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Disorders of adrenal gland, other and/or unspecified

DOID EFO Endpoint Browser PheWeb

E4_ADRENAS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E27.8, E27.9
  • Hospital discharge: ICD-9 — 255[8-9]
  • Hospital discharge: ICD-8 — 2559
  • Cause of death: ICD-10 — E27.8, E27.9
  • Cause of death: ICD-9 — 255[8-9]
  • Cause of death: ICD-8 — 2559

2 out of 7 registries used, show all original rules.

199

4. Check minimum number of events

None

199

5. Include endpoints

None

199

6. Filter based on genotype QC (FinnGen only)

189

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1308 813 486
Only index persons 1013 644 369
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 49.81 46.38 55.27
Only index persons 49.26 46.43 54.20

-FinnGen-

Key figures

All Female Male
Number of individuals 189 117 72
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 51.60 45.20 62.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
199
Matched controls
1990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
99.8
165.4
89
16
E27.9
ICD-10 Finland
Disorder of adrenal gland, unspecified
+∞
115.1
99
*
E27.8
ICD-10 Finland
Other specified disorders of adrenal gland
+∞
62.9
57
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
21.0
52.0
42
25
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
27.8
26
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
310.7
27.4
27
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
25.6
24
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
24.5
23
*
H02AA02
ATC
fludrocortisone; oral
71.0
22.4
25
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
19.4
52
135
25599
ICD-8 Finland
Diseases of adrenal glands, Other and unspecified
+∞
15.8
15
*
JN3AD
NOMESCO Finland
Abdominal CT examination
4.2
15.0
47
136
E23.03
ICD-10 Finland
Lack of ACTH
+∞
14.8
14
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
13.7
13
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
12.6
12
*
2559X
ICD-9 Finland
Disorders of adrenal glands, Unspecified disorder of adrenal glands
+∞
12.6
12
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
12.4
99
504
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.7
12.2
45
145
M05BA04
ATC
alendronic acid; oral
4.6
11.9
31
77
SPAT1301
SPAT
No procedures
2.9
11.7
82
388
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
11.6
11
*
25598
ICD-8 Finland
Diseases of adrenal glands, Alii definiti
+∞
11.6
11
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
11.5
66
279
R60.9
ICD-10 Finland
Oedema, unspecified
5.5
11.3
23
46
H02AB06
ATC
prednisolone; systemic
2.8
11.1
122
723
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
19.2
10.9
16
9
N06AX21
ATC
duloxetine; oral
3.5
10.9
44
150
R53
ICD-10 Finland
Malaise and fatigue
2.8
10.7
78
373
C03DA01
ATC
spironolactone; oral
3.6
10.7
41
135
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.5
10.6
28
70
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
10.5
78
376
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.1
10.3
31
86
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
10.1
114
673
C03CA01
ATC
furosemide; systemic
2.7
10.1
76
368
H03AA01
ATC
levothyroxine sodium; systemic
2.8
9.5
64
291
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
9.4
9
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
19.7
9.1
13
7
M05BX04
ATC
denosumab; parenteral
4.4
8.8
23
57
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.6
8.6
31
97
AA1AD
NOMESCO Finland
CT of head and brain
2.5
8.6
72
362
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
8.6
60
277
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.0
8.5
19
41
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
8.3
85
468
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.1
8.2
38
140
T78.4
ICD-10 Finland
Allergy, unspecified
5.0
8.1
18
39
N02AX02
ATC
tramadol; systemic, rectal
2.3
8.0
101
607
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.5
7.9
30
97
A02BC05
ATC
esomeprazole; systemic
2.3
7.9
95
559
R02
ICPC
Shortness of breath/dyspnoea
3.0
7.8
40
156
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
46.9
7.8
9
*
R11
ICD-10 Finland
Nausea and vomiting
3.3
7.8
31
104
WX892
NOMESCO Finland
Monitored bed care
4.0
7.7
23
63
N03AX16
ATC
[U] pregabalin
2.5
7.6
59
284
R06.0
ICD-10 Finland
Dyspnoea
2.4
7.6
73
389
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.9
7.5
40
159
X59
ICD-10 Finland
Exposure to unspecified factor
2.7
7.5
48
211
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.8
7.4
24
70
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
7.3
95
573
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.8
7.2
43
181
R03BB04
ATC
tiotropium bromide; inhalant
3.2
7.1
31
110
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.1
7.0
32
116
K59.09
ICD-10 Finland
Constipation, unspecified
3.8
6.9
22
63
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
6.9
71
386
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
6.9
67
356
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
6.9
41
173
SPAT1254
SPAT
Administration of medicine
2.7
6.8
40
167
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
6.8
29
101
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
6.7
52
249
TLC00
NOMESCO Finland
Insertion of intrauterine device
4.1
6.7
19
50
WZC00
NOMESCO Finland
Treatment plan or consultation
2.2
6.6
85
507
Z50.1
ICD-10 Finland
Other physical therapy
4.3
6.5
17
42
R03AC12
ATC
salmeterol; inhalant
4.3
6.5
17
42
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
6.4
33
128
2558X
ICD-9 Finland
Disorders of adrenal glands, Other specified disorders of adrenal glands
+∞
6.3
6
*
E27
ICD-10 Finland
Other disorders of adrenal gland
+∞
6.3
6
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
6.3
6
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.1
6.2
28
101
K92.0
ICD-10 Finland
Haematemesis
9.0
6.1
12
14
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
6.1
65
356
103
Kela drug reimbursment
Diabetes, insulin-treated
2.3
6.1
58
303
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.4
6.1
23
74
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.3
6.1
55
282
SPAT1262
SPAT
Handing over of treatment supplies
2.6
6.1
38
164

