No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
433 |
4. Check minimum number of eventsNone |
433 |
5. Include endpointsNone |
433 |
6. Filter based on genotype QC (FinnGen only) |
387 |
Control definitions (FinnGen only)
- Control exclude
- D3_NUTRIANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D50-D53
- Name in latin
- Anaemia ex deficientia folatorum
Similar endpoints
↥List of similar endpoints to
Folate deficiency anaemia
based on the number of shared cases.
Similar with more cases:
- Nutritional anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2872 | 1482 | 1356 |
| Only index persons | 2205 | 1156 | 1049 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 72.84 | 75.31 | 70.14 |
| Only index persons | 72.08 | 74.17 | 69.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 387 | 155 | 232 |
| Unadjusted period prevalence (%) | 0.09 | 0.06 | 0.11 |
| Median age at first event (years) | 70.70 | 67.82 | 72.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 404
- Matched controls
- 4040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
1132.1
315.6
269
7
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
32.9
144.6
98
39
D52.0
ICD-10 Finland
Dietary folate deficiency anaemia
+∞
93.4
86
*
D64.9
ICD-10 Finland
Anaemia, unspecified
8.1
82.8
142
253
B03BA03
ATC
hydroxocobalamin; parenteral
8.6
45.4
63
85
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.2
45.4
203
778
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
98.5
40.7
44
5
D52.8
ICD-10 Finland
Other folate deficiency anaemias
366.5
34.5
34
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
25.7
145
605
AA1AD
NOMESCO Finland
CT of head and brain
2.9
23.4
182
898
B81
ICPC
Anaemia vit B12/folate deficiency
7.7
22.8
33
46
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.5
22.5
60
150
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.6
22.5
45
88
XW000
NOMESCO Finland
Bone marrow biopsy
5.5
21.4
44
88
E87.6
ICD-10 Finland
Hypokalaemia
6.0
21.0
39
71
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
20.8
92
327
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
18.5
20.4
31
18
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.3
19.4
41
84
R53
ICD-10 Finland
Malaise and fatigue
2.7
18.8
149
727
L28
ICPC
Limited function/disability (L)
2.8
18.7
124
552
E86
ICD-10 Finland
Volume depletion
5.9
16.8
31
56
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.7
16.3
55
163
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
16.2
175
973
C03CA01
ATC
furosemide; systemic
2.4
15.9
190
1102
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.9
15.8
90
366
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
15.7
80
306
A28
ICPC
Limited function/disability NOS
2.5
15.0
121
586
