Risteys · D3_HYPERGAMMAGLONAS

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D89.2 Cause of death: ICD-10 — D89.2 2 out of 7 registries used, show all original rules.	38
4. Check minimum number of events None	38
5. Include endpoints None	38
6. Filter based on genotype QC (FinnGen only)	36

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	225	103	120
Only index persons	169	84	85
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	66.41	65.47	67.14
Only index persons	64.83	64.44	65.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	36	16	20
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	60.49	53.04	66.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037756) Immunofixation for Serum or Plasma

23.00

6.63

1.7

1.0

—

(40768446) Kidney Pathology biopsy report

+∞

6.42

2.5

0.0

—

(3012565) Volume of 24 hour Urine

+∞

5.32

2.6

0.0

1890.00

—

(3020630) Protein [Mass/volume] in Serum or Plasma

7.18

4.99

4.8

1.7

72.99

66.70

g/l

1.04

(3004588) Protein electrophoresis panel - Serum or Plasma

7.74

4.90

4.6

1.5

—

(3001604) Monocytes [#/volume] in Blood

142

4.98

4.81

11.0

6.1

0.61

0.60

e9/l

0.04

127

(3019198) Lymphocytes [#/volume] in Blood

144

4.86

4.72

11.2

6.1

2.05

1.76

e9/l

1.08

132

(3006315) Basophils [#/volume] in Blood

144

4.86

4.72

11.1

6.0

0.04

e9/l

0.62

130

(3013115) Eosinophils [#/volume] in Blood

148

4.65

4.41

11.2

6.0

0.21

0.20

e9/l

0.05

133

(3022096) Basophils/Leukocytes in Blood

136

4.07

3.83

11.5

6.6

0.69

0.02

130

(3006504) Eosinophils/Leukocytes in Blood

137

4.02

3.77

11.6

6.5

3.05

2.82

0.13

132

(3019069) Monocytes/Leukocytes in Blood

137

4.02

3.77

11.6

6.6

9.35

8.92

0.39

132

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

144

3.71

3.35

18.3

5.7

1.22

1.21

mmol/l

0.23

124

(3013650) Neutrophils [#/volume] in Blood by Automated count

167

3.77

3.35

14.4

9.7

3.66

4.14

e9/l

0.78

147

(1616796) Gas panel - Central venous blood

8.66

3.18

5.0

1.8

—

(42870588) Differential panel, method unspecified - Blood

3.31

3.13

11.6

5.6

—

(3010421) pH of Blood

6.90

2.81

5.7

2.6

7.41

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

6.90

2.81

1.3

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

8.02

2.63

5.8

2.0

9.12

7.23

kpa

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

8.02

2.63

3.0

1.3

0.20

0.25

g/l

—

(3013290) Carbon dioxide [Partial pressure] in Blood

8.02

2.63

5.8

2.0

4.64

5.33

kpa

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

8.02

2.63

3.0

1.4

1.27

0.99

g/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

5.13

2.62

3.1

5.9

23.23

24.68

mmol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

3.08

2.53

9.1

5.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.53

2.44

2.8

—

(40768443) Skin Pathology biopsy report

6.21

2.29

1.2

1.1

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

4.29

2.28

6.4

2.1

4.91

4.92

kpa

—

(3012516) Albumin [Mass/volume] in Urine

2.74

2.27

10.2

3.4

217.35

38.87

mg/l

1.10

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

4.55

2.13

7.0

2.0

-1.08

1.11

mmol/l

—

(3022313) Gas panel - Capillary blood

5.06

2.01

7.6

1.8

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.91

2.00

8.4

2.0

2.10

2.35

g/l

1.18

(3015171) Extractable nuclear Ab [Units/volume] in Serum

4.63

1.88

1.2

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.77

1.85

8.3

2.0

14.98

14.13

umol/l

0.23

(3005322) IgE [Units/volume] in Serum or Plasma

4.27

1.77

1.6

1.2

153.84

76.94

u/ml

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.81

1.65

2.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.95

1.60

2.7

1.4

—

(4035726) Immunohistochemistry procedure

2.73

1.47

2.3

1.1

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

224

2.36

1.47

7.9

4.2

32.76

11.34

mm/h

2.72

200

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.48

1.43

2.3

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.91

1.43

1.7

2.0

—

(36304419) Bacteria [Presence] in Urine

2.18

1.38

8.9

2.5

—

estimate

—

(3042936) Bacteria identified in Isolate by Culture

2.48

1.31

2.4

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.88

1.26

1.8

2.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

122

1.93

1.08

5.1

2.5

69.11

74.03

nmol/l

0.50

101

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.23

1.07

2.3

5.7

101.57

104.63

mmol/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.45

0.99

2.2

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.99

0.92

4.3

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.11

0.89

3.2

2.0

—

(40761536) Microorganisms panel - Urine sediment

2.11

0.89

17.2

3.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

218

1.88

0.86

6.6

5.0

15.21

14.98

pmol/l

0.14

197

(3002032) Base excess in Venous blood by calculation

2.35

0.79

6.6

3.0

-1.12

1.56

mmol/l

—

(3013512) EKG study

113

1.73

0.79

3.4

3.5

—

(3023368) Bacteria identified in Blood by Culture

1.80

0.77

8.7

3.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.73

0.77

4.1

2.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.92

0.76

5.3

1.6

—

(40758558) Short blood count panel - Blood

1.69

0.70

8.0

4.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.69

0.70

1.9

3.2

1085.56