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Primary adrenocortical insufficiency
E27.1 (45537966)
Other and unspecified adrenocortical insufficiency
E27.4 (45576452)
Other specified disorders of adrenal gland
E27.8 (45581362)
Disorder of adrenal gland, unspecified
E27.9 (45595808)
Corticotropin [Mass/volume] in Plasma
2141-0 (3035637)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Drug-induced adrenocortical insufficiency
E27.3 (45595807)
Disorders of adrenal glands, Unspecified disorder of adrenal glands
2559X (2000402387)
Thorax X-ray examination
GD1AA (2001303617)
hydrocortisone; oral, parenteral
H02AB09 (21602737)
Emergency Room and Inpatient Visit
ERIP (262)
Glucose [Presence] in Urine by Test strip
25428-4 (3009261)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
pH of Serum or Plasma
2753-2 (3018418)
Troponin T.cardiac [Mass/volume] in Serum or Plasma
6598-7 (3019800)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Nitrite [Presence] in Urine by Test strip
5802-4 (3021601)
Bacteria [#/volume] in Urine by Automated count
51480-2 (3031040)
Ketones [Presence] in Urine by Test strip
2514-8 (3035350)
Cortisol [Moles/volume] in Serum or Plasma
14675-3 (3036481)
Urinalysis macro (dipstick) panel - Urine
24357-6 (3037467)
Malaise and fatigue
R53 (45553741)
Asthma, unspecified
J45.9 (45562456)
Benign neoplasm: Adrenal gland
D35.0 (45576391)
Inpatient Hospital
21 (8717)
Inpatient Visit
IP (9201)
Emergency Room Visit
ER (9203)
Endocrinology
46 (38004485)
prednisolone; oral, parenteral
H02AB06 (21602734)
prednisolone
A07EA01 (21600653)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
Internal Medicine
11 (38004456)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
CBC panel - Blood by Automated count
58410-2 (40761511)
Pulmonary Disease
29 (38004472)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
tramadol; oral, parenteral, rectal
N02AX02 (21604298)
Outpatient Visit
OP (9202)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Platelets [#/volume] in Blood
26515-7 (3007461)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
MCH [Entitic mass]
28539-5 (3035941)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Gastroenterology
10 (38004455)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
CBC W Ordered Manual Differential panel - Blood
57782-5 (40760892)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
INR in Blood by Coagulation assay
