No definition available.
Other disorders of electrolyte and fluid balance, not elsewhere classified
EFO MESH Endpoint Browser PheWeb
E4_FLUIDELECTRONAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
391 |
4. Check minimum number of eventsNone |
391 |
5. Include endpointsNone |
391 |
6. Filter based on genotype QC (FinnGen only) |
348 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Aliae perturbationes aequilibrii electrolytici et humoralis
Similar endpoints
↥List of similar endpoints to
Other disorders of electrolyte and fluid balance, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4640 | 3017 | 1556 |
| Only index persons | 2688 | 1786 | 902 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.09 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 67.70 | 70.72 | 61.89 |
| Only index persons | 65.00 | 66.77 | 61.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 348 | 205 | 143 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | 63.59 | 61.70 | 66.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 359
- Matched controls
- 3590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
8511.4
297.3
244
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
97.4
206.4
109
16
2768A
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[HYPOKALAEMIA]
+∞
122.0
110
*
E87.6
ICD-10 Finland
Hypokalaemia
47.8
100.5
60
15
C03DA01
ATC
spironolactone; oral
4.7
35.0
100
271
A12BA01
ATC
potassium chloride; oral
5.7
27.1
55
110
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
26.3
121
451
E87.5
ICD-10 Finland
Hyperkalaemia
46.6
25.0
30
7
205
Kela drug reimbursment
Chronic hypertension
3.0
22.8
155
719
4019X
ICD-9 Finland
Essential hypertension, Unspecified
6.5
21.7
37
62
E86
ICD-10 Finland
Volume depletion
36.3
21.4
27
8
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.2
21.2
33
50
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.7
19.3
32
52
R11
ICD-10 Finland
Nausea and vomiting
4.1
18.7
58
163
R53
ICD-10 Finland
Malaise and fatigue
2.8
18.5
132
616
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
17.7
142
702
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.7
17.6
43
100
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.0
16.5
87
342
AA1AD
NOMESCO Finland
CT of head and brain
2.6
16.3
138
695
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
5.4
14.6
30
60
C03CA01
ATC
furosemide; systemic
2.4
14.4
164
934
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.7
14.4
35
81
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
14.1
83
345
N03AF02
ATC
oxcarbazepine; oral
6.8
13.8
22
34
K59.1
ICD-10 Finland
Functional diarrhoea
4.1
13.1
38
101
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
13.0
198
1260
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
13.0
83
359
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.6
12.9
88
393
N03AX16
ATC
[U] pregabalin
2.5
12.8
101
484
