ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
123 |
4. Check minimum number of eventsNone |
123 |
5. Include endpointsNone |
123 |
6. Filter based on genotype QC (FinnGen only) |
111 |
Control definitions (FinnGen only)
- Control exclude
- K11_ENERCOLNONINF
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K51
- Name in latin
- Pseudopolyposis coli
Similar endpoints
↥List of similar endpoints to
Pseudopolyposis of colon
based on the number of shared cases.
Similar with more cases:
- Ulcerative colitis
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 578 | 213 | 362 |
| Only index persons | 556 | 208 | 348 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.37 | 48.91 | 49.79 |
| Only index persons | 49.04 | 48.02 | 49.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 111 | 51 | 60 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 48.46 | 42.29 | 53.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 111
- Matched controls
- 1110
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
160.1
111
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
130.3
98
*
A07EC02
ATC
mesalazine; oral, rectal
1566.6
118.1
95
*
K51.5
ICD-10 Finland
Left sided colitis
+∞
105.8
84
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
+∞
91.8
75
*
UJF32
NOMESCO Finland
Coloscopy
34.3
73.3
91
130
UJF30
NOMESCO Finland
Ileoscopy through colon
30.4
72.1
59
40
L04AX01
ATC
azathioprine; systemic
246.4
68.0
64
6
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
58.6
51
*
A07EA02
ATC
hydrocortisone; rectal
910.2
56.9
51
*
A07EA06
ATC
budesonide; oral, local oral
172.7
43.4
43
*
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
42.4
38
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
14.7
38.5
42
44
A07EC01
ATC
sulfasalazine; oral, rectal
13.5
32.5
36
38
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
31.8
29
*
H02AB07
ATC
prednisone; oral
10.5
31.8
46
70
K51
ICD-10 Finland
Ulcerative colitis
+∞
29.5
27
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
27.2
25
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
24.9
23
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
22.7
21
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
22.7
21
*
H02AB06
ATC
prednisolone; systemic
7.9
21.7
87
349
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
17.1
16
*
L01BB02
ATC
mercaptopurine; oral
+∞
17.1
16
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
+∞
17.1
16
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.2
17.0
59
198
D94
ICPC
Chronic enteritis/ulcerative colitis
185.0
15.9
16
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
+∞
14.9
14
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
+∞
13.8
13
*
A07EA01
ATC
prednisolone; oral, rectal
+∞
13.8
13
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
12.7
12
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
12.7
12
*
K50.8
ICD-10 Finland
Other Crohn disease
+∞
12.7
12
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.3
12.7
49
172
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
26.4
12.0
16
7
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.7
11.3
24
51
WX002
NOMESCO Finland
Sedation and analgesia
4.5
11.3
35
103
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
11.9
11.1
20
20
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
11.0
71
348
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
9.5
9
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
20.8
9.2
13
7
P01AB01
ATC
metronidazole; oral, rectal
3.4
9.1
63
312
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
