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Diabetes insipidus

DOID EFO Endpoint Browser PheWeb

E4_DIABINSIPIDUS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E23.2
  • Hospital discharge: ICD-9 — 2535
  • Hospital discharge: ICD-8 — 25390
  • Cause of death: ICD-10 — E23.2
  • Cause of death: ICD-9 — 2535
  • Cause of death: ICD-8 — 25390

2 out of 7 registries used, show all original rules.

385

4. Check minimum number of events

None

385

5. Include endpoints

None

385

6. Filter based on genotype QC (FinnGen only)

346

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E23
Name in latin
Diabetes insipidus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1936 1022 905
Only index persons 1614 884 730
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 43.88 45.33 42.11
Only index persons 42.57 44.24 40.55

-FinnGen-

Key figures

All Female Male
Number of individuals 346 214 132
Unadjusted period prevalence (%) 0.07 0.08 0.06
Median age at first event (years) 48.53 47.29 50.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
354
Matched controls
3540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
307.7
324
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
326.3
307.7
269
34
102
Kela drug reimbursment
Diabetes insipidus
+∞
262.3
218
*
H02AB09
ATC
hydrocortisone; systemic
53.9
183.3
109
29
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
98.7
90
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
1128.1
92.1
86
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
91.7
84
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
332.1
80.0
78
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
16.9
69.9
62
44
H03AA01
ATC
levothyroxine sodium; systemic
5.4
55.0
170
514
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
151.8
50.3
52
*
2535A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Diabetes insipidus
+∞
40.4
38
*
R35
ICD-10 Finland
Polyuria
7.0
39.4
67
114
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
9.5
38.7
49
59
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
8.8
38.4
52
68
H53.4
ICD-10 Finland
Visual field defects
12.4
35.0
36
32
25390
ICD-8 Finland
Diseases of pituitary gland, Diabetes insipidus
+∞
35.0
33
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.2
30.6
72
165
R63.1
ICD-10 Finland
Polydipsia
74.9
30.5
34
5
H01AC01
ATC
somatropin; parenteral
+∞
29.6
28
*
XCK00
NOMESCO Finland
Perimetry
6.2
28.7
53
97
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.7
27.8
37
47
N05AN01
ATC
lithium; oral
8.3
23.3
32
42
301
Kela drug reimbursment
Growth hormone
+∞
23.2
22
*
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
22.1
21
*
AA1AD
NOMESCO Finland
CT of head and brain
3.1
22.0
139
618
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
64.1
21.1
24
*
N25.1
ICD-10 Finland
Nephrogenic diabetes insipidus
+∞
21.0
20
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
222.6
20.8
21
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
222.6
20.8
21
*
E23.05
ICD-10 Finland
Lack of TSH
+∞
18.9
18
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
17.9
17
*
ZXC86
NOMESCO Finland
Use of endoscopic device
52.8
17.2
20
*
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
16.8
16
*
TAB00
NOMESCO Finland
Lumbar puncture
4.6
16.0
40
95
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
15.7
15
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
15.7
15
*
N03AG01
ATC
valproic acid; systemic, rectal
4.3
15.3
42
107
N03AX14
ATC
levetiracetam; systemic
6.9
15.1
24
37
L28
ICPC
Limited function/disability (L)
2.9
15.0
87
360
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
14.8
95
414
E23.0
ICD-10 Finland
Hypopituitarism
+∞
14.7
14
*
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
14.7
14
*
WX882
NOMESCO Finland
High dependency care
12.8
13.8
24
20
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
13.6
75
300
E23.03
ICD-10 Finland
Lack of ACTH
+∞
13.6
13
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
13.3
74
298
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
13.3
54
181
N04BC06
ATC
cabergoline; oral
72.5
12.7
14
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
12.6
12
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
12.6
12
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.0
12.5
61
228
A12BA01
ATC
potassium chloride; oral
5.4
12.4
25
49
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
16.6
12.3
19
12
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
14.1
12.1
20
15
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.8
12.0
68
275
N05AH03
ATC
olanzapine; systemic
3.5
11.9
43
133
N05AA02
ATC
levomepromazine; systemic
4.6
11.9
29
67
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.2
11.9
25
51
R42
ICD-10 Finland
Dizziness and giddiness
2.4
11.8
100
493
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
11.6
97
475
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.4
11.6
44
141
9350/1-C75.2
ICD-O-3
Craniopharyngioma, NOS, of craniopharyngeal duct
+∞
11.5
11
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
11.5
11
*
R53
ICD-10 Finland
Malaise and fatigue
2.3
11.2
116
623
N05BA01
ATC
diazepam; systemic, rectal
2.7
11.1
68
286
N05AF03
ATC
chlorprothixene; systemic
5.2
10.9
23
47
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
10.8
86
411
N05CD07
ATC
temazepam; oral
3.0
10.7
52
193
C02AC05
ATC
moxonidine; oral
4.6
10.7
26
60
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
10.7
117
641
N91.1
ICD-10 Finland
Secondary amenorrhoea
14.8
10.6
17
12
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
+∞
10.5
10
*
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
10.5
10
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
