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Benign neoplasm: Spinal meninges

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_MENINGES_SPINAL

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D32.1&
  • Hospital discharge: ICD-9 — 2254
  • Hospital discharge: ICD-8 — 2254
  • Cause of death: ICD-10 — D32.1&
  • Cause of death: ICD-9 — 2254
  • Cause of death: ICD-8 — 2254

2 out of 7 registries used, show all original rules.

395

4. Check minimum number of events

None

395

5. Include endpoints

None

395

6. Filter based on genotype QC (FinnGen only)

383

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D32
Name in latin
Neoplasma benignum meningum spinalium

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2153 1510 634
Only index persons 1841 1306 535
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.02
Only index persons 0.04 0.05 0.02
Median age at first event (years)
Whole population 62.54 63.92 59.41
Only index persons 61.91 63.16 58.86

-FinnGen-

Key figures

All Female Male
Number of individuals 383 280 103
Unadjusted period prevalence (%) 0.09 0.10 0.05
Median age at first event (years) 62.99 62.93 63.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
395
Matched controls
3950
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
+∞
307.7
370
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
225.3
194
*
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
65.5
169.1
95
19
9530/0-C70.1
ICD-O-3
Meningioma, NOS, of spinal meninges
+∞
90.1
83
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
32.1
79.7
53
19
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
29.6
79.1
54
21
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
17.3
57.2
49
32
D32.01
ICD-10 Finland
Benign tumor of meninges on interhemispheric surface
78.2
53.9
60
9
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
11.7
50.4
55
54
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.5
50.4
98
192
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
15.9
39.6
35
24
9530/0-C70.9
ICD-O-3
Meningioma, NOS, of meninges, NOS
209.6
37.5
38
*
D33.45
ICD-10 Finland
Benign Schwannom in the nerve root of the spinal cord
135.7
35.3
37
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
6.4
33.5
61
110
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
78.8
32.5
36
5
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
31.8
119
389
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
27.8
28.1
38
15
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
277.8
26.0
26
*
NA2DG
NOMESCO Finland
Thoracal spine very extensive MRI examination with high intensity magnet
100.2
26.0
28
*
9560/0-C72.0
ICD-O-3
Schwannoma, NOS, of spinal cord
+∞
24.2
23
*
2254A
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Spinal meninges
+∞
23.1
22
*
N03AX12
ATC
[U] gabapentin; oral
3.2
23.0
116
450
D43.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Spinal cord
+∞
22.1
21
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.4
21.8
97
348
D33.43
ICD-10 Finland
Spinal cord
+∞
21.0
20
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
20.5
150
709
8000/0-C70.1
ICD-O-3
Neoplasm, benign of spinal meninges
+∞
20.0
19
*
NA7FT
NOMESCO Finland
Labeling lesion in spinal area with X-ray guidance
210.1
19.7
20
*
N03AX16
ATC
[U] pregabalin
2.7
19.3
142
670
2312
FHL
Extirpation or destruction
+∞
18.9
18
*
D33.4
ICD-10 Finland
Benign neoplasm: Spinal cord
+∞
18.9
18
*
D32.07
ICD-10 Finland
Secondary or multiple benign tumor of the meninges below the exam
177.2
16.6
17
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.9
16.6
53
151
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
14.6
15.7
26
19
D33.40
ICD-10 Finland
Benign glioma of the spinal cord (grade I)
+∞
15.7
15
*
G992, D321,
ICD-10 Finland
+∞
15.7
15
*
G82.2
ICD-10 Finland
Paraplegia, unspecified
23.2
15.7
22
10
R20.2
ICD-10 Finland
Paraesthesia of skin
3.7
15.5
53
158
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.1
15.1
74
277
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
14.7
64
223
N75
ICPC
Benign neoplasm nervous system
+∞
14.7
14
*
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
44.2
14.2
17
*
L28
ICPC
Limited function/disability (L)
2.4
14.0
123
617
AA1BD
NOMESCO Finland
Extensive CT of head and brain
6.3
14.0
24
40
9531/0-C70.1
ICD-O-3
Meningothelial meningioma of spinal meninges
+∞
13.6
13
*
