No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
152 |
4. Check minimum number of eventsNone |
152 |
5. Include endpointsNone |
152 |
6. Filter based on genotype QC (FinnGen only) |
138 |
Control definitions (FinnGen only)
- Control exclude
- D3_APLASTICANDOTHANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D64
- Name in latin
- Aliae anaemia sideroblasticae
Similar endpoints
↥List of similar endpoints to
Other sideroblastic anaemias
based on the number of shared cases.
Similar with more cases:
- Other anaemias
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1579 | 915 | 635 |
| Only index persons | 1006 | 616 | 390 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 71.02 | 71.37 | 70.40 |
| Only index persons | 65.44 | 64.99 | 66.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 138 | 67 | 71 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 66.70 | 63.51 | 69.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 141
- Matched controls
- 1410
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D64.3
ICD-10 Finland
Other sideroblastic anaemias
+∞
166.6
125
*
D64.9
ICD-10 Finland
Anaemia, unspecified
48.0
108.2
72
30
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
10.1
31.1
42
57
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.6
23.4
80
268
B82
ICPC
Anaemia other/unspecified
17.4
16.6
26
18
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
17.7
13.1
20
13
28500
ICD-8 Finland
Other and unspecified anaemias, Hypochromic anaemia with iron loading
+∞
12.7
12
*
UJF92
NOMESCO Finland
Capsular endoscopy
27.7
11.4
15
6
WW500
NOMESCO Finland
Blood transfusion
10.1
10.7
21
24
UJF32
NOMESCO Finland
Coloscopy
3.2
9.7
53
222
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.9
9.2
22
51
XW000
NOMESCO Finland
Bone marrow biopsy
9.5
8.6
17
20
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.2
7.9
38
146
ZX120
NOMESCO Finland
Intravenous
3.7
7.7
27
84
D64.0
ICD-10 Finland
Hereditary sideroblastic anaemia
+∞
7.3
7
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
14.8
7.0
11
8
D50.8
ICD-10 Finland
Other iron deficiency anaemias
17.8
6.8
10
6
B80
ICPC
Iron deficiency anaemia
23.8
6.8
9
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.8
6.7
22
65
B03XA02
ATC
darbepoetin alfa; parenteral
13.1
6.7
11
9
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.2
6.5
28
100
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.5
6.2
50
250
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.0
6.0
30
116
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
75
288
4.43
17.32
4.5
2.0
3.70
2.89
mg/l
1.72
68
245
22
60
4.16
7.53
1.5
1.2
—
—
—
0
0
15
21
7.85
6.91
1.3
2.5
—
—
—
0
0
26
88
3.40
6.52
18.5
5.0
11.45
11.04
mmol/l
0.08
26
83
28
108
2.99
5.64
5.5
3.3
0.01
1.32
mmol/l
0.55
22
84
26
102
2.90
5.07
2.3
2.1
0.20
0.21
g/l
0.30
21
93
32
141
2.64
5.02
10.7
4.5
1.16
1.06
mmol/l
0.54
32
132
18
59
3.35
4.71
5.5
3.3
22.47
23.78
mmol/l
0.65
18
59
37
184
2.37
4.47
3.5
2.7
0.80
0.81
mmol/l
0.19
37
171
66
419
2.08
4.34
6.7
3.2
