No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
172 |
4. Check minimum number of eventsNone |
172 |
5. Include endpointsNone |
172 |
6. Filter based on genotype QC (FinnGen only) |
141 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Alia thrombocytopenia primaria
Similar endpoints
↥List of similar endpoints to
Other primary thrombocytopenia
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1180 | 637 | 530 |
| Only index persons | 901 | 512 | 389 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 52.63 | 48.40 | 57.23 |
| Only index persons | 45.98 | 40.32 | 53.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 141 | 85 | 56 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 50.87 | 40.77 | 66.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 151
- Matched controls
- 1510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
176.8
133
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
530.2
86.2
78
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
70.4
62
*
XW000
NOMESCO Finland
Bone marrow biopsy
20.1
44.1
37
24
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
20.3
19
*
D64.9
ICD-10 Finland
Anaemia, unspecified
5.6
16.5
37
83
B02AA02
ATC
tranexamic acid; systemic
4.6
16.0
50
148
2873X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA NUD]
+∞
14.8
14
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
165.3
14.7
15
*
Z31.5
ICD-10 Finland
Genetic counselling
7.2
14.2
23
37
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
153.2
13.7
14
*
WW500
NOMESCO Finland
Blood transfusion
11.1
12.3
23
24
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
10.5
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
10.5
35
106
ZX120
NOMESCO Finland
Intravenous
4.0
8.6
27
78
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
8.4
8
*
6753
FHL
Transabdominal splenectomy
+∞
8.4
8
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
19.6
7.7
11
6
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
8.0
7.4
16
22
B02BX05
ATC
eltrombopag; oral
+∞
7.3
7
*
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
7.3
7
*
Z2221
NOMESCO Finland
Medical doctor
2.6
7.3
58
289
WX892
NOMESCO Finland
Monitored bed care
4.3
7.2
20
52
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
7.1
72
402
D01
ICPC
Abdominal pain/cramps general
3.3
7.0
30
106
H02AB06
ATC
prednisolone; systemic
2.5
6.9
87
535
UJF32
NOMESCO Finland
Coloscopy
2.6
6.8
49
232
R04.0
ICD-10 Finland
Epistaxis
3.6
6.6
23
71
L28
ICPC
Limited function/disability (L)
2.9
6.4
36
149
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
6.3
6
*
2873C