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
14.9
106
483
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
14.4
240
1580
N05AH04
ATC
quetiapine; oral
2.6
13.8
92
405
107
Kela drug reimbursment
Pernicious anaemia
+∞
13.6
13
*
JN4AD
NOMESCO Finland
Body CT examination
2.8
13.3
74
296
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
29.5
13.1
17
6
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
12.7
75
309
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
14.0
12.1
20
15
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.5
11.7
89
415
A02BC02
ATC
pantoprazole; systemic
2.2
11.6
298
2245
D52.1
ICD-10 Finland
Drug-induced folate deficiency anaemia
+∞
11.5
11
*
UJF30
NOMESCO Finland
Ileoscopy through colon
2.9
11.5
59
225
H02AB06
ATC
prednisolone; systemic
2.1
11.5
219
1471
WW500
NOMESCO Finland
Blood transfusion
4.0
11.4
33
87
N03AG01
ATC
valproic acid; systemic, rectal
3.8
11.3
36
102
SPAT1254
SPAT
Administration of medicine
2.4
10.6
82
384
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.1
10.5
47
166
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
112.8
10.5
11
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.4
10.3
84
402
D50.8
ICD-10 Finland
Other iron deficiency anaemias
17.2
9.9
15
9
SPAT1216
SPAT
Assessment of functional ability
2.3
9.9
89
444
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.8
9.6
22
48
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.7
9.5
55
223
J01DB01
ATC
cefalexin; oral
2.3
9.5
334
2719
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
9.4
143
872
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
9.3
160
1016
N30.0
ICD-10 Finland
Acute cystitis
2.3
9.2
78
379
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
9.2
81
400
F10.25
ICD-10 Finland
Alcohol dependence continuous use
8.6
9.2
19
23
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.3
9.1
36
118
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
8.9
74
356
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
8.9
131
787
F03
ICD-10 Finland
Unspecified dementia
3.2
8.8
35
115
Z51.5
ICD-10 Finland
Palliative care
2.6
8.6
54
228
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
8.6
49
197
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
8.5
65
301
U04
ICPC
Incontinence urine
2.9
8.4
40
146
28120
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Folic acid deficiency anaemia
+∞
8.4
8
*
A06AD11
ATC
lactulose; oral
2.1
8.2
85
447
Z02.7
ICD-10 Finland
Issue of medical certificate
2.8
8.2
43
166
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.3
8.1
21
51
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.9
8.0
39
144
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.3
8.0
31
100
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.8
8.0
18
39
