No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
517 |
4. Check minimum number of eventsNone |
517 |
5. Include endpointsNone |
517 |
6. Filter based on genotype QC (FinnGen only) |
472 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Chronic hepatitis NAS
based on the number of shared cases.
Similar with more cases:
- Chronic hepatitis, not elsewhere classified
- Diseases of liver
- Gastrointestinal diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3280 | 1919 | 1341 |
| Only index persons | 2815 | 1703 | 1112 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.85 | 57.41 | 53.52 |
| Only index persons | 54.73 | 56.41 | 52.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 472 | 307 | 165 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | 53.53 | 53.01 | 54.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 485
- Matched controls
- 4850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
+∞
307.7
456
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
63.2
289.7
167
40
A05AA02
ATC
ursodeoxycholic acid; oral
46.9
194.4
118
33
L04AX01
ATC
azathioprine; systemic
23.3
182.8
146
88
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
55.6
150.9
87
19
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
908.3
142.6
133
*
K76.9
ICD-10 Finland
Liver disease, unspecified
44.6
140.0
85
23
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
10.8
134.3
185
262
K74.3
ICD-10 Finland
Primary biliary cirrhosis
62.1
107.0
60
11
A07EA06
ATC
budesonide; oral, local oral
13.5
101.7
105
97
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.8
97.4
174
323
K75.4
ICD-10 Finland
Autoimmune hepatitis
494.7
85.9
83
*
K83.0
ICD-10 Finland
Cholangitis
31.2
79.5
53
19
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
17.0
73.8
64
43
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
22.4
71.5
54
27
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
23.5
63.8
47
22
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
12.8
61.6
63
56
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.4
59.0
148
365
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
19.7
56.6
45
25
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.1
51.7
246
976
L01BB02
ATC
mercaptopurine; oral
18.7
46.7
38
22
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
43.4
41
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
11.0
42.2
47
47
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
16.0
37.7
33
22
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
205.6
37.3
38
*
L04AA06
ATC
mycophenolic acid; systemic
11.4
35.3
38
36
H02AB06
ATC
prednisolone; systemic
3.1
31.0
307
1748
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
30.1
241
1217
ZX120
NOMESCO Finland
Intravenous
4.2
29.3
90
251
K51.5
ICD-10 Finland
Left sided colitis
7.6
29.3
43
61
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
7.2
29.0
45
68
R18
ICD-10 Finland
Ascites
9.8
28.6
34
37
UJF30
NOMESCO Finland
Ileoscopy through colon
3.7
26.4
96
301
C03DA01
ATC
spironolactone; oral
3.6
26.1
101
330
L04AD01
ATC
ciclosporin; systemic
9.7
25.9
31
34
