No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
185 |
6. Filter based on genotype QC (FinnGen only) |
170 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of carbohydrate metabolism
based on the number of shared cases.
Similar with more cases:
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1407 | 651 | 742 |
| Only index persons | 1083 | 514 | 569 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 27.79 | 35.37 | 20.72 |
| Only index persons | 26.10 | 32.40 | 20.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 170 | 81 | 89 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 25.04 | 29.18 | 21.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 176
- Matched controls
- 1760
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
27188
ICD-8 Finland
Congenital disorders of carbohydrate metabolism, Alii definiti
+∞
83.0
73
*
E74.0
ICD-10 Finland
Glycogen storage disease
+∞
18.0
17
*
27199
ICD-8 Finland
Congenital disorders of carbohydrate metabolism, Unspecified
+∞
13.7
13
*
E74.1
ICD-10 Finland
Disorders of fructose metabolism
+∞
11.6
11
*
E74.89
ICD-10 Finland
Other specified disorders of carbohydrate metabolism
+∞
9.5
9
*
2712A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Hereditary fructose intolerance
+∞
8.4
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.2
8.4
24
64
503
Kela drug reimbursment
Inborn metabolic disorders
+∞
7.3
7
*
E74.4
ICD-10 Finland
Disorders of pyruvate metabolism and gluconeogenesis
+∞
7.3
7
*
1310
FHL
Esophagogastroscopy
+∞
7.3
7
*
2714A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Renal glycosuria
+∞
7.3
7
*
Y0599
ICD-8 Finland
Investigation of digestive system
10.6
6.6
12
12
A02BC05
ATC
esomeprazole; systemic
2.3
6.6
76
437
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.3
6.1
25
85
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
108
657
2.67
9.08
11.9
7.8
1.21
1.21
mmol/l
0.03
93
575
94
571
2.39
7.42
8.4
5.0
36.42
35.97
g/l
0.30
89
542
96
596
2.34
7.12
10.5
7.3
1.22
1.21
mmol/l
0.87
89
557
101
648
2.31
6.84
4.5
3.1
154.92
121.22
ug/l
0.39
95
608
64
341
2.38
6.67
2.3
2.3
3.03
3.01
mg/l
0.03
56
300
27
92
3.29
6.61
7.6
4.5
93.75
80.82
ng/l
0.32
27
77
10
7
15.04
6.48
1.8
4.1
34.20
26.57
umol/l
—
10
7
42
192
2.56
6.03
2.2
1.7
1300.10
1183.29
nmol/l
0.37
31
149
75
458
2.11
5.39
4.3
2.9
2.35
2.36
mmol/l
0.07
70
425
124
956
2.01
4.25
3.8
3.6
39.85
42.95
u/l
0.35
118
907
131
1034
2.04
4.15
13.2
7.8
81.72
82.74
u/l
0.09
124
976
73
477
1.91
4.10
4.2
3.3
29.58
46.08
ng/l
0.77
55
322
86
595
1.87
4.03
4.5
2.4
75.66
74.73
nmol/l
0.11
81
535
60
369
1.95
4.02
3.0
3.3
4979.69
1069.16
ng/l
0.57
51
298
14
44
3.37
3.87
2.7
1.4
—
—
—
0
0
108
830
1.78
3.36
14.6
10.5
3.50
3.95
e9/l
1.70
101
730
30
154
2.14
3.24
9.0
5.6
5.81
5.82
kpa
0.01
30
149
40
231
1.95
3.15
3.8
2.6
15.69
13.23
umol/l
1.09
35
218
128
1048
1.81
3.07
5.3
4.3
12.01
10.90
mm/h
0.37
119
977
61
407
1.76
3.04
3.1
2.4
56.57
79.11
u/l
0.82
54
378
9
22
4.25
2.92
1.9
1.8
—
—
—
0
0
22
105
2.25
2.83
7.6
5.8
0.09
1.57
mmol/l