10.5
44
150
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
10.4
69
302
N05AH04
ATC
quetiapine; oral
2.4
10.4
88
432
ZXC95
NOMESCO Finland
Use of surgical navigator
10.5
10.1
19
19
UKC02
NOMESCO Finland
Cystoscopy
2.6
10.0
63
269
G03FB08
ATC
dydrogesterone and estrogen; systemic
3.5
9.9
35
107
R51.80
ICD-10 Finland
Headache
2.4
9.9
82
398
E21.0
ICD-10 Finland
Primary hyperparathyroidism
56.6
9.7
11
*
A06AD11
ATC
lactulose; oral
2.6
9.6
60
255
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
9.4
9
*
25310
ICD-8 Finland
Diseases of pituitary gland, Panhypopituitarismus
+∞
9.4
9
*
R60.0
ICD-10 Finland
Localized oedema
2.7
9.3
56
233
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
9.2
148
928
U04
ICPC
Incontinence urine
3.8
9.2
29
82
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.7
9.1
30
87
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.7
9.1
52
211
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
19.2
9.0
13
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
8.9
179
1209
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
8.9
48
188
ZYC01
NOMESCO Finland
Remote contact by phone
3.0
8.9
40
142
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.9
8.9
44
165
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.6
8.7
21
48
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.9
8.6
26
71
J01MA12
ATC
levofloxacin; systemic
2.3
8.6
72
349
N06AX03
ATC
mianserin; oral
3.8
8.6
27
76
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.7
8.6
19
26
R33
ICD-10 Finland
Retention of urine
3.3
8.5
34
112
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
8.5
128
780
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
8.9
8.4
17
20
2542
FHL
Transasal hypophysectomy
+∞
8.4
8
*
E23.3
ICD-10 Finland
Hypothalamic dysfunction, not elsewhere classified
+∞
8.4
8
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
8.4
8
*
E23.06
ICD-10 Finland
Empty sella
+∞
8.4
8
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.3
8.3
68
326
WX892
NOMESCO Finland
Monitored bed care
3.1
8.3
36
125
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.6
8.3
28
83
A41.9
ICD-10 Finland
Sepsis, unspecified
4.5
8.3
20
46
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
8.1
93
513
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
7.9
63
299
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.6
7.8
19
30
R50.9
ICD-10 Finland
Fever, unspecified
2.3
7.8
65
314
UJF32
NOMESCO Finland
Coloscopy
2.1
7.8
96
542
WX402
NOMESCO Finland
General anaesthesia
2.1
7.7
93
520
XKD06
NOMESCO Finland
Physiologic investigation of micturition
4.7
7.7
18
40
N05BA04
ATC
oxazepam; oral
2.0
7.6
105
616
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.9
7.5
37
138
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.6
7.4
25
74
G47.3
ICD-10 Finland
Sleep apnoea
2.0
7.4
96
552
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
7.3
7
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
7.3
7
*
E23.08
ICD-10 Finland
Hypopituitarism
+∞
7.3
7
*
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
7.3
7
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
7.3
7
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
7.6
7.3
16
22
H47.2
ICD-10 Finland
Optic atrophy
20.5
7.2
10
5
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
7.2
95
549
N03AX09
ATC
lamotrigine; oral
3.1
7.2
30
102
SPAT1255
SPAT
Intravenous administration of medicine
3.2
7.1
29
97
A50
ICPC
General and Unspecified, Medication/prescr/renewal
4.0
7.1
20
52
OAB50, ,
SPAT
2.8
7.1
36
137
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.7
7.1
40
161
T99
ICPC
Endocr/metab/nutrit disease other
6.6
7.0
17
27
Z2446
NOMESCO Finland
Social worker
3.0
6.9
32
115
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
6.9
91
524
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.3
6.9
18
44
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.9
138
912
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
6.9
98
580
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.9
6.9
18
32
N06AX21
ATC
duloxetine; oral
2.3
6.8
58
282
G04BD04
ATC
oxybutynin; oral, transdermal
3.0
6.8
30
105
R55
ICD-10 Finland
Syncope and collapse
2.5
6.8
45
196
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
6.7
46
203
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
6.6
6.7
16
25
SPAT1262
SPAT
Handing over of treatment supplies
2.2
6.7
63
320
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
6.6
57
278
N30.0
ICD-10 Finland
Acute cystitis
2.1
6.5
67
351
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
6.5
23
70
G03DB01
ATC
dydrogesterone; oral
2.3
6.5
52
246
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
6.5
54
260
Y28
ICPC
Limited function/disability (Y)
71.1
6.4
7
*
G04BD12
ATC
mirabegron; oral
2.3
6.4
49
227
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
6.4
29
103
K90
ICPC
Stroke/cerebrovascular accident
6.8
6.4
15
23
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
7.2
6.3
14
20
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
+∞
6.3
6
*
9350/1-C75.1
ICD-O-3
Craniopharyngioma, NOS, of pituitary gland
+∞
6.3
6
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.1
6.3
26
88
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
6.2
46
210
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.6
6.2
38
159
J01FF01
ATC
clindamycin; systemic
1.9
6.2
102
631
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.9
6.2
18
48
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.1
6.1
25
84
C03CA01
ATC
furosemide; systemic
1.9
6.1
93
561
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
6.0
24
79
A28
ICPC
Limited function/disability NOS
2.1
6.0
63
332
R11
ICD-10 Finland
Nausea and vomiting
2.4
6.0
42
187

