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Drug-induced tremor

EFO Endpoint Browser PheWeb

DRUGADVERS_TREMOR

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G25.1#

1 out of 7 registries used, show all original rules.

286

4. Check minimum number of events

None

286

5. Include endpoints

None

286

6. Filter based on genotype QC (FinnGen only)

242

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1381 777 594
Only index persons 1216 696 520
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 65.08 66.43 63.19
Only index persons 63.63 65.18 61.55

-FinnGen-

Key figures

All Female Male
Number of individuals 242 131 111
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 60.94 60.40 61.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
251
Matched controls
2510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G25.1
ICD-10 Finland
Drug-induced tremor
+∞
307.7
251
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
27.4
145.0
119
80
R25.1
ICD-10 Finland
Tremor, unspecified
35.9
113.3
76
30
N05AH03
ATC
olanzapine; systemic
20.0
110.6
102
83
N04AA02
ATC
biperiden; systemic
50.0
101.9
61
16
N05AX12
ATC
aripiprazole; systemic
23.9
95.0
75
44
N05AN01
ATC
lithium; oral
36.3
92.9
61
22
N03AG01
ATC
valproic acid; systemic, rectal
17.2
92.4
90
79
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
29.1
78.0
55
24
N05AH04
ATC
quetiapine; oral
9.5
73.1
135
273
N05AX08
ATC
risperidone; systemic
10.7
65.2
88
121
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
32.2
64.1
43
16
N05AA02
ATC
levomepromazine; systemic
15.7
59.2
56
45
C07AA05
ATC
propranolol; systemic
7.3
55.0
128
315
G25.0
ICD-10 Finland
Essential tremor
14.6
47.5
46
38
N05AF03
ATC
chlorprothixene; systemic
18.1
47.0
40
26
N05AB03
ATC
perphenazine; systemic, rectal
14.6
45.6
44
36
F29
ICD-10 Finland
Unspecified nonorganic psychosis
13.8
44.2
44
38
N03AX09
ATC
lamotrigine; oral
10.6
43.4
53
62
P99
ICPC
Psychological disorders other
14.2
43.0
42
35
N03AE01
ATC
clonazepam; systemic
8.4
34.9
51
74
N05AD01
ATC
haloperidol; systemic
14.0
32.1
31
25
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
44.4
31.3
38
10
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
6.7
30.2
55
101
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
7.3
29.7
49
81
N05BA04
ATC
oxazepam; oral
4.0
25.8
117
449
N05BA06
ATC
lorazepam; systemic, sublingual
6.6
25.3
45
80
N06AB04
ATC
citalopram; systemic
4.0
24.0
97
341
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
37.6
24.0
30
9
N05AH02
ATC
clozapine; systemic
21.2
23.8
35
19
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
33.8
23.4
30
10
N05CD07
ATC
temazepam; oral
4.6
22.3
64
174
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.0
22.2
32
45
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.7
21.9
60
157
N05BA01
ATC
diazepam; systemic, rectal
4.3
21.7
71
213
P29
ICPC
Psychological sympt/compl other
5.4
20.6
46
101
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
52.8
20.5
24
5
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
23.2
20.5
29
14
IGY02
NOMESCO Finland
Psychiatric monitoring contact
8.4
20.4
28
37
N06AX12
ATC
bupropion; oral
5.8
20.3
41
82
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
114.1
19.9
21
*
F31.8
ICD-10 Finland
Other bipolar affective disorders
18.7
19.7
30
18
F31
ICD-10 Finland
Bipolar affective disorder
28.8
19.6
26
10
P72
ICPC
Schizophrenia
15.9
19.2
31
22
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
30.6
19.1
25
9
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
24.0
18.6
26
12
ZY010
NOMESCO Finland
Hospital outpatient
6.4
18.6
33
58
F20.9
ICD-10 Finland
Schizophrenia, unspecified
18.4
18.3
28
17
N06AB03
ATC
fluoxetine; oral
4.2
18.2
57
164
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
7.7
17.7
26
37
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
7.3
17.4