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.8
7.9
40
151
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.2
7.9
21
52
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
7.8
146
941
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.3
7.8
20
48
A41.9
ICD-10 Finland
Sepsis, unspecified
3.5
7.7
27
82
A04
ICPC
Weakness/tiredness general
2.1
7.6
77
400
R50.9
ICD-10 Finland
Fever, unspecified
2.1
7.5
75
388
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
4.5
7.5
18
41
B82
ICPC
Anaemia other/unspecified
4.2
7.4
20
50
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
7.3
89
497
UJF32
NOMESCO Finland
Coloscopy
1.9
7.1
118
730
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
6.9
77
414
N06AX11
ATC
mirtazapine; oral
1.8
6.9
141
928
D64.8
ICD-10 Finland
Other specified anaemias
6.9
6.9
16
24
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.9
6.8
33
122
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
40.8
6.8
8
*
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
17.0
6.8
10
6
GD1AD
NOMESCO Finland
Thorax CT examination
2.7
6.7
37
146
SPAT1229
SPAT
Assessment of need for aid
2.5
6.7
43
183
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.2
6.7
26
84
J01MA02
ATC
ciprofloxacin; systemic
1.7
6.7
168
1171
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.1
6.7
18
45
M04AA01
ATC
allopurinol; systemic
2.1
6.7
73
390
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
3.6
6.7
22
64
SPAT1262
SPAT
Handing over of treatment supplies
2.0
6.6
80
443
A46
ICD-10 Finland
Erysipelas
2.0
6.6
75
406
N05AH03
ATC
olanzapine; systemic
3.0
6.6
29
101
S01.0
ICD-10 Finland
Open wound of scalp
2.4
6.6
46
204
G72.8
ICD-10 Finland
Other specified myopathies
4.2
6.4
17
42
F05.9
ICD-10 Finland
Delirium, unspecified
4.2
6.4
17
42
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
3.4
6.4
23
71
N19
ICD-10 Finland
Unspecified kidney failure
3.0
6.3
28
98
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.8
6.3
32
121
R41.0
ICD-10 Finland
Disorientation, unspecified
3.2
6.3
25
82
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.3
99
599
K70.0
ICD-10 Finland
Alcoholic fatty liver
18.4
6.3
9
5
D52
ICD-10 Finland
Folate deficiency anaemia
27.1
6.2
8
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
4.1
6.2
17
43
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
6.2
48
223
UJF92
NOMESCO Finland
Capsular endoscopy
7.9
6.2
13
17
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.2
6.1
24
78
SPAT1263
SPAT
Sampling
1.7
6.1
165
1166
N05BA12
ATC
alprazolam; oral
2.4
6.1
44
198
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
6.1
151
1045
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.8
6.1
31
118
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.9
6.0
28
101