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
151
31
84.20
273.40
4.0
1.2
294.92
272.39
mosm/kgh2o
2.51
130
23
190
317
11.78
124.01
6.0
1.8
307.63
388.14
nmol/l
4.84
180
298
199
572
6.66
71.42
4.0
2.7
449.00
520.74
mosm/kgh2o
4.11
179
499
68
82
10.03
54.15
2.5
1.1
7.66
8.75
u/l
0.28
53
64
278
1484
5.07
38.71
11.8
7.1
1.22
1.21
mmol/l
0.66
237
1292
42
47
10.00
34.92
2.6
1.4
0.24
0.32
nmol/l
0.62
30
37
252
1344
4.04
32.77
11.9
6.6
1.21
1.21
mmol/l
0.16
236
1253
47
68
7.82
31.76
2.0
1.2
—
—
—
0
0
33
34
10.60
28.99
2.1
1.1
—
—
—
0
0
82
229
4.36
27.15
4.9
2.1
13.92
14.02
nmol/l
0.03
75
214
44
77
6.38
24.79
1.9
1.2
317.03
15.33
e6/l
0.48
31
57
186
928
3.12
24.56
5.9
3.6
7.39
7.40
ph
0.31
139
653
28
29
10.40
24.42
2.2
1.0
—
—
—
0
0
44
79
6.22
24.15
1.9
1.3
1039.84
148.85
e6/l
0.85
32
60
62
159
4.51
22.71
2.4
1.3
14.38
22.21
iu/l
1.10
50
130
29
15
20.94
19.86
1.2
1.1
157.48
163.04
mmol/24h
0.08
29
15
90
331
3.31
19.43
10.6
10.6
7.42
7.42
ph
0.25
56
191
222
1331
2.79
19.22
5.3
4.6
35.25
36.29
g/l
1.75
217
1269
86
329
3.13
17.21
10.5
10.6
0.65
0.88
mmol/l
0.20
71
283
246
1658
2.59
15.17
6.4
6.4
9.13
11.05
umol/l
4.12
239
1581
92
394
2.80
14.84
10.6
7.5
105.79
104.28
mmol/l
1.09
92
394
259
1802
2.63
14.71
9.3
5.0
6.63
6.59
mmol/l
0.10
247
1702
99
450
2.67
14.15
2.7
2.2
2.39
2.34
g/l
0.32
94
418
29
60
5.18
13.57
2.0
1.8
0.70
0.85
g/l
0.21
22
48
168
992
2.32
13.40
3.3
2.5
76.07
66.16
u/l
0.17
154
916
54
188
3.21
12.45
5.4
4.1
7.42
7.42
ph
0.21
41
158
22
39
5.95
12.10
2.0
1.3
—
—
—
0
0
307
2426
3.00
11.82
9.9
4.3
15.07
14.67
pmol/l
1.79
297
2232
139
790
2.25
11.81
5.9
4.0
—
—
—
0
0
149
884
2.18
11.26
4.3
2.9
—
—
—
0
0
68
285
2.72
11.21
7.2
3.7
7.38
7.39
ph
0.87
39
164
169
1059
2.14
11.05
8.4
5.5
—
—
—
0
0
53
196
3.00
10.99
10.0
8.1
24.39
24.86
mmol/l
0.38
53
196
66
276
2.71
10.91
7.6
3.6
1.65
1.79
mmol/l
0.15
60
241
200
1360
2.08
10.27
9.8
10.8
1.10
1.19
inr
2.54
172
1101
60
250
2.69
9.95
13.4
10.5
—
—
—
0
0
139
848
2.05
9.39
3.6
2.9
0.75
0.35
e6/l
0.38
112
610
57
243
2.60
9.00
2.5
2.9
77.00
70.72
e9/l
0.89
43
174
128
771
2.03
8.85
2.4
2.0
2.69
2.94
mg/l
0.61
116
674
293
2382
2.34
8.51
10.5
7.8
78.95
77.95
u/l
0.18
285
2257
197
1397
1.92
8.30
4.0
2.4
77.30
76.65
nmol/l
0.12
184
1258
153
1001
1.93
8.20
3.8