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
8.8
25.5
33
40
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
8.8
25.5
33
40
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
27.1
24.3
33
13
UJF32
NOMESCO Finland
Coloscopy
2.7
23.8
179
852
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
4.8
21.6
51
115
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
20.1
21.6
32
17
A07EC02
ATC
mesalazine; oral, rectal
4.4
21.3
57
142
UJK02
NOMESCO Finland
ERCP
7.5
21.0
31
44
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
50.3
20.3
24
5
C03CA01
ATC
furosemide; systemic
2.5
20.1
173
867
A06AD11
ATC
lactulose; oral
3.0
19.5
100
384
N02AX02
ATC
tramadol; systemic, rectal
2.4
19.3
256
1553
Z94.4
ICD-10 Finland
Liver transplant status
31.5
18.5
24
8
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
18.2
143
683
JN3AD
NOMESCO Finland
Abdominal CT examination
2.9
18.0
97
381
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
186.5
17.6
18
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.5
17.4
64
200
JJC00
NOMESCO Finland
Allogenic transplantation of liver
41.6
16.4
20
5
A02BC02
ATC
pantoprazole; systemic
2.5
16.0
369
2738
H02AB07
ATC
prednisone; oral
2.8
15.9
96
399
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
15.7
15
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
88.0
15.7
17
*
J01MA02
ATC
ciprofloxacin; systemic
2.2
15.6
216
1300
L04AD02
ATC
tacrolimus; systemic
15.4
15.5
25
17
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
15.4
70
249
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
15.2
215
1303
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
17.2
14.9
23
14
JJA20
NOMESCO Finland
Open biopsy of liver
82.7
14.7
16
*
5714B
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ACTIVA (HBSAG-)]
82.7
14.7
16
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
37.3
14.5
18
5
D97
ICPC
Liver disease NOS
23.1
14.3
20
9
K51.8
ICD-10 Finland
Other ulcerative colitis
6.7
14.2
23
36
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
13.9
260
1734
UJK12
NOMESCO Finland
Peroral cholangioscopy
+∞
13.6
13
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
12.0
13.4
24
21
127
Kela drug reimbursment
Transplant complication
10.5
13.1
25
25
K72.9
ICD-10 Finland
Hepatic failure, unspecified
23.3
13.0
18
8
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.6
12.8
44
131
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.3
12.7
51
168
C10AC01
ATC
colestyramine; oral
5.0
12.5
27
56
UJD02
NOMESCO Finland
Gastroscopy
3.8
12.3
39
110
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
16.4
12.2
19
12
R94.5
ICD-10 Finland
Abnormal results of liver function studies
9.3
11.9
24
27
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
19.5
11.7
17
9
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
9.6
11.6
23
25
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
3.9
11.6
35
95
K72.1
ICD-10 Finland
Chronic hepatic failure
122.8
11.5
12
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
11.2
134
745
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
25.7