27
41
AA1AD
NOMESCO Finland
CT of head and brain
3.1
17.1
111
509
N05BE01
ATC
buspirone; oral
7.6
16.9
25
36
N05AC02
ATC
thioridazine; oral
15.8
16.8
27
19
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
6.4
16.6
29
50
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
20.9
15.9
23
12
N06AX16
ATC
venlafaxine; oral
3.5
15.1
62
213
N06AX11
ATC
mirtazapine; oral
2.9
15.1
122
621
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
34.1
15.0
19
6
P27
ICPC
Fear of mental disorder
38.6
14.6
18
5
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.6
14.5
29
57
A06AD11
ATC
lactulose; oral
3.5
14.2
59
204
N07BB01
ATC
disulfiram; oral
6.2
14.0
25
44
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
6.6
13.6
23
38
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
6.1
13.2
24
43
F61.0
ICD-10 Finland
Mixed personality disorders
13.3
12.9
22
18
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
34.0
12.7
16
5
IGY02, ,
SPAT
21.4
12.6
18
9
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.8
12.6
25
28
N05AA01
ATC
chlorpromazine; systemic, rectal
15.4
12.5
20
14
N06AX03
ATC
mianserin; oral
5.2
12.4
27
57
SPAT1307
SPAT
Psychosocial counselling and guidance
5.7
12.3
24
46
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.4
12.2
25
50
N05AF05
ATC
zuclopenthixol; systemic
28.3
12.2
16
6
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.5
12.2
47
154
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.9
12.1
39
113
N05CF01
ATC
zopiclone; oral
2.6
11.9
109
576
AA400
NOMESCO Finland
Electroconvulsive therapy
31.7
11.8
15
5
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
20.1
11.8
17
9
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.2
11.7
34
91
F31.31
ICD-10 Finland
Bipolar disorder depressive episode with somatic syndrome
68.2
11.7
13
*
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
125.5
11.5
12
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
11.4
55
207
F99
ICD-10 Finland
Mental disorder, not otherwise specified
13.6
11.3
19
15
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
9.3
11.3
23
27
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
12.7
11.0
19
16
SPAT1240
SPAT
Therapeutic discussion
3.6
11.0
40
126
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
10.9
70
308
A04
ICPC
Weakness/tiredness general
3.0
10.8
57
225
ZYC01
NOMESCO Finland
Remote contact by phone
4.1
10.8
32
87
N06AB06
ATC
sertraline; oral
3.2
10.7
48
172
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.4
10.7
28
69
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
62.7
10.7
12
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
5.4
10.2
21
42
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.1
10.2
30
81
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
10.2
45
160
SPAT1243
SPAT
Psychiatric/psychological examination
10.2
10.0
19
20
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
9.6
47
177
N06AX26
ATC
vortioxetine; oral
3.9
9.6
30
85
R53
ICD-10 Finland
Malaise and fatigue
2.4
9.5
90
474
188
Kela drug reimbursment
Psychosis requiring demanding treatment
22.7
9.4
13
6
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
10.1
9.4
18
19
F31.21
ICD-10 Finland
Bipolar disorder, manic episode with mood incongruent psychotic symptoms
+∞
9.4
9
*
Z2445
NOMESCO Finland
Psychologist
4.7
9.3
22
50
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
16.4
9.1
14
9
N06AB10
ATC
escitalopram; oral
2.6
9.0
65
300
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
19.5
9.0
13
7
P73
ICPC
Affective psychosis
25.1
9.0
12
5
P98
ICPC
Psychosis NOS/other
25.1
9.0
12
5
F60.9
ICD-10 Finland
Personality disorder, unspecified
13.2
9.0
15
12
N06AX21
ATC
duloxetine; oral
3.0
8.9
44
167
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.3
8.8
36
122
29580
ICD-8 Finland
Schizophrenia, Other
51.8
8.7
10
*
F31.2
ICD-10 Finland