3.1
39.55
49.80
e6/l
0.19
129
761
136
861
1.94
8.00
3.5
3.2
1171.53
1002.57
ng/l
0.30
119
719
239
1824
1.96
7.90
13.8
9.8
4.58
3.97
e9/l
2.69
220
1592
227
1706
1.92
7.82
9.6
6.4
0.19
0.19
e9/l
0.10
204
1489
58
267
2.40
7.75
2.7
2.4
10.65
10.40
g/l
0.17
50
246
26
77
3.57
7.68
5.1
2.2
7.41
7.42
ph
0.71
26
77
126
787
1.93
7.65
4.5
3.7
95.64
93.00
%
0.65
118
779
158
1064
1.88
7.61
3.7
3.3
2.34
2.35
mmol/l
0.79
149
967
219
1638
1.88
7.53
8.7
6.1
0.04
0.04
e9/l
0.26
192
1404
221
1664
1.87
7.37
8.8
6.2
1.94
1.95
e9/l
0.02
201
1464
218
1635
1.87
7.36
8.7
6.1
0.59
0.56
e9/l
1.09
191
1403
167
1154
1.85
7.33
4.6
3.7
66.86
98.69
e6/l
0.44
132
800
17
38
4.65
7.26
2.1
1.3
6.38
6.18
g/l
—
10
26
17
38
4.65
7.26
2.1
1.3
—
—
—
0
0
17
38
4.65
7.26
2.1
1.3
2.77
2.84
g/l
—
10
26
17
38
4.65
7.26
2.1
1.3
0.27
0.33
g/l
—
10
26
20
52
4.02
7.08
3.8
2.4
—
—
—
0
0
20
53
3.94
6.91
2.4
4.1
29.40
33.96
umol/l
0.50
15
46
17
41
4.31
6.62
1.9
2.0
—
—
—
0
0
69
364
2.11
6.62
2.1
2.6
6.07
7.34
umol/l
0.38
55
315
97
582
1.92
6.49
1.9
1.7
458.77
22941613.65
pmol/l
0.50
83
510
48
220
2.37
6.46
2.6
2.5
10.80
14.47
au/ml
—
5
19
181
1319
1.76
6.37
2.3
2.0
104.00
96.89
pmol/l
0.87
93
678
129
865
1.77
5.96
1.9
1.6
19.73
20.71
nmol/l
0.31
109
731
11
12
9.42
5.83
2.0
1.2
214.00
62.50
nmol/24h
1.12
11
12
197
1497
1.71
5.75
9.3
6.1
0.62
0.70
%
1.07
190
1402
17
46
3.83
5.71
3.1
2.1
7.20
6.10
pmol/l
0.45
17
46
50
246
2.20
5.70
6.3
4.4
7.39
7.34
ph
2.24
39
170
197
1505
1.70
5.57
9.4
6.1
8.42
8.77
%
1.16
190
1417
196
1499
1.69
5.49
9.2
6.0
2.70
2.79
%
0.27
189
1409
198
1520
1.69
5.46
8.7
6.0
57.72
57.12
%
0.30
192
1448
15
29
5.35
5.45
1.8
1.2
—
—
nmol/l
—
0
0
220
1737
1.70
5.45
5.4
3.6
0.02
0.01
estimate
0.17
55
310
8
5
16.31
5.43
1.0
1.0
5.99
6.66
mg/g
—
8
5
51
258
2.14
5.42
1.4
1.4
—
—
—
0
0
199
1533
1.68
5.38
9.1
6.1
27.52
28.14
%
0.31
192
1463
217
1717
1.68
5.24
5.6
3.6
0.00
4.91
estimate
0.50
59
331
185
1406
1.66
5.21
15.9
10.4
0.00
0.00
e9/l
0.79
150
1143
8
6
13.60
5.10
1.0
1.0
—
—
—
0
0
33
142
2.46
5.09
7.0
4.3
—
—
—
0
0
196
1521
1.65
5.01
3.8
2.9
120.96
106.30
ug/l
0.37
187
1427
156
1146
1.65
4.94
5.2
3.5
32.62
36.60
ng/l
0.15
123
761
108
721
1.72
4.92
1.9
1.7
1.17
1.20
mg/l
0.04
79
562
214
1707
1.64
4.83
5.4
3.6
0.00
0.00
estimate
0.50
54
327
139