11.2
15
6
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
11.2
83
379
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.7
11.1
26
58
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
10.9
91
438
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
61.4
10.7
12
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.7
10.6
25
56
A10AB05
ATC
insulin aspart; parenteral
2.8
10.5
54
205
A10AC01
ATC
insulin (human); parenteral
2.9
10.2
52
196
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
10.0
62
259
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.4
9.8
73
333
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
9.7
107
575
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
30.7
9.4
12
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
9.3
132
774
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
9.2
86
431
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.4
9.1
68
310
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
37.4
9.1
11
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.7
9.0
28
78
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
9.7
8.8
17
18
N02AA05
ATC
oxycodone; systemic
2.1
8.8
100
541
A10AE04
ATC
insulin glargine; parenteral
2.5
8.8
59
256
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
8.8
48
188
R50.9
ICD-10 Finland
Fever, unspecified
2.2
8.8
87
447
J01MA12
ATC
levofloxacin; systemic
2.1
8.6
100
545
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.9
8.6
25
66
WW500
NOMESCO Finland
Blood transfusion
3.8
8.6
26
71
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.0
8.5
110
624
5719X
ICD-9 Finland
Chronic liver disease and cirrhosis, Unspecified chronic liver disease without mention of alcohol
91.6
8.4
9
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
91.6
8.4
9
*
K29.6
ICD-10 Finland
Other gastritis
8.8
8.4
17
20
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
8.3
63
289
H02AB04
ATC
methylprednisolone; systemic
2.1
8.3
82
420
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
8.2
82
423
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
17.5
8.1
12
7
K74.0
ICD-10 Finland
Hepatic fibrosis
17.5
8.1
12
7
S97
ICPC
Chronic ulcer skin
2.7
8.1
44
172
R10.0
ICD-10 Finland
Acute abdomen
4.1
8.0
22
56
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
13.3
7.9
13
10
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
3.4
7.9
28
85
L04AA01
ATC
[U] ciclosporin
9.6
7.8
15
16
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
4.3
7.8
20
48
M05BA04
ATC
alendronic acid; oral
2.5
7.8
52
225
JJ5AT, ,
NOMESCO Finland
45.7
7.7
9
*
K92.1
ICD-10 Finland
Melaena
3.1
7.7
33
113
XG410
NOMESCO Finland
Flow-volume spirometry
3.6
7.6
25
72
C07AG02
ATC
carvedilol; oral
2.8
7.6
38
142
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
25.5
7.6
10
*
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
7.5
128
791
XW000
NOMESCO Finland
Bone marrow biopsy
3.7
7.5
24
68
K73.1
ICD-10 Finland
Chronic lobular hepatitis, not elsewhere classified
+∞
7.3
7
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.4
7.3
18
42
B18.2
ICD-10 Finland