34714-6 (3032080)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1920-8 (3013721)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Thyroxine (T4) free [Moles/volume] in Serum or Plasma
14920-3 (3008486)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
Basophils [#/volume] in Blood
26444-0 (3006315)
Laboratory Visit
OMOP4822461 (32036)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Phosphate [Moles/volume] in Serum or Plasma
14879-1 (3003458)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
Outpatient Hospital
22 (8756)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Thyrotropin [Units/volume] in Serum or Plasma
3016-3 (3009201)
25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
68438-1 (40771025)
Case Management Agency
251B00000X (38004193)
Supplier / Service Provider
OMOP5117446 (33004)
Pharmacy visit
OMOP4822462 (581458)
Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
34487-9 (3044938)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
63
12
76.36
113.93
2.3
1.4
46.22
23.76
ng/l
0.78
63
12
113
166
14.44
83.34
5.9
1.7
250.17
382.96
nmol/l
5.81
103
153
28
37
8.64
20.50
1.8
1.2
11.09
9.36
u/l
0.14
19
28
50
131
4.76
18.33
4.8
2.9
1.23
1.23
mmol/l
0.20
45
106
86
339
3.71
17.90
3.8
3.0
471.63
521.92
mosm/kgh2o
1.51
78
295
52
146
4.47
17.42
4.0
3.8
0.05
0.15
%
0.57
19
41
139
771
3.66
16.40
21.2
14.2
1.21
1.22
inr
0.08
121
641
52
158
4.10
15.55
4.0
3.6
0.79
0.92
%
0.17
19
53
49
143
4.22
15.47
2.7
2.4
9.83
10.49
g/l
0.35
44
134
144
839
3.59
15.23
11.7
6.5
1.22
1.21
mmol/l
1.45
115
734
49
149
4.04
14.57
4.2
4.3
0.00
0.31
%
0.74
14
39
98
465
3.18
14.48
5.9
4.4
—
—
—
0
0
40
105
4.52
14.44
5.5
3.4
4.74
4.52
pmol/l
0.55
33
91
23
17
15.12
14.13
1.6
1.2
—
—
nmol/l
—
0
0
25
44
6.35
14.06
3.2
2.4
7.42
7.42
ph
0.16
25
44
108
570
2.96
12.78
8.0
5.7
—
—
—
0
0
47
152
3.74
12.69
3.8
3.5
0.44
0.65
%
0.41
16
49
23
22
11.66
12.64
1.5
1.2
0.19
0.17
nmol/l
0.37
17
16
102
528
2.91
12.42
5.8
2.6
56.82
62.07
u/l
0.24
96
495
128
754
2.96
12.13
11.9
5.9
1.22
1.21
mmol/l
0.88
119
695
38
109
4.07
12.12
4.6
4.8
7.43
7.42
ph
0.26
29
87
23
24
10.68
12.12
2.8
2.0
—
—
—
0
0
134
814
2.98
11.90
8.6
5.7
2.43
2.82
%
1.19
128
763
134
819
2.95
11.68
8.7
5.9
8.57
8.63
%
0.09
129
771
129
775
2.89
11.57
4.4
2.4
76.40
76.69
nmol/l
0.04
119
708
22
26
9.37
10.87
3.1
2.2
5.05
5.00
kpa
0.11
22
26
22
26
9.37
10.87
3.1
2.2
9.06
9.15
kpa
0.05
22
26
82
402
2.77
10.74
5.2
4.9
—
—
—
0
0
61
261
2.93
10.25
1.9
2.0
28.77
29.18
s
0.29
53
254
137
882
2.78
10.20
8.2
6.1
0.04
0.04
e9/l
0.49
124
748
36
112
3.70
10.18
4.2
3.0