996
1.65
4.83
2.8
2.3
—
—
—
0
0
132
940
1.64
4.67
6.2
3.7
0.00
0.01
estimate
0.99
56
309
12
22
5.61
4.64
1.1
1.2
0.57
0.46
ratio
—
6
9
321
2892
2.18
4.51
8.8
6.1
40.03
38.99
mmol/mol
0.93
309
2737
10
15
6.82
4.49
1.7
3.7
527.80
804.47
u/ml
—
10
15
319
2870
2.13
4.46
9.5
5.3
1.59
1.87
mu/l
2.79
289
2662
49
268
1.96
4.22
3.2
5.9
0.20
0.03
%
0.77
20
65
60
352
1.85
4.19
1.8
1.7
—
—
—
0
0
74
464
1.75
4.15
1.9
1.6
1205.43
1167.25
nmol/l
0.14
60
353
183
1439
1.56
4.13
3.2
2.7
—
—
estimate
—
0
0
169
1306
1.56
4.11
5.5
3.4
0.00
0.03
estimate
1.05
44
271
14
42
3.43
4.08
1.5
1.5
—
—
—
0
0
14
42
3.43
4.08
1.5
1.5
—
—
—
0
0
14
42
3.43
4.08
1.5
1.5
—
—
—
0
0
14
42
3.43
4.08
1.5
1.5
—
—
—
0
0
75
476
1.73
4.02
1.6
1.4
349.47
578.89
titre
1.28
19
108
36
181
2.10
3.90
2.5
3.0
80.52
150.44
ng/l
1.60
31
163
107
752
1.61
3.87
4.5
5.0
—
—
—
0
0
322
2943
2.04
3.73
6.8
5.0
5.96
5.89
mmol/l
0.38
307
2733
46
257
1.91
3.73
3.3
5.4
0.17
0.13
%
0.15
18
70
48
273
1.88
3.69
3.4
5.3
1.68
0.78
%
0.99
20
87
112
804
1.57
3.68
1.5
1.3
2.89
1.43
u/ml
0.46
25
230
11
25
4.51
3.65
1.5
1.2
—
—
—
0
0
46
259
1.89
3.64
3.2
5.0
0.77
0.49
%
0.59
22
79
173
1369
1.52
3.64
4.8
3.3
6.34
6.17
ph
1.20
97
775
7
9
7.91
3.57
2.0
1.9
15.94
19.74
umol/l
—
7
9
66
418
1.71
3.55
2.4
2.2
—
—
—
0
0
11
26
4.33
3.53
1.0
1.1
—
—
—
0
0
84
568
1.63
3.53
4.0
3.5
204.13
284.30
ng/l
0.29
53
416
139
1056
1.52
3.51
3.7
3.2
6.77
7.92
mmol/l
2.01
127
907
15
52
2.97
3.51
4.9
2.2
9.09
9.07
kpa
0.01
15
52
15
52
2.97
3.51
4.9
2.2
4.92
5.02
kpa
0.22
15
52
252
2174
1.55
3.43
4.8
3.3
45.03
46.15
u/l
0.10
239
2069
25
116
2.24
3.31
1.8
2.0
21.05
20.13
s
0.65
20
107
126
948
1.51
3.29
4.4
3.0
0.00
0.01
estimate
0.74
47
266
10
24
4.26
3.22
1.5
1.2
120.40
110.21
pmol/l
—
10
24
64
415
1.66
3.15
4.0
3.4
4.21
5.53
e9/l
0.77
52
373
128
976
1.49
3.10
5.0
4.1
9.55
9.66
mg/mmol
0.01
85
600
7
12
5.93
3.03
2.3
2.3
—
—
—
0
0
65
431
1.62
2.93
1.2
1.2
—
—
—
0
0
11
32
3.51
2.92
12.0
15.0
566.45
890.50
nmol/l
1.71
11
32
41
240
1.80
2.89
5.4
3.6
—
—
—
0
0
67
449
1.61
2.89
2.0
2.3
96.14
96.87
ug/g
0.01
51
356
27
137
2.05
2.89
2.2
2.3
—
—
—
0
0
70
475
1.59
2.87
4.0
2.8
3.01
2.67
e6/l
0.09
36
223
12
42
2.92
2.57
1.1
1.2
—
—
—
0
0
123
961
1.43
2.54
4.0
3.4
45.65
52.70
mg/l
0.12
87
613
24
123
2.02
2.52