1942.10
1525.94
ng/l
0.40
60
353
57
352
2.04
3.97
2.4
1.7
19.33
21.87
nmol/l
0.72
52
284
36
187
2.24
3.90
3.7
3.2
4.44
2.64
e6/l
0.55
29
98
82
589
1.94
3.59
11.6
6.3
1.20
1.21
mmol/l
0.77
74
503
6
6
10.37
3.53
4.3
1.7
—
—
—
0
0
13
46
3.01
3.01
1.9
2.7
—
—
—
0
0
36
208
1.98
2.91
2.6
1.9
—
—
—
0
0
6
10
6.21
2.72
3.2
2.6
—
—
—
0
0
34
199
1.93
2.63
3.7
3.1
0.82
1.15
e6/l
0.49
27
110
20
96
2.26
2.58
2.6
2.9
28.53
32.52
u/l
0.49
15
79
16
70
2.45
2.52
2.4
1.6
—
—
—
0
0
65
473
1.69
2.42
6.0
4.1
31.07
54.22
ng/l
1.21
54
348
28
158
1.96
2.40
2.5
1.7
—
—
—
0
0
42
272
1.77
2.36
3.7
3.0
354.30
350.65
umol/l
0.08
37
233
15
66
2.42
2.34
2.1
3.0
1.95
2.14
mmol/l
—
6
50
79
612
1.66
2.27
20.8
9.8
3.98
4.17
e9/l
0.34
72
527
9
29
3.24
2.27
6.3
1.7
3.18
3.70
g/l
—
9
29
70
526
1.66
2.27
2.7
2.1
93.91
99.44
pmol/l
0.43
41
261
18
88
2.20
2.23
1.6
1.6
—
—
—
0
0
9
30
3.13
2.19
1.4
1.4
—
—
—
0
0
41
269
1.74
2.19
12.4
2.5
—
—
—
0
0
26
149
1.91
2.13
2.7
1.8
—
—
—
0
0
64
477
1.63
2.10
3.1
2.4
75.49
78.24
nmol/l
0.39
59
408
69
527
1.61
2.03
12.4
5.6
1.20
1.21
mmol/l
0.50
63
476
28
170
1.81
1.92
7.7
6.4
103.21
104.35
mmol/l
0.51
28
170
7
22
3.29
1.90
2.7
2.0
—
—
—
0
0
5
12
4.28
1.84
1.2
1.9
—
—
—
0
0
5
12
4.28
1.84
1.4
1.4
—
—
—
0
0
7
23
3.15
1.82
2.1
1.9
—
—
—
0
0
12
54
2.34
1.79
1.2
1.4
4.30
4.12
g/l
0.29
12
49
12
54
2.34
1.79
1.2
1.4
7.05
7.78
g/l
0.79
12
49
12
54
2.34
1.79
1.2
1.4
4.33
3.69
g/l
0.33
12
49
13
61
2.25
1.78
4.5
2.4
1.84
1.29
%
0.72
13
61
50
367
1.56
1.68
2.8
2.0
162.64
190.55
u/l
0.33
45
344
7
25
2.89
1.67
1.1
1.2
0.22
0.24
g/l
—
7
25
7
25
2.89
1.67
1.1
1.3
1.06
1.16
g/l
—
7
25
5
14
3.66
1.63
1.0
1.6
0.14
0.17
nmol/l
—
5
7
100
858
1.57
1.62
15.7
7.5
83.83
79.50
u/l
0.50
95
796
94
798
1.53
1.58
5.6
4.4
20.22
13.19
mm/h
2.09
87
724
6
21
2.94
1.52
2.7
1.8
—
—
—
0
0
6
21
2.94
1.52
2.3
2.0
—
—
—
0
0
11
52
2.21
1.49
1.2
1.4
3.20
3.24
g/l
0.05
11
47
9
38
2.46
1.48
1.3
1.2
—
—
—
0
0
5
16
3.20
1.45
2.8
1.4
—
—
—
0
0
36
255
1.55
1.39
4.2
4.9
1.01
1.02
kg/l
1.46
27
175
6
23
2.68
1.38
1.8
3.0
14.05
15.73
%
—
6
23
10
47
2.21
1.37
1.2
1.4
14.60
10.33
g/l
—
10
42
5
17
3.01
1.37
2.8
1.6
—
—
—
0
0
8
37
2.23
1.23
2.0
2.8
3.44
1.76
ratio
—
8
16
8
39
2.11
1.17
2.0
3.0
93.70
33.14
mg/l
—
8
32
8
39
2.11
1.17
2.0
3.0
115.42
205.82
mg/l
—
8
32
7
30
2.40
1.14
1.0
1.3
—
—
—
0
0
7
32
2.25
1.10
2.4
1.7
—
—
—
0
0
15
90
1.75
1.09
1.9
3.2
1.23
1.23
mmol/l
0.09
15
77
7
33
2.18
1.07
2.3
1.7
—
—
—
0
0
31
226
1.48
1.05
1.2
1.3
0.84
1.38
u/ml
—
5
65
14
85
1.72
0.98
3.3
3.4
69.57
62.61
ml/min/173m2
—
7
31
0
30
0.00
0.98
0.0
1.5
—
41.10
—
0
30
16
102
1.64
0.95
2.8
2.5
0.92
0.21
e6/l
0.63
16
97
35
267
1.41
0.94
8.4
1.6
1.27
1.52
mg/l
0.35
28
210
6
29
2.12
0.90
1.2
1.2
—
—
—
0
0
9
151
0.57
0.84
1.6
1.5
—
—
—
0
0
62
527
1.31
0.83
10.3
2.7
—
—
estimate
—
0
0
6
32
1.91
0.83
2.5
2.2
124.00
124.39
g/l
—
6
23
6
33
1.85
0.80
8.8
1.5
86.00
93.27
%
—
6
33
18
124
1.52
0.80
19.7
8.9
—
—
—
0
0
5
92
0.53
0.70
1.2
1.3
—
—
—
0
0
22
163
1.41
0.69
1.1
1.3
2.60
10.28
u/ml
—
9
58
5
29
1.75
0.64
1.0
1.2
—
—
—
0
0
5
29
1.75
0.64