Chronic viral hepatitis C
7.5
7.2
16
22
A02BC01
ATC
omeprazole; systemic
1.8
7.1
138
885
K70.1
ICD-10 Finland
Alcoholic hepatitis
12.3
7.1
12
10
TPH07
NOMESCO Finland
Cathetrisation of artery
2.2
7.1
60
289
K50.8
ICD-10 Finland
Other Crohn disease
5.6
7.0
19
35
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
14.0
6.9
11
8
H02AB09
ATC
hydrocortisone; systemic
3.9
6.9
20
53
103
Kela drug reimbursment
Diabetes, insulin-treated
1.8
6.8
131
837
V03AE01
ATC
polystyrene sulfonate; oral
9.5
6.8
13
14
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.4
6.6
23
69
Z3231
NOMESCO Finland
Registered nurse
1.8
6.6
134
868
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
10.2
6.6
12
12
Z2221
NOMESCO Finland
Medical doctor
1.7
6.6
138
904
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
70.7
6.4
7
*
0709X
ICD-9 Finland
Viral hepatitis, Unspecified viral hepatitis without mention of hepatic coma
70.7
6.4
7
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
6.4
55
266
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.8
6.4
123
785
K29
ICPC
Cardiovascular sympt/complt other
3.0
6.4
27
92
ZXD05
NOMESCO Finland
Urgent procedure
1.7
6.4
147
987
P15
ICPC
Chronic alcohol abuse
3.4
6.3
22
66
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.3
6.3
51
240
K70.4
ICD-10 Finland
Alcoholic hepatic failure
18.3
6.3
9
5
5739X
ICD-9 Finland
Other disorders of liver, Unspecified disorder of liver
+∞
6.3
6
*
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
+∞
6.3
6
*
198
Kela drug reimbursment
Sorafenib
+∞
6.3
6
*
3042, ,
Kela drug reimbursment
27.1
6.2
8
*
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
27.1
6.2
8
*
253, ,
Kela drug reimbursment
27.1
6.2
8
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
6.1
24
78
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.3
6.1
23
73
A02BC03
ATC
lansoprazole; oral
1.7
6.1
144
972
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
6.0
41
179
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
258
356
14.35
198.28
7.4
2.8
12.69
10.79
g/l
6.19
248
332
167
134
18.48
180.65
1.8
1.1
281.56
94.71
titre
1.76
32
17
240
409
10.64
151.69
5.4
2.6
0.20
0.22
g/l
1.88
220
387
191
291
10.18
130.42
2.1
1.7
1.38
1.36
g/l
0.07
177
268
78
49
18.78
93.60
1.7
1.1
—
—
titre
—
0
0
54
22
27.50
77.50
1.2
1.1
—
—
—
0
0
195
512
5.70
74.02
6.9
2.9
20.60
8.14
umol/l
2.72
179
457
69
60
13.24
68.62
1.1
1.1
1.63
1.50
g/l
1.45
62
55
347
1543
5.39
67.03
11.3
3.3
54.55
31.20
u/l
5.65
332
1452
388
1889
6.27
66.93
13.1
4.9
35.00
35.99
g/l
2.80
372
1784
411
2339
5.96
52.08
19.1
6.6
16.46
10.95
umol/l
3.66
400
2232
187
623
4.26
49.99
2.8
2.3
26.23
22.67
%
1.73
176
586
193
668
4.14
48.75
2.8
2.3
2.32
2.33
g/l
0.14
178
618
198
721
3.95
46.11
2.9
2.3
14.06
13.24
umol/l
0.69
185
673
64
89
8.13
44.73
5.0
5.7
1805.22
195.09
iu/ml
—
9
11
354
1933
4.08
43.87
17.5
12.1
1.16
1.19
inr
0.73
314
1592
61
88
7.79
41.23
1.3
1.2
275.41
216.23
u/ml
0.56
32
44
240
1089
3.38
38.30
13.2
3.9
87.29
92.21
%
2.07
233
1069
218
968
3.27
35.47
2.1
1.4
2.96
2.39
g/l
3.27
180
583
52
82
6.98
32.27
1.3
1.4
134.37
161.09
au/ml