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA ALIA DEFINITA]
+∞
6.3
6
*
D69.0
ICD-10 Finland
Allergic purpura
+∞
6.3
6
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
6.3
80
488
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
6.1
25
86
R4110
NOMESCO Finland
Physiotherapy
2.5
6.0
52
266
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
68
224
4.70
19.38
3.9
2.4
12.91
13.99
umol/l
0.52
68
208
65
209
4.70
19.06
3.6
2.4
2.45
2.32
g/l
0.92
65
189
50
173
3.83
12.60
6.1
6.5
1.07
1.07
mmol/l
0.01
50
156
28
62
5.32
12.49
1.9
1.9
1.34
1.45
g/l
0.24
23
54
24
28
9.97
12.08
4.6
1.8
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
15
6
27.51
11.38
1.4
1.0
162.33
136.33
%
—
15
6
122
777
3.97
11.02
19.7
10.2
4.27
4.11
e9/l
0.32
112
689
96
530
3.23
10.97
7.5
5.2
35.59
36.01
g/l
0.35
90
503
106
625
3.34
10.72
10.3
8.0
1.20
1.22
mmol/l
0.79
101
540
13
6
23.51
9.53
4.8
2.7
—
—
—
0
0
13
6
23.51
9.53
4.8
2.7
—
—
—
0
0
106
680
2.88
8.23
10.7
6.4
13.41
12.95
umol/l
0.09
106
647
66
334
2.73
8.22
4.2
3.2
334.23
326.47
umol/l
0.22
61
292
19
45
4.69
7.73
1.3
1.3
—
—
—
0
0
12
9
14.35
7.52
3.3
1.7
—
—
—
0
0
67
355
2.60
7.46
3.6
1.9
2.98
2.82
mg/l
0.22
60
308
18
36
5.53
6.43
2.1
2.8
0.00
0.00
g/l
-0.00
18
36
6
0
+∞
6.29
1.3
0.0
—
—
—
0
0
44
204
2.63
6.28
3.5
2.8
3.28
2.15
e6/l
0.36
20
97
12
14
9.20
6.18
2.4
1.5
32.33
31.79
pg
0.13
12
14
85
537
2.33
6.08
3.1
2.0
95.50
96.82
pmol/l
0.09
53
266
16
35
4.99
5.36
2.9
3.7
1.36
3.32
ratio
—
8
16
26
99
2.96
5.32
13.8
8.1
23.93
24.74
mmol/l
0.49
26
99
17
50
3.70
5.20
1.8
2.0
0.26
0.24
g/l
0.25
17
50
31
132
2.70
5.17
7.5
12.6
0.22
1.30
mmol/l
0.49
23
110
64
379
2.20
5.13
4.7
3.0
1.38
0.40
e6/l
0.57
46
273
44
223
2.37
5.10
3.3
2.8
3.42
0.95
e6/l
0.66
21
115
17
51
3.63
5.05
1.8
2.0
1.18
1.19
g/l
0.06
17
51
55
314
2.18
4.77
2.2
2.0
1.43
1.10
mg/l
0.48
43
243
7
5
14.58
4.62
2.3
1.6
1731.00
367.20
u/ml
—
7
5
45
244
2.20
4.39
2.8
3.4
48.61
279.63
ng/l
1.09
38
178
19
68
3.05
4.30
2.1
1.7
—
—
—
0
0
12
25
5.12
4.29
1.2
1.6
142.00
216.54
u/ml
—
5
13
12
28
4.56
3.91
1.2
1.4
—
—
—
0
0
51
306
2.01
3.75
5.3
2.2
—
—
—
0
0
7
9
8.09
3.60
1.0
5.0
110.86
105.33
%
—
7
9
12
31
4.11
3.58
1.3
1.3
—
—
—
0
0
8
13
6.43
3.55
1.1
1.2
—
—
—
0
0
13
37
3.75
3.50
2.3
2.4
—
—
—
0
0
15
53
3.03
3.47
1.3
1.7
—
—
—
0
0
33
180
2.07
3.10
12.3
8.1
104.48
104.85
mmol/l
0.18
33
180
7
12
6.06
3.05
1.0
1.0
—
—
—
0
0
66
457
1.79
3.01
5.5
3.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
11
33
3.51
2.88
4.5
3.0
0.19
0.40
iu/ml
—
5
16
12
39
3.25
2.84
1.1
1.3
360.40
351.96
ug/g
—
5
19
80
599
1.71
2.69
5.5
2.8
—
—
estimate
—
0
0
10
30