82.36
74.04
ng/l
0.19
28
102
35
107
3.76
10.15
10.4
9.4
24.69
25.07
mmol/l
0.20
35
107
96
521
2.63
10.13
7.8
3.4
7.39
7.40
ph
0.50
79
359
21
26
8.89
10.13
1.3
2.4
16.93
16.17
%
0.41
21
26
35
108
3.72
10.01
4.5
2.4
10.87
13.09
nmol/l
0.58
29
102
40
135
3.46
10.00
6.3
3.5
—
—
—
0
0
81
407
2.67
9.97
4.1
2.8
7.27
5.18
e6/l
0.64
72
372
136
879
2.73
9.94
8.3
6.0
0.62
0.57
e9/l
1.73
124
747
138
905
2.71
9.68
8.2
6.0
1.92
2.01
e9/l
0.31
129
794
103
588
2.56
9.66
4.7
3.4
20.72
174.68
e6/l
0.76
87
440
138
915
2.66
9.29
8.5
6.2
0.16
0.19
e9/l
1.50
126
792
36
119
3.47
9.26
1.5
1.2
72.00
128.67
u/ml
—
10
49
55
234
2.87
9.25
1.6
1.3
—
—
—
0
0
44
165
3.14
9.24
4.3
4.6
7.38
7.38
ph
0.20
28
90
93
523
2.46
8.80
3.0
2.1
133.44
155.87
u/l
0.38
87
501
78
405
2.52
8.77
2.4
1.7
0.73
1.16
mg/l
1.40
56
322
33
107
3.50
8.73
1.2
2.6
—
—
—
0
0
108
653
2.43
8.66
6.0
3.8
29.00
35.95
ng/l
0.34
89
448
99
578
2.42
8.56
3.5
3.3
2.33
2.35
mmol/l
0.65
94
534
21
50
4.58
8.43
5.9
6.4
8.60
8.33
kpa
0.32
21
50
109
670
2.39
8.31
5.5
4.1
50.19
68.24
e6/l
0.28
89
459
115
726
2.38
8.22
2.4
2.1
96.57
97.03
pmol/l
0.03
71
387
16
18
9.56
8.21
1.7
1.1
—
—
—
0
0
68
340
2.52
8.19
2.4
1.7
465.41
17361562.74
pmol/l
0.50
58
288
15
15
10.71
8.18
1.2
1.7
90.77
90.83
%
0.01
15
15
42
164
2.98
8.18
4.3
4.5
2.26
1.80
mmol/l
0.41
34
140
59
277
2.61
8.09
4.4
3.0
0.80
0.82
mmol/l
0.67
59
266
59
277
2.61
8.09
3.3
2.2
2.28
2.31
g/l
0.13
53
254
88
500
2.36
7.95
4.5
3.3
0.26
0.58
e6/l
0.92
70
353
142
998
2.48
7.76
9.7
9.5
4.60
4.10
e9/l
1.79
134
861
135
932
2.39
7.61
10.9
6.3
10.97
11.71
umol/l
0.18
127
890
170
1312
3.03
7.49
15.1
8.0
78.88
78.78
u/l
0.01
160
1239
25
78
3.52
6.97
1.5
1.3
—
1.62
—
0
6
125
855
2.24
6.92
5.3
2.9
152.94
105.14
ug/l
1.34
116
804
53
253
2.49
6.92
3.5
2.2
22.37
21.83
%
0.09
48
237
76
429
2.25
6.75
3.2
2.1
2.80
2.86
mg/l
0.09
69
372
40
168
2.73
6.75
4.4
4.6
5.89
5.71
kpa
0.67
40
163
54
263
2.45
6.73
1.7
1.4
497.14
530.17
titre
0.06
14
59
25
80
3.43
6.71
5.3
5.2
—
—
—
0
0
118
796
2.19
6.67
17.7
11.2
0.00
0.00
e9/l
0.68
107
654
52
252
2.44
6.54
2.5
1.6
1281.42
1164.79
nmol/l
0.36
42
189
19
51
4.01
6.53
2.6
2.6
26.68
24.88
mmol/l
0.98
19
51
58
296
2.35
6.50
3.6
2.2
12.61
12.69
umol/l
0.03
53
277
27
94
3.17
6.34
1.7
1.3
23.03
25.12
iu/l
0.10
21
83
49
236
2.43
6.22
3.5
2.4
115.72
104.54
ug/g
0.15
32
184
12
14
9.04
6.15
2.5
2.6
5.85
3.23
nmol/l
0.48
12
14
47
224
2.44
6.10
5.5
7.8
102.74
103.85
mmol/l
0.64
47
224
74
429
2.15
6.04
1.8
1.4
2.25
2.33
g/l
0.19
54
265
42
192
2.51
5.95