0.54
14
27
269
1413
3.03
31.66
5.3
2.6
63.81
64.76
u/l
0.07
256
1313
76
178
4.88
31.00
4.7
3.3
822.40
1869.50
u/ml
0.43
71
156
79
201
4.50
29.02
2.6
1.5
0.33
0.35
mg/l
0.09
32
81
157
640
3.15
28.53
2.7
1.8
30.70
29.23
s
2.53
151
620
119
415
3.47
27.90
3.5
2.5
33.76
33.80
u/l
0.00
106
346
44
70
6.81
27.00
1.5
1.3
—
—
—
0
0
375
2490
3.23
26.90
18.9
9.8
3.75
4.10
e9/l
2.59
355
2172
62
142
4.86
25.84
1.4
1.3
—
—
—
0
0
136
548
3.06
24.81
2.6
1.8
1.63
1.44
%
2.00
113
477
316
2008
2.65
22.86
3.9
2.5
74.97
77.32
nmol/l
0.84
297
1801
436
3315
4.12
22.16
26.9
8.3
106.74
78.52
u/l
15.97
425
3138
28
34
8.68
21.59
2.5
1.3
—
—
—
0
0
203
1095
2.47
20.18
3.1
2.1
3.12
2.95
mg/l
0.38
185
943
60
167
3.96
19.32
1.7
1.9
1.31
1.48
g/l
0.64
50
151
320
2164
2.41
18.43
11.7
7.0
1.21
1.21
mmol/l
0.43
284
1875
131
598
2.63
18.27
4.1
2.3
163.58
124.90
ug/g
0.79
115
481
27
40
7.09
17.59
1.0
1.0
—
—
—
0
0
106
445
2.77
17.37
4.4
4.7
3.47
24.39
ug/l
1.21
85
370
25
14
18.76
16.63
3.0
2.3
4168.00
4.42
ug/l
0.49
25
14
388
2975
2.52
15.14
10.8
3.4
127.35
45.93
u/l
11.78
371
2821
410
3236
2.73
14.87
9.0
4.3
17.85
11.59
mm/h
9.95
389
3017
285
1946
2.13
14.51
10.0
6.2
1.21
1.22
mmol/l
0.63
270
1792
300
2097
2.13
14.25
4.0
3.0
199.44
116.89
ug/l
1.51
285
1951
49
148
3.57
13.95
1.5
1.6
0.05
0.13
iu/ml
—
6
23
339
2520
2.15
13.21
9.4
5.0
7.07
6.60
mmol/l
1.70
327
2377
76
312
2.70
12.79
2.8
1.6
—
—
—
0
0
35
89
4.16
12.68
4.8
4.2
31.14
3040.33
u/ml
0.57
30
84
180
1078
2.07
12.57
3.5
2.2
—
—
—
0
0
179
1088
2.02
11.86
1.5
1.3
1.82
1.26
u/ml
0.45
42
302
19
14
14.07
11.54
3.5
3.9
0.59
0.60
mmol/l
0.25
19
14
267
1901
1.90
10.77
2.4
2.1
96.39
97.53
pmol/l
0.15
160
949
34
98
3.66
10.36
1.5
1.7
—
—
—
0
0
19
23
8.55
9.15
5.5
3.2
75.58
100.35
%
1.84
19
23
276
2049
1.81
9.14
3.8
2.7
—
—
estimate
—
0
0
119
689
1.96
8.66
2.1
1.9
—
—
—
0
0
8
0
+∞
8.35
5.9
0.0
—
—
—
0
0
15
14
11.01
8.34
1.8
1.6
10123.17
4685.25
e6/l
—
6
8
51
214
2.55
8.15
1.9
1.9
4.24
6.52
iu/ml
0.55
11
56
80
409
2.14
8.14
6.9
3.1
0.48
1.98
mmol/l
2.59
70
352
18
26
7.15
7.84
1.8
1.9
11.50
11.75
umol/l
0.08
18
26
94
521
2.00
7.68
1.8
1.8
—
—
—
0
0
42
166
2.68
7.56
1.3
1.2
29.50
3.03
u/ml
—
6
9
116
698
1.87
7.41
1.9
1.6
1157.56
1189.25
nmol/l
0.14
97
522
36
134
2.82
7.26
1.9
1.2
—
—
—
0
0
144
942
1.75
6.93
4.1
2.6
5.29
6.38
e6/l
0.42
132
853
17
28
6.25
6.83
1.3
1.5
—
—
—
0
0
113
693
1.82
6.74
3.8
2.9
1.77
2.62
e6/l
0.90
63
300
31
112
2.89
6.61
2.6
3.1
1.20
1.64
index
0.26
15
61
195
1403
1.65
6.51
5.1
3.1
45.21
89.08
e6/l
0.37
157
1038
30
109
2.87
6.34
2.4
1.6
—
—
—
0
0
119
757
1.76
6.23
3.7
2.8
0.90
0.89
e6/l
0.00
69
367
161
1115
1.66
6.17
4.4
2.6
357.96
333.71
umol/l
1.70
143
976
38
162
2.46
5.89
1.4
1.3
9.14
6.07
u/ml
—
7
31
84
496
1.84
5.60
1.8
1.9
—
—
—
0
0
168
1200
1.61
5.59
4.9
3.0
0.34
0.42
e6/l
0.31
132
841
32
129
2.59
5.57
1.3
1.2
31.98
44.75
u/ml
—
5
15
49
241
2.15
5.48
1.7
1.7
—
—
—
0
0
173
1250
1.60
5.47
2.0
1.7
18.83
20.95
nmol/l
1.16
160
1058
26
97
2.78
5.26
1.3
1.5
—
—
—
0
0
5
0
+∞
5.22
1.2
0.0
—
—
—
0
0
31
130
2.48
5.00
1.3
1.4
242.73
314.58
ug/g
0.96
22
73
13
24
5.53
4.94
1.5
1.2
—
—
—
0
0
173