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
6.0
62
324
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
210
521
7.31
89.43
2.9
2.5
26.21
23.26
%
1.24
200
489
215
559
7.08
86.80
3.0
2.5
1.96
2.21
g/l
7.57
207
522
164
332
7.63
85.00
5.1
2.8
68.04
66.89
e9/l
0.11
128
248
219
592
6.89
84.45
3.1
2.5
12.31
13.06
umol/l
0.63
211
554
302
1113
7.79
82.79
2.8
1.7
16.63
20.55
nmol/l
2.68
277
921
111
168
8.73
74.19
2.1
1.9
1.44
1.52
g/l
0.33
90
153
260
910
6.21
72.84
3.5
2.1
3.06
2.76
mg/l
1.28
239
790
165
416
6.01
66.23
5.1
4.6
287.91
247.47
u/l
0.99
159
397
75
89
10.12
60.39
1.7
1.5
—
—
—
0
0
128
323
5.34
49.79
2.7
3.0
64.75
66.75
g/l
1.56
123
294
289
1458
4.45
42.92
4.7
2.8
291.16
145.44
ug/l
5.90
275
1353
71
140
5.94
35.63
2.6
4.1
46.38
52.36
mg/l
0.15
55
122
71
140
5.94
35.63
2.6
4.1
69.86
95.31
mg/l
0.24
56
121
291
1602
3.92
35.10
3.3
2.2
81.63
94.52
pmol/l
5.56
228
846
165
653
3.58
33.17
2.6
1.7
1182.06
1167.87
nmol/l
0.06
131
504
37
39
10.34
31.98
3.6
2.0
32.89
33.28
pg
0.17
37
39
97
272
4.38
31.95
3.0
2.7
11.14
10.97
g/l
0.11
90
246
63
128
5.65
30.45
2.3
3.7
5.78
2.50
ratio
0.35
38
67
61
123
5.66
29.70
2.3
1.5
0.41
0.40
mg/l
0.02
33
57
109
350
3.90
29.62
2.7
2.3
0.18
0.21
g/l
2.63
100
323
278
1592
3.39
29.19
7.3
5.0
31.76
35.34
g/l
16.30
264
1484
304
1856
3.58
28.32
10.8
6.8
13.50
11.79
umol/l
0.65
294
1766
156
652
3.27
27.90
3.0
2.0
—
—
—
0
0
170
748
3.20
27.85
2.1
1.8
400.07
19024823.04
pmol/l
0.50
142
615
70
172
4.71
27.05
2.7
1.9
2.41
1.08
ug/l
1.01
62
148
291
1812
3.17
24.51
11.8
7.5
1.20
1.21
mmol/l
2.24
252
1572
252
1493
2.83
22.48
3.2
2.4
69.08
77.60
nmol/l
3.85
234
1317
85
275
3.65
22.39
2.3
1.7
—
—
—
0
0
140
625
2.90
21.39
2.0
1.4
3.44
2.56
g/l
2.95
103
362
61
167
4.12
20.29
2.7
1.9
4.21
3.77
g/l
0.81
56
152
287
1875
2.83
20.23
15.3
9.8
4.69
4.25
e9/l
1.92
259
1643
78
254
3.57
20.23
6.9
4.1
1.21
1.23
mmol/l
1.52
62
223
61
168
4.10
20.12
2.7
1.9
4.46
4.14
g/l
0.86
56
152
61
168
4.10
20.12
2.7
1.9
7.18
7.41
g/l
0.43
56
152
274
1756
2.74
19.93
19.4
16.4
1.26
1.31
inr
0.83
244
1486
92
337
3.24
19.76
2.3
1.7
1.90
1.51
%
3.31
77
295
42
88
5.21
19.41
3.0
2.1
114.38
129.65
g/l
3.66
37
66
58
158
4.12
19.40
2.8
2.0
3.10
3.07
g/l
0.07
52
142
72
229
3.61
19.31
4.0
3.0
2.66
2.04
mmol/l
0.62
54
169
201
1139
2.52
18.43
3.2
2.2
512.51
235.99
u/l
0.42
192
1076
50
127
4.35
18.31
1.7
1.3
—
—
—
0
0
115
500
2.82
18.07
2.6
1.9
—
—
—
0
0
256
1655
2.49
17.17
10.5
6.8
1.19
1.21
mmol/l
2.65
245
1507
33
62
5.71
17.13
2.9
1.7
—
—
—
0
0
211
1259
2.41
16.81
4.1
3.3
2965.63
1495.04
ng/l
2.49
186
1094
195
1129
2.41
16.57
4.2
2.5
52.21
65.69
u/l
1.49
185
1051
138
689
2.52
16.19
1.3
1.3
1.88
1.48
u/ml
0.26
44
170
51
145
3.88
16.00
2.4
1.9
10.61
10.85
g/l
0.13
45
128
95
396
2.83
15.98
6.1
3.5
1.36
1.44
mmol/l
0.06
82
328
30
55
5.81
15.96
4.3