Bipolar affective disorder, current episode manic with psychotic symptoms
51.8
8.7
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
8.7
63
291
G20
ICD-10 Finland
Parkinson disease
6.8
8.7
21
33
IGY99
NOMESCO Finland
Other psychiatric treatment contact
9.5
8.7
17
19
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.2
8.6
24
62
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.7
8.6
52
220
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
8.5
85
454
F39
ICD-10 Finland
Unspecified mood [affective] disorder
11.3
8.4
15
14
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.9
8.2
25
69
N05AX15
ATC
cariprazine; oral
34.6
8.1
10
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.1
8.1
37
134
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.3
8.0
32
107
Z2446
NOMESCO Finland
Social worker
3.5
7.6
27
83
A07AA02
ATC
nystatin; oral
3.6
7.6
26
78
N06AA06
ATC
trimipramine; systemic
6.8
7.6
18
28
XA800
NOMESCO Finland
Neuropsychological investigation
4.3
7.5
20
50
N06AA12
ATC
doxepin; systemic
3.6
7.5
26
79
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
82.4
7.5
8
*
F20.0
ICD-10 Finland
Paranoid schizophrenia
82.4
7.5
8
*
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
82.4
7.5
8
*
N05AL01
ATC
sulpiride; systemic
9.8
7.4
14
15
N05BA12
ATC
alprazolam; oral
2.9
7.4
38
147
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.8
7.3
23
65
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.8
7.3
23
65
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
7.3
53
244
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
16.3
7.3
11
7
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
16.3
7.3
11
7
Z72.8
ICD-10 Finland
Other problems related to lifestyle
31.0
7.2
9
*
IFA01, ,
SPAT
31.0
7.2
9
*
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
20.7
7.2
10
5
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
9.2
7.1
14
16
F22.0
ICD-10 Finland
Delusional disorder
10.5
7.1
13
13
R33
ICD-10 Finland
Retention of urine
3.0
7.1
32
115
N06AB05
ATC
paroxetine; oral
3.7
7.0
23
67
C03CA01
ATC
furosemide; systemic
2.1
7.0
94
559
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
6.0
6.9
18
32
P74
ICPC
Anxiety disorder/anxiety state
3.7
6.9
22
63
N06AA09
ATC
amitriptyline; systemic
2.8
6.8
36
141
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
17.3
6.8
10
6
N05AE05
ATC
lurasidone; oral
41.2
6.8
8
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
5.8
6.8
18
33
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.7
6.7
22
64
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.2
6.7
27
90
P28
ICPC
Limited function/disability (P)
23.2
6.7
9
*
IGV01
NOMESCO Finland
Psychiatric network contact
10.4
6.6
12
12
N03AX12
ATC
[U] gabapentin; oral
2.3
6.6
56
276
R42
ICD-10 Finland
Dizziness and giddiness
2.1
6.5
73
403
SPAT1216
SPAT
Assessment of functional ability
2.4
6.5
49
229
F21
ICD-10 Finland
Schizotypal disorder
71.6
6.5
7
*
N06AA04
ATC
clomipramine; systemic
8.5
6.4
13
16
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
8.5
6.4
13
16
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
6.4
76
429
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
18.6
6.3
9
5
RS220, ,
NOMESCO Finland
18.6
6.3
9
5
F30.20
ICD-10 Finland
Mania with mood-congruent psychotic symptoms
+∞
6.3
6
*
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
6.6
6.3
15
24
J96.0
ICD-10 Finland
Acute respiratory failure
13.0
6.1
10
8
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
13.0
6.1
10
8
P20
ICPC
Memory disturbance
2.4
6.1
47
221
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
5.8
6.1
16
29
ZY000
NOMESCO Finland
Hospital inpatient
10.4
6.1
11
11
N05AD03
ATC
melperone; systemic
10.4
6.1
11
11
SPAT1254
SPAT
Administration of medicine
2.4
6.1
45
208
L28
ICPC
Limited function/disability (L)
2.2
6.0
59
308
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.0
84
502