N18
ICPC
Paralysis/weakness
6.4
13.1
22
36
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.9
13.0
24
43
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.3
12.9
35
88
M03BX01
ATC
baclofen; systemic
5.9
12.6
23
41
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
134.1
12.5
13
*
9537/0-C70.1
ICD-O-3
Transitional meningioma of spinal meninges
+∞
11.5
11
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
16.1
10.9
17
11
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
11.0
10.9
20
19
N06AX21
ATC
duloxetine; oral
2.6
10.7
71
309
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.6
10.7
26
60
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
5.6
10.5
20
37
D42.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Spinal meninges
+∞
10.5
10
*
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
+∞
10.5
10
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
4.4
10.3
26
62
R4110
NOMESCO Finland
Physiotherapy
2.1
10.2
142
843
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.9
10.0
50
188
XKD00
NOMESCO Finland
Uroflowmetry
2.5
9.8
67
295
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
+∞
9.4
9
*
D33.47
ICD-10 Finland
Other benign neurofibromas in the nerve root of the spinal cord
+∞
9.4
9
*
N06AA09
ATC
amitriptyline; systemic
2.5
8.8
59
257
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
51.1
8.7
10
*
D33.30
ICD-10 Finland
Acoustic neuroma
16.7
8.6
13
8
N02AX02
ATC
tramadol; systemic, rectal
1.9
8.5
192
1325
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
91.9
8.4
9
*
ZXH01
NOMESCO Finland
Procedure performed within operation theatre
91.9
8.4
9
*
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
+∞
8.4
8
*
AWC00
NOMESCO Finland
Reoperation of nervous system because of deep wound infection in the nervous system
+∞
8.4
8
*
22540
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Spinal meninges
+∞
8.4
8
*
D33.46
ICD-10 Finland
Benign neurofibroma in the nerve root of the spinal cord
+∞
8.4
8
*
N02BF01
ATC
gabapentin; oral
2.4
8.2
63
292
N03AX14
ATC
levetiracetam; systemic
4.7
8.2
19
42
N28
ICPC
Limited function/disability (N)
6.5
8.1
20
32
M54.4
ICD-10 Finland
Lumbago with sciatica
2.1
8.1
91
494
WX402
NOMESCO Finland
General anaesthesia
2.0
8.1
102
578
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
8.1
98
548
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
7.9
43
169
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.4
7.7
59
273
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
25.6
7.6
10
*
N02BF02
ATC
pregabalin; oral
2.7
7.5
42
167
M48.0
ICD-10 Finland
Spinal stenosis
2.2
7.5
73
374
AWW99
NOMESCO Finland
Other reoperation in surgery of the nervous system
81.6
7.4
8
*
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
81.6
7.4
8
*
XKC03
NOMESCO Finland
Water cystometry
3.6
7.4
24
69
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
+∞
7.3
7
*
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
4.4
7.3
18
42
N02BE01
ATC
paracetamol; systemic, rectal
3.0
7.2
369
3266
AA1AD
NOMESCO Finland
CT of head and brain
1.8
7.2
140
910
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
30.6
7.2
9
*
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
20.5
7.2
10
5
M54.2
ICD-10 Finland
Cervicalgia
2.6
7.1
43
179
ZXD35
NOMESCO Finland
Usual procedure
3.8
7.0
21
57
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
6.9
160
1096
D32.04
ICD-10 Finland
Secondary or multiple benign tumor of the meninges above the exam
23.0
6.7
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
6.7
80
443
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
10.3
6.6
12
12
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.5
6.5
22
65
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.3
6.4
24
76
AAK00
NOMESCO Finland
Cranioplasty
+∞
6.3
6
*
9533/0-C70.1
ICD-O-3
Psammomatous meningioma of spinal meninges
+∞
6.3
6
*
9539/1-C70.0
ICD-O-3
Atypical meningioma of cerebral meninges
+∞
6.3
6
*
9539/1-C70.1
ICD-O-3
Atypical meningioma of spinal meninges
+∞
6.3
6
*
ABC63
NOMESCO Finland
Decompression of thoracic spinal cord
27.1
6.2
8
*
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
27.1
6.2
8
*
H02AB02
ATC
dexamethasone; systemic
2.1
6.2
63
328
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
6.1
282
2308
ZXC40
NOMESCO Finland
Use of ultrasound
12.8
6.1
10
8
M54.6
ICD-10 Finland
Pain in thoracic spine
2.5
6.0
39
167

