Benign neoplasm: Anus and anal canal

CD2_BENIGN_ANUS_ANAL_CANAL

anal neoplasm: A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D12.9&
  • Cause of death: ICD-10 D12.9&

2 out of 7 registries used, show all original rules.

1181

4. Check minimum number of events

None

1181

5. Include endpoints

None

1181

6. Filter based on genotype QC (FinnGen only)

1053

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D12
Name in latin
Neoplasma benignum ani

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6775 3595 3140
Only index persons 6211 3389 2822
Unadjusted period prevalence (%)
Whole population 0.10 0.10 0.09
Only index persons 0.12 0.12 0.11
Median age at first event (years)
Whole population 65.19 64.63 65.80
Only index persons 64.31 63.88 64.84

-FinnGen-

Key figures

All Female Male
Number of individuals 1053 546 507
Unadjusted period prevalence (%) 0.21 0.19 0.23
Median age at first event (years) 63.32 60.70 66.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1090
Matched controls
10896
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
56.2
319.3
183
39
D12.9
ICD-10 Finland
Benign neoplasm: Anus and anal canal
+∞
307.7
1089
*
UJF32
NOMESCO Finland
Coloscopy
8.3
266.8
725
2105
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
12.6
226.9
247
247
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
7.7
181.8
308
530
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
7.6
137.9
220
349
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
6.9
125.8
220
383
K62.0
ICD-10 Finland
Anal polyp
30.3
118.6
79
28
UJH02
NOMESCO Finland
Anoscopy
7.8
101.0
151
220
UJG02
NOMESCO Finland
Proctoscopy
11.2
96.5
106
104
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
5.4
79.9
175
371
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
7.7
59.6
87
122
JHB00
NOMESCO Finland
Hemorrhoidectomy
6.8
56.7
93
148
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
4.2
55.3
167
454
JGA05
NOMESCO Finland
Endoscopic polypectomy in rectum
21.3
54.2
41
20
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
5.9
52.7
100
184
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
5.1
50.8
115
248
D12
ICD-10 Finland
Benign neoplasm of colon, rectum, anus and anal canal
20.7
49.6
38
19
JHA00
NOMESCO Finland
Anal or perianal incision
11.1
49.1
53
50
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
4.6
42.1
106
249
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
7.3
41.9
63
91
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.6
41.7
322
1512
A06AC01
ATC
ispaghula (psylla seeds); oral
2.4
39.7
406
2162
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
5.5
38.3
77
149
UJF30
NOMESCO Finland
Ileoscopy through colon
3.1
38.2
184
671
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
38.0
429
2375
C05AA08
ATC
fluocortolone; rectal, topical
2.8
36.8
220
903
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
6.3
30.4
52
86
D12.7
ICD-10 Finland
Benign neoplasm: Rectosigmoid junction
7.9
30.3
42
55
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.6
30.1
108
327
JGA73
NOMESCO Finland
Transanal excision of lesion of rectum
31.0
29.6
39
13
K60.1
ICD-10 Finland
Chronic anal fissure
5.4
26.0
52
100
K62.1
ICD-10 Finland
Rectal polyp
8.7
25.8
33
39
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
5.3
24.0
49
96
ZXE00
NOMESCO Finland
One hour or less
1.9
23.6
469
3075
I84.5
ICD-10 Finland
External hemorrhoids without complication
4.3
23.1
61
148
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
4.6
22.6
54
121
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
18.9
21.8
33
18
JHA10
NOMESCO Finland
Biopsy of anal canal
61.3
20.9
24
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
20.9
319
1900
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
20.4
415
2708
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
7.3
20.4
30
42
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
19.4
288
1693
K60.3
ICD-10 Finland
Anal fistula
5.8
19.1
35
62
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
5.3
18.2
37
72
WX402
NOMESCO Finland
General anaesthesia
1.9
17.0
256
1503
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
16.8
134
619
D04
ICPC
Rectal/anal pain
5.4
16.6
33
63
J01DB01
ATC
cefalexin; oral
2.0
16.0
896
7650
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
7.0
15.7
24
35
I84
ICD-10 Finland
Hemorrhoids
3.6
15.4
51
146
A02BC05
ATC
esomeprazole; systemic
1.7
15.2
458
3276
Z2221
NOMESCO Finland
Medical doctor
1.8
15.2
312
2008
A06AC51
ATC
ispaghula, combinations; oral
2.9
14.9
74
271
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
5.1
14.8
31
62
A02BC02
ATC
pantoprazole; systemic
1.7
14.7
766
6297
A02BC03
ATC
lansoprazole; oral
1.7
14.6
342
2282
N02AX02
ATC
tramadol; systemic, rectal
1.7
14.4
496
3660
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
14.1
338
2264
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.7
13.9
74
282
K60.2
ICD-10 Finland
Anal fissure, unspecified
4.8
13.8
31
66
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
13.6
156
829
K64.2
ICD-10 Finland
Third degree haemorrhoids
4.8
13.3
30
64
K64.9
ICD-10 Finland
Haemorrhoids, unspecified
3.1
13.2
56
188
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
13.1
230
1405
N02BE01
ATC
paracetamol; systemic, rectal
2.1
12.9
979
8784
N03AX16
ATC
[U] pregabalin
1.7
12.9
269
1729
P01AB01
ATC
metronidazole; oral, rectal
1.6
12.8
427
3097
Z93.3
ICD-10 Finland
Colostomy status
6.3
12.5
21
34
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
12.4
420
3052
K61.0
ICD-10 Finland
Anal abscess
4.9
12.4
27
56
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
12.3
260
1672
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
12.3
161
896
I84.1
ICD-10 Finland
Internal hemorrhoids with other complications
3.6
12.0
40
115
K64.4
ICD-10 Finland
Residual haemorrhoidal skin tags
13.6
12.0
20
15
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
14.8
11.8
19
13
JG1CG
NOMESCO Finland
Extensive MRI of rectum
10.7
11.8
22
21
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
11.7
192
1146
I84.4
ICD-10 Finland
External hemorrhoids with other complications
5.0
11.7
25
51
K64.0
ICD-10 Finland
First degree haemorrhoids
3.6
11.5
37
104
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