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
185
1133
3.41
17.00
8.7
7.9
1.22
1.21
mmol/l
0.87
162
976
92
384
3.20
16.54
1.8
1.6
1105.00
1161.37
nmol/l
0.23
72
290
24
34
7.70
16.40
3.5
1.2
—
—
—
0
0
22
13
18.40
14.59
16.0
14.7
621.27
993.54
nmol/l
1.89
22
13
28
57
5.40
13.45
3.0
1.2
—
—
—
0
0
31
70
4.91
13.25
3.5
1.2
—
—
—
0
0
31
71
4.84
13.03
3.5
1.2
—
—
—
0
0
31
71
4.84
13.03
3.6
1.2
—
—
—
0
0
26
51
5.57
12.99
3.5
1.4
—
—
—
0
0
30
67
4.95
12.99
3.6
1.2
—
—
—
0
0
165
1050
2.67
12.24
7.8
6.8
1.22
1.21
mmol/l
0.88
155
974
93
464
2.60
11.30
1.8
1.8
79518555.27
450.12
pmol/l
0.49
83
379
14
5
29.50
10.84
2.9
2.2
25.39
20.44
umol/l
—
14
5
157
1016
2.46
10.62
2.6
2.1
91.06
96.54
pmol/l
0.75
91
520
28
72
4.25
10.16
3.8
1.2
—
—
—
0
0
118
685
2.36
10.06
2.0
1.7
20.48
21.25
nmol/l
0.21
104
570
174
1196
2.48
10.04
11.6
6.6
0.19
0.20
e9/l
0.51
161
1036
122
720
2.35
9.99
4.1
4.2
7.40
7.40
ph
0.26
94
515
176
1219
2.49
9.94
6.0
7.1
9.28
12.01
umol/l
4.33
170
1163
90
466
2.45
9.90
3.3
3.1
492.27
533.19
mosm/kgh2o
0.89
75
406
188
1344
2.59
9.88
6.7
5.3
6.87
6.67
mmol/l
0.46
179
1268
169
1155
2.42
9.75
9.0
6.3
0.56
0.59
e9/l
0.96
154
983
169
1159
2.40
9.61
9.1
6.3
0.04
0.04
e9/l
0.17
153
986
171
1180
2.41
9.57
9.3
6.3
1.94
1.84
e9/l
0.56
159
1036
120
718
2.29
9.35
3.6
2.6
55.51
68.79
u/l
0.85
113
667
119
711
2.28
9.29
3.3
2.2
347.57
183.18
u/l
1.07
110
673
198
1473
2.63
9.18
7.7
4.8
4590.67
602.95
e6/l
—
6
20
217
1704
3.02
8.77
9.3
8.7
78.63
79.59
u/l
0.12
212
1611
180
1300
2.36
8.62
18.1
10.1
4.11
4.20
e9/l
0.18
161
1133
109
645
2.22
8.54
5.4
4.5
—
—
—
0
0
123
765
2.19
8.49
7.4
6.4
—
—
—
0
0
125
784
2.18
8.43
2.9
3.4
2.35
2.35
mmol/l
0.16
113
713
149
1008
2.18
8.21
2.9
2.6
73.35
76.25
nmol/l
0.63
132
896
56
253
2.56
8.06
5.1
4.2
7.36
7.39
ph
1.18
32
147
54
241
2.58
7.97
5.2
4.3
1.57
1.77
mmol/l
0.15
47
205
92
522
2.20
7.87
7.3
4.3
1.00
1.02
kg/l
0.52
66
349
11
6
19.09
7.67
2.4
1.2
—
—
—
0
0
63
312
2.36
7.39
6.0
6.2
1.08
1.05
mmol/l
0.44
57
286
112
702
2.08
7.28
5.3
3.1
—
—
—
0
0
151
1061
2.06
7.12
8.9
6.6
8.40
8.83
%
1.19
140
1002
97
585
2.07
6.93
2.5
2.2
2.95
2.98
mg/l
0.04
84
510
150
1059