1.0
1.4
—
—
—
0
0
8
49
1.67
0.63
2.9
2.0
24.61
24.92
mmol/l
—
8
49
32
261
1.29
0.56
1.8
1.8
543.38
460.11
pmol/l
0.53
26
213
110
1035
1.29
0.56
37.8
16.8
24.84
25.77
mg/l
0.12
100
879
7
45
1.58
0.50
2.0
2.0
—
—
—
0
0
38
326
1.23
0.45
4.0
4.5
0.00
0.00
estimate
-0.00
14
102
63
571
1.19
0.42
5.1
4.5
0.00
0.00
estimate
-0.00
18
114
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
103
977
1.20
0.39
7.4
6.9
40.55
39.81
mmol/mol
0.34
93
904
63
576
1.17
0.37
5.3
4.5
0.00
0.00
estimate
-0.00
18
118
5
78
0.63
0.36
6.4
5.4
24.92
24.38
mmol/l
—
5
72
63
581
1.15
0.32
5.3
4.6
0.00
0.00
estimate
-0.00
15
111
36
404
0.85
0.31
4.8
5.7
2.61
2.83
ug/l
0.08
31
355
7
57
1.24
0.29
3.9
3.5
3.56
4.34
pmol/l
—
7
49
28
319
0.85
0.29
3.9
4.9
15.77
22.17
%
—
10
167
8
65
1.24
0.27
14.2
6.0
15.36
15.24
%
—
8
60
29
324
0.87
0.23
5.6
3.7
0.00
0.00
estimate
-0.00
12
92
59
552
1.12
0.23
2.6
2.9
—
—
—
0
0
5
42
1.20
0.21
2.2
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
47
440
1.10
0.17
5.0
4.5
0.08
0.00
estimate
0.47
13
96
12
139
0.85
0.15
4.8
5.4
31.60
33.86
%
—
5
88
82
792
1.08
0.15
4.1
4.2
14.79
14.98
pmol/l
0.25
76
707
11
128
0.85
0.14
1.3
1.4
—
—
—
0
0
98
1003
0.92
0.12
4.9
5.4
3.96
4.51
mmol/l
5.25
91
921
10
116
0.85
0.12
3.8
3.6
—
—
—
0
0
7
67
1.05
0.08
1.4
1.7
—
—
—
0
0
25
235
1.08
0.08
3.0
3.2
0.61
0.77
ug/l
0.66
15
167
98
997
0.94
0.08
4.9
5.3
1.39
1.47
mmol/l
0.94
89
914
112
1109
1.05
0.04
60.6
25.6
90.41
91.52
fl
0.94
112
1093
112
1110
1.04
0.03
61.2
25.8
118.21
133.72
g/l
14.66
112
1092
112
1110
1.04
0.03
61.5
26.2
36.20
39.84
%
7.95
112
1093
96
958
1.01
0.00
5.2
5.4
1.86
2.02
mu/l
0.72
89
862
96
958
1.01
0.00
4.2
4.5
1.19
1.26
mmol/l
0.57
86
870
39
391
1.00
0.00
4.0
4.0
8.51
11.78
mg/mmol
0.23
27
245
102
1016
1.01
0.00
5.3
6.3
2.19
2.59
mmol/l
5.05
94
935
101
1006
1.01
0.00
5.8
5.6
6.26
6.02
mmol/l
1.01
92
915
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
18.28
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
76
0.92
-0.00
2.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
4.51
—
0
6
0
6
0.00
-0.00
0.0
3.8
—
9.90
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
44.24
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_SIDEROANAMIEAOTHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SIDEROANAMIEAOTHER | 2.545 [1.95, 3.32] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 302 out of 565 females with D3_SIDEROANAMIEAOTHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SIDEROANAMIEAOTHER | 2.558 [1.77, 3.69] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 213 out of 380 males with D3_SIDEROANAMIEAOTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_SIDEROANAMIEAOTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.199% | 0.607% |
| 5 | 1.237% | 3.073% |
| 10 | 2.959% | 8.425% |
| 15 | 5.515% | 15.674% |
| 20 | 9.1% | 26.053% |
Relationships between endpoints
↥Index endpoint: D3_SIDEROANAMIEAOTHER – Other sideroblastic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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