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
+∞
12.6
12
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.8
12.1
39
112
N19
ICD-10 Finland
Unspecified kidney failure
4.9
11.6
26
56
C08CA01
ATC
amlodipine; oral
2.1
11.0
165
1025
C02EA02, ,
ATC
3.8
10.9
35
100
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
10.8
130
740
R4190
NOMESCO Finland
Nutritional therapy
5.3
10.7
22
44
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
8.1
10.6
23
30
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.1
10.4
30
79
F50.9
ICD-10 Finland
Eating disorder, unspecified
33.6
10.4
13
*
N05BA01
ATC
diazepam; systemic, rectal
2.7
10.4
65
276
N05AH04
ATC
quetiapine; oral
2.5
10.4
75
342
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
10.3
59
239
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.0
10.3
49
180
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
10.1
139
829
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
20.7
9.9
14
7
N03AG01
ATC
valproic acid; systemic, rectal
3.7
9.9
32
92
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.0
9.7
21
44
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
9.6
58
241
A06AD11
ATC
lactulose; oral
2.4
9.6
79
381
R42
ICD-10 Finland
Dizziness and giddiness
2.2
9.6
103
556
P15
ICPC
Chronic alcohol abuse
7.9
9.6
21
28
E87.2
ICD-10 Finland
Acidosis
102.6
9.5
10
*
E87
ICD-10 Finland
Other disorders of fluid, electrolyte and acid-base balance
+∞
9.4
9
*
E87.3
ICD-10 Finland
Alkalosis
+∞
9.4
9
*
N05AA02
ATC
levomepromazine; systemic
4.3
9.1
24
59
N03AX14
ATC
levetiracetam; systemic
7.1
9.0
21
31
N30.0
ICD-10 Finland
Acute cystitis
2.3
9.0
75
364
F05.9
ICD-10 Finland
Delirium, unspecified
5.1
8.9
19
39
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.9
8.9
20
43
N05BA04
ATC
oxazepam; oral
2.1
8.9
113
648
N05AH03
ATC
olanzapine; systemic
3.6
8.8
30
89
TPH07
NOMESCO Finland
Cathetrisation of artery
2.7
8.8
52
214
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.2
8.7
83
425
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
8.7
52
215
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
8.7
54
228
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.8
8.6
47
186
N05CD07
ATC
temazepam; oral
2.4
8.5
63
289
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.3
8.5
33
107
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.4
8.5
66
310
N06AX11
ATC
mirtazapine; oral
2.0
8.3
135
842
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
8.3
141
893
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
8.4
8.2
17
21
UJF32
NOMESCO Finland
Coloscopy
2.0
7.9
109
640
J01MA02
ATC
ciprofloxacin; systemic
1.9
7.9
149
975
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
7.9
56
252
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
4.4
7.8
20
48
C08CA02
ATC
felodipine; oral
2.6
7.8
47
195
N30.9
ICD-10 Finland
Cystitis, unspecified
3.0
7.8
35
124
F10.25
ICD-10 Finland