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Excision of lesion of spinal canal
ABB00 (2001300450)
Meningioma, NOS, of spinal meninges
9530/0-C70.1 (44500955)
Benign tumor of meninges on interhemispheric surface
D32.01 (2000501308)
Benign neoplasm: Spinal meninges
D32.1 (45576389)
Benign tumor of the meninges on the outer surface of the cerebrum
D32.00 (2000501307)
Thoracal spine extensive MRI examination with high intensity magnet
NA2CG (2001307017)
Extirpation of intracranial lesion
AAB00 (2001300256)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Benign neoplasm of brain and other parts of nervous system, Spinal meninges
2254A (2000402130)
Benign Schwannom in the nerve root of the spinal cord
D33.45 (2000501340)
Myelopathy in diseases classified elsewhere and Benign neoplasm: Spinal meninges
G99.2*D32.1 (2000503905)
Thoracal spine MRI examination with high intensity magnet
NA2BG (2001307013)
Intraoperative use of conventional X-ray imaging
ZXM10 (2001311446)
Meningioma, NOS, of meninges, NOS
9530/0-C70.9 (44498989)
Extirpation or destruction
2312 (2000100265)
Extensive MRI examination of brain with high intensity magnet
AA1CG (2001300116)
Physiotherapy
R4110 (2001310233)
General anaesthesia
WX402 (2001310806)
General anesthesia, balanced
WX408 (2001310808)
Respiratory and circulatory monitoring
WX700 (2001310817)
More than one and less than three hours
ZXE10 (2001311401)
More than three and less than five hours
ZXE20 (2001311408)
Physiotherapist
Z3226 (2001311560)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Prothrombin time (PT) actual/Normal
5894-1 (3033658)
Blood type and Crossmatch panel - Blood
34531-4 (3044640)
Oncology Clinic/Center
261QX0200X (38004268)
Neurology
13 (38004458)
Physical Medicine And Rehabilitation
25 (38004468)
Urology
34 (38004474)
Neoplasm, benign of spinal meninges
8000/0-C70.1 (44503436)
Essential (primary) hypertension
I10 (45591453)
ABO and Rh group [Type] in Blood by Confirmatory method
77397-8 (46236098)
Office Visit
OMOP4822458 (581477)
Neurosurgery
14 (38004459)
Outpatient Visit
OP (9202)
Scheduled procedure
ZXD10 (2001311387)
pregabalin; oral
N02BF02 (955152)
Outpatient Hospital
22 (8756)
tramadol; oral, parenteral, rectal
N02AX02 (21604298)
Inpatient Hospital
21 (8717)
Inpatient Visit
IP (9201)
Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
2157-6 (3007220)
gabapentin; oral
N02BF01 (955005)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Supplier / Service Provider
OMOP5117446 (33004)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
amitriptyline; oral, parenteral
N06AA09 (21604696)
Platelets [#/volume] in Blood
26515-7 (3007461)
Blood group antibody screen [Presence] in Serum or Plasma
890-4 (3001079)
MCH [Entitic mass]
28539-5 (3035941)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Emergency Room Visit