11.5
165
945
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
11.2
333
2333
WX002
NOMESCO Finland
Sedation and analgesia
1.7
10.9
226
1443
Z71.8
ICD-10 Finland
Other specified counselling
1.6
10.8
354
2537
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
10.8
219
1390
C21.1
ICD-10 Finland
Malignant neoplasm: Anal canal
60.6
10.6
12
*
JF2BD
NOMESCO Finland
Extensive colon CT
8.6
10.6
22
26
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.9
10.3
48
170
UJF92
NOMESCO Finland
Capsular endoscopy
3.7
10.1
32
89
K96
ICPC
Haemorrhoids
3.0
10.0
43
146
WX702
NOMESCO Finland
Supraglottic ventilation device
2.4
9.9
71
312
Z12.1
ICD-10 Finland
Special screening examination for neoplasm of intestinal tract
4.6
9.8
23
51
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
9.8
723
6127
R4110
NOMESCO Finland
Physiotherapy
1.6
9.7
305
2152
K59.0
ICD-10 Finland
Constipation
2.2
9.7
78
361
K44
ICD-10 Finland
Diaphragmatic hernia
5.4
9.7
19
36
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
2.8
9.6
46
166
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.2
9.4
85
412
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.5
9.2
56
228
Z3231
NOMESCO Finland
Registered nurse
1.6
9.2
293
2070
D01
ICPC
Abdominal pain/cramps general
1.9
9.2
131
747
JFF23
NOMESCO Finland
Transversostomy
4.3
9.1
23
54
Z01.2
ICD-10 Finland
Dental examination
1.5
9.1
441
3408
JGA75
NOMESCO Finland
Endoscopic microsurgical excision of lesion of rectum
50.4
8.7
10
*
A02BC01
ATC
omeprazole; systemic
1.5
8.7
298
2139
WX892
NOMESCO Finland
Monitored bed care
2.0
8.7
95
496
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
8.6
196
1278
A07EA02
ATC
hydrocortisone; rectal
3.5
8.5
29
85
K92.1
ICD-10 Finland
Melaena
2.2
8.5
73
347
N05CF01
ATC
zopiclone; oral
1.5
8.5
354
2645
JGA96
NOMESCO Finland
Other proctotomy or local operation on rectum
27.7
8.5
11
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.0
8.5
99
528
K62.3
ICD-10 Finland
Rectal prolapse
4.2
8.5
22
53
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
8.5
369
2783
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.0
8.1
93
494
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
2.2
8.0
64
295
A02BA04
ATC
nizatidine; systemic
2.0
8.0
92
488
N06AB04
ATC
citalopram; systemic
1.6
7.8
214
1455
K62.9
ICD-10 Finland
Disease of anus and rectum, unspecified
8.5
7.8
16
19
JFA45
NOMESCO Finland
Endoscopic contact coagulation in colon
8.5
7.8
16
19
Z3226
NOMESCO Finland
Physiotherapist
1.6
7.8
194
1290
A03CA02
ATC
clidinium and psycholeptics; oral
2.1
7.6
70
342
K57
ICD-10 Finland
Diverticular disease of intestine
3.2
7.6
29
92
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.3
7.6
54
238
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.6
7.5
202
1367
E0000UV, ,
ATC
1.4
7.5
417
3281
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
3.2
7.4
29
93
K60.0
ICD-10 Finland
Acute anal fissure
4.4
7.4
18
41
M79.7
ICD-10 Finland
Fibromyalgia
2.6
7.3
40
155
J02AC01
ATC
fluconazole; systemic
1.4
7.3
359
2757
H02AB06
ATC
prednisolone; systemic
1.4
7.2
501
4091
M79.6
ICD-10 Finland
Pain in limb
1.4
7.2
453
3634
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
7.2
375
2909
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.0
7.2
31
106
R35
ICD-10 Finland
Polyuria
1.9
7.1
84
450
J02AC02
ATC
itraconazole; systemic
1.6
7.0
169
1114
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
7.0
461
3725
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
7.0
112
662
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
5.9
6.9
18
31
UKC02
NOMESCO Finland
Cystoscopy
1.6
6.9
186
1259
S18
ICPC
Laceration/cut
1.4
6.8
504
4148
UJF34
NOMESCO Finland
Left colonoscopy
6.1
6.8
17
28
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.8
208
1449
JHC60
NOMESCO Finland
Transanal submucous or intersphincteric injection
40.3
6.8
8
*
N06AX21
ATC
duloxetine; oral
1.7
6.7
122
747
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.1
6.7
59
284
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
6.7
382
3003
K57.9
ICD-10 Finland
Diverticular disease of intestine, part unspecified, without perforation or abscess
2.7
6.7
35
133
UJD02
NOMESCO Finland
Gastroscopy
2.2
6.7
57
271
JN4BD
NOMESCO Finland
Extensive body CT
1.7
6.6
119
726
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.6
108
642
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.5
130
815
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.4
6.5
44
189
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
2.4
6.5
42
177
WX320
NOMESCO Finland
Spinalanesthesy
1.5
6.5
268
1982
C10AC01
ATC
colestyramine; oral
2.6
6.5
35
135
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
6.5
109
653
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
6.5
527
4395
JFA55
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in colon
7.4
6.4
14
19
L01
ICPC
Neck symptom/complaint
1.6
6.4
160
1063
K64.1
ICD-10 Finland
Second degree haemorrhoids
2.8
6.3
30
108
JG1BG
NOMESCO Finland
MRI of rectum
6.0
6.3
16
27
R01AD08
ATC
fluticasone; nasal
1.5
6.3
260
1922
A07EC02
ATC
mesalazine; oral, rectal
2.1
6.3
56
271
JHB96
NOMESCO Finland
Other procedure for haemorrhoids or prolapse of mucosa
9.3
6.3
12
13
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.5
6.3
230
1661
D01.2
ICD-10 Finland
Carcinoma in situ: Rectum
+∞
6.3
6
*
R32
ICD-10 Finland
Unspecified urinary incontinence
2.6
6.2
35
138
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.5
6.2
37
150
C21.0
ICD-10 Finland
Malignant neoplasm: Anus, unspecified
26.8
6.2
8
*
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.5
6.2
260
1928
R06.5
ICD-10 Finland
Mouth breathing
1.8
6.2
85
480
K59.09
ICD-10 Finland
Constipation, unspecified
1.8
6.1
82
459
ZXA05
NOMESCO Finland
Left side
1.5
6.1
263
1959
D64.9
ICD-10 Finland
Anaemia, unspecified
1.6
6.1
130
831
U07
ICPC
Urine symptom/complaint other
1.8
6.1
96
565
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.1
501
4172
R60.0
ICD-10 Finland
Localized oedema
1.6
6.0
145
954
K59.01
ICD-10 Finland
Constipation outlet obstruction type
3.5
6.0
20
58
N06AX11
ATC
mirtazapine; oral
1.4
6.0
345
2705
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
6.1
6.0
15
25
D06
ICPC
Abdominal pain localized other
1.8
6.0
87
499