2.4
1.6
—
—
—
0
0
58
309
2.24
5.81
5.1
3.5
50.70
163.90
ng/l
0.62
43
233
14
24
6.19
5.64
2.0
1.8
5.09
7.34
pmol/l
1.48
14
24
59
320
2.20
5.64
1.7
2.0
—
—
—
0
0
167
1342
2.52
5.61
9.0
4.4
14.93
14.60
pmol/l
1.02
161
1227
18
52
3.71
5.60
1.2
3.8
21.56
39.08
mg/l
2.19
12
47
41
191
2.44
5.56
11.6
7.5
1.21
1.14
mmol/l
0.04
35
156
15
30
5.32
5.38
2.9
2.1
91.51
90.86
%
0.19
15
30
30
122
2.72
5.35
1.2
1.5
—
—
—
0
0
5
0
+∞
5.23
10.0
0.0
2.00
—
nmol/l
—
5
0
9
9
10.40
5.08
2.0
3.2
65.67
62.00
nmol/l
—
9
9
48
249
2.22
5.07
2.6
2.0
—
—
—
0
0
40
192
2.36
5.06
12.0
7.5
7.42
7.42
ph
0.01
25
124
15
41
3.88
5.03
3.9
2.6
60.67
61.51
%
0.08
15
41
45
230
2.24
4.91
3.9
3.1
3.92
5.59
e9/l
0.93
39
202
17
52
3.48
4.87
1.2
3.8
24.88
25.06
mg/l
0.01
11
46
82
531
1.93
4.70
6.9
3.3
0.05
0.01
estimate
0.41
38
147
73
457
1.94
4.61
1.7
1.3
0.94
1.12
u/ml
0.16
23
127
7
5
14.43
4.61
1.4
4.8
58.36
50.60
%
—
7
5
13
27
5.07
4.59
3.6
3.3
4.77
5.01
e9/l
0.10
13
27
80
521
1.90
4.46
6.6
4.2
0.00
0.00
estimate
-0.00
45
174
39
197
2.22
4.36
1.6
2.7
1.75
1.81
%
0.13
33
176
13
29
4.72
4.33
1.1
5.4
—
—
—
0
0
82
544
1.86
4.28
3.4
3.1
8.30
7.92
mmol/l
0.23
70
450
76
493
1.88
4.25
2.2
1.7
19.71
20.31
nmol/l
0.12
68
415
81
538
1.85
4.20
4.9
3.1
—
—
—
0
0
39
202
2.16
4.09
1.3
1.6
—
—
—
0
0
15
48
3.30
4.02
1.1
3.6
1.03
2.35
ratio
—
7
29
60
366
1.92
4.02
1.8
1.3
48.98
27.55
iu/ml
0.31
14
112
18
65
2.95
3.97
1.3
1.4
—
—
—
0
0
78
520
1.82
3.95
4.6
3.7
8.56
8.77
mg/mmol
0.01
43
327
30
143
2.29
3.83
1.7
2.8
71.07
70.97
e9/l
0.00
23
103
43
238
2.03
3.78
2.0
1.3
—
—
—
0
0
49
286
1.95
3.71
1.3
1.6
—
—
—
0
0
28
132
2.30
3.67
11.7
9.2
—
—
—
0
0
188
1685
3.09
3.57
43.3
17.3
139.30
139.67
mmol/l
1.02
183
1651
13
36
3.79
3.57
1.2
1.4
122.38
315.41
u/ml
—
8
17
81
561
1.75
3.52
4.9
3.4
—
—
—
0
0
188
1688
3.06
3.50
43.2
17.4
3.91
3.96
mmol/l
1.76
183
1651
7
10
7.21
3.39
1.6
1.7
137.29
140.40
nmol/l
—
7
10
104
782
1.69
3.29
3.5
2.7
—
—
estimate
—
0
0
46
273
1.89
3.29
3.5
3.1
4.39
2.80
e6/l
0.53
29
117
22
99
2.37
3.20
6.4
4.0
—
—
—
0
0
177
1564
2.19
3.11
9.1
5.9
41.26
38.71
mmol/mol
2.18
170
1474
19
82
2.46
3.02
1.2
1.1
—
—
—
0
0
186
1682
2.62
3.01
36.2
15.2
21.87
23.29
mg/l
0.31
168
1369
96
720
1.64
2.98
7.4
3.9
0.05
0.01
estimate
0.40
41
153
175
1548
2.08
2.93
10.0
5.4
1.69
1.87
mu/l
1.18
165
1440
7
13
5.54
2.89
1.1
1.1
—
—
—
0
0
6
9
6.83
2.89
1.3
1.3
1895.00
1714.44
ml
—
6
9
72
507
1.66
2.83
3.5
3.2
57.94
48.48
mg/l
0.09
45
335
62
424
1.67
2.71
2.7
2.8
328.79
339.72
umol/l
0.36
56
375
76
548
1.63
2.70
3.3