1.9
2.00
1.60
mmol/l
1.30
30
55
228
1445
2.33
15.34
26.1
11.5
0.00
0.00
e9/l
0.09
193
1190
35
77
4.88
15.24
1.7
1.5
—
—
—
0
0
87
359
2.81
14.84
6.8
3.4
—
—
—
0
0
291
2083
2.42
14.25
10.3
5.3
6.81
6.79
mmol/l
0.06
283
1996
290
2081
2.39
13.99
5.9
3.4
91.09
50.41
u/l
4.27
274
1940
224
1456
2.21
13.58
7.6
4.1
42.82
39.18
ng/l
0.20
201
1118
336
2598
2.74
13.45
14.4
8.3
89.94
79.29
u/l
2.45
331
2451
47
147
3.49
12.77
3.3
2.1
0.77
0.79
g/l
0.02
41
130
159
932
2.16
12.19
4.2
3.0
381.14
353.97
umol/l
1.99
143
814
63
243
2.89
12.05
2.0
1.8
—
—
—
0
0
80
354
2.57
11.71
7.9
7.6
1.99
1.42
mmol/l
1.18
80
345
23
44
5.48
11.67
2.7
1.5
—
—
—
0
0
38
110
3.71
11.57
1.4
1.5
217.77
281.19
ug/g
0.97
22
61
36
101
3.82
11.46
2.9
1.6
—
—
—
0
0
254
1806
2.09
11.38
6.6
4.1
0.00
0.00
estimate
-0.00
92
364
96
470
2.37
11.27
2.7
2.0
—
—
—
0
0
179
1129
2.05
11.05
4.7
3.2
37.90
33.00
u/l
0.90
171
1064
34
94
3.86
11.04
2.7
1.6
—
—
—
0
0
224
1535
2.03
10.94
4.1
2.8
—
—
estimate
—
0
0
298
2271
2.19
10.85
7.7
5.0
617.80
1717.29
e6/l
—
10
45
255
1840
2.05
10.67
6.7
4.1
0.00
0.87
estimate
0.51
90
350
317
2492
2.26
10.43
7.2
4.4
22.44
12.91
mm/h
12.33
302
2290
166
1037
2.02
10.36
6.9
4.1
0.00
0.01
estimate
0.50
84
339
253
1833
2.02
10.31
6.7
4.1
0.00
5.03
estimate
0.50
92
374
191
1256
1.99
10.28
3.0
3.6
2.32
2.35
mmol/l
1.83
174
1128
85
412
2.35
10.12
5.0
3.0
18.16
8.51
umol/l
1.09
72
371
64
276
2.57
9.80
3.5
3.7
98.19
88.20
ng/l
0.33
51
240
196
1320
1.94
9.66
5.6
3.5
—
—
—
0
0
312
2468
2.16
9.63
5.0
4.1
15.29
14.87
pmol/l
1.97
292
2214
29
79
3.88
9.61
2.2
1.5
—
—
—
0
0
39
131
3.19
9.44
1.5
2.2
12.20
12.07
iu/ml
—
8
30
14
10
14.45
8.75
1.6
1.2
—
—
iu/ml
—
0
0
20
44
4.73
8.68
2.8
1.4
—
—
—
0
0
24
62
4.05
8.55
2.5
1.6
—
—
—
0
0
25
67
3.91
8.48
3.1
3.1
9.52
9.40
pmol/l
0.02
25
67
23
59
4.07
8.27
1.4
1.2
—
—
—
0
0
26
75
3.64
7.96
2.4
1.5
—
—
—
0
0
38
140
2.89
7.85
1.2
2.3
38.89
40.83
u/l
0.16
28
125
157
1038
1.84
7.75
5.1
3.5
0.52
0.41
e6/l
0.58
127
771
50
214
2.53
7.74
2.3
1.4
—
—
—
0
0
29
93
3.28
7.57
1.9
1.4
—
—
—
0
0
129
814
1.86
7.32
3.5
2.5
—
—
—
0
0
28
91
3.23
7.16
2.4
1.5
—
—
—
0
0
22
61
3.76
7.12
1.7
1.4
—
—
—
0
0
17
40
4.39
6.81
2.5
1.8
—
—
—
0
0
44
192
2.45
6.54
1.6
1.2
2754.19
253.63
u/ml
1.07
38
177
16
26
6.36
6.53
3.0
1.5
—
—
—
0
0
14
19
7.59
6.46
1.1
1.2
—
—
—
0
0
14
19
7.59
6.46
1.1
1.2
—
—
—
0
0
20
57
3.64
6.24
1.3
1.2
345.40
260.04
u/ml
—
10
24
22
69
3.31
5.96
1.2
1.2
3.85
3.80
mmol/l
0.07
22
64
35
145
2.55
5.80
3.0
3.4
—
—
—
0
0
22
71
3.22
5.70
1.2
1.2
500.38
16.14
e6/l
0.48
16
56
17
36
4.88
5.67
2.5
1.9
—
—
—
0
0
34
141
2.54
5.63
3.3
1.9
—
—
—
0
0
341
2973
1.94
5.59
6.5
5.1
2.05
1.97
mu/l
0.54
329
2691
116
765
1.72
5.45
2.2
1.6
1.20
1.45
mg/l
0.69
97
613
116
770
1.71
5.30
3.0
3.1
2.47
2.45
mmol/l
0.83
107
692
11
15
7.50
5.17
3.4