Alcohol dependence continuous use
9.2
7.6
15
17
3071A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Anorexia nervosa
81.7
7.4
8
*
C07AB07
ATC
bisoprolol; oral
1.8
7.4
197
1429
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
11.2
7.4
13
12
R55
ICD-10 Finland
Syncope and collapse
2.4
7.3
55
253
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.0
7.3
33
117
124
Kela drug reimbursment
Inborn metabolic disorders
+∞
7.3
7
*
A10BH01
ATC
sitagliptin; oral
2.6
7.3
44
183
C02AC05
ATC
moxonidine; oral
3.9
7.2
21
56
101
Kela drug reimbursment
Anterior pituitary hypofunction
30.7
7.2
9
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
20.5
7.2
10
5
7803A
ICD-9 Finland
General symptoms, Convulsions
20.5
7.2
10
5
C09BA02
ATC
enalapril and diuretics; systemic
2.7
7.1
39
154
N02AC04
ATC
dextropropoxyphene; oral
3.7
7.1
23
66
F10.24
ICD-10 Finland
Alcohol depence active use
9.1
7.1
14
16
R50.9
ICD-10 Finland
Fever, unspecified
2.3
7.0
60
293
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
6.9
233
1798
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
8.5
6.9
14
17
N03AF01
ATC
carbamazepine; oral, rectal
3.0
6.9
31
110
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
6.9
26
83
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
5.9
6.9
18
32
N02AA05
ATC
oxycodone; systemic
2.0
6.8
85
479
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.8
146
983
K59.09
ICD-10 Finland
Constipation, unspecified
2.8
6.8
35
134
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.5
6.7
44
191
B01AC04
ATC
clopidogrel; oral
2.1
6.6
66
343
N05CF01
ATC
zopiclone; oral
1.8
6.5
132
871
A10AE04
ATC
insulin glargine; parenteral
2.6
6.5
39
162
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
3.7
6.4
20
56
L28
ICPC
Limited function/disability (L)
2.0
6.4
85
490
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
9.5
6.3
12
13
N06AB04
ATC
citalopram; systemic
2.0
6.3
83
476
SPAT1211
SPAT
Application of soft bandage
2.5
6.3
42
183
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
+∞
6.3
6
*
2768X
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[NESTE-, ELEKTROLYYTTI- JA HAPPOEMÄSTASAP MUUT HÄIR]
+∞
6.3
6
*
2761A
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hyposmolality and/or hyponatraemia
+∞
6.3
6
*
JN4AD
NOMESCO Finland
Body CT examination
2.3
6.3
52
250
N05AB03
ATC
perphenazine; systemic, rectal
4.1
6.2
17
43
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.5
6.2
15
24
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
6.2
25
83
N06AA09
ATC
amitriptyline; systemic
2.5
6.2
41
178
SPAT1234
SPAT
Support of social functional capacity
2.9
6.2
30
111
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
7.9
6.2
13
17
WX882
NOMESCO Finland
High dependency care
4.2
6.2
16
39
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.6
6.1
20
58
A28
ICPC
Limited function/disability NOS
1.9
6.1
84
489
