No definition available.
Benign neoplasm: Central nervous system, other parts/unspecified
CD2_BENIGN_CNS_NOS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
152 |
4. Check minimum number of eventsNone |
152 |
5. Include endpointsNone |
152 |
6. Filter based on genotype QC (FinnGen only) |
133 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D33
- Name in latin
- Neoplasma benignum alterius partis specificatae systematis nervosi centralis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Central nervous system, other parts/unspecified
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of brain and other parts of central nervous system
- Benign neoplasms
- Neoplasms
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1132 | 596 | 527 |
| Only index persons | 873 | 465 | 408 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 48.75 | 50.58 | 46.64 |
| Only index persons | 46.11 | 47.21 | 44.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 133 | 70 | 63 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 50.01 | 51.47 | 48.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 138
- Matched controls
- 1380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
+∞
139.1
109
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.7
20.0
38
74
2259X
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Nervous system, part unspecified
+∞
18.1
17
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
33.0
15.7
20
7
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
13.8
13
*
XCK00
NOMESCO Finland
Perimetry
6.2
12.3
23
43
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
12.1
11.2
20
19
22599
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Unspecified site
+∞
10.5
10
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
28.4
10.0
13
5
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
32.6
9.6
12
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.3
8.9
19
40
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.0
8.8
28
82
D33.30
ICD-10 Finland
Acoustic neuroma
95.7
8.5
9
*
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
95.7
8.5
9
*
9560/0-C72.9
ICD-O-3
Schwannoma, NOS, of nervous system, NOS
+∞
8.4
8
*
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
+∞
7.4
7
*
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
+∞
7.4
7
*
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
23.9
6.8
9
*
D33.07
ICD-10 Finland
Colloid coast in cerebral ventricle
73.1
6.5
7
*
2152
FHL
Extraction, big brain
+∞
6.3
6
*
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
45
234
2.37
4.99
2.6
2.6
2.43
2.45
mmol/l
0.69
38
205
49
272
2.24
4.62
2.4
2.7
—
—
—
0
0
30
141
2.44
4.09
4.7
7.7
—
—
—
0
0
30
145
2.37
3.84
6.4
14.0
0.82
1.07
mmol/l
0.15
25
123
64
418
1.99
3.80
2.5
3.5
2.37
2.36
mmol/l
0.41
56
372
19
81
2.56
3.15
1.2
1.1
25.87
124.92
u/ml
—
6
30
72
521
1.80
2.89
3.3
3.1
—
—
estimate
—
0
0
8
20
4.18
2.61
2.1
1.5
0.16
0.16
nmol/l
—
8
12
