No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
485 |
4. Check minimum number of eventsNone |
485 |
5. Include endpointsNone |
485 |
6. Filter based on genotype QC (FinnGen only) |
472 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Chronic hepatitis NAS
based on the number of shared cases.
Similar with more cases:
- Chronic hepatitis, not elsewhere classified
- Diseases of liver
- Gastrointestinal diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3280 | 1919 | 1341 |
| Only index persons | 2815 | 1703 | 1112 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.85 | 57.41 | 53.52 |
| Only index persons | 54.73 | 56.41 | 52.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 472 | 307 | 165 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | 53.53 | 53.01 | 54.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 485
- Matched controls
- 4850
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Proper column names.
- Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV not working.
- No filters and sorters.
- Limited amount of endpoints with TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
K73.89 (2000502933)
JJ2AT (2001305254)
65752-8 (40768441)
K73.9 (45552949)
K75.9 (45562509)
JN1AE (2001305517)
SMOKING-2-3-5 (2002330114)
14212-5 (3002222)
13294-4 (3006922)
20575-7 (3016650)
49693-5 (3029023)
60621009 (4245997)
274774002 (436238)
Z94.4 (45566478)
K73.0 (45572227)
K76.9 (45572233)
K76.0 (45601189)
SMOKING-2-3-0 (2002330113)
29760-6 (3005772)
8095-2 (3007566)
5195-3 (3019284)
1825-9 (3026285)
20483-4 (3034770)
29953-7 (3037522)
50373000 (4177340)
R17 (45587498)
K75.4 (45601188)
GD1AA (2001303617)
UJD10 (2001304788)
JN3AE (2001305555)
Z2221 (2001311556)
SMOKING-1-1-0 (2002330116)
A05AA02 (21600513)
L01BB02 (21601428)
ERIP (262)
26478-8 (3002030)
2465-3 (3005719)
14631-6 (3006140)
26450-7 (3006504)
2458-8 (3007164)
22314-9 (3013327)
1920-8 (3013721)
14338-8 (3013742)
14749-6 (3013826)
1798-8 (3016771)
26511-6 (3018010)
26485-3 (3019069)
16933-4 (3021879)
30180-4 (3022096)
2064-4 (3022756)
1845-7 (3023183)
2472-9 (3028026)
5894-1 (3033658)
2 (38004447)
10 (38004455)
44 (38004484)
106 (44777669)
K51.5 (45533604)
K73.2 (45543340)
K83.0 (45552955)
I48 (45596206)
K70.3 (45596343)
77397-8 (46236098)
OMOP4822458 (581477)
L04AX01 (21603927)
OP (9202)
1751-7 (3024561)
A07EC02 (21600664)
A07EA01 (21600653)
H02AB06 (21602734)
2324-2 (3026910)
11 (38004456)
A07EA06 (21600658)
C03DA01 (21601534)
1742-6 (3006923)
34714-6 (3032080)
6768-6 (3035995)
69738-3 (42870588)
L04AD01 (21603924)
H02AB04 (21602732)
OMOP4822462 (581458)
R10.4 (45568113)
30385-9 (3002385)
26484-6 (3001604)
26444-0 (3006315)
26449-9 (3013115)
26474-7 (3019198)
26515-7 (3007461)
30428-7 (3024731)
718-7 (3000963)
20570-8 (3009542)
26464-8 (3010813)
28539-5 (3035941)
26453-1 (3026361)
58410-2 (40761511)
751-8 (3013650)
2276-4 (3001122)
715-3 (3021589)
22 (8756)
K51.9 (45605941)
16128-1 (3017143)
21 (8717)
57782-5 (40760892)
93 (38004510)
31017-7 (3019050)
4537-7 (3013707)
UJF30 (2001305028)
OMOP5117446 (33004)
ER (9203)
N02AX02 (21604298)
1988-5 (3020460)
60517-0 (40763571)
UJF32 (2001305029)
3034-6 (3004789)
C03CA01 (21601518)
30248-9 (3015399)
OMOP4822461 (32036)
A02BC02 (21600097)
ZX120 (2001311495)
1 (38004446)
14798-3 (3022948)
207NI0002X (38003841)
ZXE00 (2001311394)
K74.6 (45538546)
68438-1 (40771025)
19072-8 (3016431)
A07EA03 (21600655)
H02AB07 (21602735)
1805-1 (3016417)
202 (2001600200)
29 (38004472)
62238-1 (40764999)
A12AA20 (21600872)
21573-1 (3003031)
251B00000X (38004193)
28541-1 (3002179)
2951-2 (3019550)
14682-9 (3020564)
2823-3 (3023103)
43409-2 (3042936)
I10 (45591453)
22664-7 (3020779)
J01DB01 (21602870)
28540-3 (3003338)
Z71.8 (45581061)
66 (38004491)
NK6QA (2001308500)
TPH04 (2001309597)
19176-7 (3015916)
JKE98 (2001305336)
9838-4 (3003265)
L04AA06 (21603896)
ZXD10 (2001311387)
WX002 (2001310758)
J01CA04 (21602823)
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint CHRONHEP_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 2.925 [2.5, 3.42] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 1704 females with CHRONHEP_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 3.58 [2.98, 4.31] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 1151 males with CHRONHEP_NAS died.
Mortality risk
Mortality risk for people of age
years, who have CHRONHEP_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.504% |
| 5 | 1.625% | 3.958% |
| 10 | 3.561% | 9.484% |
| 15 | 6.913% | 18.168% |
| 20 | 12.624% | 29.866% |
Relationships between endpoints
↥Index endpoint: CHRONHEP_NAS – Chronic hepatitis NAS
GWS hits: -