ER (9203)
Tissue Pathology biopsy report
66121-5 (40768804)
Limited function/disability (L)
L28 (2002000647)
General Surgery
2 (38004447)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
tizanidine; oral
M03BX02 (21604116)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
Urinalysis microscopic panel [#/volume] - Urine by Automated count
50554-5 (3029287)
Infiltration anesthesia
WX110 (2001310767)
Laboratory Visit
OMOP4822461 (32036)
Implementation of physical therapy rehabilitation plan
SPAT1223 (2001700324)
Case Management Agency
251B00000X (38004193)
paracetamol; oral, parenteral, rectal
N02BE01 (21604344)
Laceration/cut
S18 (2002000983)
pH of Arterial blood
2744-1 (3019977)
Oxygen [Partial pressure] in Arterial blood
2703-7 (3027801)
Carbon dioxide [Partial pressure] in Arterial blood
2019-8 (3027946)
Uroflowmetry
44856007 (4261340)
Base excess in Arterial blood by calculation
1925-7 (3003396)
ibuprofen
R02AX02 (1588667)
ibuprofen; oral, parenteral, rectal
M01AE01 (21603967)
12 lead EKG panel
34534-8 (3044889)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
CBC panel - Blood by Automated count
58410-2 (40761511)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
202
1160
2.52
18.01
2.8
2.4
—
—
—
0
0
109
471
2.82
17.30
4.6
6.6
0.59
1.04
mmol/l
0.58
83
401
107
477
2.71
15.85
4.8
6.6
7.41
7.42
ph
0.83
65
275
302
2175
2.65
15.39
5.8
4.8
6.42
6.68
mmol/l
1.76
290
2058
85
346
2.86
14.91
1.4
1.4
—
—
—
0
0
67
244
3.10
14.30
4.5
7.6
24.22
24.45
mmol/l
0.28
67
239
164
934
2.29
13.98
3.9
3.9
93.03
91.33
%
0.40
157
913
272
1991
2.18
11.43
7.3
6.6
1.21
1.21
mmol/l
0.43
235
1718
213
1468
1.98
10.00
2.4
2.2
—
—
—
0
0
184
1211
1.97
9.83
2.7
2.1
202.50
171.48
u/l
0.22
171
1149
26
65
4.21
9.66
2.2
1.1
—
—
—
0
0
232
1683
1.92
8.98
3.5
2.7
—
—
estimate
—
0
0
244
1812
1.91
8.66
6.7
6.0
1.21
1.21
mmol/l
0.76
222
1667
20
34
6.14
7.79
2.3
1.0
—
—
—
0
0
93
552
1.90
6.30
4.2
5.9
105.28
104.13
mmol/l
1.65
93
552
179
1301
1.69
6.01
4.1
3.4
—
—
—
0
0
228
1782
1.66
5.67
15.9
14.4
1.19
1.24
inr
0.93
194
1451
62
335
2.01
5.49
1.9
2.8
66.40
66.56
g/l
0.06
52
306
65
362
1.95
5.28
4.6
6.0
1.18
1.34
mmol/l
0.78
65
356
221
1734
1.62
5.24
5.6
4.5
35.41
35.41
g/l
0.00
212
1630
230
1847
1.59
4.76
7.1
5.9
0.57
0.58
e9/l
0.27
187
1568
34
153
2.34
4.75
1.3
1.9
9.07
10.56
g/l
2.41
26
135
230
1854
1.58
4.63
7.2
5.9
0.04
0.04
e9/l
0.02
187
1575
62
355
1.89
4.62
3.4
3.9
7.36
7.36
ph
0.04
39
251
60
340
1.90
4.62
5.7
7.0
—
—
—
0
0
144
1046
1.59
4.53
5.3
4.3
—
—
—
0
0
234
1906
1.56
4.41
7.4
6.2
0.17
0.19
e9/l
0.86
193
1649
15
45
3.43
4.37
1.4
1.3
—
—
—
0
0
54
302
1.91
4.32
1.8
2.5
—
—
—
0
0
231
1881
1.55
4.32
7.2
6.0
1.72
1.93
e9/l
1.55
192
1651
69
420
1.78
4.23
1.8
1.7
—
—
—
0
0
167
1283
1.52
3.98
3.6
3.5
27.33
109.58
e6/l
0.91
123
991
214
1734
1.51
