Benign neoplasm: Lymph nodes

CD2_BENIGN_LYMPHNODES

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D36.0& Hospital discharge: ICD-9 — 2298A Cause of death: ICD-10 — D36.0& Cause of death: ICD-9 — 2298A 2 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	96

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D36
Name in latin: Neoplasma benignum lymphonodorum

NAME	CD2_BENIGN_LYMPHNODES
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D360
HD_ICD_9	2298A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D360
COD_ICD_9	2298A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Lymph nodes based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	852	474	370
Only index persons	714	415	299
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	49.64	50.35	48.54
Only index persons	47.74	49.63	45.12

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	96	65	31
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	47.21	45.81	50.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
98: Matched controls
980

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D36.0

ICD-10 Finland

Benign neoplasm: Lymph nodes

+∞

133.0

PJD41

NOMESCO Finland

Excision of cervical lymph nodes

46.5

16.1

PJA10

NOMESCO Finland

Exploration of lymph nodes

43.2

6.9

R22.1

ICD-10 Finland

Localized swelling, mass and lump, neck

9.8

6.8

R59.0

ICD-10 Finland

Localized enlarged lymph nodes

8.6

6.4

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.8

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768795) Lymph node Pathology biopsy report

10.54

3.54

1.0

—

(21494815) CD4 cells/Lymphocytes in Specimen

7.89

3.10

2.2

1.0

38.55

40.80

—

(3006315) Basophils [#/volume] in Blood

452

2.10

3.06

9.0

6.1

0.05

0.04

e9/l

0.57

397

(3001604) Monocytes [#/volume] in Blood

453

2.09

3.02

8.8

6.1

0.57

0.58

e9/l

0.08

399

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

10.43

3.01

1.8

3.0

—

(3013115) Eosinophils [#/volume] in Blood

467

2.07

2.90

9.0

6.7

0.20

0.19

e9/l

0.12

414

(3006504) Eosinophils/Leukocytes in Blood

412

2.00

2.80

9.0

5.8

2.90

2.81

0.11

391

(3019198) Lymphocytes [#/volume] in Blood

461

2.03

2.79

8.8

6.1

1.91

1.80

e9/l

0.68

415

(3008757) Leukocyte morphology finding [Identifier] in Blood

8.69

2.78

1.6

4.7

—

(3023520) Reticulocytes [#/volume] in Blood

2.62

2.73

8.0

3.4

66.07

76.42

e9/l

0.53

(3023368) Bacteria identified in Blood by Culture

227

2.01

2.68

5.8

4.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

5.73

2.58

1.2

1.4

—

(3048689) Calprotectin [Mass/mass] in Stool

122

2.16

2.42

2.2

2.8

84.00

149.66

ug/g

0.80

100

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.39

2.30

2.1

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

473

1.85

2.19

5.1

4.2

0.00

estimate

-0.00

106

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

105

2.14

2.15

6.0

3.8

257.70

246.58

u/l

0.09

(3035350) Ketones [Presence] in Urine by Test strip

479

1.80

2.04

5.1

4.3

0.00

14.76

estimate

0.50

110

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

345

1.77

2.02

3.6

3.9

27.14

38.63

ng/l

0.53

234

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.28

1.98

2.2

1.4

—

(3026008) Bacteria identified in Urine by Culture

283

1.77

1.97

3.6

3.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

3.92

1.96

1.2

2.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

215

1.81

1.91

5.3

4.9

—

(3009261) Glucose [Presence] in Urine by Test strip

485

1.76

1.90

5.1

4.3

0.00

estimate

-0.00

100

(3005322) IgE [Units/volume] in Serum or Plasma