1.7
—
—
—
0
0
11
15
7.50
5.17
1.2
1.0
—
—
—
0
0
76
451
1.84
5.07
9.9
8.7
1.52
1.05
mmol/l
0.26
57
373
138
970
1.64
5.04
6.9
3.6
0.04
0.09
estimate
0.23
73
291
33
143
2.42
4.99
2.1
2.1
426.94
312.67
ug/l
0.56
33
136
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
112
2.61
4.99
5.5
2.6
0.36
0.41
iu/ml
0.26
13
65
15
41
3.76
4.97
2.0
1.2
—
—
—
0
0
47
238
2.10
4.94
3.7
2.5
1.37
1.14
%
1.01
47
238
31
132
2.46
4.87
3.1
1.7
—
—
—
0
0
9
10
9.17
4.80
1.1
1.1
—
—
—
0
0
11
17
6.62
4.80
3.4
1.6
—
—
—
0
0
15
43
3.58
4.66
1.4
1.3
—
—
—
0
0
11
18
6.25
4.63
2.8
2.3
—
—
—
0
0
181
1379
1.57
4.63
7.3
4.1
0.10
0.04
estimate
0.41
71
307
89
571
1.72
4.54
1.3
1.3
64.81
36.58
iu/ml
0.32
30
190
59
335
1.89
4.50
2.1
2.6
44.41
32.75
u/l
0.45
49
272
26
107
2.53
4.40
1.7
1.4
—
—
—
0
0
66
392
1.82
4.38
10.6
9.6
110.33
121.93
g/l
3.42
66
385
11
21
5.35
4.17
3.4
1.6
—
—
—
0
0
7
7
10.15
4.02
1.0
2.9
—
—
—
0
0
353
3197
1.83
3.97
40.6
17.7
25.96
25.98
mg/l
0.00
342
2688
63
380
1.78
3.97
2.8
4.6
6.53
26.99
ug/l
0.89
57
309
12
27
4.55
3.96
1.3
1.1
—
—
—
0
0
26
113
2.39
3.94
1.7
1.6
0.01
0.16
iu/ml
—
5
21
216
1764
1.48
3.71
3.3
2.7
—
—
—
0
0
341
3076
1.70
3.66
36.7
17.5
71.21
76.45
ml/min/173m2
3.78
330
2883
11
25
4.49
3.65
1.7
1.1
—
—
—
0
0
12
30
4.09
3.62
2.2
1.5
11.46
7.69
mmol/l
0.59
12
30
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
13
6.25
3.51
1.1
1.2
—
—
—
0
0
158
1226
1.47
3.45
4.5
4.2
12.52
8.45
mg/mmol
0.50
99
785
343
3112
1.68
3.44
6.4
5.5
6.22
6.03
mmol/l
1.38
311
2819
338
3057
1.65
3.41
7.9
6.9
38.89
39.88
mmol/mol
1.19
317
2853
8
14
5.80
3.35
1.3
1.0
—
—
—
0
0
8
14
5.80
3.35
5.0
2.0
38.52
41.78
g/l
—
8
14
359
3307
1.77
3.27
46.1
21.6
138.70
139.71
mmol/l
8.90
359
3250
13
39
3.41
3.25
2.1
1.5
—
—
—
0
0
17
67
2.60
3.17
1.1
1.2
—
48.73
—
0
11
13
44
3.02
3.16
2.2
1.5
—
—
—
0
0
13
44
3.02
3.16
2.2
1.5
—
—
—
0
0
12
35
3.50
3.13
2.4
1.8
—
—
—
0
0
12
35
3.50
3.13
2.4
1.8
—
—
—
0
0
12
35
3.50
3.13
2.4
1.8
—
—
—
0
0
33
175
1.96
3.10
4.5
7.2
1.55
1.58
%
0.06
33
165
78
532
1.58
3.08
1.3
1.3
14.89
13.51
u/ml
0.05
32
194
8
16
5.08
3.06
1.0
1.1
—
—
—
0
0
13
45
2.95
3.05
2.2
1.5
—
—
—
0
0
13
45
2.95
3.05
2.2
1.5
—
—
—
0
0
7
12
5.92
3.03
1.3
1.0
178.77
109.05
iu/ml
—
7
12
9
21
4.36
3.01
6.0
4.3
1.33
0.90
%
—
9
21
47
283
1.75
2.99
2.5
2.5
46.94
61.71
ml/min/173m2
1.90
29
126
13
46
2.89
2.94
2.2
1.5
—
—
—
0
0
13
46
2.89
2.94
2.2
1.5
—
—
—
0
0
91
649
1.52
2.94
4.1
3.1
2.98
1.00
e6/l
2.32
60
361
9
22
4.16
2.90
1.0
1.0
—
—
—
0
0
363
3380
1.73
2.83
48.0
23.6
96.94
82.37
umol/l
2.71
363
3347
14
53
2.70
2.82
1.8
1.4
—
168.34
—
0
13
5
6
8.42
2.75
1.2
1.2
—
—
—
0
0
7
14
5.07
2.74
1.6
1.3
—
—
—
0
0
6
10
6.07
2.70
7.5
5.6
—
—
—
0
0
153
1227
1.40
2.64
3.7
3.4
6.55
7.64
mmol/l
2.77
121
1039
10
250
0.38
2.46
2.5
2.0
3.51
3.39
ratio
—
10
202
17
78