C01DA14
ATC
isosorbide mononitrate; oral
2.1
6.1
67
360
C07AB02
ATC
metoprolol; systemic
1.9
6.1
86
505
H02AB09
ATC
hydrocortisone; systemic
5.7
6.1
16
29
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.0
6.1
17
44
R60.0
ICD-10 Finland
Localized oedema
2.2
6.0
56
282
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
29
19.87
62.10
1.6
1.4
266.03
283.60
mosm/kgh2o
4.89
37
20
145
450
4.73
43.74
6.3
3.0
0.77
0.82
mmol/l
5.74
139
424
110
283
5.16
41.64
7.1
2.9
2.83
2.17
mmol/l
0.73
98
247
101
259
5.03
38.10
2.5
1.9
397.75
376.30
nmol/l
0.44
96
241
118
395
3.96
30.73
16.5
5.5
99.32
104.44
mmol/l
7.37
118
395
89
256
4.29
28.39
6.6
2.5
4.13
4.29
kpa
0.38
89
249
78
211
4.45
26.88
2.3
1.4
—
—
—
0
0
64
152
4.91
25.89
3.9
3.3
3.69
1.92
mmol/l
1.30
44
121
41
67
6.78
24.67
3.7
3.0
8.48
7.98
kpa
1.05
41
67
75
228
3.89
21.80
6.6
4.5
10.50
10.35
mmol/l
0.06
75
215
161
805
2.81
20.10
3.1
2.2
2.76
3.17
mg/l
1.81
148
678
43
90
5.29
19.98
1.6
1.1
—
—
—
0
0
240
1512
2.77
18.40
15.6
6.1
1.20
1.21
mmol/l
2.60
219
1274
89
346
3.09
17.31
15.6
7.6
2.01
1.06
mmol/l
0.97
76
281
85
323
3.14
17.18
3.0
4.5
219.80
245.54
u/l
2.05
80
309
111
497
2.79
16.61
2.7
2.1
11.81
12.41
umol/l
0.39
103
461
114
519
2.75
16.51
2.4
1.8
—
—
—
0
0
168
928
2.52
16.31
4.5
2.5
56.39
72.91
u/l
1.29
160
852
222
1398
2.54
16.18
17.6
15.2
1.28
1.29
inr
0.13
198
1158
218
1366
2.52
15.99
16.3
5.4
1.20
1.21
mmol/l
2.69
210
1235
103
459
2.74
15.42
2.7
2.1
2.19
2.27
g/l
0.62
97
417
211
1322
2.45
15.19
8.1
4.3
33.55
34.98
g/l
2.90
203
1221
62
217
3.24
14.23
3.4
2.6
94.00
82.61
ng/l
0.38
55
177
179
1070
2.34
13.97
6.1
3.6
109.66
147.89
e6/l
0.22
144
768
127
670
2.39
13.04
3.9
2.6
5.37
5.26
e6/l
0.04
122
612
200
1288
2.25
12.66
3.4
2.3
76.56
78.81
nmol/l
0.53
186
1113
68
269
2.88
12.55
2.4
1.7
1.84
1.40
%
2.06
58
224
161
953
2.25
12.49
5.0
3.2
15.81
151.66
e6/l
1.28
139
739
229
1567
2.27
12.38
9.6
6.3
11.38
11.68
umol/l
0.14
223
1488
141
814
2.21
11.41
4.9
3.1
0.35
0.43
e6/l
0.30
119
598
231
1629
2.17
11.01
12.4
9.0
4.17
4.06
e9/l
0.36
203
1430
117
635
2.25
10.94
1.4
1.2
0.70
1.52
u/ml
1.16
33
162
24
51
4.97
10.88
3.3
2.4
15.66
15.95
%
0.15
24
51
154
940
2.12
10.64
2.1
1.7
21.43
20.82
nmol/l
0.17
143
753
66
284
2.62
10.27
2.6
2.6
0.20
0.20
g/l
0.08
57
264
192
1284
2.06
10.26
3.9
2.7
163.28
130.23
ug/l
0.92
185
1165
32
90
3.81
10.18
1.5
1.6
0.49
0.32
mg/l
0.52
17
31
179
1170
2.06
10.15
6.7
3.8
24.90
82.27
ng/l
0.69
148
886
13
6
22.40
9.41
2.7
1.3
176.92
126.94
mmol/24h
—
13
6
78
383
2.32
9.07
2.5
1.8
—
—
—
0
0
74
358
2.34
8.89
2.6
1.8
—
—
—
0
0
40
142
3.04
8.87
6.2
7.8
1.68
1.61
%
0.16
40
132
29
86
3.58
8.55
1.5
1.4
231.67
280.03
ug/g
0.73
21
57
29
87
3.54
8.40
1.3
1.2
—
—
—
0
0
192
1349
1.91
8.27
2.5
2.1
97.22
96.65
pmol/l
0.06
117
688
65
309
2.35
8.09
3.3
2.8
12.77
8.02
umol/l
0.36
53
265
152
1007
1.88
7.69
3.8
3.2
2875.35
1336.72
ng/l
1.31
140
844
155
1047
1.85
7.28
3.6
3.2
2.35
2.35
mmol/l
0.20
143
932
273
2202
2.00
7.26
13.4
7.7
85.27
80.68
u/l
0.72
262
2061
210
1564
1.83
7.10
7.1
4.0
0.00
0.00
estimate
-0.00
62
348
101
600
1.95
7.00
2.0
1.7
1275.58
1179.99
nmol/l
0.41
85
450
208
1549
1.82
6.99
7.1
4.0
0.00
0.00
estimate
-0.00
60
335
248
1955
1.87
6.85
8.7
4.8
3514.29
4251.00
e6/l
—
7
34
210
1580
1.79
6.70
7.2
4.0
0.00
0.90
estimate
0.50
59
335
101
609
1.92
6.66
2.1
1.6
1.40
1.38
mg/l
0.03
84
477
13
15
8.94
6.61
1.3
1.3
—
—
—
0
0
43
189
2.45
6.33
26.0
7.2
92.81
94.11
%
0.44
43
189
113
717
1.84
6.32
3.6
2.5
353.97
340.63
umol/l
0.56
103
614
27
93
3.06
6.30
1.4
3.6
49.44
111.16
mg/l
0.47
21
79
140
952
1.77
6.19
3.7
3.0
5.63
7.27
mmol/l
4.97
121
784
50
238
2.28
6.16
3.9
2.5
45.29
29.66
u/l
0.57
45
198
38
160
2.54
6.12
1.7
1.4
—
—
—
0
0
83
485
1.93
5.95
4.5
2.8
0.66
1.20
e6/l
1.91
53
260
12
15
8.23
5.88
1.3
1.3
—
—
—
0
0
16
42
3.94
5.60
3.1
1.6
1.58
1.60
mmol/l
0.04
16
42
102
653
1.79
5.43
2.1
1.8
452.51
22034348.42
pmol/l
0.50
90
531
222
1756
1.69
5.40
5.3
3.1
83.62
50.42
u/l
2.63
212
1635
194
1483
1.67
5.37
3.4
2.8
—
—
—
0
0
40
186
2.29
5.20
2.4
1.7
—
—
—
0
0
136
954
1.69
5.19
4.3
3.6
20.39
5.86
mg/mmol
1.61
90
568
24
87
2.88
5.15
1.5
3.3
1.47
3.02
ratio
1.14
14
51
34
148
2.43
5.12
16.4
10.4
14.95
15.80
%
0.94
34
140
72
428
1.85
4.84
4.7
3.0
1.69
1.85
e6/l
0.10
41
201
87
552
1.76
4.71
6.6
3.6
92.95
279.55
ng/l
1.50
73
443
17
53
3.32
4.67
2.5
2.8
129.68
119.90
ug/min
0.04
12
32
19
65
3.03
4.51
1.7
1.1
—
—
—
0
0
15
38
4.07
4.35
4.6
1.6
10.87
10.58
mmol/l
0.08
15
38
168
1294
1.56
4.14
4.0
2.8
—
—
estimate
—
0
0
19
69
2.85
4.08
1.1
1.2
—
—
—
0
0
27
118
2.39
4.05
1.6
1.6
4.43
4.26
g/l
0.38
27
104
27
118
2.39
4.05
1.6
1.6
3.66
3.78
g/l
0.13
27
104
15
49
3.15
3.85
3.4
1.8
7.12
6.52
pmol/l
0.18
15
49
53
307
1.85
3.84
5.2
3.5
—
—
—
0
0
20
78
2.66
3.78
1.9
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
67
2.78
3.71
3.1
2.3
0.45
0.33
iu/ml
—
10
40
8
12
6.79
3.69
1.1
1.1
—
—
—
0
0
100
703
1.59
3.57
3.8
2.4
—
—
—
0
0
91
630
1.60
3.46
3.5
2.9
2.45
2.46
mmol/l
0.24
80
565
7
10
7.11
3.38
1.0
1.1
—
—
—
0
0
10
23
4.44
3.33
1.1
1.3
88.60
100.70
pmol/l
—
10
23
6
7
8.69
3.27
1.8
1.3
—
—
—
0
0
114
843
1.52
3.21
6.4
3.5
0.54
0.10
estimate
0.38
48
259
14
50
2.87
3.12
2.4
1.7
—
—
—
0
0
13
41
3.25
3.09
1.1
1.4
—
—
—
0
0
13
41
3.25
3.09
2.1
1.4
—
—
—
0
0
6
8
7.60
3.06
2.8
2.0
10.13
9.36
kpa
—
6
8
6
8
7.60
3.06
2.8
2.0
5.20
4.84
kpa
—
6
8
15
58
2.66
2.91
1.0
1.3
—
46.93
—
0
9
152
1210
1.44
2.90
7.5
4.0
10.29
0.01
estimate
0.50
49
277
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
9
6.76
2.88
1.0
1.1
—
—
—
0
0
9
23
3.99
2.79
1.0
1.0
—
—
—
0
0
19
85
2.30
2.75
1.9
1.2
—
—
—
0
0
19
85
2.30
2.75
1.9
1.2
—
—
—
0
0
11
34
3.30
2.75
2.2
1.4
—
—
—
0
0
7
14
5.08
2.74
2.9
3.1
—
—
—
0
0
10
29
3.52
2.71
1.3
1.9
—
—
—
0
0
24
120
2.07
2.68
2.0
1.9
—
—
—
0
0
249
2193
1.44
2.60
5.7
4.2
15.50
15.00
pmol/l
1.89
233
1966
244