2.35

1.87

1.6

1.3

581.42

408.11

u/ml

0.15

(3019150) Specific gravity of Urine by Refractometry

209

1.79

1.83

5.7

4.5

1.01

1.02

kg/l

0.61

142

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

362

1.71

1.82

5.1

4.2

0.00

0.01

estimate

0.49

(42870588) Differential panel, method unspecified - Blood

298

1.72

1.80

8.3

5.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.82

1.61

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

3.45

1.54

1.2

1.9

48.40

60.25

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.84

1.46

3.0

5.2

—

(3015736) pH of Urine

379

1.59

1.42

5.0

3.9

6.17

6.18

0.02

219

(3037522) Nuclear Ab [Titer] in Serum

138

1.77

1.42

2.0

1.5

257.78

756.36

titre

—

(3037756) Immunofixation for Serum or Plasma

3.04

1.37

2.4

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

173

1.68

1.37

1.6

1.4

1.28

11.09

u/ml

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

132

1.75

1.34

2.6

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

100

1.85

1.34

2.6

1.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.40

1.30

1.8

2.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

118

1.76

1.26

4.3

4.1

1.04

1.01

mmol/l

0.19

108

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

194

1.62

1.26

1.6

1.3

11.36

26.62

iu/ml

—

(3041096) Erythrocytes [Presence] in Urine by Automated

275

1.55

1.24

3.9

3.5

0.00

estimate

-0.00

(3027315) Oxygen [Partial pressure] in Blood

2.72

1.23

3.8

2.8

8.36

8.79

kpa

—

(3024928) Oxygen saturation in Venous blood

2.72

1.23

1.2

2.2

49.22

62.37

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.72

1.23

3.8

2.8

5.14

4.91

kpa

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.72

1.23

1.0

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.82

1.23

2.7

2.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.20

1.21

2.4

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.83

1.19

4.7

3.8

—

(3044290) Cell count panel - Cerebral spinal fluid

2.58

1.16

1.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.58

1.16

2.0

2.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

512

1.51

1.13

12.7

10.2

3.95

4.09

e9/l

0.23

454

(3029937) Albumin [Presence] in Urine by Test strip

272

1.51

1.10

4.7

4.3

0.00

estimate

—

101

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

166

1.59

1.08

4.7

3.0

141.06

89.75

ng/l

0.30

110

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

436

1.47

1.06

9.9

6.2

1.23

1.21

mmol/l

0.62

367

(4035726) Immunohistochemistry procedure

1.82

1.05

1.6

1.3

—

(3012544) pH of Venous blood

1.74

1.04

2.3

3.1

7.37

7.39

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

185

1.55

1.04

2.4

2.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

159

1.58

1.04

2.4

1.6

—

(3030467) Casts [#/volume] in Urine by Automated count

267

1.48

1.02

3.0

2.9

0.67

0.52

e6/l

0.12

196

(40768804) Tissue Pathology biopsy report

352

1.45

1.00

2.5

2.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.02

0.99

1.1

1.4

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.02

0.99

5.1

2.6

27.00

43.74

u/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.77

0.97

2.6

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.30

0.95

2.2

2.6

—

(3018418) pH of Serum or Plasma

280

1.45

0.94

8.1

3.8

7.41

7.40

0.98

209

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.22

0.93

1.7

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

319

1.43

0.91

3.3

3.2

—

(3008898) HLA-B27 [Presence]