3.95
2.3
2.2
98.25
96.77
pmol/l
0.14
108
869
153
1162
1.52
3.81
3.5
2.4
54.09
69.62
u/l
1.60
141
1065
60
363
1.77
3.75
2.1
2.2
0.00
0.04
estimate
0.49
11
69
209
1697
1.49
3.75
8.0
6.1
0.67
0.69
%
0.14
195
1578
76
493
1.67
3.70
5.1
4.8
1.07
1.03
mmol/l
0.83
69
452
210
1712
1.48
3.66
2.7
2.6
79.84
80.01
nmol/l
0.03
191
1521
211
1722
1.48
3.65
7.9
6.1
25.27
27.46
%
2.04
197
1626
209
1704
1.48
3.63
7.9
6.0
2.55
2.80
%
0.93
194
1586
90
613
1.61
3.61
3.1
3.3
1.91
2.67
e6/l
0.60
45
291
288
2510
1.54
3.58
6.4
4.9
—
1.61
—
0
5
209
1707
1.48
3.58
7.6
6.0
59.87
57.62
%
1.79
196
1616
153
1177
1.49
3.53
1.7
1.7
20.96
21.73
nmol/l
0.22
126
989
208
1705
1.46
3.45
8.1
6.1
8.78
8.82
%
0.06
193
1592
236
1986
1.47
3.39
7.9
6.3
11.70
11.30
umol/l
0.07
224
1883
98
691
1.56
3.38
1.9
1.7
1107.10
1218.18
nmol/l
0.61
71
510
171
1355
1.46
3.35
4.1
3.7
—
0.80
—
0
5
61
385
1.69
3.28
2.7
2.0
347.46
381.53
nmol/l
0.68
56
361
34
179
1.98
3.26
2.1
2.2
0.00
0.02
estimate
—
9
53
10
24
4.25
3.21
1.9
1.3
180.50
74.99
ng/l
—
10
24
20
85
2.43
3.20
1.8
1.1
67.45
15.11
e6/l
0.44
11
62
180
1452
1.44
3.16
4.3
4.2
51.41
83.24
e6/l
0.77
126
1025
20
87
2.37
3.06
1.9
1.1
1216.31
153.82
e6/l
0.66
13
66
242
2070
1.44
3.03
10.5
9.6
4.14
4.12
e9/l
0.05
203
1800
142
1103
1.45
3.02
3.7
3.4
0.68
0.51
e6/l
0.36
100
812
254
2193
1.44
3.02
4.4
3.2
43.40
46.54
u/l
0.39
240
2034
173
1396
1.43
2.99
3.5
3.5
2.35
2.36
mmol/l
0.55
158
1261
12
37
3.31
2.96
2.2
1.1
—
—
—
0
0
80
556
1.55
2.92
2.5
2.1
—
—
—
0
0
51
318
1.69
2.88
5.2
4.8
0.73
0.90
%
0.25
22
109
68
458
1.59
2.84
2.1
2.9
1.67
1.82
%
0.87
60
413
149
1180
1.42
2.82
3.2
3.1
28.45
29.90
u/l
0.27
136
1110
360
3365
1.79
2.78
24.9
17.1
21.15
24.24
mg/l
1.45
334
2772
126
974
1.43
2.71
3.0
2.2
3.16
3.03
mg/l
0.25
109
836
48
300
1.68
2.69
5.4
5.0
0.00
0.13
%
2.18
19
91
8
19
4.27
2.69
1.9
3.1
631.88
901.11
u/ml
—
8
19
307
2779
1.47
2.60
11.1
8.2
78.87
79.28
u/l
0.06
294
2613
11
37
3.03
2.50
1.4
1.2
—
—
—
0
0
47
299
1.65
2.47
5.2
4.9
0.36
0.53
%
0.48
22
97
100
756
1.43
2.40
3.3
3.0
514.75
519.18
mosm/kgh2o
0.08
87
658
11
39
2.87
2.36
1.8
1.4
15.20
30.71
ng/l
0.98
11
39
69
487
1.51
2.34
1.7
1.4
—
—
—
0
0
6
13
4.67
2.28
7.8
4.0
—
—
—
0
0
58
397
1.54
2.27
3.5
2.6
4.98
6.88
umol/l
1.97
52
350
5
9
5.61
2.22
1.0
1.3
—
—
—
0
0
28
160
1.81
2.16
5.1
3.6
—
—
—
0
0
17
81
2.15
2.16
1.2
1.2
—
—
—
0
0
191
1629
1.33
2.13
12.8
11.7
0.00
0.00
e9/l
0.67
148
1326
74
540
1.46
2.13
1.4
1.2
—
—
—
0
0
47
311
1.58
2.13
6.0
5.4
0.12
0.18
%
0.16
17
88
59
414
1.50
2.06
3.7
3.2
7.38
7.38
ph
0.15
32
238
59
414
1.50
2.06
3.9
3.2
5.71
5.76
kpa
0.17
59
401
21
111
1.94
2.05
1.5
1.4
28.54
27.41
iu/l
0.05
21
92
12
50
2.44
2.04
1.5
1.8
89.31
90.02
%
0.18
12
50
113
899
1.36
1.98
2.9
2.8
4.80
6.30
e6/l
0.65
102
828
43
284
1.58
1.97
2.3
3.0
9.47
10.65
g/l
1.04
37
265
108
854
1.36
1.96
3.1
2.8
2.45
2.46