1274
1.56
4.94
3.0
3.2
2290.75
1044.54
ng/l
0.96
164
1078
12
22
5.56
4.63
1.3
2.1
—
—
—
0
0
79
485
1.75
4.61
11.8
8.8
-0.24
1.00
mmol/l
1.16
59
406
10
15
6.78
4.48
1.2
1.1
—
—
—
0
0
12
23
5.32
4.48
3.6
3.7
4008.50
812.43
u/ml
0.63
12
23
42
211
2.08
4.47
1.7
2.4
42.82
39.85
u/l
0.42
37
191
194
1496
1.49
4.35
4.6
3.3
6.54
7.70
mmol/l
3.60
166
1258
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
108
2.49
4.30
3.0
2.5
0.30
0.37
iu/ml
0.47
13
64
20
73
2.81
4.23
1.5
1.7
—
—
—
0
0
33
155
2.21
4.16
1.9
1.3
—
—
—
0
0
451
4197
2.06
4.15
36.6
15.2
19.61
22.36
mg/l
1.37
418
3417
124
877
1.56
4.13
1.4
1.3
39.08
35.06
iu/ml
0.12
43
275
125
886
1.55
4.13
1.8
1.7
460.82
15789910.82
pmol/l
0.50
102
741
14
42
3.40
4.07
1.5
1.2
—
—
—
0
0
14
42
3.40
4.07
1.5
1.2
—
—
—
0
0
118
829
1.56
4.04
3.8
4.0
247.89
340.94
ng/l
0.35
91
625
21
81
2.66
4.02
1.1
1.2
—
—
—
0
0
21
82
2.63
3.94
1.1
1.5
—
—
—
0
0
21
82
2.63
3.94
1.1
1.5
—
—
—
0
0
116
819
1.55
3.88
1.4
1.3
18.02
12.16
u/ml
0.32
37
305
42
223
1.97
3.87
2.0
1.4
—
—
—
0
0
14
44
3.25
3.80
1.5
1.2
—
—
—
0
0
14
44
3.25
3.80
1.5
1.2
—
—
—
0
0
184
1434
1.46
3.79
5.3
4.1
19.15
7.26
mg/mmol
0.92
116
876
58
349
1.75
3.63
2.9
2.5
67.97
67.41
ml/min/173m2
0.03
23
150
139
1034
1.48
3.61
1.9
1.7
2.16
1.20
mg/l
1.78
114
808
57
342
1.76
3.60
4.4
3.4
1.22
1.23
mmol/l
0.63
52
293
175
1365
1.44
3.54
2.7
2.1
143.25
235.50
u/l
1.14
170
1290
14
47
3.04
3.44
1.5
1.2
—
—
—
0
0
42
235
1.86
3.34
4.6
3.1
1.30
1.80
mmol/l
0.28
30
175
29
143
2.09
3.28
2.0
1.9
72.62
94.98
%
2.78
29
138
26
124
2.16
3.20
1.9
2.5
12.70
11.81
mg/l
0.24
26
119
25
119
2.16
3.10
1.4
1.6
—
—
—
0
0
270
2309
1.38
3.08
5.3
3.9
21.05
10.32
estimate
0.20
63
476
8
16
5.06
3.06
1.1
1.6
—
—
—
0
0
5
5
10.08
2.98
1.2
2.8
58.20
34.60
u/l
—
5
5
8
17
4.77
2.93
1.5
1.2
9.78
8.54
ug/l
—
8
17
29
150
1.99
2.91
2.4
2.0
—
—
—
0
0
189
1536
1.38
2.90
3.5
3.4
2.34
2.36
mmol/l
0.65
177
1392
24
117
2.11
2.82
1.5
1.6
—
—
—
0
0
8
18
4.50
2.80
1.6
1.7
—
—
—
0
0
8
18
4.50
2.80
1.6
1.7
—
—
—
0
0
10
28
3.62
2.80
3.3
1.3
—
—
—
0
0
5
6
8.40
2.75
1.0
1.0
—
—
—
0
0
14
54
2.64
2.72
1.5
1.2
—
—
—
0
0
451
4283
1.76
2.62
36.1
17.8
138.92
139.75
mmol/l
10.20
445
4213
269
2335
1.34
2.61
5.3
3.9
0.00
0.02
estimate
0.97
54
439
7
15
4.72
2.60
1.1
1.1
—
—
—
0
0
24
121
2.03
2.60
1.1
3.8
1.10
1.92
ratio
1.06
15
69
14
56
2.54
2.55
1.3
1.2
—
—
—
0
0
27
144
1.93
2.51
1.9
1.8
—
—
—
0
0
13
51
2.59
2.46
1.3
1.5
—
—
—
0
0
26
138
1.93
2.46
2.1
2.6
—
—
—
0
0
13
52
2.54
2.37
1.5
1.4
—
—
—
0
0
262
2288
1.32
2.33
5.3
3.8
0.02
0.00
estimate
0.41
60
467
450
4289
1.68
2.32
36.6
17.9
3.94
3.96
mmol/l
1.26
445
4209
11
40
2.79
2.28
2.0
1.9
90.24
90.17
%
0.02
11
40
13
54
2.45
2.21
1.3
1.4
—
—
—
0
0
10
36
2.81
2.15
1.5
1.4
0.45
1.12
promille
—
5
27
23
124
1.90
2.10
1.3
1.3
—
—
—
0
0
11
43
2.59
2.09
1.6
1.9
—
—
—
0
0
7
20
3.54
2.06
1.0
1.0
—
—
—
0
0
7
20
3.54
2.06
1.0
1.4
—
—
—
0
0
112
880
1.35
2.04
2.6
2.7
2.46
2.45
mmol/l
0.21
100
798
12
50
2.44
2.04
2.0
1.9
33.50
31.44
pg
1.10
12
50
8
26
3.11
2.02
1.7
3.3
896.63
1042.50
mg
—
8
26
11
47
2.37
1.79
1.6
1.9
—
—
—
0
0
194
1671
1.27
1.78
4.9
3.7
43.32