1.1
1.3
—
—
—
0
0
327
3070
1.85
2.50
28.0
14.1
22.16
22.44
mg/l
0.06
286
2506
26
138
1.95
2.48
1.4
1.3
0.76
1.31
u/ml
—
8
8
9
27
3.39
2.41
1.8
1.3
1.61
1.35
promille
—
9
22
18
351
0.49
2.38
1.3
1.4
—
—
—
0
0
121
956
1.40
2.31
9.9
6.4
—
—
—
0
0
13
53
2.51
2.30
2.7
5.7
—
—
—
0
0
9
29
3.16
2.24
3.8
3.4
—
—
—
0
0
9
30
3.05
2.16
1.1
1.1
—
—
—
0
0
19
95
2.06
2.15
1.6
1.3
275.69
295.71
ug/g
0.18
13
54
94
720
1.42
2.12
1.6
1.4
2.06
2.39
g/l
1.29
64
446
12
49
2.50
2.12
1.2
1.1
46.60
8.90
iu/ml
—
5
10
9
31
2.95
2.08
1.1
1.2
—
—
—
0
0
100
778
1.40
2.06
2.8
2.8
356.65
337.31
umol/l
0.93
84
692
6
15
4.05
2.04
1.0
1.7
—
—
—
0
0
27
156
1.79
2.03
1.6
2.2
2.62
4.77
iu/ml
—
8
35
7
21
3.38
1.97
2.3
4.7
6.96
8.17
mmol/l
—
7
21
6
16
3.80
1.94
3.5
5.9
17.38
17.27
%
—
6
16
18
92
2.01
1.93
2.9
1.9
346.62
5.13
iu/l
—
9
41
31
190
1.69
1.92
1.8
2.5
—
—
—
0
0
56
396
1.49
1.92
2.0
1.5
—
—
—
0
0
16
79
2.07
1.88
1.4
1.2
—
—
—
0
0
99
781
1.37
1.86
6.0
3.5
1.01
1.02
kg/l
3.83
70
509
6
17
3.57
1.84
1.0
1.0
—
—
—
0
0
23
131
1.81
1.82
1.1
1.2
—
—
—
0
0
7
23
3.08
1.81
1.3
1.3
—
—
—
0
0
8
29
2.80
1.80
1.1
1.2
—
—
—
0
0
5
135
0.36
1.79
1.0
1.1
1.11
0.91
g/l
—
5
135
55
394
1.47
1.77
1.5
1.2
—
—
—
0
0
7
24
2.95
1.73
3.6
3.7
5.30
22.70
mg/l
—
7
19
0
48
0.00
1.71
0.0
1.0
—
2.68
—
0
25
10
40
2.54
1.68
1.2
1.2
—
—
—
0
0
14
69
2.07
1.67
2.4
2.4
45.71
91.39
ug/min
—
7
39
8
31
2.62
1.67
2.3
2.6
13.36
10.55
%
—
8
31
7
25
2.84
1.66
1.1
1.0
219.57
314.56
ng/l
—
7
16
5
133
0.37
1.65
1.0
1.1
1.66
1.57
g/l
—
5
133
37
249
1.54
1.60
1.6
1.5
—
—
—
0
0
8
32
2.53
1.60
1.8
2.6
—
—
—
0
0
6
20
3.03
1.58
1.3
1.9
8.55
11.94
umol/l
—
6
20
27
169
1.65
1.57
3.7
2.1
0.00
0.02
estimate
—
5
58
5
15
3.37
1.53
2.0
1.7
58.40
70.33
umol/l
—
5
15
0
44
0.00
1.52
0.0
1.1
—
7.23
—
0
17
28
182
1.58
1.42
1.1
1.2
—
—
—
0
0
18
104
1.77
1.39
9.0
9.6
—
—
—
0
0
6
23
2.64
1.37
1.0
1.0
—
—
—
0
0
40
285
1.45
1.35
1.2
1.2
—
—
—
0
0
11
54
2.07
1.34
1.2
1.2
11.48
12.89
u/l
0.19
11
47
0
40
0.00
1.33
0.0
1.1
—
0.06
—
0
15
5
18
2.80
1.29
1.0
1.5
135.40
138.28
nmol/l
—
5
18
66
519
1.33
1.26
1.9
1.6
—
—
—
0
0
6
25
2.42
1.25
2.3
3.0
—
—
—
0
0
26
172
1.55
1.24
1.4
1.5
0.17
0.33
mg/l
—
7
77
21
132
1.63
1.23
2.4
1.9
—
—
—
0
0
140
1217
1.25
1.23
2.5
2.1
—
—
—
0
0
95
792
1.27
1.18
5.5
4.9
2.79
2.17
ug/l