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
335
1120
3.87
85.39
1.7
1.3
—
—
—
0
0
527
3737
1.79
19.47
2.8
2.2
—
—
—
0
0
209
1128
2.05
17.75
4.6
4.2
3.60
23.26
ug/l
2.00
181
940
605
4594
1.71
16.51
6.3
5.1
35.21
35.19
g/l
0.03
570
4295
470
3349
1.71
16.10
6.4
6.0
—
—
—
0
0
234
1380
1.89
15.16
1.4
1.2
—
—
—
0
0
222
1289
1.91
15.08
1.5
1.4
—
—
—
0
0
198
1119
1.94
14.54
3.0
2.3
138.51
132.17
ug/g
0.11
151
891
588
4589
1.61
13.14
2.4
2.2
96.68
94.93
pmol/l
0.38
311
2447
676
5494
1.61
12.45
9.6
9.6
4.27
4.19
e9/l
0.32
580
4777
581
4565
1.58
12.29
6.1
6.2
58.14
58.18
%
0.02
552
4360
612
4872
1.58
12.20
19.4
17.2
1.27
1.30
inr
0.56
506
4073
581
4577
1.58
12.06
6.6
6.3
8.83
8.99
%
0.57
548
4287
579
4562
1.57
11.98
6.5
6.2
2.69
2.82
%
0.73
545
4270
561
4404
1.56
11.68
3.9
3.1
150.90
133.74
ug/l
0.28
526
4057
578
4570
1.56
11.65
6.6
6.3
0.65
0.68
%
0.41
548
4276
849
7384
1.68
11.09
10.6
8.4
78.86
80.39
u/l
0.36
813
6980
425
3160
1.56
11.08
3.4
2.6
94.19
87.40
u/l
0.06
390
2934
583
4660
1.54
10.89
6.5
6.3
26.71
26.56
%
0.11
559
4414
341
2445
1.57
10.25
3.2
2.5
—
—
—
0
0
159
932
1.83
10.23
3.0
2.4
38.87
35.28
u/l
0.30
135
784
348
2511
1.57
10.16
4.8
4.1
87.57
87.26
%
0.08
342
2463
378
2779
1.55
10.15
2.8
2.3
3.02
2.97
mg/l
0.12
328
2370
696
5829
1.54
10.14
5.7
5.1
6.73
6.75
mmol/l
0.08
667
5556
562
4500
1.51
10.11
3.3
2.9
—
—
estimate
—
0
0
237
1570
1.65
9.83
2.8
2.7
21.17
22.31
%
0.63
221
1465
71
317
2.33
9.59
1.6
1.4
301.12
288.21
ug/g
0.21
43
197
422
3218
1.51
9.39
3.2
2.6
—
—
—
0
0
544
4373
1.49
9.31
2.6
2.4
80.84
78.58
nmol/l
1.02
489
3901
618
5097
1.49
9.30
6.5
6.3
0.19
0.19
e9/l
0.28
537
4407
603
4955
1.48
9.20
6.2
6.1
0.04
0.04
e9/l
0.06
518
4215
181
1142
1.70
8.98
2.5
2.6
7.71
8.36
umol/l
0.17
149
1011
246
1679
1.60
8.96
2.8
2.7
2.29
2.28
g/l
0.06
226
1555
609
5030
1.48
8.95
6.2
6.2
1.96
1.92
e9/l
0.13
535
4385
398
3024
1.50
8.89
5.2
4.4
—
—
—
0
0
259
1798
1.58
8.76
2.8
2.7
11.87
12.56
umol/l
0.86
244
1675
477
3769
1.47
8.71
4.8
4.2
125.12
130.21
e6/l
0.05
347
2724
569
4676
1.45
8.34
7.2
6.5
1.21
1.21
mmol/l
0.14
525
4311
596
4944
1.45
8.29
6.2
6.1
0.59
0.60
e9/l
0.26
514
4204
617
5155
1.45
8.24
8.1
7.3
1.21
1.21
mmol/l
0.15
527
4438
975
8987
1.80
8.21
23.8
18.0
24.11
25.62
mg/l
0.74
857
7552
998
9265
1.91
8.21
27.3
21.9
3.97
3.99
mmol/l
1.33
980
9074
996
9257
1.88
7.92
26.8
21.7
139.63
139.63
mmol/l
0.02
980
9081
692
5964
1.44
7.45
3.8
3.4
52.58
52.51
u/l
0.00
646
5566
375
2901
1.45
7.32
3.9
3.4
0.62
0.44
e6/l
0.29
280
2176
625
5302
1.42
7.26
7.6
6.5
11.02
11.55
umol/l
0.72
593
5070
421
3372
1.40
6.61
4.0
3.5
227.83
82.14
e6/l
0.34
327
2621
792
7063
1.44
6.60
5.0
4.4
15.03
14.96
pmol/l
0.32
735
6426
914
8393
1.55
6.51
6.2
5.5
1.92
1.95
mu/l
0.20
852
7675
271
2011
1.46
6.46
4.4
4.3
103.53
351.37
ng/l
3.76
226
1647
929
8568
1.57
6.42
7.4
6.9
39.83
39.86
mmol/mol
0.03
868
7967
232
1673
1.49
6.38
3.4
3.2
2.04
2.05
e6/l
0.01
113
848
153
1014
1.59
6.17
2.3
2.2
0.21
0.21
g/l
0.16
139
949
404
3243
1.39
6.15
3.5
3.4
—
—
—
0
0
508
4235
1.37
6.13
14.1
12.0
0.00
0.00
e9/l
1.01
405
3459
272
2045
1.44
6.00
3.5
3.1
511.55
529.42
mosm/kgh2o
0.77
235
1799
137
893
1.61
5.92
1.6
1.5
—
—
—