0.96
16
82
8
20
4.14
2.60
1.3
1.2
—
—
—
0
0
6
11
5.60
2.56
1.7
1.2
86.83
120.91
pmol/l
—
6
11
31
177
1.91
2.51
6.3
7.0
104.48
104.44
mmol/l
0.02
31
177
75
552
1.63
2.51
2.6
1.9
97.91
98.78
pmol/l
0.06
49
293
93
724
1.60
2.45
12.7
6.6
12.87
11.88
umol/l
0.28
85
686
59
411
1.66
2.44
3.6
2.8
0.00
0.23
estimate
0.52
19
113
10
33
3.15
2.40
2.1
1.6
—
—
—
0
0
9
28
3.33
2.34
1.4
1.5
—
—
—
0
0
11
40
2.86
2.32
3.4
4.6
24.48
24.25
mmol/l
0.09
11
40
7
18
4.00
2.27
7.9
1.8
10.49
6.32
pmol/l
—
7
18
5
9
5.68
2.23
1.0
1.2
—
—
—
0
0
11
42
2.72
2.18
1.3
1.4
—
—
—
0
0
145
1279
1.76
2.15
4.8
4.0
1.32
1.30
mmol/l
0.10
135
1175
23
125
1.97
2.15
4.7
3.4
—
—
—
0
0
52
362
1.62
2.12
1.8
1.5
2.85
1.80
u/ml
0.26
15
89
10
37
2.80
2.10
1.7
3.6
—
—
—
0
0
7
20
3.60
2.07
4.6
2.7
16.21
16.25
%
—
7
20
11
45
2.54
1.97
2.0
1.5
—
—
—
0
0
20
107
1.98
1.96
12.8
6.5
22.89
24.07
mmol/l
1.45
20
107
5
11
4.64
1.95
1.4
8.1
9.60
9.09
%
—
5
11
5
11
4.64
1.95
1.4
8.4
—
—
—
0
0
5
12
4.25
1.83
1.0
1.8
—
—
—
0
0
9
35
2.65
1.83
1.7
1.3
—
—
—
0
0
5
13
3.92
1.72
1.0
1.2
226.80
196.92
mg/l
—
5
13
24
144
1.77
1.68
6.5
6.7
—
—
—
0
0
10
43
2.40
1.62
1.8
1.8
—
—
—
0
0
54
402
1.50
1.61
5.7
3.7
13.50
6.55
mg/mmol
0.55
39
243
91
754
1.43
1.53
4.0
3.3
65.91
0.00
estimate
0.48
23
150
73
581
1.44
1.53
3.6
3.2
0.00
0.00
estimate
-0.00
20
128
14
72
2.03
1.53
1.7
1.5
—
—
—
0
0
11
53
2.15
1.42
8.1
10.5
1.71
1.16
mg/l
1.27
11
46
51
387
1.45
1.36
3.7
3.0
0.20
0.27
e6/l
0.35
45
287
9
42
2.20
1.36
1.0
1.1
—
—
—
0
0
89
747
1.39
1.34
4.0
3.3
0.00
0.00
estimate
-0.00
23
147
141
1282
1.50
1.34
5.5
4.8
1.75
1.90
mu/l
0.99
132
1189
144
1315
1.52
1.33
5.4
4.6
5.98
5.86
mmol/l
0.46
131
1214
147
1349
1.54
1.32
5.5
4.5
1.47
1.44
mmol/l
0.32
138
1252
90
759
1.38
1.30
4.1
3.3
0.00
2.03
estimate
0.50
19
148
8
35
2.35
1.28
1.0
3.0
53.60
204.92
mg/l
—
8
29
8
35
2.35
1.28
1.0
3.0
32.39
23.47
mg/l
—
8
29
147
1353
1.52
1.26
5.5
4.6
4.61
4.64
mmol/l
0.16
139
1270
121
1075
1.40
1.26
4.8
4.0
15.02
14.70
pmol/l
0.71
115
990
14
78
1.86
1.25
4.7
4.6
1.17
1.32
%
0.21
14
78
15
86
1.81
1.23
2.4
1.8
—
—
—
0
0
52
403
1.41
1.23
4.3
3.6
0.00
0.00
estimate
-0.00
22
140
7
31
2.31
1.11
1.0
2.4
2.00
1.44
ratio
—
7
16
9
45
2.05
1.06
2.0
1.9
—
—
—
0
0
33
242
1.45
1.05
1.3
1.3
0.91
4.14
u/ml
—
10
91
14
83
1.75
1.05
1.1
1.3
—
—
—
0
0
147
1369
1.45
1.02
6.1
5.2
2.62
2.74
mmol/l
0.91
140
1274
25
175
1.50
1.00
4.2
4.4
9.95
7.31
umol/l
0.32
20
153
9
50
1.84
0.98
1.4
1.6
—
—
—
0
0
13
77
1.74
0.98
4.6
4.7
0.61
0.60
%
0.04
13
77
15
93
1.67
0.97
2.5
2.8
61.33
65.78
ml/min/173m2
—
6
37
0
31
0.00
0.97
0.0
1.4
—
—
—
0
0
36
274
1.39
0.94
1.5
1.3
21.66
31.31
iu/ml
—
9
86
151
1419
1.45
0.93
25.3
14.2
25.69
23.50
mg/l
0.28
124
1137
8
42
1.95
0.90
1.0
1.1
—
—
—
0
0
39
306
1.35
0.85
1.5
1.8
—
—
—
0
0
8
46
1.77
0.83
1.8
1.5
—
—
—
0
0
30
227
1.39
0.82
2.6
3.3
8.86
505.79
ng/l
1.89
21
163
6
33
1.85
0.80
1.3
1.4
—
—
—
0
0
17
116
1.52
0.77
16.9
10.1
24.47
25.25
mmol/l
0.57
17
116
6
34
1.79
0.77
1.8
1.9
—
—
—
0
0
5
24
2.11
0.75
1.4
1.2
—
—
—
0
0
7
38
1.88
0.74
3.4
2.0
—
—
—