mmol/l
0.21
99
766
6
16
3.79
1.94
2.7
2.5
—
—
—
0
0
6
16
3.79
1.94
7.8
3.4
—
—
—
0
0
83
633
1.39
1.88
2.9
2.4
11.08
12.80
umol/l
1.33
73
592
150
1255
1.31
1.85
4.6
4.0
7.39
7.40
ph
0.27
116
894
101
802
1.35
1.78
2.0
1.8
471.29
25574721.04
pmol/l
0.72
83
653
68
509
1.41
1.71
1.5
1.3
741.33
562.17
titre
0.22
15
129
18
97
1.90
1.69
1.8
1.8
3.63
4.84
iu/l
—
6
38
189
1648
1.28
1.66
3.7
3.0
141.98
112.78
ug/l
0.62
176
1513
49
350
1.46
1.59
2.4
2.8
66.22
70.77
e9/l
0.52
35
261
7
26
2.72
1.58
1.0
1.2
—
—
—
0
0
224
2003
1.27
1.58
5.1
4.3
0.00
0.01
estimate
0.69
42
382
30
194
1.59
1.53
3.6
3.8
1.02
1.02
ratio
0.29
25
182
49
355
1.43
1.49
2.2
2.3
33.60
30.07
u/l
0.33
42
291
35
238
1.52
1.45
4.5
3.5
7.42
7.42
ph
0.40
30
196
13
66
2.00
1.45
1.8
2.0
42.92
44.61
nmol/l
0.08
13
66
5
16
3.15
1.44
1.6
1.1
126.40
186.63
mmol/24h
—
5
16
6
22
2.75
1.44
1.0
1.2
—
—
—
0
0
111
924
1.28
1.38
1.4
1.3
—
—
—
0
0
48
352
1.41
1.38
2.3
2.1
0.20
0.21
g/l
0.22
40
332
5
17
2.96
1.36
1.2
2.1
—
—
—
0
0
41
294
1.44
1.33
3.8
2.9
5.98
6.11
ph
0.53
25
204
6
24
2.52
1.31
1.0
1.2
145.33
105.62
pmol/l
—
6
24
59
455
1.35
1.26
1.5
1.7
—
—
—
0
0
17
100
1.73
1.25
3.8
3.1
16.50
1.75
index
—
8
53
61
474
1.34
1.25
1.3
1.3
—
—
—
0
0
104
869
1.27
1.25
1.4
1.3
0.89
1.42
u/ml
0.57
22
216
20
124
1.65
1.23
1.6
4.0
1.47
2.63
ratio
0.98
13
67
79
639
1.30
1.22
2.5
2.8
0.84
0.81
mmol/l
1.62
70
600
129
1108
1.24
1.22
5.4
4.4
0.00
0.01
estimate
0.50
42
371
5
19
2.65
1.22
2.8
1.6
44.54
42.61
%
—
5
19
168
1485
1.23
1.21
4.4
4.0
32.53
54.24
ng/l
0.46
133
1120
102
855
1.26
1.19
1.9
1.7
1.02
1.31
mg/l
0.73
83
689
59
460
1.33
1.18
5.7
3.2
3.93
5.59
e9/l
1.11
42
402
218
1983
1.22
1.18
4.9
4.3
0.00
8.46
estimate
0.80
45
414
341
3262
1.33
1.16
7.4
7.0
39.44
39.63
mmol/mol
0.16
314
3037
216
1966
1.22
1.15
4.9
4.3
0.00
0.00
estimate
-0.00
45
405
5
21
2.40
1.09
1.0
1.0
—
—
—
0
0
5
21
2.40
1.09
1.4
4.4
56.80
168.67
nmol/l
—
5
21
10
52
1.95
1.07
1.5
1.3
—
—
—
0
0
7
33
2.14
1.06
1.7
1.9
10.30
9.90
%
—
7
33
16
251
0.62
1.06
1.6
1.4
—
—
—
0
0
56
442
1.31
1.04
1.2
1.3
—
—
—
0
0
5
22
2.29
1.03
1.0
1.4
78.00
73.18
umol/l
—
5
22
337
3233
1.29
1.00
6.7
5.7
1.80
1.96
mu/l
1.91
311
2956
7
35
2.02
1.00
1.0
1.1
—
2.08
—
0
10
7
36
1.96
0.97
1.0
1.0
—
—
—
0
0
56
447
1.29
0.97
3.2
4.2
2.79
18.73
ug/l
1.03
45
374
53
421
1.30
0.95
1.6
1.5
—
—
—
0
0
9
51
1.78
0.95
2.4
3.1
—
—
—
0
0
21
143
1.49
0.92
1.0
1.1
—
—
—
0
0
6
29
2.08
0.89
1.0
1.3
—
—
—
0
0
8
42
1.92
0.89
1.3
1.0
—
—
—
0
0
71
591
1.25
0.89
2.9
2.4
2.26
2.32
g/l
0.31
62
552
55
445
1.27
0.87
2.3
2.1
85.65
129.60
ug/g
1.10
43
344
16
104
1.56
0.86
4.1
4.3
—
—
—
0
0
19
131
1.47
0.80
3.9
2.8
374.88
211.95
mg/l
—
8
44
40
316
1.30
0.77
3.1
2.6
3.29
4.93
ug/l
1.57
35
280
364
3549
1.33
0.77
16.1
12.8
25.69
24.38
u/l
0.34
356
3435
148
1339
1.17
0.77
3.3
3.2
6.26
7.01
mmol/l
1.66
123
1107
66
555