2.03
6.90
8.8
6.5
0.61
0.67
%
0.74
140
992
75
416
2.15
6.63
3.0
3.5
0.81
0.82
mmol/l
0.15
69
394
139
964
1.99
6.62
6.1
3.8
6.50
6.25
ph
2.08
83
540
150
1070
2.00
6.57
21.9
12.7
1.29
1.23
inr
0.57
131
879
149
1063
1.99
6.50
8.9
6.4
2.62
2.85
%
0.73
140
998
56
278
2.31
6.48
5.2
8.1
1.55
0.92
mmol/l
0.57
44
242
119
787
1.97
6.46
3.8
3.6
25.19
138.48
e6/l
0.75
106
599
56
279
2.30
6.42
5.3
8.1
7.40
7.42
ph
1.09
38
154
19
52
3.87
6.33
2.5
3.8
33.15
36.72
umol/l
0.30
19
47
151
1089
1.97
6.30
9.3
6.5
28.52
26.96
%
0.90
142
1032
204
1647
2.27
6.15
6.9
4.2
14.37
14.85
pmol/l
2.28
194
1488
148
1070
1.93
6.02
9.2
6.4
56.43
57.91
%
0.78
142
1021
89
547
1.97
5.85
2.4
2.8
5.60
4.88
e6/l
0.29
83
499
105
687
1.91
5.71
3.5
3.4
0.38
0.50
e6/l
0.41
90
502
188
1489
2.05
5.69
6.0
3.5
54.28
50.65
u/l
0.20
178
1406
52
266
2.20
5.55
2.8
2.2
175.07
130.07
ug/g
0.32
45
212
117
799
1.87
5.52
3.8
3.4
6.14
7.71
mmol/l
3.58
104
672
33
138
2.60
5.49
5.7
3.9
—
—
—
0
0
126
886
1.85
5.38
4.7
4.3
93.37
75.20
e6/l
0.14
105
627
5
0
+∞
5.22
1.6
0.0
40.12
—
nmol/l
—
5
0
159
1209
1.86
5.21
6.6
4.1
0.00
0.00
estimate
-0.00
29
264
105
703
1.85
5.20
11.7
6.3
—
—
—
0
0
160
1221
1.86
5.16
6.7
4.2
50.23
6.04
estimate
0.41
30
269
229
1988
2.73
5.14
8.7
5.2
1.97
1.92
mu/l
0.23
215
1826
160
1232
1.82
4.89
6.7
4.2
0.00
0.01
estimate
0.50
24
247
126
909
1.78
4.76
6.1
4.1
32.59
35.12
ng/l
0.13
98
674
44
226
2.15
4.62
5.3
9.2
—
—
—
0
0
100
682
1.78
4.52
5.9
4.2
0.00
0.00
estimate
-0.00
26
247
28
119
2.52
4.51
1.2
1.3
—
—
—
0
0
85
553
1.81
4.50
6.0
4.1
—
0.17
—
0
6
64
388
1.87
4.22
3.6
3.4
3.41
2.03
e6/l
0.58
39
186
28
126
2.38
4.01
1.9
3.2
4.17
4.37
pmol/l
0.45
19
112
35
179
2.11
3.71
1.2
1.2
—
—
—
0
0
7
9
7.96
3.58
1.4
1.0
159.29
158.00
nmol/l
—
7
9
25
113
2.35
3.55
1.9
1.5
0.25
0.36
mg/l
—
7
44
106
775
1.64
3.51
4.0
4.1
9.01
9.50
mg/mmol
0.05
69
486
54
332
1.80
3.36
6.5
7.6
104.43
104.08
mmol/l
0.20
54
332
9
19
4.87
3.27
1.3
1.2
—
—
—
0
0
71
477
1.68
3.22
4.6
4.0
231.62
414.52
ng/l
0.39
52
376
12
35
3.55
3.15
2.0
1.4
—
—
—
0
0
9
20
4.63
3.14
1.1
1.1
—
—
—
0
0
48
292
1.80
3.08
1.4
1.5
—
—
—
0
0
38
215
1.90
3.06
2.3
2.2
0.00
0.06
