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Duodenal ulcer - Unspecified as acute or chronic, without haemorrhage or perforation, drug-induced

Endpoint Browser PheWeb

DUODENAL_ULCER_UNSPE_ACUTE_CHRONIC_WO_HAEMORRHAGE_PERFORATION

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs — ANY
  • Hospital discharge: ICD-10 — K26.9#

1 out of 7 registries used, show all original rules.

151

4. Check minimum number of events

None

151

5. Include endpoints

None

151

6. Filter based on genotype QC (FinnGen only)

131

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 131 46 85
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 55.94 54.60 56.66

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
137
Matched controls
1370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K26.9
ICD-10 Finland
Duodenal ulcer, unspecified as acute or chronic, without haemorrhage or perforation
+∞
186.6
137
7
UJD02
NOMESCO Finland
Gastroscopy
20.4
49.9
43
30
A02BA02
ATC
ranitidine; systemic
6.3
26.4
74
214
A02BC01
ATC
omeprazole; systemic
6.0
24.5
84
286
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.8
18.6
76
284
A02BX
ATC
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
32.4
17.1
22
8
A02BC03
ATC
lansoprazole; oral
4.3
15.9
72
283
A02BD01
ATC
omeprazole, amoxicillin and metronidazole; systemic
41.7
12.5
15
*
A02BD03
ATC
lansoprazole, amoxicillin and metronidazole; systemic
5.2
11.9
28
65
A02BA04
ATC
nizatidine; systemic
4.9
10.4
26
63
K26.0
ICD-10 Finland
Duodenal ulcer, acute with haemorrhage
39.5
9.2
11
*
P01AB01
ATC
metronidazole; oral, rectal
2.7
7.2
65
348
A02BA07
ATC
ranitidine bismuth citrate; oral
73.1
6.5
7
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
452
0.50
2.70
4.4
4.3
—
—
—
0
0
33
193
1.94
2.57
2.4
1.9
—
—
—
0
0
48
326
1.73
2.29
5.6
6.9
—
—
—
0
0
22
372
0.51
2.18
5.4
4.5
0.00
0.02
estimate
—
7
128
18
324
0.49
2.15
4.7
3.9
—
—
—
0
0
52
369
1.66
2.08
5.8
4.7
7.40
7.40
ph
0.09
43
261
6
16
3.87
1.95
1.3
1.1
—
—
—
0
0
6
17
3.64
1.86
1.5
1.9
—
—
—
0
0
33
473
0.60
1.75
5.4
4.7
0.33
0.02
estimate
—
6
126
21
120
1.89
1.74
2.1
1.9
—
—
—
0
0
0
46
0.00
1.74
0.0
1.6
—
—
—
0
0
5
13
3.95
1.73
1.6
1.6
—
—
—
0
0
15
76
2.09
1.72
1.6
1.3
—
—
—
0
0
22
345
0.57
1.63
4.1
4.2
0.33
0.00
estimate
—
6
120
26
166
1.70
1.51
8.1
7.4
7.41
7.42
ph
0.46
14
100
52
394
1.52
1.50
4.5
4.9
—
—
—
0
0
23
147
1.68
1.34
8.3
8.0
93.79
94.97
%
0.14
23
142
5
116
0.41
1.32
2.4
4.2
1.24
1.21
mmol/l
—
5
95
18
281
0.59
1.29
2.5
1.8
460.17
427.56
pmol/l
0.29
18
229
8
36
2.30
1.26
10.1
12.9
—
—
—
0
0
25
166
1.62
1.26
8.3
7.4
12.82
11.54
kpa
0.48
25
159
25
166
1.62
1.26
8.3
7.4
5.10
5.04
kpa
0.17
25
159
29
200
1.57
1.26
2.9
3.4
1.13
2.46
e6/l
0.82
18
113
12
68
1.84
1.04
1.7
1.4
—
—
—
0
0
19
125
1.60
1.00
1.6
1.4
—
—
—
0
0
8
140
0.55
0.89
1.1
1.4
—
—
—
0
0
82
910
0.75
0.83
4.5
4.8
1.31
1.28
mmol/l
0.15
77
814
8
48
1.71
0.80
1.4
2.1
—
—
—
0
0
0
24
0.00
0.80
0.0
3.5
—
0.98
—
0
15
0
26
0.00
0.79
0.0
2.2
—
10.38
—
0
26
8
134
0.57
0.78
1.0
1.3
—
—
—
0
0
9
56
1.65
0.74
1.1
1.3
129.73
553.87
u/ml
—
9
50
48
400
1.31
0.73
2.4
3.7
2.33
2.35
mmol/l
0.60
43
358
59
514
1.26
0.63
2.0
2.3
95.22
90.44
pmol/l
0.35
28
260
12
173
0.66
0.62
1.7
3.5
1.57
1.77
%
0.38
12
149
16
114
1.46
0.62
12.4
10.0
—
—
—
0
0
0
20
0.00
0.61
0.0
3.6
—
31.95
—
0
20
15
107
1.45
0.58
2.1
1.5
—
—
—
0
0
56
491
1.24
0.55
9.9
14.4
0.00
0.01
e9/l
0.54
47
406
13
92
1.46
0.53
4.5
5.8
25.35
24.50
mmol/l
0.44
13
87
32
264
1.28
0.52
2.1
3.2
2.48
2.46
mmol/l
0.21
25
234
35
413
0.80
0.52
2.5
2.4
—
—
—
0
0
46
399
1.23
0.49
2.1
2.0
1.35
1.30
mmol/l
0.11
40
304
16
207
0.74
0.47
1.3
1.4
1.95
2.86
g/l
—
6
124
42
481
0.82
0.47
4.2
4.1
6.08
6.18
ph
0.25
20
276
13
95
1.41
0.45
4.5
3.6
—
—
—
0
0
42
366
1.21
0.43