0.26
86
716
37
267
1.43
1.18
2.5
2.3
0.30
0.17
e6/l
0.47
32
252
32
225
1.46
1.17
1.1
1.2
78.51
145.47
u/ml
0.93
11
102
53
410
1.34
1.14
1.6
1.5
—
—
—
0
0
7
30
2.36
1.13
1.1
1.1
—
—
—
0
0
15
89
1.72
1.09
2.9
3.0
2.50
1.75
index
—
6
52
18
114
1.61
1.04
3.8
3.9
232.14
176.73
mg/l
—
7
49
41
309
1.37
1.04
3.2
2.0
0.00
0.05
estimate
—
9
66
9
48
1.90
1.01
3.7
2.8
4.61
4.56
e9/l
—
9
48
22
317
0.67
1.00
1.6
1.7
—
—
—
0
0
30
217
1.42
0.97
2.9
2.5
3.41
6.21
ug/l
1.91
24
195
6
27
2.24
0.94
1.5
2.0
44.38
40.06
%
—
6
27
10
55
1.84
0.93
1.3
1.1
—
9.22
—
0
23
15
96
1.59
0.85
1.1
1.1
—
—
—
0
0
30
224
1.37
0.83
1.4
1.3
78.75
394.87
u/ml
1.71
30
206
29
216
1.37
0.82
1.2
1.2
—
—
—
0
0
302
2908
1.26
0.81
5.1
4.2
1.40
1.30
mmol/l
1.47
285
2701
252
2644
0.84
0.77
37.0
18.3
331.07
332.72
g/l
1.88
252
2635
115
1285
0.84
0.77
4.2
3.1
—
—
—
0
0
5
24
2.10
0.75
1.2
3.3
2593.40
1036.71
mg
—
5
24
34
266
1.31
0.71
3.6
2.3
6.21
6.13
ph
0.20
21
169
13
85
1.55
0.70
2.1
1.9
—
—
—
0
0
14
203
0.68
0.69
1.8
1.6
—
—
—
0
0
9
59
1.54
0.69
1.0
1.1
—
—
—
0
0
7
42
1.68
0.68
1.6
1.2
—
—
—
0
0
7
42
1.68
0.68
3.6
3.3
0.29
1.23
%
—
7
37
325
3172
1.30
0.65
26.7
12.4
—
—
—
0
0
5
30
1.68
0.61
1.0
1.6
33.20
32.37
pg
—
5
30
11
72
1.54
0.59
1.1
1.7
—
—
—
0
0
75
657
1.18
0.59
1.5
1.3
17.46
32.05
iu/ml
1.93
27
194
10
65
1.55
0.56
1.0
1.6
—
—
—
0
0
41
342
1.22
0.54
1.4
1.6
—
—
—
0
0
147
1367
1.13
0.51
1.9
1.9
1.50
1.37
mmol/l
1.18
126
1174
5
31
1.62
0.43
1.6
2.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.5
—
89.82
—
0
11
15
115
1.32
0.39
1.0
1.4
139.90
265.14
miu/ml
—
8
61
5
37
1.36
0.37
1.4
2.6
3.88
4.02
mmol/l
—
5
37
5
37
1.36
0.37
1.4
2.6
105.80
106.43
mmol/l
—
5
37
5
37
1.36
0.37
1.4
2.6
1.19
1.19
mmol/l
—
5
37
9
70
1.29
0.37
1.2
1.4
—
—
—
0
0
6
43
1.40
0.35
1.2
1.2
—
—
—
0
0
66
601
1.12
0.33
2.1
1.9
—
—
—
0
0
12
154
0.77
0.32
1.5
1.5
—
—
—
0
0
7
96
0.72
0.31
1.0
1.2
—
—
—
0
0
35
392
0.88
0.26
1.3
1.5
—
—
—
0
0
9
72
1.26
0.26
3.7
2.6
61.56
57.42
%
—
9
72
29
327
0.88
0.24
3.5
4.5
3.50
41.15
ug/l
0.91
23
270
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
309
3050
1.10
0.21
6.0
5.0
4.58
4.72
mmol/l
1.77
294
2871
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
65
607
1.09
0.21
1.6
1.3
3.33
10.20
u/ml
1.68
30
248
308
3042
1.10
0.20
6.0