0
0
87
504
1.79
5.81
2.5
2.4
—
—
—
0
0
332
2599
1.40
5.80
2.8
2.8
362.93
350.78
umol/l
1.07
296
2268
810
7323
1.41
5.70
28.7
22.3
13.95
13.78
%
2.59
804
7235
208
1506
1.47
5.55
1.9
2.0
—
—
—
0
0
387
3129
1.37
5.50
2.9
3.2
31.63
32.56
u/l
0.21
357
2956
243
1819
1.43
5.43
3.2
3.1
1.17
1.10
e6/l
0.07
124
997
741
6627
1.37
5.37
4.9
4.5
—
0.33
—
0
15
388
3148
1.36
5.36
5.3
4.3
7.40
7.40
ph
0.11
268
2274
1004
9512
1.70
5.31
30.0
23.9
83.26
80.42
umol/l
1.23
993
9398
140
943
1.56
5.26
2.4
2.1
362.06
381.42
nmol/l
0.48
131
870
1014
9648
1.73
5.06
34.9
27.4
245.92
245.71
e9/l
0.03
997
9468
1014
9648
1.73
5.06
34.7
27.3
91.39
91.50
fl
0.30
1004
9537
1014
9650
1.72
5.03
34.7
27.2
30.30
30.39
pg
0.88
1004
9537
1014
9650
1.72
5.03
35.4
27.8
39.64
39.93
%
0.91
1004
9532
1014
9650
1.72
5.03
34.9
27.3
4.41
4.43
e12/l
0.68
997
9442
973
9169
1.57
5.00
21.6
16.3
—
—
—
0
0
1014
9652
1.72
5.00
34.9
27.4
6.93
6.82
e9/l
0.75
997
9439
1014
9652
1.72
5.00
35.2
27.6
132.23
133.63
g/l
2.12
1004
9538
432
3591
1.34
5.00
4.2
3.5
2.35
2.35
mmol/l
0.02
391
3246
279
2176
1.38
4.86
1.8
1.6
1.05
1.34
mg/l
1.86
223
1698
86
528
1.68
4.72
2.8
3.3
4.41
4.43
pmol/l
0.06
77
464
390
3221
1.33
4.63
2.2
2.2
181.60
234.10
u/l
0.78
370
3058
94
599
1.62
4.48
1.2
1.3
—
—
—
0
0
177
1304
1.43
4.27
6.3
7.1
7.41
7.42
ph
0.61
81
755
260
2044
1.36
4.25
1.3
1.3
1.10
1.43
u/ml
0.37
51
547
44
228
1.97
4.20
5.4
3.8
—
—
—
0
0
296
2378
1.34
4.19
3.1
2.8
5.83
5.41
e6/l
0.21
267
2180
929
8737
1.43
4.16
6.0
5.5
6.00
6.01
mmol/l
0.08
862
7934
49
265
1.89
4.14
3.6
3.5
1.89
1.91
index
0.01
27
145
143
1018
1.47
4.14
6.3
6.6
1.42
1.33
mmol/l
0.35
138
1000
176
1305
1.42
4.09
1.2
1.4
627.88
459.11
titre
0.38
33
293
127
889
1.48
4.00
1.5
1.4
—
—
—
0
0
9
14
6.47
3.98
1.7
1.3
58.78
48.29
umol/l
—
9
14
177
1321
1.41
3.96
2.2
1.8
—
—
—
0
0
134
950
1.47
3.96
7.2
7.9
—
—
—
0
0
272
2178
1.33
3.90
4.1
3.0
2.46
2.46
mmol/l
0.22
244
1965
175
1309
1.40
3.86
6.4
7.0
5.01
5.08
kpa
0.50
164
1265
987
9414
1.51
3.86
15.5
12.7
24.74
25.24
u/l
0.55
963
9125
209
1611
1.37
3.85
2.0
2.0
29.32
29.44
s
0.13
203
1558
175
1310
1.40
3.85
6.4
7.0
12.17
11.94
kpa
0.28
166
1268
348
2895
1.30
3.77
7.2
6.4
—
—
—
0
0
471
4074
1.27
3.74
3.4
3.7
6.13
6.24
ph
1.22
235
2269
139
1005
1.44
3.71
2.9
2.7
63.90
69.78
e9/l
1.00
97
757
406
3451
1.28
3.71
3.0
3.3
1832.62
1549.63
ng/l
0.42
357
3001
80
517
1.59
3.63
1.8
2.0
1.69
1.51
g/l
0.84
68
464
61
369
1.69
3.59
3.6
3.3
252.32
328.20
mg/l
0.27
28
152
112
783
1.48
3.56
3.1
2.7
10.75
10.98
g/l
0.19
105
717
10
21
4.79
3.56
1.2
1.7
48.70
85.71
nmol/24h
—
10
21
114
801
1.47
3.54
5.9
4.2
—
—
—
0
0
463
4018
1.26
3.52
4.6
4.2
43.72
81.22
ng/l
0.94
334
3039
128
922
1.44
3.49
1.7
1.6
—
—
—
0
0
118
837
1.46
3.49
4.4
3.9
93.79
90.16
ng/l
0.15
98
719
171
1297
1.38
3.47
6.4
7.0
0.36
1.00
mmol/l
1.05
147
1062
232
1844
1.33
3.47
1.7
1.5
2.32
2.54
g/l
1.10
141
1114
313
2594
1.29
3.44
2.9
3.3
0.00
0.04
—
5
76
371
3144
1.27
3.41
1.9
1.8
20.24
20.13
nmol/l
0.05
318
2648
240
1922
1.32
3.40
1.9
1.8
1038.80
1191.64
nmol/l
2.04
174
1432
222
1760
1.33
3.38
3.6
3.2
0.81
0.82
mmol/l
0.61
205
1660
170
1298
1.37
3.31
2.8
2.6
1.72
1.84
%
0.96
149
1170
218
1730
1.32