72.64
ng/l
0.37
145
1153
14
67
2.12
1.77
1.4
1.4
—
—
—
0
0
14
67
2.12
1.77
1.4
1.4
—
—
—
0
0
23
132
1.78
1.77
3.1
3.6
1.36
1.35
mmol/l
0.02
23
126
8
30
2.69
1.73
1.5
1.2
—
—
—
0
0
428
4078
1.42
1.72
32.8
14.7
81.84
82.48
ml/min/173m2
0.23
414
3779
5
13
3.87
1.72
1.0
1.4
—
—
—
0
0
14
68
2.09
1.72
1.4
1.4
—
—
—
0
0
17
90
1.92
1.67
1.4
1.3
—
—
—
0
0
6
146
0.40
1.67
1.2
1.1
1.55
1.56
g/l
—
6
146
14
69
2.06
1.66
1.4
1.4
—
—
—
0
0
14
69
2.06
1.66
1.4
1.4
—
—
—
0
0
14
69
2.06
1.66
1.4
1.4
—
—
—
0
0
10
41
2.47
1.65
1.1
1.1
—
—
—
0
0
10
42
2.41
1.62
1.1
1.2
—
—
—
0
0
20
115
1.77
1.55
1.2
1.2
706.40
467.09
mg/l
0.34
20
107
18
102
1.79
1.47
1.1
1.2
4.79
3.77
mmol/l
0.69
18
93
17
96
1.80
1.40
2.5
2.6
127.20
76.71
ug/min
—
9
53
22
346
0.62
1.40
1.9
1.9
3.18
3.54
mmol/l
0.44
13
262
14
77
1.84
1.26
5.1
2.6
7.64
8.09
pmol/l
0.06
14
77
15
85
1.79
1.24
1.1
2.0
3.97
5.17
mmol/24h
0.70
15
75
8
37
2.18
1.22
2.8
2.2
—
—
—
0
0
19
117
1.65
1.20
1.8
1.3
—
—
—
0
0
288
2663
1.20
1.18
3.1
3.2
—
—
—
0
0
8
39
2.07
1.15
1.3
1.5
—
—
—
0
0
5
20
2.51
1.15
3.2
1.8
—
—
—
0
0
145
1261
1.21
1.15
4.5
3.3
4.98
0.01
estimate
0.50
51
373
8
41
1.97
1.09
1.8
1.8
—
—
—
0
0
8
41
1.97
1.09
1.8
1.8
—
—
—
0
0
8
41
1.97
1.09
1.8
1.8
—
—
—
0
0
7
33
2.14
1.06
2.3
1.4
8.81
6.71
u/l
—
7
28
5
22
2.29
1.03
4.4
3.6
1.40
0.91
index
—
5
22
35
468
0.73
1.02
1.8
2.1
3.70
3.49
ratio
0.21
27
382
21
139
1.53
1.02
2.4
2.0
0.78
2820.02
u/l
—
5
51
7
35
2.01
1.00
1.6
1.7
4.96
4.00
mg/l
—
7
35
18
116
1.57
0.98
1.1
1.2
—
—
—
0
0
9
50
1.81
0.97
1.2
1.1
—
—
—
0
0
9
51
1.78
0.95
1.2
1.1
—
—
—
0
0
6
27
2.24
0.93
1.8
1.8
—
—
—
0
0
6
27
2.24
0.93
1.8
1.8
—
—
—
0
0
6
27
2.24
0.93
1.8
1.8
—
—
—
0
0
6
27
2.24
0.93
1.8
1.8
—
—
—
0
0
12
70
1.73
0.93
1.3
1.8
—
—
—
0
0
9
52
1.74
0.93
1.0
1.3
—
—
—
0
0
454
4436
1.37
0.91
32.7
12.1
39.26
25.71
u/l
14.61
448
4324
31
228
1.38
0.91
1.0
1.0
—
—
—
0
0
10
56
1.80
0.88
1.5
1.3
8.02
7.34
mmol/l
—
10
46
8
43
1.87
0.87
1.1
1.1
—
—
—
0
0
32
240
1.36
0.85
6.0
2.4
1.44
1.23
%
0.78
32
240
6
31
1.95
0.84
1.2
1.5
—
—
—
0
0
6
113
0.53
0.84
1.2
1.5
—
—
—
0
0
21
146
1.46
0.84
1.5
1.4
308.73
241.92
miu/ml
0.32
11
68
6
32
1.89
0.82
2.0
1.1
—
—
—
0
0
17
114
1.51
0.80
1.2
1.1
—
4.32
—
0
17
15
98
1.55
0.79
1.2
1.5
—
—
—
0
0
15
98
1.55
0.79
1.1
1.1
56.60
10.65
e6/l
—
10
72
17
115
1.50
0.78
2.0
1.5
8260.27
18243.25
e6/l
0.76
11
83
66
553
1.22
0.77
5.8
4.9
33.52
32.10
%
0.47
54
366
113
998
1.17
0.75
5.4
3.9
1.02
1.02
kg/l
0.24
81
653
31
238
1.32
0.73
6.1
2.4
0.63
0.60
%
0.18
31
238
353
3391
1.15
0.69
4.7
4.5
14.77
14.79
pmol/l
0.04
332
3108
188
1737
1.13
0.67
5.3
3.7
2.26
0.03
estimate
0.52
47
395
21
154
1.38
0.66
3.0
1.2
0.88
0.92
g/l
0.39
21
154
5
29
1.73
0.64
1.2
1.0
—
—
—
0
0
12
79
1.53
0.63
1.3
1.5
—
—
—
0
0
8
52
1.55
0.59
2.6
4.1
—
—
—
0
0
22
166
1.34
0.59
1.6
1.6
—
—
—
0
0
10
149
0.66
0.57
1.5
1.5
—
—
—
0
0
11
73
1.52
0.56
1.1
1.1
—
14.76
—
0
22
39
322
1.23
0.55
3.4
2.6
23.04
18.92
au/ml
—
7
26
51
436
1.19
0.52
4.0
3.1
—
—
—
0
0
407
3974
1.15
0.51
6.0
5.5
1.95
1.90
mu/l
0.40
389
3683
19
144
1.33
0.51
1.2
1.1
—
—
—
0
0
410
4006
1.15
0.51
5.1
4.3
1.32
1.28
mmol/l
0.52