1.94

0.90

1.0

1.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

228

1.46

0.88

1.6

1.3

0.85

1.87

u/ml

0.71

(3019060) Gas panel - Arterial blood

1.85

0.86

4.1

5.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.76

0.83

1.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

168

1.48

0.81

1.6

1.8

682.00

503.11

pmol/l

0.56

143

(3017143) Hepatitis C virus Ab [Presence] in Serum

125

1.54

0.80

2.4

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

205

1.44

0.79

1.9

0.77

1.43

mg/l

1.05

165

(3019832) Treponema pallidum Ab [Presence] in Serum

100

1.59

0.78

1.9

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.70

0.76

2.8

6.7

25.79

25.12

mmol/l

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

171

1.45

0.75

1.6

2.4

2.52

2.45

mmol/l

1.15

152

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.05

0.74

1.0

1.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.97

0.71

2.2

1.8

—

(3010421) pH of Blood

1.97

0.71

3.8

2.7

7.41

7.42

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

111

1.53

0.71

2.2

2.1

—

(3020891) Body temperature

1.72

0.70

3.4

4.1

36.87

36.98

°c

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

1.90

0.69

1.4

1.5

—

17.76

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.90

0.69

1.4

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.68

0.68

1.3

1.6

—

(3045414) Leukocytes [Presence] in Urine

1.57

0.67

1.7

2.1

—

0.00

estimate

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

211

1.39

0.67

2.0

—

(3018095) Leukocytes [#/volume] in Urine

363

1.33

0.65

4.1

3.9

27.10

61.79

e6/l

1.04

250

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.76

0.64

1.0

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.76

0.64

1.4

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.76

0.64

1.4

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.76

0.64

1.4

1.1

—

(3032080) INR in Blood by Coagulation assay

393

1.32

0.64

19.1

14.2

1.25

1.24

inr

0.03

334

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.69

0.64

2.8

2.4

25.13

24.78

mmol/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.69

0.64

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

114

1.48

0.64

1.4

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.52

0.63

2.3

2.1

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.63

0.61

2.2

1.5

1.27

1.22

g/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.48

0.58

3.1

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

198

1.35

0.57

2.0

1.5

2.63

2.70

g/l

0.06

113

(40761535) Cells panel - Urine sediment

1.58

0.57

3.6

4.1

—

(3025941) Bacteria identified in Stool by Culture

1.52

0.56

1.1

1.2

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

390

1.28

0.55

6.3

4.8

35.06

35.72

g/l

0.32

375

(3019977) pH of Arterial blood

101

1.45

0.53

5.9

6.5

7.40

7.42

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

166

1.34

0.48

1.4

1.6

—

(3002256) Pathology report gross observation

103

1.42

0.48

1.4

1.2

—

(40761511) CBC panel - Blood by Automated count

868

0.71

0.48

25.2

14.1

—

(3017732) Neutrophils [#/volume] in Blood

130

1.37

0.48

3.4

3.5

3.92

6.30

e9/l

0.69

116

(3044640) Blood type and Crossmatch panel - Blood

290

1.26

0.46

3.6

2.1

—

(1761868) Lipid panel - Serum or Plasma

362

0.79

0.45

3.3

3.1

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.47

0.44

1.1

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

1.64

0.43

1.6

1.5

—

1.61

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

1.64

0.43

1.6

1.5

—

3.87

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.41

0.43

2.1

1.9

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

4.5

—

26.18

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

15.03

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.36

0.41

1.4

1.9

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.50

0.41

1.6

1.5

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

313

1.24

0.41

3.8

3.4

49.78

28.69

u/l

0.47

298

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.45

0.40

1.4

2.4

232.20

194.57

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

422

1.22

0.39

4.6

2.6

—

estimate

—

(3000764) Benzodiazepines [Presence] in Urine

1.41

0.39

1.2

1.5

—

(3027008) Opiates [Presence] in Urine

1.41

0.39

1.2

1.5

—

(3028300) Cannabinoids [Presence] in Urine

1.41

0.39

1.2

1.5

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.36

0.36

2.4

2.7

0.23

0.22

g/l

0.20

(40768797) Stomach Pathology biopsy report

130

0.74

0.32

1.2

1.3

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.23

0.27

2.9

3.0

107.38

77.89

ng/l

—

(40758558) Short blood count panel - Blood

274

0.84

0.27

9.3

6.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.27

0.26

2.7

2.0

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.26

0.26

5.9

3.6

1.20

1.23

mmol/l

—

(3027944) Amphetamines [Presence] in Urine

1.37

0.24

1.2

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.76

0.23

9.0