3.29
1.3
1.3
28.68
32.89
iu/ml
0.23
59
560
65
410
1.62
3.28
5.0
3.3
115.67
3725.20
u/ml
0.85
57
351
33
172
1.95
3.16
4.1
3.2
3.63
4.45
e9/l
1.63
33
172
203
1613
1.32
3.03
1.4
1.3
5.90
13.47
u/ml
1.20
67
577
130
969
1.39
2.94
7.7
7.1
11.31
10.61
mmol/l
0.45
123
932
438
3836
1.24
2.92
2.1
2.0
1.34
1.34
mmol/l
0.07
362
3199
298
2505
1.26
2.86
1.4
1.4
—
—
—
0
0
179
1410
1.32
2.84
6.5
5.7
1.05
1.04
mmol/l
0.33
163
1305
16
65
2.48
2.79
2.4
2.7
7.30
6.82
mmol/l
—
9
40
66
436
1.55
2.78
2.4
2.8
—
—
—
0
0
152
1173
1.34
2.77
6.2
7.3
96.03
95.38
%
1.15
146
1141
567
5121
1.22
2.76
4.4
4.2
0.00
3.09
estimate
0.80
140
1136
21
98
2.16
2.71
1.1
1.2
—
—
—
0
0
231
1904
1.27
2.59
3.9
3.4
0.77
0.80
ug/l
0.16
162
1285
5
7
7.17
2.55
1.2
4.4
—
—
—
0
0
30
165
1.84
2.50
2.7
1.8
1.63
1.65
mmol/l
0.03
30
160
115
864
1.37
2.50
2.8
3.2
260.50
226.24
ng/l
0.34
101
800
146
1139
1.32
2.49
1.7
1.6
—
—
—
0
0
49
311
1.60
2.47
1.6
1.6
10.46
14.99
u/ml
—
5
57
24
123
1.97
2.46
1.5
1.3
—
—
nmol/l
—
0
0
21
103
2.06
2.42
1.4
1.6
29.42
36.04
ng/l
0.17
21
103
39
235
1.68
2.41
1.2
1.2
—
—
—
0
0
6
12
5.02
2.40
1.0
1.0
8.79
7.20
mg/g
—
6
12
37
220
1.71
2.40
4.5
2.5
15.87
16.05
%
0.13
37
215
106
792
1.37
2.40
3.2
2.7
—
—
—
0
0
939
9007
1.30
2.39
6.5
6.1
2.64
2.63
mmol/l
0.10
886
8275
312
2683
1.23
2.39
4.3
3.7
2.45
0.04
estimate
0.48
102
881
14
58
2.43
2.37
1.1
1.1
281.36
264.88
mg/l
0.14
14
51
21
104
2.04
2.37
1.6
1.1
—
—
—
0
0
884
8429
1.26
2.28
4.5
4.4
1.30
1.28
mmol/l
0.40
810
7637
12
47
2.57
2.27
1.2
1.1
0.49
0.50
ratio
—
6
27
6
13
4.63
2.27
1.0
1.0
—
—
—
0
0
77
550
1.43
2.26
2.2
1.7
—
—
—
0
0
565
5165
1.19
2.24
4.4
4.2
0.00
0.30
estimate
0.54
134
1068
23
121
1.92
2.21
1.5
1.3
0.20
0.19
nmol/l
0.31
16
93
554
5064
1.19
2.17
4.4
4.2
0.00
0.00
estimate
0.50
139
1105
98
739
1.36
2.11
5.0
3.7
5.12
5.14
kpa
0.07
93
709
31
506
0.60
2.11
3.7
3.9
1.02
1.02
ratio
0.11
26
469
20
102
1.98
2.11
1.7
1.2
—
—
—
0
0
916
8793
1.26
2.08
5.5
5.2
1.47
1.46
mmol/l
0.31
852
8049
5
10
5.02
2.07
1.6
1.3
—
—
—
0
0
93
699
1.36
2.05
1.2
1.2
—
—
—
0
0
79
578
1.39
2.05
1.3
1.4
13.82
50.58
au/ml
—
5
44
114
884
1.32
2.05
3.7
4.4
0.81
0.60
%
0.39
47
279
31
185
1.69
2.02
1.4
1.1
—
—
—
0
0
38
240
1.60
2.00
1.2
1.3
—
—
—
0
0
119
933
1.31
1.98
3.8
4.5
0.72
0.96
%
0.78
50
303
113
883
1.31
1.93
3.9
4.6
0.00
0.13
%
6.04
45
255
84
629
1.36
1.91
2.3
1.7
2.21
1.47
g/l
0.52
77
572
17
85
2.02
1.90
3.1
3.2
103.35
18.36
mg/l
—
10
63
35
221
1.60
1.86
4.1
3.0
56.23
59.56
%
0.82
35
221
9
35
2.58
1.80
55.9
30.7
6.79
6.86
ug/l
—
9
30
94
725
1.32
1.78
5.1
3.7
7.42
7.42
ph
0.10
80
613
392
3525
1.17
1.77
3.5
3.4
7.47
7.37
mmol/l
0.15
334
2972
26
154
1.70
1.77
2.1
1.7
0.88
0.88
g/l
0.01
19
124
15
74
2.04
1.75
2.7
2.1
14.19
16.18
%
1.47
15
74
26
156
1.68
1.70
2.5
2.7
—
—
—
0
0
20
112
1.80
1.65
4.7
4.7
—
—
—
0
0
119
963
1.26
1.59
4.0
4.5
7.39
7.36
ph
3.74
94
694
916
8853
1.21
1.58
5.7
5.3
4.59
4.55
mmol/l
0.48
858
8176
7
27
2.60
1.51
1.3
1.9
—
—
—
0
0
69
523
1.34
1.50
1.8
1.8
3.41
3.51
mmol/l
0.27
49
379
146
1218
1.23
1.50
2.9
3.4
4.20
5.06
e9/l
0.97
125
1045
361
3262
1.16
1.50
6.4
5.9
4.58
2.85
ug/l
0.48
326
2903
82
638
1.31
1.49
2.4
2.6
8.20
18.73
au/ml
—
5
52
64
480
1.35
1.49