0
0
12
77
1.60
0.70
2.3
3.8
187.83
132.31
ng/l
0.22
12
70
137
1287
1.29
0.68
7.9
5.5
39.70
38.70
mmol/mol
0.59
128
1213
7
43
1.65
0.67
1.6
1.3
—
—
—
0
0
5
28
1.81
0.66
2.4
1.7
—
—
—
0
0
32
392
0.78
0.61
3.6
4.0
20.76
21.63
%
0.13
11
183
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
8
55
1.48
0.57
1.3
1.8
0.22
0.22
g/l
—
8
55
8
55
1.48
0.57
1.6
2.4
51.13
41.43
u/l
—
8
50
38
316
1.26
0.56
3.5
1.9
1.33
0.94
mg/l
0.21
30
247
14
190
0.71
0.53
1.6
2.1
—
—
—
0
0
70
626
1.20
0.52
6.7
2.8
—
—
estimate
—
0
0
7
48
1.48
0.47
2.9
3.5
5.14
682.48
u/ml
—
7
40
10
69
1.48
0.45
3.0
12.9
22.53
24.85
mmol/l
—
10
64
5
32
1.58
0.42
1.0
1.3
—
—
—
0
0
17
132
1.32
0.42
6.1
11.1
0.68
1.35
mmol/l
0.54
12
109
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
42.92
—
0
16
0
17
0.00
0.41
0.0
3.7
—
14.43
—
0
10
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.4
1.2
—
—
—
0
0
5
35
1.44
0.39
2.6
1.6
—
—
—
0
0
103
969
1.15
0.37
3.2
3.3
—
—
—
0
0
13
166
0.77
0.35
1.3
1.9
—
—
—
0
0
12
97
1.25
0.23
2.2
2.0
—
—
—
0
0
62
580
1.11
0.22
2.5
1.8
1.75
1.34
mmol/l
0.46
51
486
5
41
1.23
0.22
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
15.45
—
0
11
0
12
0.00
0.21
0.0
1.3
—
13.83
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
37
337
1.12
0.21
8.8
2.4
—
—
—
0
0
16
136
1.19
0.21
6.0
10.8
13.23
12.23
kpa
0.30
16
131
16
136
1.19
0.21
6.0
10.8
5.00
5.30
kpa
0.64
16
130
0
14
0.00
0.20
0.0
3.1
—
32.26
—
0
14
133
1297
1.10
0.19
24.4
13.0
83.84
84.08
ml/min/173m2
0.04
126
1186
24
215
1.13
0.17
3.1
2.9
1.58
1.81
e6/l
0.10
12
102
26
235
1.12
0.17
2.5
2.7
2.11
0.88
e6/l
0.41
14
123
8
71
1.13
0.16
2.1
3.8
4.26
4.70
pmol/l
—
8
63
8
72
1.12
0.16
10.4
9.6
24.66
24.88
mmol/l
—
8
72
25
227
1.12
0.15
2.2
2.0
—
—
—
0
0
9
82
1.10
0.15
2.6
1.9
—
—
—
0
0
29
314
0.91
0.14
1.9
3.0
0.53
0.70
ug/l
1.24
17
188
18
164
1.11
0.10
2.6
1.8
—
—
—
0
0
10
114
0.87
0.10
4.1
2.4
0.67
0.19
e6/l
—
10
109
5
62
0.80
0.08
3.2
1.2
1.12
0.90
g/l
—
5
62
51
492
1.05
0.07
3.7
4.7
1.58
2.47
ug/l
0.70
45
439
7
80
0.87
0.07
3.0
1.8
—
—
—
0
0
9
86
1.05
0.07
1.0
1.1
—
—
—
0
0
37
355
1.05
0.06
3.6
3.4
1.02
1.02
kg/l
0.46
28
219
17
158
1.08
0.06
2.6
1.9
—
—
—
0
0
17
159
1.08
0.05
5.5
4.2
31.18
30.86
%
0.03
11
103
21
199
1.06
0.05
1.6
1.4
—
—
—
0
0
14
133
1.06
0.01
1.5
1.5
—
—
—
0
0
10
99
1.01
0.00
1.2
1.3
91.62
139.98
u/ml
—
5
39
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
1.04
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
19.33
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
106.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.02
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
0.29
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
1.58
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint E4_CARBO and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_CARBO.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_CARBO – Other disorders of carbohydrate metabolism
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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