2.2
—
—
—
0
0
10
30
3.45
2.64
4.8
2.5
—
—
—
0
0
16
68
2.47
2.63
1.9
1.9
0.72
5.41
ug/l
0.60
16
61
5
7
7.29
2.56
1.0
1.0
—
—
—
0
0
177
1592
2.01
2.51
6.5
4.8
6.01
5.85
mmol/l
0.59
165
1483
8
21
3.92
2.49
3.3
3.1
1.19
1.19
mmol/l
—
8
21
19
90
2.23
2.48
2.9
4.8
0.58
0.59
%
0.05
19
90
8
22
3.74
2.39
2.8
2.3
—
—
—
0
0
8
22
3.74
2.39
3.3
3.0
105.38
106.09
mmol/l
—
8
22
8
22
3.74
2.39
3.3
3.0
4.01
3.99
mmol/l
—
8
22
5
8
6.37
2.38
1.2
1.8
4.26
2.96
mg/l
—
5
8
5
8
6.37
2.38
1.4
1.1
—
—
g/l
—
0
0
11
39
2.92
2.38
5.8
4.5
—
—
—
0
0
19
92
2.18
2.36
2.9
4.8
0.83
1.34
%
2.13
19
92
68
492
1.58
2.33
1.5
1.5
—
—
—
0
0
51
346
1.64
2.27
1.8
1.3
21.56
8.21
u/ml
0.27
14
128
20
101
2.09
2.25
1.5
1.2
—
—
—
0
0
10
35
2.95
2.24
1.3
1.1
—
—
—
0
0
5
9
5.66
2.22
1.4
1.2
4.52
7.58
ug/l
—
5
9
8
24
3.43
2.20
1.4
2.4
33.13
32.92
pg
—
8
24
34
212
1.73
2.06
1.8
1.4
—
—
—
0
0
115
954
1.49
2.00
7.3
4.0
0.02
8.55
estimate
0.50
48
190
114
945
1.48
1.98
7.1
4.0
0.00
0.00
estimate
-0.00
47
185
8
27
3.04
1.96
1.1
1.1
—
—
—
0
0
6
16
3.83
1.95
1.2
1.1
—
—
—
0
0
9
34
2.72
1.89
1.1
1.6
—
—
—
0
0
8
28
2.93
1.88
1.3
1.7
—
—
—
0
0
8
28
2.93
1.88
1.3
1.8
—
—
—
0
0
8
28
2.93
1.88
1.3
1.7
—
—
—
0
0
8
28
2.93
1.88
1.3
1.8
—
—
—
0
0
6
17
3.60
1.85
2.7
3.5
—
—
—
0
0
5
12
4.24
1.83
1.0
1.0
306.00
292.83
mg/l
—
5
12
9
36
2.57
1.76
1.7
1.5
—
—
—
0
0
28
173
1.72
1.76
5.3
2.5
29.61
29.28
u/l
0.03
23
145
49
350
1.53
1.73
2.5
2.8
2.49
2.44
mmol/l
1.55
40
316
5
13
3.92
1.72
4.8
1.9
92.80
69.77
umol/l
—
5
13
12
56
2.22
1.64
2.1
1.4
283.14
297.04
ug/g
—
7
32
114
967
1.42
1.63
7.4
4.0
0.09
0.02
estimate
0.33
43
177
8
32
2.56
1.61
3.0
1.5
182.38
206.11
pmol/l
—
8
27
6
20
3.06
1.59
4.3
5.5
14.12
14.03
mg/l
—
6
20
135
1185
1.43
1.56
6.8
3.2
62.34
42.13
u/l
1.17
122
1122
0
42
0.00
1.54
0.0
1.5
—
—
—
0
0
11
51
2.22
1.53
1.5
1.2
—
—
—
0
0
7
27
2.65
1.53
1.3
1.1
—
—
—
0
0
0
45
0.00
1.52
0.0
1.6
—
—
—
0
0
90
740
1.39
1.50
2.0
1.9
1.59
1.34
mmol/l
1.34
75
619
91
750
1.39
1.50
5.1
3.6
6.40
6.19
ph
0.97
61
431
54
412
1.43
1.37
6.6
4.2
1.02
1.02
kg/l
0.11
40
276
169
1564
1.53
1.35
5.0
4.2
1.48
1.24
mmol/l
3.06
151
1456
23
146
1.65
1.33
1.3
1.2
—
—
—
0
0
0
41
0.00
1.32
0.0
1.5
—
1.26
—
0
30
14
77
1.88
1.29
3.9
4.6
36.97
36.96
°c
0.09
14
77
14
77
1.88
1.29
2.4
2.0
—
—
—
0
0
8
35
2.34
1.28
2.1
3.8
65.88
56.48
%
—
8
35
15
85
1.83
1.27
5.4
3.6
1.02
1.02
ratio
1.02
15
80
6
25
2.44
1.25
2.0
1.3
—
—
—
0
0
5
20
2.54
1.16
1.0
1.3
—
—
—
0
0
182
1725
1.64
1.15
32.6
13.1
—
—
—
0
0
82
688
1.33
1.13
2.6
2.1
—
—
—
0
0
32
229
1.47