2.0
2.2
0.00
1.74
estimate
0.50
20
144
110
892
1.26
1.46
4.0
4.8
0.02
0.14
%
1.25
41
234
7
28
2.51
1.45
3.1
1.5
—
—
—
0
0
22
135
1.64
1.36
1.0
1.1
129.04
129.41
iu/ml
—
5
29
33
224
1.49
1.34
1.3
1.4
54.96
62.93
mmol/l
0.76
25
193
24
152
1.59
1.32
1.8
2.2
32.04
32.67
pg
0.28
24
152
65
500
1.32
1.31
1.5
1.2
—
—
—
0
0
113
935
1.23
1.27
1.8
1.6
—
—
—
0
0
381
3491
1.14
1.27
4.5
4.2
7.43
8.74
mg/mmol
0.37
234
2197
145
1233
1.20
1.25
1.4
1.4
—
—
—
0
0
8
37
2.17
1.21
1.1
1.3
5.00
9.84
mm/h
—
8
37
29
198
1.48
1.17
1.5
1.2
—
—
—
0
0
0
34
0.00
1.16
0.0
1.1
—
21.33
—
0
6
29
201
1.45
1.10
7.1
4.5
2.99
2.64
mmol/l
0.21
22
139
18
112
1.62
1.09
2.2
2.3
—
—
—
0
0
7
32
2.19
1.08
1.0
1.1
395.57
214.68
iu/ml
—
7
32
31
219
1.43
1.07
1.2
1.2
—
—
—
0
0
57
445
1.30
1.07
1.3
1.3
—
—
—
0
0
23
153
1.51
1.06
4.1
2.7
—
—
—
0
0
39
288
1.37
1.06
10.2
11.2
—
—
—
0
0
19
121
1.58
1.06
2.6
2.6
—
—
—
0
0
13
75
1.74
1.03
2.5
5.8
203.20
46.44
u/ml
—
5
25
35
256
1.38
1.01
3.9
2.2
123.21
127.81
g/l
0.52
28
204
30
214
1.41
1.00
1.5
1.2
5.50
81.06
e6/l
1.16
22
155
76
621
1.24
1.00
1.3
1.4
—
—
—
0
0
13
76
1.72
0.99
2.4
3.3
13.38
13.26
%
0.15
13
76
5
23
2.18
0.98
1.6
2.3
6.36
7.85
mmol/l
—
5
14
25
173
1.45
0.98
2.2
2.3
0.88
0.91
%
0.09
16
122
30
216
1.40
0.96
1.5
1.3
551.78
728.91
e6/l
0.11
23
164
10
55
1.83
0.92
1.2
1.2
—
—
—
0
0
228
2064
1.13
0.91
5.0
4.9
—
—
—
0
0
366
3408
1.11
0.90
3.7
3.5
53.96
48.09
mg/l
0.15
227
2210
6
29
2.07
0.89
1.0
1.4
1.60
1.90
umol/l
—
6
24
206
2276
0.88
0.88
4.2
4.4
1.02
1.02
kg/l
0.63
139
1532
49
388
1.27
0.86
4.5
3.9
47.75
56.16
mg/l
0.25
39
338
49
388
1.27
0.86
4.5
3.9
78.39
65.18
mg/l
0.19
39
338
98
837
1.19
0.86
6.3
3.8
1.23
1.23
mmol/l
0.24
79
723
378
3534
1.11
0.85
4.3
3.9
—
0.75
—
0
12
10
57
1.76
0.83
1.1
1.1
161.00
143.55
nmol/l
—
10
57
26
189
1.38
0.81
4.8
1.5
1.26
0.87
nmol/l
1.32
21
156
19
130
1.47
0.81
1.4
1.6
—
—
—
0
0
19
131
1.46
0.78
1.3
2.0
—
—
—
0
0
0
26
0.00
0.78
0.0
1.2
—
—
—
0
0
39
305
1.29
0.77
4.2
6.6
1.35
1.30
mmol/l
0.06
30
271
45
360
1.26
0.75
1.2
1.6
0.44
0.34
mg/l
0.36
16
156
123
1084
1.15
0.75
3.6
3.4
1.64
1.91
mmol/l
0.36
102
927
134
1189
1.14
0.74
1.5
1.8
—
—
—
0
0
44
352
1.26
0.74
1.3
1.7
—
—
—
0
0
5
25
2.00
0.72
1.0
1.4
—
—
—
0
0
7
39
1.80
0.72
3.6
3.1
—
—
—
0
0
29
220
1.33
0.72
1.2
1.2
3.84
3.78
mmol/l
0.12
29
204
44
354
1.25
0.71
4.3
3.6
10.01
3.54
ratio
0.41
23
213
18
126
1.44
0.70
1.2
1.2
—
—
—
0
0
25
186
1.35
0.70
1.1
1.4
—
10.68
—
0
5
19
135
1.41
0.69
1.8
1.3
53.49
55.95
mu/l
0.03
19
125
60
502
1.21
0.68
5.2
4.0
—
—
—
0
0
7
42
1.67
0.68
1.4
1.2
212.51
146.02
pmol/l
—
7
42
9
59
1.53
0.68
7.3
4.0
0.33
0.86
index
—
9
59
126
1122
1.14
0.67
3.8
3.5
7.38
7.38
ph
0.14
67
662
30
232
1.30
0.66
2.3
1.8
3.41
3.81
iu/l
0.14
12
86
28
215
1.31
0.65
1.2
1.5
—
—
—
0
0
28
215
1.31
0.65
1.2
1.5
—
—
—
0
0
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
5
29
1.73
0.64
1.0
1.4
5.38
7.93
mmol/l
—
5
29
8
131
0.61
0.63
1.1
1.5
—
—
—
0
0
8
131
0.61
0.63
1.1
1.5
—
—
—
0
0
8
131
0.61
0.63
1.1
1.5
—
—
—
0
0
8
131
0.61
0.63
1.1
1.5
—
—
—
0
0
46
379
1.22
0.62
1.1
1.1
—
—
—
0
0
77
666
1.17
0.62
1.5
1.4
—
—
—
0
0
8
49
1.64
0.62
2.0
2.0
233.88
234.57
e6/l
—
8
44