estimate
—
6
52
69
469
1.65
2.98
2.3
2.7
2.45
2.45
mmol/l
0.07
58
417
14
52
2.79
2.94
1.1
1.1
1.67
3.26
e6/l
—
9
39
73
512
1.60
2.76
6.0
5.2
—
—
—
0
0
231
2120
2.12
2.75
28.3
16.9
22.59
23.52
mg/l
0.19
205
1752
12
40
3.10
2.73
1.2
1.2
—
—
—
0
0
6
10
6.11
2.71
2.7
2.1
59.00
49.40
umol/l
—
6
10
21
100
2.20
2.67
3.0
2.1
—
—
—
0
0
117
923
1.50
2.57
7.1
4.0
0.19
0.02
estimate
0.41
16
227
38
228
1.79
2.55
2.7
2.6
43.91
33.79
u/l
0.26
33
188
30
169
1.88
2.46
7.3
3.8
7.41
7.42
ph
1.25
30
144
74
534
1.55
2.44
1.5
1.3
2.56
1.55
u/ml
0.31
12
128
15
64
2.43
2.44
8.9
4.8
—
—
—
0
0
6
12
5.09
2.41
1.0
2.8
489.17
984.75
u/ml
—
6
12
13
52
2.58
2.40
1.1
1.6
—
—
—
0
0
24
128
1.97
2.31
1.3
1.2
85.80
132.03
u/ml
—
5
45
0
62
0.00
2.25
0.0
1.1
—
—
—
0
0
128
1049
1.45
2.22
3.6
3.0
137.33
118.17
ug/l
0.49
119
978
61
827
0.65
2.19
4.1
3.3
—
—
—
0
0
18
88
2.13
2.17
1.1
1.3
—
—
—
0
0
40
256
1.67
2.15
1.7
1.6
—
—
—
0
0
25
139
1.89
2.14
5.9
3.1
0.70
0.62
%
0.73
25
139
7
177
0.38
2.13
1.0
1.4
—
—
—
0
0
97
760
1.45
2.11
3.6
3.4
38.74
58.43
mg/l
0.63
64
495
28
163
1.81
2.09
1.4
2.6
—
—
—
0
0
36
226
1.69
2.08
2.2
3.1
73.02
73.50
e9/l
0.02
27
164
16
303
0.50
2.02
1.3
1.2
—
—
—
0
0
25
143
1.83
1.97
5.9
3.1
1.16
1.34
%
0.60
25
143
17
85
2.07
1.95
3.3
5.3
157.75
263.38
mg/l
—
8
34
21
115
1.90
1.89
3.0
2.4
—
—
—
0
0
40
265
1.61
1.89
2.1
3.6
5.28
8.36
umol/l
0.95
32
236
232
2179
1.85
1.85
27.5
14.9
—
—
—
0
0
69
524
1.44
1.73
2.0
1.8
1.13
1.44
mg/l
0.58
57
425
30
190
1.66
1.69
2.4
2.4
5.77
7.83
ug/l
0.33
21
175
12
56
2.20
1.64
2.7
1.8
—
—
—
0
0
5
14
3.62
1.62
1.2
1.0
—
—
—
0
0
30
193
1.63
1.60
7.5
4.9
7.37
7.36
ph
0.52
21
141
221
2064
1.59
1.60
7.6
5.3
6.21
5.97
mmol/l
1.77
203
1898
64
486
1.43
1.60
1.4
1.4
2.53
2.56
g/l
0.05
34
281
91
738
1.37
1.54
3.2
2.4
—
—
—
0
0
9
38
2.42
1.47
1.4
1.7
—
—
—
0
0
9
38
2.42
1.47
1.4
1.7
—
—
—
0
0
9
38
2.42
1.47
1.4
1.7
—
—
—
0
0
9
38
2.42
1.47
1.4
1.7
—
—
—
0
0
18
104
1.79
1.41
10.6
4.5
37.01
36.92
°c
1.31
18
104
20
120
1.72
1.39
9.8
4.2
—
—
—
0
0
8
36
2.26
1.25
1.6
2.6
32.25
32.47
pg
—
8
36
8
37
2.20
1.22
2.4
3.0
—
—
—
0
0
5
19
2.66
1.22
1.2
1.3
—
—
—
0
0
12
208
0.56
1.18
1.7
1.5
—
—
—
0