8.9
27
77
J01MA02
ATC
ciprofloxacin; systemic
3.3
8.9
60
291
TPH04
NOMESCO Finland
Cathetrisation of vein
3.6
8.7
38
140
L04AB02
ATC
infliximab; parenteral
97.1
8.5
9
*
A07EC03
ATC
olsalazine; oral
+∞
8.4
8
*
A06AC01
ATC
ispaghula (psylla seeds); oral
3.4
7.8
38
149
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
7.4
7
*
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
7.4
7
*
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
+∞
7.4
7
*
UJF92
NOMESCO Finland
Capsular endoscopy
42.7
6.8
8
*
K83.0
ICD-10 Finland
Cholangitis
42.7
6.8
8
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.8
6.5
22
67
WX302
NOMESCO Finland
Thoracal epidural anesthesy
9.0
6.5
13
16
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
73.9
6.5
7
*
Z93.2
ICD-10 Finland
Ileostomy status
+∞
6.3
6
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
16.1
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
45
10.45
25.76
2.0
1.6
—
—
—
0
0
89
388
7.53
19.48
4.3
2.6
72.56
72.95
nmol/l
0.05
84
348
61
203
5.45
17.97
2.8
2.1
2.76
3.09
mg/l
0.51
51
179
89
547
4.16
9.01
18.3
10.1
4.24
4.08
e9/l
0.26
84
477
70
388
3.18
8.00
7.3
6.3
1.20
1.21
mmol/l
0.75
64
361
74
433
3.13
7.51
7.5
7.5
1.21
1.21
mmol/l
0.32
59
374
16
23
7.93
7.31
1.4
1.4
—
—
—
0
0
34
132
3.27
7.05
2.5
2.5
20.06
25.03
%
1.34
34
126
36
155
2.96
6.17
2.7
2.4
12.29
14.45
umol/l
0.94
36
147
9
7
13.84
5.69
1.1
1.0
—
—
—
0
0
10
11
9.85
5.41
1.0
1.1
—
—
—
0
0
58
353
2.35
4.65
6.0
2.8
31.94
30.71
u/l
0.17
53
327
9
16
6.02
3.74
1.0
1.4
—
—
—
0
0
10
21
5.12
3.65
1.6
1.3
—
—
—
0
0
7
9
8.20
3.61
1.3
2.0
—
—
—
0
0
9
17
5.66
3.59
1.4
1.3
—
—
—
0
0
59
390
2.09
3.58
1.9
2.0
100.18
97.88
pmol/l
0.13
37
205
9
18
5.34
3.45
1.8
1.3
—
—
—
0
0
7
10
7.38
3.41
1.3
1.9
—
—
—
0
0
7
10
7.38
3.41
1.3
1.9
—
—
—
0
0
7
10
7.38
3.41
1.3
1.9
—
—
—
0
0
7
10
7.38
3.41
1.3
1.9
—
—
—
0
0
7
10
7.38
3.41
1.3
1.9
—
—
—
0
0
13
44
3.21
3.26
5.2
2.4
90.80
166.35
ng/l
0.49
13
39
9
22
4.35
2.95
1.8
1.3
—
—
—
0
0
6
9
6.97
2.90
3.0
1.0
—
—
titre
—
0
0
5
6
8.65
2.77
1.0
1.0
1523.80
1954.17
miu/ml
—
5
6
8
19
4.45
2.73
1.6
1.3
—
—
—
0
0
12
45
2.87
2.54
1.4
1.6
—
—
—
0
0
8
21
4.02
2.51
2.1
1.3
—
—
—
0
0
40
257
1.87
2.43
1.9
1.6
18.45
20.30
nmol/l
0.37
35
214
8
22
3.83
2.41
1.5
1.4
—
—
—
0
0
5
8
6.48
2.39
4.4
1.0
—
—
—
0
0
33
200
1.93
2.38
1.5
1.8
0.77
0.83
mg/l
0.11
25
165
5
9
5.75
2.23
1.2
1.3
—
—
—
0
0
24
133
2.03
2.22
10.7
7.7
103.50
103.87
mmol/l
0.13
24
133
7
20
3.66
2.09
1.3
1.3
—
—
—
0
0
5
11
4.70
1.96
1.8
1.5
—
—
—
0
0
29
179
1.84
1.95
6.6
2.9
600.29
191.41
ng/l
0.42
17
122
19
101
2.06
1.95
10.9
9.5
4.82
5.23
kpa
0.78
19
95
32
207
1.77
1.85
5.4
3.6
1.02
1.02
kg/l
0.09
22
129
9
35
2.71
1.85
1.3
1.8
—
—
—
0
0
58
442
1.65
1.83
3.5
2.6
—
—
estimate
—
0
0
22
127
1.91
1.81
4.8
6.0
0.99
0.99
mmol/l
0.00
22
115
6
19
3.28
1.68
1.8
1.3
9931.83
1088.09
e6/l
—
6
11
7
25
2.92
1.68
1.1
1.4
—
—
—
0
0
35
241
1.66
1.60
2.5
2.2
—
—
—
0
0
15
79
2.04
1.58
7.6
5.2
2.74
62.31
ug/l
—
10
62
35
242
1.65
1.57
1.6
1.4
0.63
1.09
u/ml
—
8
76
8
33
2.53
1.57
1.4
2.0
—
—
—
0
0
84
722
1.67
1.50
4.4
4.4
14.75
14.74
pmol/l
0.00
77
672
5
16
3.22
1.45
1.4
1.2
—
—
—
0
0
17
97
1.89
1.45
11.9
9.8
2.73
1.07
mmol/l
1.55
11
81
99
896
1.97
1.41
28.6
13.2
89.75
85.91
ml/min/173m2
1.15
94
821
0
37
0.00
1.37
0.0
1.9
—
4.38
—
0
27
9
44
2.14
1.30
4.6
3.4
22.52
24.35
mmol/l
—
9
44
96
866
1.80
1.30
5.4
5.2
1.56
1.90
mu/l
2.67
89
807
19
117
1.75
1.28
3.4
4.1
32.09
30.88
%
0.17
11
75
0
36
0.00
1.16
0.0
1.3
—
0.95
—
0
24
0
36
0.00
1.16
0.0
1.3
—
0.98
—
0
24
0
36
0.00
1.16
0.0
1.3
—
1.08
—
0
24
5
21
2.44
1.10
1.8
1.1
—
—