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
32
254
1.27
0.60
1.3
1.7
—
—
—
0
0
402
3825
1.08
0.59
4.6
4.2
4.81
0.04
estimate
0.49
104
925
11
72
1.53
0.59
1.5
1.7
—
—
—
0
0
66
567
1.17
0.59
1.3
1.2
119.43
131.46
u/ml
0.10
24
234
239
2226
1.09
0.59
1.9
1.8
438.23
21813622.84
pmol/l
1.66
205
1820
6
35
1.72
0.57
3.2
2.3
0.59
0.61
mmol/l
—
6
35
6
36
1.67
0.56
1.7
1.4
—
—
—
0
0
14
98
1.43
0.56
5.4
3.7
9.67
11.39
index
—
9
59
11
73
1.51
0.56
1.3
1.1
—
—
—
0
0
27
212
1.28
0.55
1.2
1.5
—
—
—
0
0
80
703
1.15
0.54
2.5
2.3
13.07
13.20
nmol/l
0.05
73
627
6
38
1.58
0.54
1.0
1.2
5.42
6.51
mmol/l
—
6
38
45
377
1.20
0.54
1.0
1.2
—
—
—
0
0
308
2913
1.08
0.53
4.9
4.3
0.00
0.01
estimate
1.15
123
1019
10
66
1.52
0.52
1.3
1.1
—
—
—
0
0
25
197
1.27
0.51
1.2
1.5
—
—
—
0
0
33
270
1.23
0.50
1.3
1.2
11.32
8.68
u/ml
—
5
41
30
244
1.24
0.48
1.0
1.1
—
—
—
0
0
7
47
1.49
0.47
1.3
1.1
—
—
—
0
0
7
49
1.43
0.46
2.0
1.8
505.86
637.80
e6/l
—
7
41
19
147
1.30
0.45
2.6
1.9
1050.17
1727.67
u/l
—
6
53
26
210
1.24
0.45
1.3
1.3
192.91
233.95
miu/ml
—
10
87
56
489
1.15
0.44
1.8
1.9
0.96
1.99
ug/l
0.91
49
436
19
148
1.29
0.43
1.5
1.3
2566.15
1602.28
e6/l
0.33
13
98
11
78
1.41
0.43
1.3
1.3
—
—
—
0
0
5
31
1.62
0.43
1.0
1.0
—
0.16
—
0
7
34
285
1.20
0.43
1.1
1.2
—
7.34
—
0
5
32
267
1.20
0.42
1.3
1.2
—
—
—
0
0
36
304
1.19
0.42
4.7
2.8
2.13
1.68
mg/l
1.35
36
271
0
15
0.00
0.41
0.0
1.1
—
0.02
—
0
15
0
15
0.00
0.41
0.0
4.0
—
—
—
0
0
0
16
0.00
0.41
0.0
6.4
—
8.39
—
0
16
335
3209
1.06
0.40
3.5
3.3
—
—
—
0
0
5
34
1.47
0.40
1.0
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
5
35
1.43
0.39
1.0
1.0
—
0.22
—
0
9
26
215
1.21
0.38
1.2
1.5
—
—
—
0
0
5
36
1.39
0.38
4.4
3.3
—
—
—
0
0
47
411
1.15
0.38
1.5
1.8
8.82
7.64
iu/ml
—
5
95
8
114
0.70
0.37
1.8
2.4
—
—
—
0
0
18
143
1.26
0.37
1.3
1.6
—
—
—
0
0
6
42
1.43
0.35
1.2
1.4
—
—
—
0
0
6
42
1.43
0.35
1.3
1.8
3.65
5.86
nmol/l
—
6
34
25
209
1.20
0.34
1.3
1.2
39.43
50.49
u/ml
—
6
23
99
914
1.09
0.33
2.2
2.5
7.16
7.06
ug/l
0.02
85
806
121
1128
1.08
0.33
3.8
3.4
5.75
5.80
kpa
0.27
115
1100
6
90
0.66
0.32
1.0
1.1
—
—
—
0
0
96
887
1.09
0.32
2.6
2.5
0.35
0.49
e6/l
0.42
91
843
11
83
1.33
0.32
1.2
1.3
—
—
—
0
0
12
92
1.31
0.31
1.3
1.2
13.42
10.88
u/l
0.34
12
83
7
96
0.73
0.31
2.1
2.4
—
—
—
0
0
8
110
0.73
0.29
1.9
1.7
—
—
—
0
0
19
159
1.20
0.26
1.1
1.1
—
—
—
0
0
11
86
1.28
0.26
1.1
1.3
—
—
—
0
0
69
636
1.09
0.26
1.3
1.4
—
—
—
0
0
16
132
1.21
0.25
1.6
1.4
—
—
—
0
0
22
256
0.86
0.25
3.9
5.1
—
—
—
0
0
52
474
1.10
0.24
2.1
2.1
—
—
—
0
0
9
76
1.19
0.24
1.2
1.3
—
—
—
0
0
19
161
1.18
0.24
1.3
1.6
—
—
—
0
0
15
124
1.21
0.24
1.5
1.7
61.11
59.93
%
—
9
81
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
26
228
1.14
0.22
1.0
1.2
1.60
1.56
g/l
0.27
26
228
5
42
1.19
0.21
1.2
1.8
36.90
40.09
g/l
—
5
42
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
74.67
—
0
12
5
43
1.16
0.21
1.4
1.4
161.60
174.81
mmol/24h
—
5
43
0
13
0.00
0.21
0.0
1.8
—
0.68
—
0
13
24
211
1.14
0.20
1.0
1.1
0.79
0.69
ratio
—
6
32
0
14
0.00
0.20
0.0
2.1
—
3.00
—
0
6
13
108
1.21
0.20
1.3
1.2
—
—
—
0
0
27
241
1.12
0.19
1.1
1.2
0.92
0.92
g/l
0.01
27
241
6
53
1.13
0.18
1.5
1.5
—
—
—
0
0
15
128
1.17
0.18
1.5
1.3
13630.88
79960.18
e6/l
—
8
68
32