1.23
0.76
3.0
2.4
20.73
22.31
%
0.35
56
525
43
344
1.28
0.76
1.5
1.5
—
—
—
0
0
85
735
1.20
0.75
5.7
5.8
2.62
2.48
ug/l
0.09
76
660
140
1265
1.17
0.73
3.3
3.2
1376.81
1181.07
ng/l
0.25
130
1086
86
746
1.20
0.73
5.0
4.1
122.19
197.12
ng/l
0.31
72
608
86
747
1.19
0.72
1.6
1.4
1.96
2.50
g/l
2.80
46
422
17
118
1.46
0.70
6.2
4.0
26.26
25.44
mmol/l
0.40
17
112
25
187
1.36
0.70
5.2
3.1
24.79
25.14
mmol/l
0.18
25
182
146
1331
1.15
0.68
4.0
4.0
13.04
7.22
mg/mmol
0.46
88
781
7
43
1.64
0.67
1.4
2.1
—
—
—
0
0
82
720
1.18
0.62
1.4
1.3
31.08
38.25
iu/ml
0.22
30
211
126
1146
1.15
0.60
6.6
6.4
—
—
—
0
0
172
1598
1.14
0.59
4.3
3.8
6.31
6.25
ph
0.29
86
879
32
256
1.27
0.59
4.4
2.8
123.16
127.40
g/l
0.68
32
248
15
106
1.43
0.58
2.3
2.4
1.34
1.50
mg/l
0.34
15
93
6
35
1.73
0.58
1.2
1.5
—
—
—
0
0
16
115
1.41
0.57
1.0
1.1
—
—
—
0
0
6
38
1.59
0.54
1.2
1.2
—
—
—
0
0
108
1186
0.88
0.54
3.2
3.6
—
—
—
0
0
29
233
1.26
0.52
1.2
1.3
—
—
—
0
0
17
127
1.35
0.50
1.2
1.4
0.22
0.27
mg/l
—
5
53
16
119
1.36
0.49
1.9
1.3
282.09
307.21
ug/g
0.19
11
70
15
111
1.37
0.47
2.3
1.6
6781.70
20595.69
e6/l
—
10
75
10
68
1.48
0.47
1.0
1.4
—
—
—
0
0
10
68
1.48
0.47
1.0
1.4
—
—
—
0
0
10
68
1.48
0.47
1.0
1.4
—
—
—
0
0
140
1301
1.12
0.47
3.5
3.3
59.66
38.24
mg/l
0.33
89
791
7
49
1.44
0.46
2.1
1.3
—
—
—
0
0
23
183
1.27
0.46
2.5
2.4
—
—
—
0
0
14
103
1.37
0.46
5.8
9.4
—
—
—
0
0
7
50
1.41
0.45
1.1
1.2
—
—
—
0
0
10
69
1.46
0.44
1.0
1.4
—
—
—
0
0
36
304
1.20
0.44
1.1
1.1
—
—
—
0
0
85
770
1.13
0.43
5.4
5.2
—
—
—
0
0
351
3443
1.17
0.43
21.5
15.3
—
—
—
0
0
5
32
1.57
0.42
1.0
1.2
—
—
—
0
0
5
32
1.57
0.42
1.0
1.3
—
—
—
0
0
13
96
1.37
0.42
1.2
1.7
—
—
—
0
0
342
3350
1.16
0.41
6.0
5.6
5.88
5.97
mmol/l
1.01
312
3054
5
33
1.52
0.41
1.6
1.2
—
—
—
0
0
5
34
1.48
0.40
4.6
2.8
—
—
—
0
0
95
1031
0.90
0.39
4.9
3.8
0.00
0.00
estimate
0.50
39
326
50
440
1.16
0.39
3.0
3.3
1.05
0.76
ug/l
0.33
33
291
11
80
1.39
0.39
1.8
1.4
—
—
—
0
0
9
67
1.35
0.38
1.0
1.4
—
—
—
0
0
5
37
1.36
0.37
3.2
2.0
—
—
—
0
0
11
81
1.37
0.36
2.8
3.3
—
—
—
0
0
9
121
0.74
0.35
1.6
1.2
—
—
—
0
0
6
42
1.44
0.35
1.2
1.9
—
—
—
0
0
6
44
1.37
0.34
1.0
1.1
—
—
—
0
0
18
147
1.24
0.31
1.2
1.3
—
—
—
0
0
286
2790
1.09
0.30
5.5
4.5
15.09
14.93
pmol/l
0.47
263
2529
21
176
1.20
0.29
1.8
2.1
3.27
6.68
iu/ml
—
6
47
366
3618
1.16
0.28
37.0
26.3
4.38
4.41
e12/l
0.58
361
3524
366
3618
1.16
0.28
37.2
26.3
6.83
6.68
e9/l
0.56
361
3524
13
104
1.26
0.26
1.8
2.2
55.22
56.93
%
0.11
13
99
149
1553
0.93
0.24
2.0
2.0
1.42
1.32
mmol/l
1.00
129
1285
6
84
0.71
0.24
1.2
1.2
1.50
1.59
g/l
—
6
84
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
26
230
1.14
0.21
3.2
2.3
0.57
0.62
%
0.60
26
230
0
14
0.00
0.20
0.0
4.0
—
51.75
—
0
14
18
207
0.86
0.19
1.9
2.1
—
—
—
0
0
11
92
1.20
0.16
1.1
1.2
—
116.25
—
0
8
26
235
1.11
0.16
3.2
2.3
1.07
1.16
%
0.25
26
235
21
188
1.12
0.15
1.2
1.3
—
—
—
0
0
7
87