—
0
0
20
286
0.63
1.03
4.3
4.3
17.39
22.18
%
0.80
11
118
43
343
1.41
0.95
4.3
3.4
104.99
32.73
ng/l
0.57
31
237
6
27
2.29
0.95
1.2
1.1
—
5.30
—
0
7
6
28
2.21
0.93
1.2
2.0
—
—
—
0
0
20
139
1.54
0.87
4.0
1.7
—
—
—
0
0
15
220
0.63
0.86
2.9
2.8
0.63
0.72
ug/l
—
10
118
6
31
1.99
0.86
2.8
1.6
—
—
—
0
0
10
58
1.80
0.82
1.2
3.4
4.85
4.52
pmol/l
—
10
50
11
66
1.74
0.82
4.4
3.4
57.60
63.34
ml/min/173m2
—
5
29
8
135
0.56
0.79
1.9
2.1
3.41
3.53
ratio
—
8
113
46
388
1.32
0.68
5.4
3.2
0.08
0.00
estimate
0.47
12
100
5
29
1.76
0.64
1.8
1.2
—
—
—
0
0
5
29
1.76
0.64
1.4
1.0
—
—
—
0
0
5
29
1.76
0.64
1.4
1.0
—
—
—
0
0
36
297
1.31
0.62
4.0
2.8
0.00
0.00
estimate
—
10
92
12
81
1.54
0.60
4.1
9.8
1.92
1.36
mmol/l
0.42
12
81
57
506
1.26
0.54
5.1
3.5
0.00
0.00
estimate
-0.00
13
100
9
63
1.47
0.54
2.2
2.1
—
—
—
0
0
33
277
1.27
0.49
6.2
3.4
0.08
0.00
estimate
0.47
13
105
13
95
1.42
0.46
4.8
1.6
—
—
—
0
0
11
78
1.46
0.45
2.1
2.1
—
—
—
0
0
8
56
1.46
0.44
1.8
1.2
29.69
22.58
iu/l
—
8
49
5
31
1.64
0.43
1.0
1.2
3.92
3.82
mmol/l
—
5
31
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
8
60
1.36
0.41
1.0
1.4
194.00
322.15
mu/l
—
8
54
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
5
35
1.45
0.40
1.2
1.2
—
—
—
0
0
5
36
1.41
0.38
2.2
1.7
—
—
—
0
0
5
36
1.41
0.38
1.0
1.3
355.20
437.31
mg/l
—
5
36
24
201
1.25
0.36
1.6
1.7
—
—
—
0
0
17
137
1.28
0.34
1.5
1.6
—
—
—
0
0
85
810
1.21
0.32
38.5
16.6
13.92
13.48
%
2.29
85
805
54
500
1.16
0.28
5.2
3.4
0.00
0.00
estimate
-0.00
13
111
12
96
1.28
0.26
4.5
3.1
—
—
—
0
0
9
75
1.22
0.25
5.3
2.0
16.50
5.54
ug/l
—
9
66
15
125
1.23
0.24
3.9
2.5
11.84
15.10
nmol/l
0.86
15
119
5
37
1.37
0.24
3.0
1.3
—
—
—
0
0
54
506
1.13
0.22
5.2
3.4
0.00
0.00
estimate
-0.00
13
111
0
11
0.00
0.21
0.0
1.2
—
17.28
—
0
6
0
11
0.00
0.21
0.0
4.1
—
9.66
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
20
177
1.16
0.18
1.2
1.4
1.43
7.20
u/ml
—
10
74
7
62
1.14
0.17
9.9
13.0
0.59
0.65
%
—
7
62
69
662
1.11
0.17
3.7
3.4
—
—
—
0
0
91
889
1.13
0.14
4.6
4.6
5.72
5.88
mmol/l
0.78
82
829
11
94
1.19
0.13
5.9
1.6
—
—
—
0
0
14
155
0.89
0.10
2.6
2.2
—
—
—
0
0
5
48
1.04
0.09
1.4
1.6
—
—
—
0
0
6
53
1.14
0.09
1.3
1.2
—
—
—
0
0
5
60
0.83
0.08
2.8
10.3
23.76
25.48
mmol/l
—
5
60
7
64
1.10
0.08
10.0
12.7
0.94
1.29
%
—
7
64
8
73
1.10
0.08
4.3
2.5
0.14
0.13
e6/l
—
8
68
13
139
0.93
0.03
2.6
2.0
—
—
—
0
0
27
278
0.96
0.02
5.7
4.3
6.74
9.66
mg/mmol
0.21
21
189
10
106
0.94
0.01
16.6
6.8
—
—
—
0
0
96
962
0.98
0.00
5.9
5.4
2.71
2.77
mmol/l
0.22
90
907
42
419
1.00
0.00
2.7
2.0
1.57
1.43
mmol/l
0.38
37
355
95
953
0.98
0.00
5.3
4.7
1.39
1.41
mmol/l
0.25
90
895
91
907
1.02
0.00
4.4
4.0
1.32
1.30
mmol/l
0.10
84
845
19
194
0.98
0.00
1.4
1.4
14.10
31.60
iu/ml
—
6
53
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.26
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
8
81
0.99
-0.00
1.9
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
31.94
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint COLONPSEUDOP and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| COLONPSEUDOP | 1.439 [1.04, 2.0] | 0.029 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 325 males with COLONPSEUDOP died.
Mortality risk
Mortality risk for people of age
years, who have COLONPSEUDOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.245% |
| 5 | No data | 1.514% |
| 10 | No data | 3.885% |
| 15 | No data | 7.248% |
| 20 | No data | 12.735% |
Relationships between endpoints
↥Index endpoint: COLONPSEUDOP – Pseudopolyposis of colon
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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