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Non-seminoma of testis

C3_TESTIS_NONSEMINOMA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only males

244368

2. Check conditions

None

244368

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C62.02&, C62.12&, C62.92&
  • Cause of death: ICD-9 186B
  • Cancer registry: Topography ICD-O-3 C62
  • Cancer registry: Morphology ICD-O-3 907[01]|9080|9100
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

106

4. Check minimum number of events

None

106

5. Include endpoints

None

106

6. Filter based on genotype QC (FinnGen only)

99

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 99 - 99
Unadjusted period prevalence (%) 0.05 - 0.05
Median age at first event (years) 28.58 - 28.58

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
101
Matched controls
1010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
KFC00
NOMESCO Finland
Unilateral orchiectomy
785.7
82.9
71
*
C62.12
ICD-10 Finland
Malignant tumor of the descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
75.8
63
*
9070/3-C62.9
ICD-O-3
Embryonal carcinoma, NOS, of testis, NOS
+∞
63.3
54
*
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
319.6
61.8
57
*
130
Kela drug reimbursment
Malignant tumour
+∞
60.7
52
*
A03FA01
ATC
metoclopramide; systemic, rectal
28.1
60.6
50
34
JN4BD
NOMESCO Finland
Extensive body CT
29.9
50.9
38
20
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
23.9
22
*
L03AA02
ATC
filgrastim; parenteral
261.8
21.4
21
*
C62.10
ICD-10 Finland
Malignant tumor of the descending testicle, no histological verification
+∞
20.5
19
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
18.9
18.8
29
21
A04AA02
ATC
granisetron; systemic, transdermal
+∞
18.3
17
*
9080/3-C62.9
ICD-O-3
Teratoma, malignant, NOS, of testis, NOS
+∞
18.3
17
*
KFH50
NOMESCO Finland
Insertion of prosthetic replacement for testis
+∞
18.3
17
*
C62.19
ICD-10 Finland
Malignant tumor of the descending testicle, other or undetermined histology
+∞
18.3
17
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.0
17.9
66
240
C62.92
ICD-10 Finland
Malignant tumor in unspecified location in testis, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
17.2
16
*
H02AB02
ATC
dexamethasone; systemic
49.1
17.1
20
5
C62.1
ICD-10 Finland
Malignant neoplasm: Descended testis
+∞
16.1
15
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.4
15.8
33
71
A04AA01
ATC
ondansetron; systemic, rectal
27.3
14.9
20
9
JN4AD
NOMESCO Finland
Body CT examination
16.2
14.3
23
18
7511
FHL
Orchidectomy (unilateral), also includes funicularectomy
+∞
13.9
13
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
13.9
13
*
9070/3-C62.1
ICD-O-3
Embryonal carcinoma, NOS, of descended testis
+∞
12.8
12
*
C62.99
ICD-10 Finland
Malignant tumor in unspecified location in testis,other or undetermined histology
+∞
12.8
12
*
18699
ICD-8 Finland
Malignant neoplasm of testis
+∞
12.8
12
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
11.7
11
*
C62.02
ICD-10 Finland
Malignant tumor of the non-descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
11.7
11
*
Z85.4
ICD-10 Finland
Personal history of malignant neoplasm of genital organs