4.9
1.40
1.48
mmol/l
2.58
292
2845
12
99
1.22
0.20
1.3
1.2
—
—
—
0
0
6
51
1.18
0.19
1.0
1.0
—
—
—
0
0
7
58
1.21
0.18
1.3
1.5
—
—
—
0
0
14
119
1.18
0.18
1.6
1.6
10.00
10.04
u/ml
—
5
27
22
196
1.13
0.17
1.2
1.1
—
—
—
0
0
8
69
1.16
0.16
5.4
4.2
—
—
—
0
0
9
80
1.13
0.15
2.1
1.2
—
—
—
0
0
95
916
1.05
0.13
1.4
1.4
—
—
—
0
0
38
355
1.08
0.13
1.3
1.3
—
—
—
0
0
12
105
1.15
0.11
2.0
2.9
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
14
154
0.91
0.08
1.4
1.5
—
—
—
0
0
14
154
0.91
0.08
1.4
1.5
—
—
—
0
0
311
3093
1.05
0.07
6.8
5.7
2.69
2.78
mmol/l
0.93
297
2897
14
151
0.92
0.05
1.4
1.5
—
—
—
0
0
37
357
1.04
0.05
1.6
1.5
—
—
—
0
0
12
111
1.08
0.04
1.3
1.4
—
—
—
0
0
46
472
0.97
0.03
3.4
2.8
1.01
0.75
ug/l
0.27
38
281
10
108
0.92
0.03
1.5
1.6
—
—
—
0
0
334
3347
0.96
0.01
45.4
22.1
134.49
136.36
g/l
1.66
334
3319
334
3346
0.97
0.00
44.8
21.8
30.16
30.30
pg
0.73
334
3320
334
3346
0.97
0.00
46.1
22.4
52.49
40.74
%
0.48
334
3317
14
145
0.96
0.00
1.1
1.5
—
—
—
0
0
334
3345
0.97
0.00
44.9
21.9
90.97
90.87
fl
0.15
334
3319
16
156
1.03
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.74
—
0
6
0
6
0.00
0.00
0.0
1.0
—
53.33
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.1
—
48.06
—
0
8
0
8
0.00
-0.00
0.0
6.3
—
7.63
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
12
120
1.00
-0.00
1.1
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.1
—
37.50
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_DIABINSIPIDUS and mortality.

Females

Parameter HR [95% CI] p-value
E4_DIABINSIPIDUS 3.239 [2.46, 4.27] < 0.001
Birth year 1.001 [0.99, 1.01] 0.864

During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 716 females with E4_DIABINSIPIDUS died.

Males

Parameter HR [95% CI] p-value
E4_DIABINSIPIDUS 2.412 [1.78, 3.27] < 0.001
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 595 males with E4_DIABINSIPIDUS died.

Mortality risk

Mortality risk for people of age

years, who have E4_DIABINSIPIDUS.

N-year risk Females Males
1 0.39% 0.489%
5 2.107% 3.104%
10 5.629% 7.422%
15 10.58% 13.857%
20 18.654% 22.663%

Relationships between endpoints

↥

Index endpoint: E4_DIABINSIPIDUS – Diabetes insipidus

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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