290
1.11
0.18
1.0
1.1
—
—
—
0
0
7
63
1.11
0.17
2.1
2.7
—
—
—
0
0
5
67
0.74
0.17
1.6
1.3
0.48
1.02
promille
—
5
57
8
69
1.16
0.16
1.0
1.0
—
—
—
0
0
98
936
1.05
0.16
2.0
2.2
0.00
0.02
estimate
0.50
22
186
10
119
0.84
0.15
1.3
1.3
—
—
—
0
0
14
121
1.16
0.15
1.4
1.3
—
—
—
0
0
14
123
1.14
0.12
1.6
1.3
—
—
—
0
0
14
123
1.14
0.12
1.1
1.2
—
—
—
0
0
10
85
1.18
0.12
1.1
1.1
92.30
106.72
pmol/l
—
10
85
12
105
1.14
0.11
1.4
1.1
—
—
—
0
0
10
114
0.88
0.09
1.2
1.2
—
—
—
0
0
11
97
1.13
0.09
1.0
1.2
—
—
—
0
0
12
134
0.89
0.09
1.4
1.2
2.67
7.09
u/ml
—
6
57
6
56
1.07
0.08
1.0
1.3
4.77
6.41
ug/l
—
6
48
10
112
0.89
0.07
1.3
1.2
—
—
—
0
0
9
103
0.87
0.06
1.0
1.1
—
—
—
0
0
17
158
1.08
0.06
1.0
1.1
—
—
—
0
0
14
129
1.09
0.05
1.0
1.1
—
—
—
0
0
14
129
1.09
0.05
1.0
1.1
—
—
—
0
0
29
280
1.04
0.03
1.8
1.6
20313.82
12806.20
e6/l
0.22
17
199
19
181
1.05
0.03
1.4
1.4
—
—
—
0
0
17
163
1.04
0.01
1.3
1.4
162.75
172.37
au/ml
—
8
44
96
952
1.01
0.01
3.4
2.8
4.62
4.47
kpa
0.28
91
926
10
94
1.06
0.01
1.2
1.2
—
—
—
0
0
18
177
1.02
0.00
1.4
1.2
288.33
268.53
u/ml
—
9
92
10
98
1.02
0.00
1.7
1.6
11.08
10.29
%
—
10
98
25
250
1.00
0.00
1.2
1.3
—
—
—
0
0
24
244
0.98
0.00
3.4
2.4
116.16
100.39
ug/min
0.10
14
151
75
753
1.00
0.00
2.8
2.8
5.95
6.08
ph
0.45
31
525
18
180
1.00
0.00
1.7
1.6
—
—
—
0
0
8
88
0.91
-0.00
1.3
1.8
—
—
—
0
0
7
79
0.89
-0.00
2.6
1.9
6.33
8.24
mmol/l
—
7
79
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.06
—
0
5
8
81
0.99
-0.00
1.0
1.1
—
—
—
0
0
8
88
0.91
-0.00
2.4
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
391.60
—
0
5
6
66
0.91
-0.00
1.3
1.8
115.67
101.29
ng/l
—
6
66
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
82
0.98
-0.00
1.5
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.6
—
0.24
—
0
8
0
5
0.00
-0.00
0.0
1.8
—
288.20
—
0
5
8
85
0.94
-0.00
1.5
1.6
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
17.0
—
118.83
—
0
6
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.0
1.0
—
—
—
0
0
9
97
0.93
-0.00
1.6
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
0.04
—
0
9
0
8
0.00
-0.00
0.0
1.5
—
484.61
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
0.03
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
34.06
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_ANUS_ANAL_CANAL and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_ANUS_ANAL_CANAL 1.11 [0.99, 1.24] 0.066
Birth year 0.998 [0.99, 1.01] 0.643

During the follow-up period (1.1.1998 — 31.12.2019), 811 out of 3244 females with CD2_BENIGN_ANUS_ANAL_CANAL died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_ANUS_ANAL_CANAL 1.233 [1.1, 1.39] < 0.001
Birth year 0.991 [0.98, 1.0] 0.046

During the follow-up period (1.1.1998 — 31.12.2019), 997 out of 2848 males with CD2_BENIGN_ANUS_ANAL_CANAL died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_ANUS_ANAL_CANAL.

N-year risk Females Males
1 0.12% 0.274%
5 0.735% 1.418%
10 1.683% 3.814%
15 3.423% 7.36%
20 6.062% 12.725%

Relationships between endpoints

Index endpoint: CD2_BENIGN_ANUS_ANAL_CANAL – Benign neoplasm: Anus and anal canal

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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