3.49
2.66
2.8
3.2
0.80
1.32
index
—
5
22
63
443
1.72
2.65
4.7
3.3
39.93
28.98
u/l
0.50
56
428
12
42
3.01
2.62
1.8
1.4
0.00
0.07
iu/ml
—
5
10
9
28
3.35
2.35
1.6
1.7
—
—
—
0
0
139
1250
2.41
2.32
33.0
15.4
20.22
22.54
mg/l
0.50
129
1037
9
30
3.12
2.18
2.7
1.4
—
—
—
0
0
117
1001
1.75
2.16
4.8
4.4
14.49
14.81
pmol/l
0.59
112
917
35
220
1.77
2.13
2.5
1.8
—
—
—
0
0
6
15
4.12
2.06
1.2
1.3
—
—
—
0
0
7
21
3.44
1.99
1.6
1.1
—
—
—
0
0
26
154
1.83
1.92
2.7
1.7
—
—
—
0
0
27
162
1.81
1.91
2.7
1.7
—
—
—
0
0
5
12
4.27
1.84
1.2
1.3
—
—
—
0
0
5
12
4.27
1.84
1.0
1.1
—
—
—
0
0
8
29
2.85
1.82
1.9
1.3
—
—
—
0
0
8
29
2.85
1.82
1.3
1.3
—
—
—
0
0
6
18
3.43
1.76
1.5
1.2
—
—
—
0
0
5
13
3.94
1.73
2.2
1.2
—
—
—
0
0
132
1193
1.85
1.72
30.5
14.7
80.46
82.68
ml/min/173m2
0.45
122
1107
8
31
2.67
1.68
1.5
1.4
12955.63
4440.71
e6/l
—
8
21
16
84
2.01
1.67
3.0
5.3
0.38
1.17
mmol/l
—
9
61
9
37
2.52
1.51
1.7
1.7
—
—
—
0
0
21
127
1.76
1.46
3.2
4.7
2.65
10.46
ug/l
1.37
13
98
10
46
2.26
1.43
1.2
1.2
—
7.77
—
0
6
9
40
2.33
1.43
1.1
1.3
—
—
—
0
0
7
29
2.48
1.41
1.4
1.2
—
—
—
0
0
9
41
2.27
1.39
2.0
1.3
—
—
—
0
0
16
90
1.87
1.39
2.9
1.5
—
—
—
0
0
12
61
2.05
1.37
11.0
3.7
0.52
0.65
%
0.68
12
61
9
42
2.21
1.36
2.0
1.4
—
—
—
0
0
53
409
1.46
1.34
5.1
4.0
6.61
10.02
mg/mmol
0.58
41
253
51
392
1.45
1.32
3.6
2.1
851.27
381.71
u/l
0.33
51
376
11
55
2.08
1.31
1.1
1.4
270.20
248.11
miu/ml
—
5
28
8
36
2.29
1.26
2.3
1.4
—
—
—
0
0
10
49
2.11
1.25
1.7
1.4
—
—
—
0
0
5
19
2.69
1.22
2.0
1.5
—
—
—
0
0
5
19
2.69
1.22
1.2
1.4
—
—
—
0
0
12
65
1.92
1.17
11.0
3.6
1.45
1.23
%
0.22
12
65
12
65
1.92
1.17
1.4
1.2
—
—
—
0
0
34
248
1.48
1.13
3.0
2.9
2.42
2.45
mmol/l
0.83
26
217
45
347
1.42
1.13
1.6
1.3
0.59
1.36
u/ml
—
7
87
59
479
1.38
1.10
4.9
3.8
57.41
36.48
ng/l
0.48
41
324
54
437
1.37
1.01
4.4
3.1
2.31
2.36
mmol/l
1.74
47
403
83
719
1.34
0.99
5.2
3.8
0.00
10.28
estimate
0.50
22
158
82
710
1.34
0.98
5.2
3.8
0.00
0.00
estimate
-0.00
22
157
32
240
1.42
0.93
1.5
1.4
1.43
5.98
u/ml
1.57
12
95
35
267
1.40
0.92
1.5
1.3
63.12
29.42
iu/ml
0.34
11
85
83
725
1.32
0.91
5.1
3.9
0.00
0.00
estimate
-0.00
20
146
130
1218
1.48
0.89
5.1
5.0
4.37
4.60
mmol/l
1.75
125
1135
8
45
1.82
0.86
1.1
1.8
0.56
7.55
ug/l
—
8
39
6
31
1.97
0.85
2.5
1.4
—
—
—
0
0
16
106
1.57
0.83
3.4
3.7
1.23
1.22
mmol/l
0.16
16
91
6
33
1.85
0.80
1.0
1.2
—
—
—
0
0
6
33
1.85
0.80
1.0
1.2
—
—
—
0
0
12
75
1.65
0.77
1.6
4.2
4.87
4.66
pmol/l
0.23
12
66
6
34
1.80
0.77
2.5
1.8
—
—
—
0
0
5
24
2.12
0.75
1.8
1.4
—
—
—
0
0
124
1163
1.37
0.73
7.0
6.3
38.42
39.11
mmol/mol
0.41
119
1099
5
26
1.95
0.71
3.2
2.8
8.34
8.74
pmol/l
—
5
26
7
41
1.74
0.71
1.1
1.1
—
—
—
0
0
25