2.23
2.34
1.3
1.2
—
—
—
0
0
7
188
0.36
2.34
2.1
1.8
3.01
3.44
mmol/l
—
7
140
336
3105
1.49
2.33
5.3
5.2
1.35
1.43
mmol/l
2.69
307
2822
18
85
2.17
2.32
4.4
3.9
17.58
28.17
mg/l
0.75
13
59
6
13
4.67
2.28
4.7
2.0
92.50
92.15
%
—
6
13
18
86
2.14
2.26
1.7
1.4
—
—
—
0
0
7
18
3.94
2.26
3.1
2.0
5024.14
1106.06
u/ml
—
7
18
337
3122
1.48
2.25
5.3
5.4
4.32
4.47
mmol/l
1.55
309
2865
9
29
3.15
2.24
1.0
1.1
—
—
—
0
0
8
24
3.38
2.19
1.8
1.8
—
—
—
0
0
9
30
3.04
2.16
1.2
1.3
—
—
—
0
0
364
3434
1.61
2.16
59.1
26.7
119.59
135.08
g/l
45.68
364
3395
17
81
2.15
2.16
1.5
1.4
—
—
—
0
0
16
75
2.18
2.11
1.1
1.9
6.79
4.54
iu/l
—
5
29
81
603
1.43
2.09
4.5
3.3
4.87
1.94
e6/l
0.93
49
320
9
31
2.95
2.08
1.9
3.4
858.72
757.97
mg
—
9
31
17
83
2.09
2.04
2.1
3.1
0.95
0.88
nmol/l
—
10
67
363
3432
1.57
2.01
58.3
26.5
93.77
91.60
fl
8.69
363
3396
363
3433
1.57
2.00
59.5
27.1
36.08
40.24
%
29.83
363
3394
7
21
3.37
1.97
1.7
1.4
—
—
—
0
0
7
21
3.37
1.97
3.0
2.6
—
—
—
0
0
7
21
3.37
1.97
1.7
1.4
—
—
—
0
0
6
16
3.79
1.94
3.5
2.1
—
—
—
0
0
6
16
3.79
1.94
3.3
2.1
—
—
—
0
0
6
16
3.79
1.94
1.8
1.3
—
—
—
0
0
6
16
3.79
1.94
3.5
2.1
—
—
—
0
0
6
16
3.79
1.94
1.8
1.3
—
—
—
0
0
6
16
3.79
1.94
3.5
2.1
—
—
—
0
0
341
3190
1.44
1.93
5.9
6.2
2.42
2.59
mmol/l
2.39
313
2912
321
2972
1.39
1.93
4.8
4.5
1.45
1.27
mmol/l
3.74
292
2680
7
22
3.22
1.88
1.0
1.2
71.43
100.86
pmol/l
—
7
22
8
28
2.89
1.87
1.5
1.5
—
24.00
—
0
5
6
17
3.57
1.84
16.7
10.9
596.00
930.18
nmol/l
—
6
17
12
54
2.26
1.75
3.2
2.8
1.16
1.19
mmol/l
1.01
12
54
17
89
1.95
1.72
1.8
1.6
—
—
—
0
0
5
13
3.88
1.72
1.0
1.0
1040.80
1487.69
miu/ml
—
5
13
49
345
1.48
1.70
4.0
2.5
9.87
8.20
ug/l
0.24
42
305
12
55
2.22
1.69
3.3
2.7
4.00
4.05
mmol/l
0.12
12
55
12
55
2.22
1.69
3.2
2.7
104.67
105.73
mmol/l
0.31
12
55
6
20
3.03
1.58
1.5
1.5
132.17
81.30
umol/l
—
6
20
27
169
1.64
1.56
1.1
1.2
42.00
109.73
u/ml
—
9
64
5
16
3.15
1.44
1.0
1.3
—
—
—
0
0
16
91
1.79
1.31
1.1
1.2
—
—
—
0
0
8
34
2.38
1.30
1.0
1.1
—
—
—
0
0
8
34
2.38
1.30
1.5
1.2
—
—
—
0
0
8
35
2.31
1.27
1.1
1.1
—
—
—
0
0
23
348
0.64
1.27
2.0
1.5
—
—
—
0
0
8
36
2.25
1.25
1.1
1.1
—
—
—
0
0
32
450
0.69
1.24
1.4
1.5
—
—
—
0
0
16
93
1.75
1.23
1.1
1.2
—
—
—
0
0
13
72
1.83
1.16
1.3
1.3
—
—
—
0
0
13
72
1.83
1.16
1.3
1.2
—
—
—
0
0
39
286
1.40
1.14
1.5
1.4
—
—
—
0
0
5
21
2.40
1.09
1.2
1.1
—
—
—
0
0
5
21
2.40
1.09
1.2
1.1
—
—
—
0
0
8
41
1.97
1.09
2.8
2.4
—
—
—
0
0
165
1469
1.21
1.07
5.5
5.8
2.31
3.10
ug/l
0.75
149
1314
244
2617
0.83
1.05
47.0
23.2
330.37
332.23
g/l
2.08
244
2603
5
22
2.29
1.03
1.2
1.0
—
—
—
0
0
27
191
1.44
0.97
2.1
1.8
—
—
—
0
0
9
50
1.82
0.97
1.4
1.2
—
—
—
0
0
6
27
2.24
0.94
1.3
1.1
—
—
—
0
0
6
28
2.16
0.92
1.0
1.4
—
—
—
0
0
54
437
1.27
0.85
4.7
5.1
32.20
31.91
%
0.06
40
273
6
31
1.95
0.84
1.2
1.2
—
—
—
0
0
6
31
1.95
0.84
1.2
1.2
—
—
—
0
0
12
73
1.66
0.82
1.5