943.97

ng/l

0.08

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.91

0.62

1.5

1.3

—

(3022145) Colonoscopy Study observation

1.85

0.61

1.2

1.3

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.79

0.60

4.0

4.1

27.83

26.30

u/l

—

(3015736) pH of Urine

130

1.57

0.58

7.4

3.2

6.17

6.07

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

170

1.54

0.56

10.6

7.1

9.76

12.32

umol/l

0.91

161

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

174

1.48

0.47

3.8

2.9

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

244

0.68

0.46

30.5

19.0

332.43

332.30

g/l

0.02

244

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.41

0.0

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

140

0.70

0.37

3.4

2.5

—

estimate

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

272

1.54

0.37

7.3

5.5

2.47

2.03

mu/l

0.70

248

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

132

1.37

0.33

2.8

2.0

87.82

93.70

pmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

127

0.71

0.32

11.9

3.6

0.00

estimate

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.39

0.31

5.0

2.5

112.58

51.96

u/l

0.48

(1761868) Lipid panel - Serum or Plasma

125

0.73

0.29

3.9

3.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

118

1.30

0.24

13.1

2.8

—

(40768797) Stomach Pathology biopsy report

1.33

0.22

1.0

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.22

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.22

0.0

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.22

0.0

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.22

0.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

2.2

—

(3026008) Bacteria identified in Urine by Culture

1.30

0.19

3.4

3.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.25

0.18

3.8

2.2

—

(40761511) CBC panel - Blood by Automated count

300

0.85

0.18

27.9

13.5

—

(3003694) ABO and Rh group [Type] in Blood

0.73

0.17

2.3

1.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

202

1.22

0.16

11.7

4.7

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

274

0.83

0.12

11.6

6.6

41.95

39.32

mmol/mol

0.63

254

(3010813) Leukocytes [#/volume] in Blood

315

0.90

0.09

47.3

22.9

6.90

6.46

e9/l

0.64

310

(3026361) Erythrocytes [#/volume] in Blood

315

0.90

0.09

47.0

22.9

4.19

4.48

e12/l

3.08

310

(3031040) Bacteria [#/volume] in Urine by Automated count

200

1.12

0.05

7.9

4.2

—

30.60

—

(3009261) Glucose [Presence] in Urine by Test strip

169

0.91

0.04

12.2

3.8

0.00

estimate

—

(3044640) Blood type and Crossmatch panel - Blood

1.06

0.00

3.6

2.2

—

(3035350) Ketones [Presence] in Urine by Test strip

166

1.04

0.00

11.6

3.7

0.00

estimate

—

(40768804) Tissue Pathology biopsy report

119

1.01

0.00

2.9

2.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

163

0.97

0.00

12.2

3.7

0.00

estimate

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

6.04

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

5.0

—

1.21

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

5.5

—

17.50

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

228.00

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(4034850) Laboratory test

0.00

-0.00

0.0

5.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

5.0

—

4.10

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.8

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

2.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

283

1.11

-0.00

33.7

15.2

70.91

81.26

ml/min/173m2

0.96

265

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

20.66

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

9.89

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

3.85

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

5.0

—

105.80

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

3.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.5

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

-0.00

0.0

8.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

16.68

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.4

—

100.40

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.1

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

20.52

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

309

1.02

-0.00

24.6

12.4

22.74

25.67

u/l

0.88

303

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.6

—

20.29

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_HYPERGAMMAGLONAS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
D3_HYPERGAMMAGLONAS	2.562 [1.51, 4.34]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.015

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 109 males with D3_HYPERGAMMAGLONAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_HYPERGAMMAGLONAS.

N-year risk	Females	Males
1	No data	0.467%
5	No data	2.937%
10	No data	7.793%
15	No data	14.578%
20	No data	23.334%

Relationships between endpoints

↥

Index endpoint: D3_HYPERGAMMAGLONAS – Hypergammalglobulinemia, unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	D3_HYPERGAMMAGLONAS
CONTROL_EXCLUDE	D3_IMMUNEMECHANISM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D892
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D892
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Hypergammalglobulinemia, unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints