7
1.43
1.69
ug/l
0.51
26
324
7
137
0.49
1.17
2.6
1.4
—
—
—
0
0
18
114
1.66
1.09
2.1
4.7
1.50
0.74
%
—
8
38
116
1057
1.47
1.08
8.3
4.9
1.97
1.83
mu/l
0.66
109
985
23
156
1.56
1.07
1.9
1.6
—
—
—
0
0
17
107
1.67
1.05
1.9
5.1
0.00
0.33
%
—
6
30
17
107
1.67
1.05
2.1
4.8
0.29
0.13
%
—
7
30
9
48
1.93
1.02
2.1
1.4
—
—
—
0
0
43
335
1.40
1.02
13.0
4.7
7.39
7.39
ph
0.26
35
243
10
55
1.88
0.94
7.1
5.1
36.92
36.94
°c
—
10
55
51
414
1.36
0.94
4.2
3.4
31.16
21.30
ng/l
0.98
40
253
11
63
1.81
0.93
2.2
12.5
—
—
—
0
0
8
140
0.55
0.88
1.5
1.4
—
—
—
0
0
8
46
1.78
0.84
4.9
3.2
—
—
—
0
0
0
28
0.00
0.77
0.0
1.1
—
—
—
0
0
11
68
1.67
0.74
5.2
2.8
23.71
24.54
mmol/l
0.18
11
68
5
25
2.03
0.73
2.2
2.6
64.28
62.27
%
—
5
25
10
156
0.61
0.72
3.3
3.5
3.30
5.90
e9/l
—
10
142
7
41
1.74
0.71
1.3
1.2
—
—
—
0
0
117
1235
0.74
0.70
24.6
12.4
—
—
—
0
0
5
27
1.88
0.69
1.0
1.3
310.40
60.58
pmol/l
—
5
27
45
375
1.29
0.67
2.9
2.4
—
—
—
0
0
39
319
1.30
0.67
4.9
3.1
0.28
0.34
e6/l
0.17
30
230
5
28
1.81
0.67
1.2
1.1
—
—
—
0
0
13
184
0.68
0.61
1.6
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
2.4
—
6.25
—
0
14
15
107
1.45
0.58
7.6
2.8
0.43
0.21
e6/l
0.44
15
102
13
90
1.49
0.57
2.2
1.7
1.16
1.06
g/l
0.16
13
84
6
39
1.56
0.53
3.8
3.6
60.43
48.52
mg/l
—
6
31
6
39
1.56
0.53
3.8
3.6
57.52
25.40
mg/l
—
6
31
44
376
1.24
0.53
6.6
3.2
9.52
31.93
e6/l
1.49
36
290
113
1186
0.79
0.51
28.9
14.4
29.05
23.02
mg/l
0.78
97
936
7
45
1.58
0.49
1.0
1.3
—
—
—
0
0
14
103
1.40
0.47
1.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
243.20
—
0
15
0
15
0.00
0.41
0.0
3.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.6
—
39.13
—
0
16
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
42
476
0.83
0.40
2.1
2.0
—
—
—
0
0
113
1177
0.82
0.39
9.1
4.7
4.22
4.67
mmol/l
6.52
108
1115
48
428
1.18
0.38
6.9
3.9
94.94
61.34
e6/l
0.30
38
298
18
144
1.29
0.37
1.4
1.3
—
—
—
0
0
22
182
1.25
0.36
3.9
3.0
2.11
2.33
e6/l
0.05
11
86
19
155
1.26
0.34
2.5
1.9
—
—
—
0
0
18
219
0.80
0.34
2.3
1.6
—
—
—
0
0
22
183
1.24
0.34
1.4
1.5
468.57
482.16
titre
—
7
37
6
86
0.68
0.34
2.2
2.6
—
19.58
—
0
5
113
1173
0.84
0.34
8.9
4.6
1.57
1.40
mmol/l
3.45
108
1107
11
142
0.76
0.32
1.1
1.6
—
—
—
0
0
66
611
1.15
0.31
5.5
3.5
0.00
0.00
estimate
-0.00
18
127
121
1170
1.20
0.31
32.8
16.2
138.50
139.75
mmol/l
6.68
116
1150
7
57
1.24
0.29
17.6
17.7
14.16
15.90
%
—
7
52
50
456
1.15
0.29
2.3
2.1
112.33
95.10
pmol/l
1.14
29
244
51
554
0.88
0.28
5.9
2.9
—
—
—
0
0
23
266
0.84
0.27
4.0
3.8
1.02
1.02
kg/l
0.25
14
181
12
95
1.29
0.27
8.0
3.6
—
—
—
0
0
121
1174
1.18
0.27
34.5
16.2
4.05
3.95
mmol/l
3.42
116
1153
6
81
0.73
0.25
1.5
1.8
46.83
33.88
nmol/l
—
6
81
53
491
1.12
0.24
4.5
3.3
6.59
6.23
ph
1.66
34
280
5
37
1.36
0.24
1.0
2.0
—
—
—
0
0
34
306
1.14
0.24
4.1
6.2
—
—
—
0
0
66
620
1.12
0.24
5.6
3.5
0.23
0.00
estimate
0.47
13
121
37
336
1.14
0.23
6.4
3.7
0.00
0.01
estimate
0.50
14
122
0
11
0.00
0.21
0.0
1.8
—
13.74
—
0
11
0
11
0.00
0.21
0.0
3.9
—
48.67
—
0
6
0
11
0.00
0.21
0.0
1.5
—
62.55
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
14.8
—
0.61
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
7.1
—
7.93
—
0
14
0
14
0.00
0.20
0.0
3.6
—
45.00
—
0
14
24
268
0.87
0.19
4.5
3.7
—
0.00
—
0
5
109
1120
0.89
0.19
7.2
4.0
1.15
1.34
mmol/l
2.34
103
1050
7
61
1.15
0.18
1.1
1.8
—
—
—
0
0
5
65
0.76
0.17
1.0
1.2
—
—
—
0
0
67
701
0.92
0.16
10.9
11.0
4.35
4.13
e9/l
0.38
62
623
23
207
1.13
0.16
10.6
4.1
0.80
0.81
mmol/l
0.18
23
202
7
88
0.79
0.15
1.3
1.4
37.29
310.74
u/ml
—
7
81
38
357
1.09
0.13
5.6
2.9
0.13
0.01
estimate
0.43
15
105
64
618
1.06
0.10
5.6
3.6
62.25
12.40
estimate
0.36
20
131
5
44
1.14
0.10
1.2
1.2
—
—
—
0
0
55
529
1.06
0.10
3.7
2.9
—
—
estimate
—
0
0
5
46
1.09
0.09
1.6
2.3
—
—
—
0
0
37
389
0.93
0.09
7.6
6.5
—
—
—
0
0
62
640
0.95
0.09
7.2
7.3
0.20
0.19
e9/l
0.33
57
575
38
362
1.07
0.09
6.3
7.0
—
—
—
0
0
49
471
1.06
0.09
5.6
3.5
0.00
0.00
estimate
-0.00
16
109
39
372
1.07
0.09
7.9
3.6
2.35
2.36
mmol/l
0.26
39
352
6
57
1.05
0.08
1.8
2.0
—
4.90
—
0
17
33
313
1.07
0.08
2.5
2.2
—
—
—
0
0
60
618
0.95
0.07
7.4
7.2
0.54
0.57
e9/l
0.50
55
546
8
73
1.10
0.07
3.0
3.0
—
—
—
0
0
8
75
1.07
0.07
1.1
1.7
—
—
—
0
0
34
356
0.94
0.07
1.6
1.4
—
—
—
0
0
60
617
0.95
0.07
7.4
7.2
0.05
0.04
e9/l
1.32
55
545
27
256
1.07
0.07
1.6
1.8
0.71
1.16
mg/l
0.83
21
198
17
158
1.09
0.06
1.2
1.2
—
—
—
0
0
78
768
1.03
0.04
7.8
4.1
—
—
—
0
0
22
210
1.06
0.04
1.4
1.3
38.76
7.54
u/ml
—
10
93
26
256
1.02
0.00
2.0
1.8
—
—
—
0
0
23
233
0.98
0.00
1.3
1.3
16.87
26.59
iu/ml
—
6
74
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
159.57
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
0.00
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
159.13
—
0
5
0
5
0.00
0.00
0.0
1.6
—
55.20
—
0
5
0
8
0.00
0.00
0.0
1.5
—
8.01
—
0
8
0
5
0.00
0.00
0.0
1.4
—
132.20
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
38.67
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
82
0.97
-0.00
1.1
1.6
—
—
—
0
0
8
83
0.96
-0.00
1.1
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
17.65
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
11.89
—
0
6
0
6
0.00
-0.00
0.0
3.3
—
30.33
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
88.67
—
0
9
5
57
0.87
-0.00
1.2
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
82
0.97
-0.00
1.1
1.4
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.2
—
—
—
0
0
8
83
0.96
-0.00
1.1
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_HYPOCOMA and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
E4_HYPOCOMA 4.588 [1.64, 12.87] 0.004
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 143 males with E4_HYPOCOMA died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPOCOMA.

N-year risk Females Males
1 No data 0.841%
5 No data 5.63%
10 No data 13.552%
15 No data 23.531%
20 No data 36.266%

Relationships between endpoints

Index endpoint: E4_HYPOCOMA – Nondiabetic hypoglycaemic coma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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