1.2
—
—
—
0
0
6
32
1.89
0.82
1.2
1.2
—
—
—
0
0
6
32
1.89
0.82
1.2
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
6
106
0.56
0.73
2.0
1.6
6.93
3.64
mg/l
—
6
82
6
108
0.55
0.73
2.0
1.7
29.83
41.91
nmol/l
—
6
100
7
40
1.76
0.71
1.1
1.2
—
—
—
0
0
27
206
1.33
0.67
2.2
1.9
—
—
—
0
0
7
43
1.64
0.67
1.3
1.5
—
—
—
0
0
51
425
1.23
0.65
18.6
7.4
—
—
—
0
0
5
29
1.73
0.64
1.2
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
19
140
1.37
0.59
1.2
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
180.11
—
0
23
6
36
1.68
0.57
1.2
1.2
—
—
—
0
0
5
88
0.56
0.56
2.4
1.7
265.60
211.29
pmol/l
—
5
82
6
95
0.63
0.42
1.5
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
12.83
—
0
18
0
18
0.00
0.40
0.0
3.3
—
95.83
—
0
18
6
41
1.47
0.36
1.3
1.3
0.22
0.19
nmol/l
—
6
28
5
78
0.64
0.36
2.0
1.2
0.66
0.89
g/l
—
5
78
82
754
1.11
0.33
5.8
4.1
110.93
341.69
ng/l
1.81
72
627
8
62
1.30
0.28
1.4
1.4
—
—
—
0
0
25
216
1.17
0.26
14.5
12.0
15.12
15.97
%
0.71
25
207
9
75
1.20
0.25
1.0
1.1
—
1.19
—
0
7
10
78
1.29
0.24
1.3
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
9.07
—
0
13
0
13
0.00
0.21
0.0
1.6
—
46.79
—
0
13
19
165
1.16
0.19
2.1
3.8
24.86
2420.07
u/ml
1.39
14
143
137
1327
1.05
0.15
1.9
2.0
1.44
1.33
mmol/l
0.46
103
1103
5
47
1.06
0.09
2.4
3.7
—
—
—
0
0
5
60
0.83
0.08
1.6
1.8
—
—
—
0
0
8
75
1.07
0.07
1.4
1.3
—
—
—
0
0
8
75
1.07
0.07
1.1
1.1
—
4.99
—
0
8
120
1189
1.01
0.02
4.2
4.8
19.56
22.06
%
1.41
64
598
84
838
1.00
0.00
6.3
4.2
1.02
1.02
kg/l
0.05
65
557
10
95
1.05
0.00
1.7
2.1
—
—
—
0
0
16
155
1.03
0.00
1.1
1.0
—
—
—
0
0
86
864
0.99
0.00
3.2
3.3
0.80
0.79
ug/l
0.08
62
587
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
131.67
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
22.13
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.4
—
5.54
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
13.3
—
10.40
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_ANAEMIA_FOLATEDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA_FOLATEDEF | 2.382 [1.91, 2.97] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.288 |
During the follow-up period (1.1.1998 — 31.12.2019), 554 out of 967 females with D3_ANAEMIA_FOLATEDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA_FOLATEDEF | 2.386 [1.81, 3.15] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 830 males with D3_ANAEMIA_FOLATEDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_ANAEMIA_FOLATEDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.443% |
| 5 | 1.258% | 2.584% |
| 10 | 3.126% | 6.782% |
| 15 | 6.507% | 13.05% |
| 20 | 11.211% | 21.332% |
Relationships between endpoints
↥Index endpoint: D3_ANAEMIA_FOLATEDEF – Folate deficiency anaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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