1.13
1.4
1.3
—
—
—
0
0
24
162
1.55
1.10
1.5
1.4
—
—
—
0
0
14
85
1.70
0.97
2.6
1.6
0.16
0.30
mg/l
—
8
32
174
1648
1.44
0.93
6.0
5.0
4.63
4.68
mmol/l
0.30
162
1547
11
63
1.79
0.92
1.6
1.5
—
—
—
0
0
173
1639
1.42
0.90
5.9
4.9
1.44
1.51
mmol/l
1.25
158
1531
6
30
2.03
0.87
2.3
1.6
3.67
4.19
u/ml
—
6
30
81
700
1.27
0.85
3.7
3.2
—
—
—
0
0
11
65
1.73
0.84
1.6
1.5
—
—
—
0
0
175
1667
1.41
0.82
6.4
5.6
2.66
2.74
mmol/l
0.65
162
1560
11
67
1.68
0.77
1.4
1.5
—
—
—
0
0
11
67
1.68
0.77
1.6
1.5
—
—
—
0
0
9
54
1.70
0.75
1.2
1.2
—
—
—
0
0
11
68
1.65
0.73
1.7
1.5
—
—
—
0
0
188
1821
1.59
0.73
49.4
22.9
7.56
6.75
e9/l
5.14
183
1785
188
1821
1.59
0.73
49.3
22.8
4.46
4.47
e12/l
0.18
183
1786
61
520
1.25
0.71
8.4
6.5
—
—
—
0
0
0
20
0.00
0.60
0.0
5.1
—
10.53
—
0
20
17
124
1.41
0.58
1.2
1.3
—
—
—
0
0
8
55
1.47
0.57
1.5
1.2
—
—
—
0
0
10
65
1.57
0.56
2.9
2.9
—
—
—
0
0
23
178
1.33
0.56
1.6
1.9
—
—
—
0
0
21
168
1.28
0.42
2.0
2.3
0.00
0.00
estimate
—
9
41
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
7
105
0.65
0.40
1.6
1.8
—
—
—
0
0
0
19
0.00
0.39
0.0
2.9
—
—
—
0
0
16
125
1.30
0.38
2.2
2.3
10.44
4.88
ug/l
0.49
16
113
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
11
89
1.25
0.21
1.2
1.1
—
—
—
0
0
5
68
0.73
0.17
1.0
1.1
1.47
1.63
g/l
—
5
68
49
461
1.08
0.15
6.1
5.5
3.01
2.61
ug/l
0.10
41
418
19
208
0.90
0.11
1.3
1.5
—
—
—
0
0
27
278
0.97
0.02
2.8
3.2
2.10
0.72
ug/l
0.50
17
183
0
6
0.00
0.00
0.0
4.0
—
37.17
—
0
6
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
69
0.87
-0.00
1.2
1.1
0.96
0.92
g/l
—
6
69
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
-0.00
4.8
1.7
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.2
—
—
—
0
0
18
180
1.00
-0.00
1.4
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ADRENAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_ADRENAS 2.633 [1.78, 3.89] < 0.001
Birth year 0.998 [0.99, 1.01] 0.58

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 411 females with E4_ADRENAS died.

Males

Parameter HR [95% CI] p-value
E4_ADRENAS 2.646 [1.65, 4.25] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 264 males with E4_ADRENAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_ADRENAS.

N-year risk Females Males
1 0.191% 0.525%
5 1.462% 3.045%
10 3.893% 7.638%
15 7.674% 14.4%
20 13.363% 23.783%

Relationships between endpoints

↥

Index endpoint: E4_ADRENAS – Disorders of adrenal gland, other and/or unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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