7.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.5

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.5

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.21

0.0

1.7

—

837.30

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.3

—

287.33

—

(1002224) Polysomnography panel

1.24

0.20

1.2

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.20

0.0

1.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.21

0.20

1.0

—

(36304419) Bacteria [Presence] in Urine

253

1.15

0.20

3.2

2.9

—

estimate

—

(40761536) Microorganisms panel - Urine sediment

1.26

0.19

3.4

3.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

158

1.17

0.18

1.8

1.5

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

121

1.18

0.16

1.5

1.8

1.71

1.45

0.32

105

(36660697) Celiac disease serology panel - Serum

1.17

0.16

1.1

1.2

—

(3003694) ABO and Rh group [Type] in Blood

253

0.88

0.16

2.1

1.5

—

(3000991) Gas panel - Venous blood

1.14

0.15

2.9

5.7

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.14

0.15

2.4

2.6

0.12

0.14

e6/l

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

161

1.14

0.14

4.3

2.7

0.77

0.80

mmol/l

1.04

154

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.04

0.09

1.4

40.62

27.68

iu/l

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.03

0.08

1.9

2.4

5.71

4.91

ug/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

852

0.90

0.07

28.3

15.8

22.29

22.56

mg/l

0.03

693

(3000492) Spirometry study

0.88

0.07

1.0

1.4

—

(3021589) Normoblasts [#/volume] in Blood

419

1.05

0.04

20.8

11.0

0.00

e9/l

0.50

344

(3020682) Albumin/Creatinine [Ratio] in Urine

259

0.95

0.03

4.2

4.1

36.32

10.04

mg/mmol

0.41

171

(3042936) Bacteria identified in Isolate by Culture

134

1.05

0.00

2.9

2.1

—

(3022145) Colonoscopy Study observation

122

0.98

0.00

1.8

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

147

1.02

0.00

3.4

4.2

20.78

22.78

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

565

0.98

0.00

4.3

3.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

365

0.98

0.00

2.4

1.8

1.63

1.37

mmol/l

0.86

305

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

115

0.95

0.00

2.9

2.6

0.79

0.78

ug/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

125

1.05

0.00

4.8

5.8

104.38

103.74

mmol/l

0.22

125

(3012516) Albumin [Mass/volume] in Urine

251

0.99

0.00

3.3

3.4

126.09

60.95

mg/l

0.35

173

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.05

0.00

1.4

1.6

—

(3000494) Fungus identified in Specimen by Culture

111

0.99

0.00

3.5

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

386

1.02

0.00

2.4

2.0

90.83

98.41

pmol/l

0.58

188

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.3

—

1415.00

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.5

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.7

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.3

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.8

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.0

—

118.80

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

4.60

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.2

—

6.12

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.5

—

107.00

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.85

-0.00

3.8

7.7

94.70

93.39

—

(21494755) Public health laboratory ask at order entry panel

0.97

-0.00

1.4

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

3.2

—

0.67

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

9.4

—

991.80

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.4

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3044007) Cell count panel - Peritoneal fluid

0.00

-0.00

0.0

1.4

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

51.57

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

40.40

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.93

-0.00

2.0

3.2

18.33

61.84

u/ml

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

18.50

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.7

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

139.60

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

19.0

—

1834.67

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_LYMPHNODES and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_LYMPHNODES	1.777 [1.35, 2.34]	< 0.001
Birth year	1.0 [0.99, 1.01]	0.901

During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 393 females with CD2_BENIGN_LYMPHNODES died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_LYMPHNODES	2.227 [1.65, 3.0]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.086

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 327 males with CD2_BENIGN_LYMPHNODES died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_LYMPHNODES.

N-year risk	Females	Males
1	0.232%	0.424%
5	1.325%	2.999%
10	3.068%	7.057%
15	5.479%	13.282%
20	9.918%	22.164%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_LYMPHNODES – Benign neoplasm: Lymph nodes

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Lymph nodes

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints