No definition available.
Drug-induced interstitial lung disorders, unspecified
DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
76 |
4. Check minimum number of eventsNone |
76 |
5. Include endpointsNone |
76 |
6. Filter based on genotype QC (FinnGen only) |
69 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced interstitial lung disorders, unspecified
based on the number of shared cases.
Similar with more cases:
- Respiratory conditions due to other external agents
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 294 | 177 | 116 |
| Only index persons | 245 | 147 | 98 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.00 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 70.11 | 70.84 | 68.94 |
| Only index persons | 68.88 | 69.62 | 67.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 69 | 46 | 23 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 67.71 | 67.41 | 68.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 71
- Matched controls
- 710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J70.4
ICD-10 Finland
Drug-induced interstitial lung disorders, unspecified
+∞
102.0
71
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
16.8
28.2
29
28
B01AB10
ATC
tinzaparin; parenteral
9.0
15.7
24
38
GD1AA
NOMESCO Finland
Thorax X-ray examination
10.4
14.6
62
282
J18.9
ICD-10 Finland
Pneumonia, unspecified
6.4
14.0
42
131
JN4AD
NOMESCO Finland
Body CT examination
6.9
13.2
27
58
H02AB06
ATC
prednisolone; systemic
9.5
13.1
61
277
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.3
10.9
23
50
UGC12
NOMESCO Finland
Flexible bronchoscopy
9.5
10.4
22
32
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.2
10.1
29
83
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.5
9.7
24
60
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
10.4
9.6
19
24
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.6
9.3
22
53
H02AB02
ATC
dexamethasone; systemic
5.0
8.8
25
70
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
9.8
8.5
17
22
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
38.2
8.3
10
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
4.3
8.1
30
103
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
8.9
8.1
17
24
TPH07
NOMESCO Finland
Cathetrisation of artery
5.5
8.0
18
41
TGC00
NOMESCO Finland
Bronchial lavation
14.1
8.0
13
11
A03FA01
ATC
metoclopramide; systemic, rectal
4.1
7.8
34
131
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.0
7.7
16
22
JN4BD
NOMESCO Finland
Extensive body CT
5.0
7.6
20
52
M04AA01
ATC
allopurinol; systemic
4.8
7.6
21
57
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
89.0
7.6
8
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
14.1
7.4
12
10
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.9
7.3
32
123
R06.0
ICD-10 Finland
Dyspnoea
3.8
7.2
35
144
A04AA02
ATC
granisetron; systemic, transdermal
7.9
7.1
16
25
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