31
183
1.90
2.34
7.0
9.1
104.48
103.93
mmol/l
0.22
31
183
53
374
1.68
2.18
4.9
4.0
0.00
0.03
estimate
0.74
17
112
105
894
1.73
2.00
5.9
4.3
14.86
14.76
pmol/l
0.15
99
811
17
88
2.06
1.84
2.9
2.6
69.00
64.26
ml/min/173m2
—
5
31
9
35
2.68
1.84
1.3
1.3
—
—
—
0
0
40
275
1.64
1.78
2.0
2.0
0.84
1.56
mg/l
1.38
33
228
81
661
1.55
1.70
4.7
4.0
0.00
0.00
estimate
-0.00
17
122
104
899
1.64
1.69
4.9
4.4
10.77
12.32
mm/h
0.56
97
830
75
604
1.53
1.66
8.9
9.8
1.21
1.21
mmol/l
0.06
66
525
86
715
1.54
1.63
7.2
10.6
4.55
4.14
e9/l
0.78
75
630
81
665
1.53
1.63
4.7
4.0
0.00
12.79
estimate
0.50
17
127
81
670
1.51
1.54
4.7
4.1
0.00
0.00
estimate
-0.00
17
118
19
110
1.84
1.52
8.5
11.0
1.31
1.29
mmol/l
0.05
19
110
9
38
2.46
1.49
1.3
1.7
—
—
—
0
0
56
440
1.46
1.32
3.6
3.6
—
—
—
0
0
60
478
1.45
1.32
4.4
3.8
40.98
31.01
ng/l
0.18
47
351
125
1158
1.84
1.28
20.3
16.6
21.92
23.73
mg/l
0.28
107
944
29
202
1.55
1.21
1.8
1.7
1377.33
1248.06
nmol/l
0.33
24
148
5
20
2.55
1.16
2.8
3.2
125.14
187.50
u/ml
—
5
20
32
230
1.51
1.16
1.4
1.3
15.78
31.16
iu/ml
—
10
75
40
302
1.46
1.14
4.6
4.1
1.02
1.02
kg/l
0.32
28
197
7
31
2.32
1.12
1.1
2.8
—
—
—
0
0
7
35
2.05
1.01
1.1
1.2
—
—
—
0
0
7
35
2.05
1.01
1.1
1.2
—
—
—
0
0
17
109
1.64
0.99
1.2
1.4
—
—
—
0
0
7
37
1.94
0.95
2.7
2.3
0.00
0.00
g/l
—
7
37
60
502
1.35
0.92
5.0
3.9
0.00
0.03
estimate
0.50
11
101
125
1178
1.65
0.91
25.1
19.9
3.93
3.98
mmol/l
1.50
125
1153
125
1178
1.65
0.91
25.4
19.8
139.72
139.59
mmol/l
0.23
125
1156
114
1059
1.44
0.84
7.0
5.4
1.76
1.92
mu/l
0.81
108
960
41
498
0.75
0.79
1.8
2.0
1.50
1.37
mmol/l
0.43
36
418
5
24
2.12
0.75
1.2
1.3
—
—
—
0
0
12
76
1.63
0.74
2.1
5.5
23.89
24.56
mmol/l
0.20
12
76
10
60
1.72
0.74
4.6
4.1
24.78
24.43
mmol/l
—
10
60
36
289
1.33
0.71
2.5
2.1
2.87
2.80
mg/l
0.08
31
260
17
121
1.46
0.66
2.1
2.8
0.22
0.22
g/l
0.02
17
111
62
543
1.26
0.63
3.0
2.8
77.88
75.71
nmol/l
0.38
56
486
8
51
1.60
0.61
2.1
1.8
0.86
6.35
ug/l
—
8
45
0
21
0.00
0.60
0.0
1.7
—
—
—
0
0
13
89
1.51
0.60
9.4
11.2
25.92
25.03
mmol/l
0.52
13
89
59
516
1.25
0.60
2.6
2.2
91.64
94.47
pmol/l
0.23
36
270
26
205
1.33
0.58
1.4
1.3
1.30
7.97
u/ml
—
9
83
6
36
1.70
0.57
1.2
1.4
—
—
—
0
0
6
37
1.65
0.56
1.2
1.9
—
—
—
0
0
9
61
1.51
0.55
1.1
1.3
—
—
—
0
0
30
245
1.29
0.53
1.9
1.8
487.83
453.70
pmol/l
0.25
24
205
6
40
1.52
0.52
1.8
1.1
—
—
—
0
0
27
219
1.29
0.50
1.9
1.6
—
—
—
0
0
5
31
1.64
0.43
1.2
1.4
—
—
—
0
0
5
33
1.53
0.42
1.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
17.30
—
0
15
5
34
1.49
0.41
1.4
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.8
—
—
—
0
0
116
1115
1.25
0.38
20.7
15.4
82.47
80.95
ml/min/173m2
0.35
110
1035
115
1105
1.24
0.38
4.9
4.4
1.23
1.26
mmol/l
0.28
105
1006
26
218
1.24
0.38
1.8
1.9
—
—
—
0
0
42
374
1.18
0.34
2.0
1.7
16.05
22.11
nmol/l
2.71
37
313
6
46
1.32
0.33
3.0
3.0
204.67
202.61
%
—
6
46
10
75
1.36
0.31
4.3
2.7
0.74
0.64
%
—
10
75
7
54
1.31
0.31
3.7
2.0
—
—
—
0
0
80
753
1.15
0.30
3.6
3.2
—
—
—
0
0
17
204
0.81