2.4
3.3
1.11
0.39
e6/l
0.99
33
278
5
32
1.58
0.42
1.0
1.1
—
—
—
0
0
26
310
0.80
0.42
2.2
3.2
354.50
364.52
umol/l
0.21
26
255
0
15
0.00
0.41
0.0
1.9
—
10.53
—
0
15
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
48
537
0.84
0.41
4.0
4.5
37.56
45.59
ng/l
0.33
36
439
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
10
136
0.71
0.40
2.4
2.9
4.22
6.13
e9/l
—
10
115
18
223
0.78
0.39
3.4
5.9
—
—
—
0
0
8
112
0.70
0.39
2.1
1.4
—
—
—
0
0
55
604
0.85
0.37
4.6
4.5
0.00
0.00
estimate
—
10
142
59
538
1.17
0.36
7.0
6.4
0.62
0.62
e9/l
0.00
53
457
48
432
1.17
0.34
2.9
3.6
13.67
196.88
e6/l
0.69
38
344
59
540
1.16
0.34
7.0
6.5
0.04
0.04
e9/l
0.05
53
458
41
365
1.18
0.33
6.8
6.3
—
—
—
0
0
8
106
0.74
0.30
1.8
2.5
0.16
0.21
g/l
—
8
96
57
613
0.88
0.27
4.5
4.6
0.00
0.03
estimate
—
9
136
30
266
1.16
0.25
4.4
4.7
1.02
1.02
kg/l
0.04
22
180
14
115
1.24
0.24
2.2
1.6
—
—
—
0
0
57
610
0.89
0.24
4.5
4.5
0.00
0.00
estimate
—
10
148
74
700
1.12
0.24
6.1
5.6
7.11
6.88
mmol/l
0.33
69
668
59
551
1.12
0.24
7.3
6.5
1.80
1.77
e9/l
0.09
52
485
12
97
1.26
0.24
2.4
1.6
—
—
—
0
0
59
552
1.12
0.23
7.1
6.8
0.19
0.20
e9/l
0.15
52
476
0
11
0.00
0.21
0.0
2.1
—
35.35
—
0
11
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
44.66
—
0
13
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
15
175
0.84
0.20
1.2
1.2
18.69
51.65
iu/ml
—
7
59
8
69
1.17
0.17
3.0
3.7
37.04
36.95
°c
—
8
69
50
471
1.10
0.16
4.3
4.2
112.58
98.53
e6/l
0.05
38
355
30
326
0.90
0.16
3.3
3.5
0.62
0.86
ug/l
1.28
23
227
6
76
0.78
0.16
1.3
2.3
1.63
1.54
g/l
—
6
66
7
90
0.77
0.15
1.6
3.8
—
—
—
0
0
61
635
0.93
0.12
15.6
15.5
1.36
1.31
inr
0.23
47
535
19
209
0.89
0.12
1.1
1.2
1.14
2.14
u/ml
—
5
59
5
48
1.04
0.09
4.2
5.6
—
—
—
0
0
25
267
0.92
0.09
1.4
1.3
—
—
—
0
0
51
529
0.94
0.09
3.2
3.0
—
—
estimate
—
0
0
14
154
0.90
0.08
1.1
1.3
—
—
—
0
0
6
58
1.04
0.08
1.3
2.6
—
—
—
0
0
5
60
0.83
0.08
1.0
1.3
—
—
—
0
0
7
68
1.03
0.08
1.1
1.1
—
—
—
0
0
6
73
0.81
0.08
1.5
2.4
—
—
—
0
0
8
93
0.85
0.07
1.4
1.7
—
—
—
0
0
42
405
1.05
0.06
3.5
3.3
46.58
53.07
mg/l
0.10
32
275
13
119
1.10
0.06
2.8
2.3
67.63
66.11
g/l
0.43
13
109
39
376
1.05
0.06
3.1
3.5
—
—
—
0
0
10
90
1.12
0.05
7.4
4.6
123.16
91.27
ng/l
—
10
76
43
417
1.05
0.05
4.3
4.1
6.56
9.16
mg/mmol
0.31
34
275
100
1011
0.96
0.04
19.2
18.9
—
—
—
0
0
38
369
1.04
0.04
2.8
2.6
—
—
—
0
0
13
138
0.94
0.02
6.7
4.1
7.36
7.39
ph
—
6
89
11
103
1.07
0.02
3.4
2.0
—
—
—
0
0
10
106
0.94
0.01
1.1
5.3
0.40
1.06
%
—
5
41
100
999
1.00
0.00
22.5
20.7
31.65
27.56
mg/l
0.58
91
865
32
318
1.01
0.00
2.5
2.2
2.58
2.95
mg/l
0.54
27
271
61
614
0.99
0.00
9.6
10.4
4.53
4.34
e9/l
0.26
54
537
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
1.67
—
0
8
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
12
120
1.00
-0.00
1.7
2.2
361.83
412.75
nmol/l
0.46
12
107
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
4.44
—
0
9
0
6
0.00
-0.00
0.0
1.7
—
7.90
—
0
6
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
100.71
—
0
7
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.79
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
27.00
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
2160.00
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
15
150
1.00
-0.00
1.2
1.3
1.21
13.35
u/ml
—
7
48
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
7.10
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
80.40
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
30.40
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
140.20
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: DUODENAL_ULCER_UNSPE_ACUTE_CHRONIC_WO_HAEMORRHAGE_PERFORATION – Duodenal ulcer - Unspecified as acute or chronic, without haemorrhage or perforation, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).