+∞
10.6
10
*
9071/3-C62.9
ICD-O-3
Yolk sac tumor, NOS, of testis, NOS
+∞
9.5
9
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
5.6
9.0
19
40
DFF00
NOMESCO Finland
Pure tone audiometry
5.5
8.5
18
38
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
+∞
8.4
8
*
PJD53
NOMESCO Finland
Block dissection of aortic lymph nodes
+∞
8.4
8
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
8.4
8
*
C62.90
ICD-10 Finland
Malignant tumor in unspecified location in testis, no histological verification
+∞
8.4
8
*
1869B
ICD-9 Finland
Malignant neoplasm of testis, Other and unspecified testis[NEOPL MAL TESTIS (SCROT),CA EMBR/TERATOCA/CHORIOCA]
+∞
8.4
8
*
WZC00
NOMESCO Finland
Treatment plan or consultation
3.5
8.4
43
177
ZXE00
NOMESCO Finland
One hour or less
3.5
8.3
43
178
121
Kela drug reimbursment
Severe hypofunction of sexual glands
27.4
7.7
10
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
7.4
7
*
JN3AD
NOMESCO Finland
Abdominal CT examination
4.3
7.4
22
62
WX408
NOMESCO Finland
General anesthesy, balanced
3.4
7.0
32
121
D70.82
ICD-10 Finland
Drug-induced neutropenia
43.0
6.9
8
*
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
9.1
6.6
13
16
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
74.3
6.5
7
*
L03AA13
ATC
pegfilgrastim; parenteral
74.3
6.5
7
*
E89.5
ICD-10 Finland
Postprocedural testicular hypofunction
+∞
6.3
6
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
37
17.24
39.95
3.2
1.5
6.68
4.25
u/l
1.60
28
31
31
0
+∞
34.34
12.8
0.0
2687.59
—
pmol/l
—
23
0
30
12
34.85
23.46
1.1
1.2
—
—
—
0
0
66
276
5.01
14.14
8.9
8.9
1.20
1.20
mmol/l
0.05
54
248
90
545
6.98
10.68
14.5
6.1
75.99
73.60
u/l
0.23
90
526
74
409
4.03
9.33
13.1
8.9
3.42
4.11
e9/l
2.23
66
361
32
105
4.00
8.83
1.5
1.6
—
—
—
0
0
45
188
3.51
8.64
1.8
1.5
—
—
—
0
0
48
212
3.41
8.39
6.1
6.4
—
—
—
0
0
37
149
3.34
7.36
1.8
1.5
—
—
—
0
0
39
163
3.27
7.29
3.2
3.5
7.40
7.39
ph
0.62
29
111
37
150
3.31
7.27
1.8
1.7
—
—
—
0
0
37
161
3.05
6.34
7.3
4.2
—
—
—
0
0
47
237
2.84
6.12
4.2
2.6
—
—
estimate
—
0
0
25
89
3.40
5.93
6.7
1.7
2.45
2.41
mmol/l
0.98
25
82
40
190
2.83
5.77
2.1
2.7
19.18
11.40
e6/l
0.35
25
141
62
377
2.67
5.39
6.7
7.5
1.77
1.92
e9/l
0.65
55
339
58
342
2.63
5.36
10.5
8.3
0.00
0.00
e9/l
0.50
46
281
43
223
2.62
5.13
2.3
2.0
—
—
—
0
0
39
196
2.61
4.92
1.3
1.3
—
—
—
0
0
42
219
2.57
4.92
2.5
3.2
13.00
51.37
e6/l
0.49
25
147
34
162
2.66
4.75
2.3
2.7
1.05
0.11
e6/l
0.55
20
115
59
367
2.46
4.66
6.5
6.9
0.61
0.58
e9/l
0.42
50
323
7
5
14.88
4.64
1.0
1.6
14.00
17.28
ug/l
—
7
5
35
172
2.58
4.58
3.0
2.0
—
—
—
0
0
59
370
2.43
4.54
6.4
6.9
0.04
0.04
e9/l
0.81
50
326
59
380
2.33
4.14
6.9
7.7
0.16
0.19
e9/l
0.99
50
336
9
16
6.06
3.75
1.3
3.6
50.67
45.75
%
—
9
16
9
16
6.06
3.75
2.7
7.1
10.67
7.81
%
—
9
16
94
795
3.63
3.65
23.3
10.4
22.03
26.24
mg/l
0.74
79
615
7
10
7.42
3.42
2.6
5.6
60.14
55.10
%
—
7
10
20
87
2.62
3.26
1.8
2.1
—
—
—
0
0
29
151
2.29
3.23
1.6
1.6
1.89
0.65
mg/l
1.38
22
105
6
8
7.88
3.10
2.7
6.6
4.91
3.68
e9/l
—
6
8
5
5
10.42
3.01
1.2
1.2
—
—
—
0
0
19
84
2.55
3.00
3.4
2.4
11.81
14.51
umol/l
0.82
19
79
34
195
2.12
2.97
7.3
5.2
—
—
—
0
0
12
38
3.44
2.97
5.4
14.3
26.30
25.27
mmol/l