0
118
1025
1.29
1.17
16.8
12.2
0.00
0.00
e9/l
0.48
96
835
12
65
1.89
1.15
1.2
1.3
—
—
—
0
0
44
332
1.39
1.14
1.3
1.4
256.00
584.58
titre
—
5
83
39
289
1.41
1.12
1.5
1.2
—
—
—
0
0
46
351
1.38
1.12
2.0
1.8
—
—
—
0
0
5
21
2.41
1.09
1.2
1.5
13.78
17.79
ng/l
—
5
21
12
67
1.83
1.06
13.8
7.8
—
—
—
0
0
13
77
1.73
0.97
1.2
3.8
1.42
2.35
ratio
—
7
40
0
31
0.00
0.97
0.0
1.2
—
—
—
0
0
0
31
0.00
0.97
0.0
1.2
—
—
—
0
0
9
51
1.79
0.95
1.2
1.2
—
—
—
0
0
7
37
1.92
0.95
1.4
2.6
0.97
0.93
%
—
7
23
12
71
1.72
0.90
4.3
3.1
8.91
8.30
kpa
0.74
12
71
6
29
2.09
0.90
5.8
1.9
3.70
0.68
mmol/l
—
6
29
13
202
0.62
0.87
1.3
1.4
—
—
—
0
0
6
33
1.84
0.79
1.0
1.2
—
—
—
0
0
8
48
1.69
0.79
1.8
3.0
9.28
9.65
pmol/l
—
8
48
0
26
0.00
0.79
0.0
1.1
—
—
—
0
0
52
623
0.79
0.76
1.3
1.5
—
—
—
0
0
36
451
0.76
0.75
2.6
3.2
0.74
0.76
ug/l
0.09
23
296
9
54
1.69
0.75
1.2
1.2
—
—
—
0
0
5
25
2.02
0.73
1.0
1.1
—
—
—
0
0
71
610
1.23
0.73
2.5
3.1
376.75
350.77
umol/l
1.01
63
532
209
1998
1.28
0.71
9.2
6.7
40.85
39.56
mmol/mol
1.16
198
1884
5
27
1.87
0.69
2.6
3.8
7.64
3.78
nmol/l
—
5
27
25
190
1.35
0.66
3.9
4.5
0.00
0.17
%
—
6
53
5
29
1.74
0.64
1.0
1.4
—
—
—
0
0
5
29
1.74
0.64
1.0
1.2
—
—
—
0
0
46
383
1.25
0.63
1.4
1.3
1.17
8.26
u/ml
3.12
16
153
221
2137
1.29
0.60
6.9
6.1
2.50
2.66
mmol/l
1.80
204
1983
8
52
1.56
0.60
2.3
2.5
—
—
—
0
0
5
90
0.55
0.56
1.0
1.1
—
—
—
0
0
216
2088
1.25
0.55
6.0
5.2
1.33
1.46
mmol/l
5.16
199
1932
26
205
1.30
0.55
3.8
4.4
0.07
0.95
%
—
7
68
18
134
1.37
0.54
1.2
1.2
—
—
—
0
0
6
38
1.59
0.54
2.2
2.8
3.00
4.88
e9/l
—
6
38
29
356
0.79
0.53
2.4
1.6
—
—
—
0
0
7
47
1.50
0.48
3.1
4.5
32.33
23.04
mg/l
—
7
34
216
2096
1.22
0.47
6.1
5.3
4.36
4.57
mmol/l
2.27
202
1951
5
82
0.60
0.46
1.6
3.1
—
—
—
0
0
8
56
1.44
0.43
2.0
2.7
49.71
60.03
%
—
8
56
17
216
0.77
0.42
1.5
1.5
—
—
—
0
0
36
419
0.84
0.41
2.4
1.9
—
—
—
0
0
5
33
1.53
0.41
2.4
2.2
7.14
10.63
mmol/l
—
5
33
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
487.50
—
0
8
0
15
0.00
0.41
0.0
1.1
—
77.70
—
0
10
8
59
1.37
0.41
2.9
1.9
129.00
128.50
g/l
—
8
44
112
1052
1.12
0.35
3.6
2.8
—
—
estimate
—
0
0
17
210
0.80
0.35
1.9
1.8
—
—
—
0
0
206
2005
1.15
0.34
5.3
4.4
1.58