0.80
0.14
1.1
1.2
0.82
0.90
g/l
—
7
87
95
915
1.05
0.13
3.3
2.8
330.19
336.94
umol/l
0.25
84
782
85
884
0.95
0.13
5.1
4.4
1.02
1.02
kg/l
0.49
57
588
31
334
0.92
0.13
1.9
1.5
—
—
—
0
0
5
45
1.11
0.10
1.0
1.4
—
—
—
0
0
344
3417
1.05
0.09
6.5
6.4
2.68
2.67
mmol/l
0.06
317
3125
6
54
1.11
0.09
1.0
1.0
—
—
—
0
0
6
57
1.05
0.08
3.8
2.5
—
—
—
0
0
6
58
1.04
0.08
1.2
1.1
—
—
—
0
0
63
652
0.96
0.08
1.4
1.3
2.14
13.11
u/ml
3.19
28
238
27
254
1.07
0.08
1.3
1.3
—
—
—
0
0
16
173
0.92
0.07
1.7
1.7
—
—
—
0
0
15
138
1.09
0.06
1.7
1.3
—
—
—
0
0
11
121
0.91
0.06
2.5
1.8
—
—
—
0
0
273
2746
0.98
0.04
31.2
22.9
330.79
330.78
g/l
0.00
273
2731
10
92
1.09
0.03
2.2
1.2
—
—
—
0
0
336
3350
1.02
0.02
5.7
5.5
4.63
4.65
mmol/l
0.11
311
3075
25
242
1.04
0.02
1.2
1.2
87.33
130.77
u/ml
—
8
90
319
3199
0.99
0.02
4.8
4.5
1.27
1.26
mmol/l
0.07
284
2892
333
3338
0.98
0.01
5.7
5.4
1.50
1.53
mmol/l
0.46
304
3049
30
293
1.03
0.01
5.9
4.4
—
—
—
0
0
18
178
1.01
0.00
1.1
1.2
—
—
—
0
0
148
1478
1.00
0.00
5.3
4.3
0.00
0.03
estimate
1.47
41
335
14
143
0.98
0.00
3.1
2.9
—
—
—
0
0
20
196
1.02
0.00
1.9
1.9
3.29
3.37
mmol/l
0.12
15
156
7
75
0.93
0.00
1.0
1.2
1.09
0.90
nmol/l
—
7
58
8
82
0.98
0.00
3.4
2.5
8.06
8.80
pmol/l
—
8
82
5
56
0.89
-0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
-0.00
1.8
1.4
—
—
—
0
0
5
52
0.96
-0.00
1.6
2.4
4.20
4.00
mmol/l
—
5
52
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
2.57
—
0
7
5
52
0.96
-0.00
1.6
2.4
106.00
105.94
mmol/l
—
5
52
5
52
0.96
-0.00
1.6
2.4
1.19
1.19
mmol/l
—
5
52
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
56
0.89
-0.00
1.8
1.4
—
—
—
0
0
5
56
0.89
-0.00
1.8
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
7.24
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
0.02
—
0
6
6
59
1.02
-0.00
3.5
2.1
30.67
31.98
pg
—
6
59
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
68.57
—
0
7
0
9
0.00
-0.00
0.0
2.2
—
150.56
—
0
9

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_MENINGES_SPINAL and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_MENINGES_SPINAL 1.32 [1.11, 1.57] 0.002
Birth year 0.995 [0.99, 1.0] 0.287

During the follow-up period (1.1.1998 — 31.12.2019), 262 out of 1097 females with CD2_BENIGN_MENINGES_SPINAL died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_MENINGES_SPINAL 1.558 [1.19, 2.03] 0.001
Birth year 0.986 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 448 males with CD2_BENIGN_MENINGES_SPINAL died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MENINGES_SPINAL.

N-year risk Females Males
1 0.099% 0.339%
5 0.788% 1.945%
10 2.149% 4.442%
15 3.812% 8.205%
20 6.545% 13.631%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_MENINGES_SPINAL – Benign neoplasm: Spinal meninges

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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