0.29
3.1
3.6
5.78
2.72
e6/l
—
9
107
10
76
1.34
0.29
4.3
2.6
1.40
1.32
%
—
10
76
8
67
1.21
0.27
1.0
1.1
—
—
—
0
0
125
1223
1.23
0.24
27.6
21.2
76.27
78.46
umol/l
0.46
125
1211
5
38
1.33
0.23
2.2
1.9
—
—
—
0
0
5
39
1.29
0.23
5.0
4.0
1.80
4.67
ratio
—
5
18
15
126
1.21
0.22
1.5
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
214.16
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
14
118
1.21
0.20
4.6
3.5
—
—
—
0
0
27
243
1.14
0.19
3.8
3.7
16.83
284.19
ng/l
1.44
18
182
11
131
0.83
0.18
2.4
4.1
2.15
44.76
ug/l
0.71
11
107
8
68
1.19
0.17
1.3
1.6
—
—
—
0
0
19
168
1.15
0.17
1.8
1.8
—
—
—
0
0
119
1168
1.14
0.15
6.1
5.9
2.77
2.70
mmol/l
0.43
111
1081
112
1098
1.11
0.13
6.9
6.3
38.95
39.27
mmol/mol
0.15
107
1021
124
1222
1.15
0.13
14.5
12.3
24.78
25.74
u/l
0.32
124
1187
15
168
0.88
0.12
1.4
1.5
—
—
—
0
0
5
45
1.12
0.10
5.6
4.6
21.44
72.92
mg/l
—
5
38
5
45
1.12
0.10
5.6
4.6
14.64
25.67
mg/l
—
5
38
18
165
1.10
0.09
1.8
1.9
—
—
—
0
0
116
1144
1.09
0.09
5.7
5.2
1.44
1.46
mmol/l
0.25
109
1051
38
397
0.94
0.08
3.1
4.0
3.63
9.67
mg/mmol
1.54
22
254
7
67
1.05
0.08
1.3
1.3
—
—
—
0
0
116
1147
1.07
0.06
5.6
5.2
4.68
4.61
mmol/l
0.33
109
1061
11
100
1.11
0.05
2.7
1.4
—
—
—
0
0
126
1250
1.09
0.05
32.2
25.7
40.67
40.47
%
0.22
126
1236
126
1250
1.09
0.05
31.5
24.9
90.88
91.08
fl
0.24
126
1239
22
231
0.94
0.04
3.3
2.9
0.88
0.92
ug/l
0.05
16
134
126
1251
1.08
0.04
31.8
25.1
135.67
135.37
g/l
0.08
126
1237
12
112
1.08
0.03
1.4
2.0
—
—
—
0
0
30
309
0.96
0.02
1.3
1.3
0.73
1.83
u/ml
1.14
15
79
36
354
1.02
0.00
4.9
3.5
0.00
0.00
estimate
-0.00
14
96
22
219
1.01
0.00
2.6
3.4
0.54
0.93
e6/l
0.76
14
120
31
308
1.01
0.00
4.9
4.6
21.47
21.91
%
0.07
17
148
97
966
1.01
0.00
23.4
21.3
13.62
13.65
%
0.09
97
959
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
3.6
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
16.18
—
0
6
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
11.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
76.29
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
14.00
—
0
7
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_CNS_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_CNS_NOS | 1.387 [1.01, 1.9] | 0.041 |
| Birth year | 1.001 [0.99, 1.01] | 0.808 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 315 females with CD2_BENIGN_CNS_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_CNS_NOS | 1.853 [1.28, 2.68] | 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 283 males with CD2_BENIGN_CNS_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_CNS_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.154% | 0.343% |
| 5 | 0.934% | 2.159% |
| 10 | 2.392% | 5.722% |
| 15 | 4.796% | 10.819% |
| 20 | 8.598% | 17.648% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_CNS_NOS – Benign neoplasm: Central nervous system, other parts/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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