1.28
mmol/l
4.09
191
1843
6
46
1.31
0.33
1.3
1.1
—
—
—
0
0
24
280
0.84
0.29
2.4
1.5
—
—
—
0
0
16
194
0.81
0.29
4.4
3.7
—
—
—
0
0
28
244
1.17
0.27
1.4
4.4
3.31
23.78
ug/l
0.60
21
196
73
679
1.11
0.27
6.3
3.5
0.14
0.00
estimate
0.46
22
217
8
67
1.20
0.26
1.1
1.3
—
2.97
—
0
13
84
891
0.91
0.25
2.2
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.5
—
8.36
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.9
—
2254.09
—
0
11
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
0.00
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
193.62
—
0
13
6
50
1.20
0.20
1.0
1.4
—
—
—
0
0
8
68
1.18
0.17
1.4
1.2
—
—
—
0
0
91
948
0.94
0.16
2.0
2.0
1.57
1.33
mmol/l
1.87
82
789
30
276
1.10
0.14
1.2
1.3
—
—
—
0
0
13
116
1.13
0.09
1.2
1.1
—
—
—
0
0
5
60
0.83
0.08
1.2
1.3
—
—
—
0
0
40
418
0.95
0.08
1.4
1.3
9.58
26.97
iu/ml
3.19
11
129
17
184
0.92
0.07
2.2
1.4
—
—
—
0
0
76
759
1.00
0.00
4.8
5.4
1.88
2.32
ug/l
0.39
68
682
24
236
1.02
0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
36.34
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
89
1.01
-0.00
2.7
3.8
1.54
1.46
mg/l
—
9
79
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
18.60
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
97
0.93
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
29.00
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_TREMOR and mortality.

Females

Parameter HR [95% CI] p-value
DRUGADVERS_TREMOR 1.727 [1.43, 2.08] < 0.001
Birth year 0.994 [0.99, 1.0] 0.175

During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 683 females with DRUGADVERS_TREMOR died.

Males

Parameter HR [95% CI] p-value
DRUGADVERS_TREMOR 2.187 [1.73, 2.77] < 0.001
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 212 out of 529 males with DRUGADVERS_TREMOR died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_TREMOR.

N-year risk Females Males
1 0.176% 0.271%
5 1.097% 2.284%
10 2.546% 5.616%
15 4.83% 10.66%
20 8.486% 17.829%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_TREMOR – Drug-induced tremor

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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