11.1
7.1
13
14
ZXE00
NOMESCO Finland
One hour or less
3.8
7.0
42
197
D70.82
ICD-10 Finland
Drug-induced neutropenia
19.1
7.0
10
6
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
19.1
7.0
10
6
J01MA12
ATC
levofloxacin; systemic
4.0
6.9
27
95
ZX070
NOMESCO Finland
Intensity modified radiotherapy
25.4
6.9
9
*
XW000
NOMESCO Finland
Bone marrow biopsy
14.2
6.8
11
9
XX3DW
NOMESCO Finland
Time consuming IT work
4.5
6.7
20
57
N02AA05
ATC
oxycodone; systemic
3.8
6.6
28
104
TPH04
NOMESCO Finland
Cathetrisation of vein
3.7
6.3
27
100
ZXE10
NOMESCO Finland
More than one and less than three hours
3.4
6.1
37
172
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
81
7.99
17.37
2.7
2.0
—
—
—
0
0
32
66
8.01
16.68
4.7
5.9
239.03
246.67
u/l
0.17
32
61
35
85
7.15
15.41
2.7
1.9
—
—
—
0
0
40
113
6.82
15.00
2.9
2.0
—
—
—
0
0
39
111
6.58
14.40
5.7
3.3
0.82
0.80
mmol/l
0.67
39
102
21
19
15.15
12.60
1.8
1.9
—
—
—
0
0
24
52
6.46
11.49
6.2
3.8
1.22
1.23
mmol/l
0.16
24
44
19
20
12.52
10.59
1.7
1.9
—
—
—
0
0
16
12
16.78
10.27
1.8
1.9
—
—
—
0
0
15
10
18.58
10.05
1.7
1.8
—
—
—
0
0
17
16
13.55
9.95
1.8
1.8
—
—
—
0
0
24
59
5.63
9.93
6.0
3.3
—
—
—
0
0
14
8
21.34
9.87
1.9
2.1
—
—
—
0
0
64
378
8.01
9.77
24.1
11.1
4.49
4.06
e9/l
0.90
59
327
13
7
22.29
9.33
1.8
1.7
—
—
—
0
0
17
19
11.37
9.17
1.8
1.8
—
—
—
0
0
21
50
5.54
8.92
3.5
11.1
1.48
1.17
mmol/l
1.00
21
50
15
15
12.32
8.53
1.8
1.6
—
—
—
0
0
15
16
11.54
8.27
1.9
1.8
—
—
—
0
0
57
308
5.31
8.22
8.8
6.8
1.20
1.21
mmol/l
0.55
57
282
60
343
5.84
7.91
10.5
7.9
1.20
1.21
mmol/l
0.68
48
296
12
10
14.12
7.40
4.3
1.8
7.99
7.52
kpa
—
12
10
48
247
3.91
6.96
4.4
3.4
—
—
—
0
0
42
200
3.69
6.81
4.1
3.3
0.35
0.27
e6/l
0.17
35
146
14
20
8.43
6.61
2.0
1.3
—
—
—
0
0
11
10
12.74
6.55
4.2
3.3
14.38
16.29
%
—
11
10
27
99
3.79
6.45
7.8
8.1
102.19
104.10
mmol/l
1.05
27
99
11
13
9.77
5.80
4.0
2.1
26.15
24.65
mmol/l
0.55
11
13
15
30
6.05
5.65
3.5
2.6
—
—
—
0
0
21
74
3.61
5.20
4.0
3.6
6.07
5.84
kpa
0.41
21
74
9
9
11.23
5.19
2.0
1.0
—
—
—
0
0
15
36
5.00
4.88
1.6
1.7
0.36
8.93
ug/l
0.55
15
31
14
32
5.18
4.76
4.1
12.4
23.95
25.91
mmol/l
0.89
14
32
38
205
2.84
4.46
2.0
1.8
19.65
23.69
nmol/l
0.89
31
170
17
61
3.35
4.03
2.7
2.8
4.34
4.34
kpa
0.00
17
61
7
9
8.47
3.65
1.1
1.1
4.91
6.02
pmol/l
—
7
9
16
60
3.15
3.51
4.3
3.4
116.08
73.65
ng/l
—
10
52
34
191
2.50
3.47
5.3
3.1
0.00
0.00
estimate
-0.00
23
56
51
350
2.62
3.33
5.6
4.0
0.00
0.00
estimate
-0.00
24
71
51
356
2.54
3.11
5.6
4.1
0.00
0.00
estimate
-0.00
24
68
5
5
10.61
3.02
1.6
1.4
259.00
135.32
u/l
—
5
5
15
59
2.96
3.02
2.1
2.7
8.44
5.94
ug/l
0.24
15
54
7
13
5.84
2.94
2.1
1.7
—
—
—
0
0
7
13
5.84
2.94
2.1
1.7
—
—
—
0
0
13
48
3.09
2.90
5.7
11.5
93.94
94.40
%
0.09
13
48
9
23
4.32
2.89
1.1
1.2
—
—
—
0
0
50
354
2.39
2.83
5.7
4.0
0.00
0.00
estimate
-0.00
24
74
13
49
3.02
2.80
5.6
11.1
0.53
0.73
%
0.93
13
49
46
318
2.27
2.71
3.2
2.7
—
—
—
0
0
13
50
2.96
2.71
2.1
1.6
1.36
1.66
%
—
8
43
13
50
2.96
2.71
5.6
11.1
1.55
1.36
%
0.38
13
50
34
208
2.22
2.71
5.5
4.3
0.00
0.00
estimate
-0.00
23
66
5
7
7.57
2.59
2.0
1.0
—
—
—
0
0
40
265
2.17
2.57
7.4
3.9
20.69
37.19
ng/l
0.66
33
205
22
114
2.35
2.57
1.6
1.4
39.44
31.83
iu/ml
—
7
42
7
16
4.73
2.54
1.3
1.3
—
—
—
0
0
7
16
4.73
2.54
1.7
1.6
—
—
—
0
0
25
139
2.23
2.47
2.0
1.7
518.30
491.75
pmol/l
0.12
20
118
11
40
3.06
2.40
1.8
1.6
—
—
—
0
0
11
41
2.99
2.33
4.6
3.0
24.59
24.00
mmol/l
0.35
11
41
5
9
5.88
2.25
1.4
1.3
—
—
—
0
0
42
297
2.01
2.14
4.0
2.7
—
—
estimate
—
0
0
6
15
4.26
2.08
1.7
2.4
—
—
—
0
0
6
16
3.99
1.98
4.8
1.4
81.33
95.88
%
—
6
16
6
16
3.99
1.98
4.8
2.3
228.33
186.69
%
—
6
16
39
275
1.93
1.94
5.3
4.0
0.00
0.00
estimate
-0.00
22
59
5
12
4.39
1.85
8.0
2.0
10.80
7.99
mmol/l
—
5
12
11
48
2.53
1.81
1.5
1.7
—
—
—
0
0
6
18
3.54
1.78
3.8
3.7
29.67
55.58
u/ml
—
6
18
7
24
3.12
1.77
1.3
1.3
1.33
1.15
g/l
—
7
24
7
24
3.12
1.77
1.3
1.3
0.25
0.23
g/l
—
7
24
41
301
1.86
1.74
2.2
2.3
85.13
93.70
pmol/l
0.52
22
138
5
14
3.76
1.64
1.2
1.3
—
—
—
0
0
9
38
2.56
1.52
1.8
1.4
—
—
—
0
0
6
23
2.75
1.40
4.3
1.6
0.00
0.00
g/l
—
6
23
8
36
2.37
1.29
1.3
1.1
—
104.46
—
0
10
6
25
2.53
1.27
1.3
1.2
—
—
—
0
0
18
119
1.69
1.01
4.4
3.2
0.60
0.96
e6/l
0.50
11
67
7
36
2.05
1.00
2.7
3.7
25.16
25.06
mmol/l
—
7
36
16
103
1.71
0.98
4.8
3.4
0.67
3.15
e6/l
—
9
52
64
589
1.88
0.88
5.2
5.5
5.93
5.90
mmol/l
0.08
57
538
5
23
2.26
0.78
1.2
1.2
—
3.12
—
0
5
11
68
1.73
0.77
1.6
1.4
—
—
—
0
0
5
24
2.16
0.76
1.4
1.8
—
—
—
0
0
5
24
2.16
0.76
1.8
2.0
—
—
—
0
0
7
40
1.83
0.74
3.1
3.1
43.63
43.54
%
—
7
40
6
40
1.55
0.53
2.8
2.8
2.00
1.04
%
—
6
40
19
149
1.38
0.48
1.2
1.3
0.47
1.05
u/ml
—
6
35
20
159
1.36
0.47
4.3
2.2
—
—
—
0
0
6
94
0.61
0.46
8.2
7.6
—
—
—
0
0
16
124
1.37
0.43
1.5
1.7
1702.71
1273.43
nmol/l
—
10
95
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
8
99
0.78
0.14
1.5
1.5
—
—
—
0
0
11
96
1.17
0.11
2.0
1.5
—
—
—
0
0
11
101
1.11
0.04
2.2
3.1
0.38
0.72
ug/l
—
6
76
25
244
1.04
0.00
4.8
3.9
23.00
10.98
mg/mmol
0.28
13
141
0
6
0.00
-0.00
0.0
1.5
—
43.23
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
1.05
—
0
5
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1146.00
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
-0.00
0.0
2.6
—
108.57
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
116.33
—
0
6
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
146.67
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE | 2.1 [1.45, 3.04] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.217 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 143 females with DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.214% | No data |
| 5 | 1.23% | No data |
| 10 | 3.312% | No data |
| 15 | 5.661% | No data |
| 20 | 9.969% | No data |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE – Drug-induced interstitial lung disorders, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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