2145
1.43
2.54
6.8
4.4
17.93
12.83
mm/h
4.18
238
1977
121
943
1.43
2.52
8.1
4.0
0.00
0.00
estimate
-0.00
55
313
17
77
2.27
2.41
2.4
1.5
—
—
—
0
0
6
12
5.06
2.41
1.0
1.4
—
—
—
0
0
6
12
5.06
2.41
1.0
1.4
—
—
—
0
0
8
22
3.69
2.37
2.1
1.4
—
—
—
0
0
7
17
4.18
2.37
2.3
2.1
397.71
718.06
mg
—
7
17
38
233
1.71
2.31
2.6
2.8
68.06
62.91
ml/min/173m2
0.39
17
88
15
66
2.33
2.27
2.7
1.4
—
—
—
0
0
7
18
3.94
2.26
2.4
1.2
—
—
—
0
0
10
35
2.91
2.22
1.5
1.3
—
—
—
0
0
23
123
1.93
2.17
1.8
1.6
4.50
4.30
iu/ml
—
8
28
11
42
2.67
2.16
1.4
1.3
—
—
—
0
0
11
42
2.67
2.16
1.4
1.3
—
—
—
0
0
11
42
2.67
2.16
1.3
1.3
—
—
—
0
0
12
49
2.50
2.12
2.6
1.4
—
—
—
0
0
17
82
2.13
2.10
1.7
1.6
0.00
0.00
g/l
-0.00
17
73
11
43
2.61
2.10
1.4
1.3
—
—
—
0
0
11
43
2.61
2.10
1.4
1.3
—
—
—
0
0
11
43
2.61
2.10
1.4
1.3
—
—
—
0
0
5
10
5.05
2.07
1.2
1.1
—
—
—
0
0
5
10
5.05
2.07
1.0
1.8
101.40
94.60
%
—
5
10
6
15
4.05
2.04
1.0
1.0
—
—
—
0
0
8
27
3.01
1.94
1.4
1.9
—
—
—
0
0
7
22
3.22
1.89
4.3
4.3
1.43
1.23
%
—
7
22
16
79
2.07
1.88
2.4
1.5
—
—
—
0
0
6
17
3.57
1.84
1.2
1.2
—
—
—
0
0
6
17
3.57
1.84
1.2
1.2
—
—
—
0
0
7
23
3.08
1.80
2.3
2.3
—
—
—
0
0
23
132
1.79
1.78
2.0
1.3
—
—
—
0
0
6
18
3.37
1.75
2.7
1.2
—
—
—
0
0
6
18
3.37
1.75
1.2
1.2
—
—
—
0
0
6
18
3.37
1.75
1.2
1.2
—
—
—
0
0
20
111
1.85
1.72
1.8
1.7
—
—
—
0
0
26
158
1.70
1.67
1.1
1.5
—
44.50
—
0
15
6
19
3.19
1.67
1.2
1.2
—
—
—
0
0
6
19
3.19
1.67
1.2
2.9
74.17
149.32
nmol/l
—
6
19
17
92
1.89
1.59
2.8
1.4
—
—
—
0
0
6
20
3.03
1.58
2.7
1.3
—
—
—
0
0
6
20
3.03
1.58
2.2
1.9
—
—
—
0
0
5
15
3.36
1.53
1.4
1.0
—
—
—
0
0
7
27
2.62
1.52
2.3
1.8
—
—
—
0
0
7
27
2.62
1.52
2.3
1.8
—
—
—
0
0
7
27
2.62
1.52
2.3
1.8
—
—
—
0
0
6
21
2.89
1.51
2.5
1.2
76.00
78.62
umol/l
—
6
21
280
2605
1.34
1.50
7.0
5.2
1.94
2.00
mu/l
0.33
269
2348
10
45
2.26
1.47
1.1
1.3
—
—
—
0
0
68
524
1.37
1.47
1.4
1.3
19.02
39.70
iu/ml
1.66
21
155
7
28
2.53
1.46
2.0
1.2
—
—
—
0
0
6
22
2.76
1.44
1.2
1.1
—
—
—
0
0
294
2764
1.35
1.40
38.7
15.6
25.39
25.39
mg/l
0.00
274
2273
12
60
2.03
1.39
2.9
1.4
—
—
—
0
0
19
113
1.72
1.34
2.4
3.0
—
—
—
0
0
47
347
1.41
1.31
3.0
4.3
94.85
41.36
ug/l
0.25
38
295
11
55
2.03
1.28
1.9
1.7
4.90
3.98
iu/l
—
6
19
12
63
1.94
1.24
2.2
2.3
13.84
12.44
mg/l
0.16
12
58
8
37
2.19
1.22
2.5
2.6
3.21
3.38
nmol/l
—
8
37
6
26
2.33
1.19
1.0
1.2
—
—
—
0
0
11
57
1.96
1.18
2.8
1.4
—
—
—
0
0
15
87
1.76
1.17
1.6
1.8
—
—
—
0
0
302
2871
1.33
1.16
53.5
18.5
136.78
139.77
mmol/l
22.91
296
2811
14
80
1.78
1.14
1.9
1.3
—
—
—
0
0
302
2875
1.32
1.12
52.0
18.6
3.98
3.98
mmol/l
0.15
296
2810
9
46
1.98
1.04
1.0
1.2
—
—
—
0
0
10
53
1.91
1.02
2.4
1.4
—
—
—
0
0
10
53
1.91
1.02
2.4
1.4
—
—
—
0
0
6
28
2.16
0.92
1.2
1.0
—
—
—
0
0
24
169
1.45
0.90
7.1
3.4
98.58
140.95
u/ml
0.22
24
163
82
698
1.23
0.85
7.5
4.2
1.02
1.02
kg/l
1.78
61
451
8
45
1.80
0.85
1.5
1.7
—
—
—
0
0
12
73
1.67
0.82
2.7
3.4
2.80
1.61
index
—
5
41
6
32
1.89
0.82
3.2
3.3
—
—
—
0
0
11
67
1.66
0.76
1.0
1.1
—
15.49
—
0
7
5
24