393
3705
366
3551
1.13
0.51
43.3
18.8
14.24
13.60
%
9.17
366
3515
85
761
1.14
0.49
1.6
1.5
—
—
—
0
0
54
620
0.85
0.48
2.9
3.1
0.77
0.75
ug/l
0.03
45
381
36
301
1.21
0.47
2.2
2.4
14.12
13.72
nmol/l
0.08
30
278
16
120
1.34
0.46
1.3
1.9
54.25
39.61
nmol/l
0.80
16
114
5
31
1.62
0.43
1.4
1.5
—
29.80
—
0
5
5
32
1.57
0.42
2.4
1.3
—
—
—
0
0
5
32
1.57
0.42
2.4
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
33
278
1.20
0.41
7.5
3.0
111.55
130.09
g/l
3.89
33
272
24
196
1.24
0.40
12.5
3.2
23.25
25.05
mmol/l
1.68
24
191
9
71
1.27
0.36
1.1
1.1
—
1.43
—
0
13
6
43
1.40
0.35
1.5
1.3
3.64
3.25
ug/l
—
6
36
135
1268
1.09
0.34
5.0
3.8
0.02
0.01
estimate
0.13
57
440
18
145
1.25
0.34
1.2
1.1
—
—
—
0
0
6
89
0.67
0.33
6.8
3.9
16.83
25.74
u/ml
—
6
89
12
152
0.78
0.30
2.7
1.7
—
—
—
0
0
425
4193
1.11
0.29
6.4
5.2
4.51
4.69
mmol/l
2.82
408
3928
15
121
1.25
0.29
1.5
1.9
3.51
4.76
iu/l
—
6
46
8
63
1.27
0.28
1.3
1.6
—
—
—
0
0
99
1055
0.92
0.27
5.5
5.0
2.12
2.40
ug/l
0.25
92
948
8
64
1.25
0.27
1.1
1.3
0.60
0.59
nmol/l
—
8
59
195
1876
1.07
0.27
2.4
1.9
1.30
1.34
mmol/l
0.33
171
1579
5
74
0.67
0.26
1.0
1.2
3.60
4.32
u/ml
—
5
28
36
321
1.13
0.25
1.2
1.2
70.84
127.94
u/ml
—
10
133
88
828
1.08
0.23
1.7
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
6
51
1.18
0.19
1.2
1.1
—
—
—
0
0
413
4090
1.07
0.17
6.4
5.1
6.09
5.90
mmol/l
1.89
394
3787
9
81
1.11
0.15
1.2
1.5
—
—
—
0
0
19
169
1.13
0.15
1.8
1.5
—
—
—
0
0
421
4177
1.06
0.14
6.2
5.1
1.44
1.49
mmol/l
1.73
402
3895
37
345
1.08
0.13
1.5
1.5
—
—
—
0
0
80
829
0.96
0.10
4.3
4.3
23.98
22.23
%
0.42
41
382
395
3979
0.96
0.10
8.5
6.3
40.11
39.11
mmol/mol
1.27
381
3758
24
222
1.09
0.10
1.7
1.8
—
—
—
0
0
5
60
0.83
0.08
1.6
1.5
—
—
—
0
0
7
67
1.05
0.08
5.1
5.3
361.29
350.34
umol/l
—
7
59
11
99
1.11
0.06
1.3
1.9
199.45
223.48
pmol/l
0.20
11
93
24
227
1.06
0.06
1.2
1.3
—
—
—
0
0
427
4253
1.03
0.06
6.8
5.9
2.60
2.74
mmol/l
2.64
407
3973
46
448
1.03
0.03
1.6
2.0
—
—
—
0
0
47
482
0.97
0.03
1.6
2.1
—
—
—
0
0
456
4554
1.02
0.00
53.3
23.7
39.39
40.44
%
4.36
451
4511
27
275
0.98
0.00
1.7
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
49
490
1.00
-0.00
7.6
6.4
—
—
—
0
0
5
55
0.91
-0.00
15.0
2.9
1.20
1.19
mmol/l
—
5
55
6
60
1.00
-0.00
1.3
1.5
24.28
26.59
u/l
—
6
51
5
55
0.91
-0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
15.0
2.9
106.00
105.76
mmol/l
—
5
55
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CHRONHEP_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 2.925 [2.5, 3.42] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 1704 females with CHRONHEP_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 3.58 [2.98, 4.31] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 1151 males with CHRONHEP_NAS died.
Mortality risk
Mortality risk for people of age
years, who have CHRONHEP_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.504% |
| 5 | 1.625% | 3.958% |
| 10 | 3.561% | 9.484% |
| 15 | 6.913% | 18.168% |
| 20 | 12.624% | 29.866% |
Relationships between endpoints
↥Index endpoint: CHRONHEP_NAS – Chronic hepatitis NAS
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data