189
1.39
0.70
2.8
3.3
0.73
0.76
ug/l
0.07
17
129
7
42
1.70
0.69
2.0
1.5
—
—
—
0
0
5
27
1.88
0.69
1.2
1.4
39.60
57.44
ug/l
—
5
27
5
27
1.88
0.69
1.2
1.1
—
1.67
—
0
7
7
43
1.66
0.68
1.4
1.3
0.90
0.88
g/l
—
7
43
8
127
0.61
0.67
6.9
6.9
—
—
—
0
0
128
1213
1.36
0.65
5.1
4.9
1.34
1.48
mmol/l
3.34
123
1120
5
30
1.69
0.62
2.0
1.5
—
—
—
0
0
15
107
1.45
0.58
2.2
2.1
—
—
—
0
0
14
100
1.44
0.54
5.7
3.0
49.44
61.82
ml/min/173m2
—
9
38
9
65
1.41
0.51
1.2
1.3
—
—
—
0
0
46
399
1.22
0.48
3.8
3.4
0.00
0.00
estimate
-0.00
16
132
7
51
1.39
0.44
1.7
2.1
—
—
—
0
0
9
71
1.28
0.37
1.1
1.0
—
—
—
0
0
6
42
1.45
0.36
1.2
1.2
1.33
1.60
g/l
—
6
42
6
42
1.45
0.36
1.5
1.3
—
—
—
0
0
12
91
1.35
0.35
2.1
2.0
—
—
—
0
0
45
402
1.17
0.34
5.6
3.9
0.00
0.00
estimate
-0.00
21
144
6
45
1.35
0.34
1.7
1.7
58.78
56.96
ug/l
—
6
38
16
132
1.24
0.27
4.3
3.4
—
—
—
0
0
34
305
1.15
0.24
4.2
3.9
1.02
1.02
kg/l
0.43
21
198
6
49
1.23
0.20
1.5
2.0
—
—
—
0
0
20
175
1.16
0.19
1.9
2.1
—
—
—
0
0
122
1192
1.12
0.18
5.7
4.9
5.83
5.89
mmol/l
0.22
115
1097
35
325
1.10
0.15
5.2
5.8
1.92
3.06
ug/l
0.53
30
286
12
104
1.17
0.13
1.3
1.3
—
—
—
0
0
90
875
1.07
0.12
4.0
3.3
—
—
—
0
0
12
106
1.14
0.10
2.9
2.6
0.55
1.09
e6/l
0.25
12
96
5
44
1.14
0.10
1.6
1.5
1.87
1.30
ratio
—
5
27
5
44
1.14
0.10
1.6
1.5
1.33
1.13
ratio
—
5
27
5
44
1.14
0.10
1.6
1.5
0.81
0.93
ratio
—
5
27
31
294
1.07
0.08
2.2
1.7
—
—
—
0
0
14
153
0.91
0.07
1.3
2.2
4.33
3.21
ratio
—
8
128
27
258
1.06
0.05
3.8
4.6
22.12
22.65
%
—
8
135
11
120
0.91
0.05
1.1
2.0
3.58
3.30
mmol/l
—
6
98
24
229
1.06
0.04
1.5
1.5
—
—
—
0
0
53
536
0.98
0.00
4.8
3.8
0.00
0.01
estimate
0.50
16
133
16
159
1.01
0.00
1.8
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
21.96
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHPRIMTHROMBOCYTOPENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHPRIMTHROMBOCYTOPENIA | 2.493 [1.72, 3.61] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 392 females with D3_OTHPRIMTHROMBOCYTOPENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHPRIMTHROMBOCYTOPENIA | 2.598 [1.6, 4.21] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 333 males with D3_OTHPRIMTHROMBOCYTOPENIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHPRIMTHROMBOCYTOPENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.238% | 0.479% |
| 5 | 1.336% | 2.855% |
| 10 | 3.226% | 6.937% |
| 15 | 6.591% | 13.331% |
| 20 | 11.845% | 21.59% |
Relationships between endpoints
↥Index endpoint: D3_OTHPRIMTHROMBOCYTOPENIA – Other primary thrombocytopenia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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