2.10
0.75
1.0
1.0
—
—
—
0
0
14
92
1.54
0.73
1.6
1.4
—
—
—
0
0
7
39
1.81
0.73
1.3
1.4
—
—
—
0
0
31
239
1.33
0.72
1.6
1.5
—
—
—
0
0
11
69
1.61
0.69
1.2
1.5
—
—
—
0
0
5
28
1.80
0.66
1.0
1.1
—
—
—
0
0
5
28
1.80
0.66
3.2
1.4
—
—
—
0
0
30
380
0.77
0.66
21.3
6.6
—
—
—
0
0
57
491
1.19
0.55
1.4
1.3
40.91
10.88
u/ml
0.74
18
180
258
2675
0.87
0.52
5.2
4.9
1.48
1.51
mmol/l
0.41
241
2426
18
137
1.33
0.48
1.3
1.0
—
—
—
0
0
302
2942
1.17
0.47
50.7
20.8
84.88
77.29
umol/l
1.89
295
2899
13
94
1.40
0.46
1.8
2.2
—
—
—
0
0
34
403
0.83
0.45
4.7
4.6
37.72
33.27
%
2.14
29
251
22
175
1.27
0.44
1.8
2.0
—
—
—
0
0
44
505
0.85
0.41
3.1
3.2
0.70
0.76
ug/l
0.23
35
331
11
79
1.40
0.41
1.8
2.1
—
—
—
0
0
6
43
1.40
0.35
1.3
1.1
—
—
—
0
0
62
673
0.90
0.27
5.6
4.7
23.80
21.81
%
0.47
35
352
296
2909
1.10
0.25
19.9
11.8
24.82
24.35
u/l
0.24
289
2811
22
189
1.17
0.25
2.1
2.1
—
—
—
0
0
264
2694
0.92
0.24
5.2
5.0
4.41
4.64
mmol/l
2.87
251
2459
272
2669
1.08
0.22
38.0
15.3
74.40
76.34
ml/min/173m2
0.67
259
2486
270
2749
0.93
0.22
6.0
5.7
2.42
2.69
mmol/l
4.90
256
2491
268
2630
1.08
0.21
8.2
6.2
40.68
39.33
mmol/mol
1.45
260
2422
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
0.96
—
0
7
79
837
0.93
0.21
5.7
5.3
3.70
4.13
ug/l
0.09
72
741
36
393
0.91
0.18
1.4
1.4
—
—
—
0
0
7
62
1.13
0.17
1.1
1.2
—
—
—
0
0
7
63
1.11
0.17
1.1
1.1
—
6.46
—
0
5
8
73
1.10
0.16
1.7
1.4
—
—
—
0
0
275
2712
1.06
0.15
5.8
5.2
6.29
5.95
mmol/l
2.00
248
2431
9
79
1.14
0.15
1.2
1.2
—
—
—
0
0
302
2994
1.05
0.11
53.4
23.9
260.09
245.48
e9/l
2.71
296
2931
302
2995
1.05
0.10
53.4
23.9
4.19
4.43
e12/l
10.18
294
2918
115
1133
1.02
0.05
2.1
1.9
1.46
1.32
mmol/l
0.75
99
927
39
382
1.02
0.01
1.8
1.7
—
—
—
0
0
256
2557
1.00
0.00
4.4
4.2
1.32
1.23
mmol/l
1.11
239
2302
16
165
0.97
0.00
1.3
1.2
142.39
134.56
u/ml
—
7
66
0
9
0.00
0.00
0.0
1.8
—
8.46
—
0
9
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
6
69
0.87
0.00
1.3
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
0.34
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint E4_FLUIDELECTRONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRONAS | 2.068 [1.65, 2.59] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.524 |
During the follow-up period (1.1.1998 — 31.12.2019), 438 out of 950 females with E4_FLUIDELECTRONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRONAS | 5.006 [2.97, 8.43] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 272 out of 534 males with E4_FLUIDELECTRONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_FLUIDELECTRONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.87% |
| 5 | 1.318% | 5.3% |
| 10 | 3.19% | 13.38% |
| 15 | 6.384% | 24.389% |
| 20 | 10.98% | 38.141% |
Relationships between endpoints
↥Index endpoint: E4_FLUIDELECTRONAS – Other disorders of electrolyte and fluid balance, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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