0.50
12
38
20
96
2.35
2.65
8.9
10.2
104.75
103.90
mmol/l
0.35
20
96
12
45
2.89
2.55
4.0
2.2
—
—
—
0
0
5
8
6.50
2.40
1.0
1.0
—
—
—
0
0
13
54
2.62
2.30
1.0
1.1
—
—
—
0
0
32
196
1.93
2.27
3.8
2.7
—
—
—
0
0
15
70
2.34
2.11
12.5
18.7
7.41
7.42
ph
—
8
36
5
10
5.19
2.09
1.0
1.0
—
—
—
0
0
19
99
2.13
2.07
2.3
2.4
—
—
—
0
0
7
24
3.05
1.75
5.4
2.2
—
—
—
0
0
15
78
2.08
1.64
3.8
2.4
2.43
2.20
g/l
1.08
15
73
6
20
3.12
1.60
1.3
1.6
84.68
216.06
pmol/l
—
6
20
94
862
2.30
1.47
23.6
8.5
—
—
—
0
0
46
348
1.59
1.46
2.8
2.7
0.00
0.00
estimate
-0.00
14
70
46
349
1.58
1.44
2.8
2.7
0.00
0.00
estimate
-0.00
15
71
6
23
2.71
1.39
1.8
4.2
1.02
1.02
ratio
—
6
23
12
62
2.06
1.34
11.8
13.3
—
—
—
0
0
5
18
2.87
1.30
1.4
1.1
—
—
—
0
0
39
293
1.54
1.24
3.0
2.6
6.45
6.22
ph
0.62
21
181
23
154
1.64
1.17
1.2
1.4
2.54
2.40
g/l
0.17
15
106
5
20
2.57
1.16
1.0
1.3
—
—
—
0
0
9
45
2.10
1.08
12.9
16.7
0.51
0.71
%
—
9
45
17
107
1.71
1.08
2.2
1.6
—
—
—
0
0
14
83
1.80
1.08
2.6
2.6
—
—
—
0
0
9
46
2.05
1.07
13.0
16.5
1.29
1.94
%
—
9
46
9
47
2.00
1.05
13.0
16.1
95.30
91.45
%
—
9
47
13
76
1.82
1.05
1.2
1.2
—
—
—
0
0
44
353
1.44
0.97
2.9
2.7
0.00
0.00
estimate
—
10
60
0
32
0.00
0.97
0.0
5.1
—
—
—
0
0
0
32
0.00
0.97
0.0
1.4
—
—
—
0
0
35
270
1.45
0.95
4.1
2.6
43.47
38.01
ng/l
0.12
26
159
13
81
1.69
0.86
5.2
4.0
7.37
7.39
ph
—
8
51
11
66
1.75
0.82
2.0
1.5
—
—
—
0
0
6
33
1.87
0.80
1.3
1.2
—
54.00
—
0
5
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
5
24
2.14
0.75
1.4
1.1
—
—
—
0
0
5
24
2.14
0.75
3.0
2.0
—
—
—
0
0
12
78
1.61
0.69
5.6
3.9
2.55
1.60
mmol/l
0.76
12
71
31
250
1.35
0.63
2.5
1.7
94.83
91.14
pmol/l
0.18
17
139
5
30
1.70
0.62
1.0
1.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
0
21
0.00
0.61
0.0
1.1
—
6.92
—
0
9
0
22
0.00
0.60
0.0
1.1
—
10.72
—
0
13
0
23
0.00
0.59
0.0
3.3
—
284.88
—
0
16
57
507
1.29
0.56
4.1
3.2
—
—
—
0
0
6
38
1.61
0.55
11.0
17.4
—
—
—
0
0
7
47
1.53
0.49
1.1
1.3
—
—
—
0
0
7
49
1.46
0.47
3.1
3.1
1.66
1.72
%
—
7
49
7
50
1.43
0.46
3.1
3.1
0.51
0.56
%
—
7
50
37
424
0.80
0.46
2.5
2.6
—
—
—
0
0
11
78
1.46
0.45
1.6
1.6
0.18
0.37
mg/l
—
6
38
5
31
1.64
0.43
2.0
1.2
—
—
—
0
0
11
79
1.44
0.43
1.4
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.49
0.41
1.4
1.2
—
—
—
0
0
5
35
1.45
0.40
1.2
1.2
—
—
—
0
0
32
275
1.24
0.40
3.0
2.6
0.00
0.00
estimate
-0.00
13
59
0
19
0.00
0.39
0.0
13.1
—
1315.21
—
0
19
72
674
1.24
0.38
3.8
3.6
1.72
1.86
mu/l
0.47
67
629
24
201
1.25
0.37
3.2
2.1
0.00
0.00
estimate
—
10
53
6
44
1.39
0.35
1.2
1.1
—
—
—
0
0
14
110
1.32
0.34
1.2
1.9
3.85
3.77
mmol/l
—
8
77
6
46
1.32
0.33
1.7
2.7
—
—
—
0
0
7
51
1.40
0.32
1.0
1.3
—
—
—
0
0
21
176
1.24
0.32
1.1
1.4
0.71
1.30
u/ml
—
7
52
7
53
1.34
0.31
1.4
2.1
0.17
0.16
e6/l
—
7
48
23
196
1.22
0.30
3.4
4.5
11.71
8.21
mg/mmol
0.13
17
144
9
76
1.20
0.25
2.9
2.2
—
—
—
0
0
21
181
1.20
0.25
4.2
5.6
—
—
—
0
0
6
85
0.69
0.25
1.2
1.1
—
—
—
0
0
13
157
0.80
0.24
1.2
1.3
—
—
—
0
0
5
41
1.23
0.22
4.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.25
—
0
5
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
86.70
—
0
10
0
12
0.00
0.21
0.0
8.6
—
0.52
—
0
12
20
177
1.16
0.18
3.5
2.7
0.17
0.02
estimate
0.42
12
66
6
76
0.78
0.16
2.3
1.8
—
—
—
0
0
9
106
0.83
0.13
4.4
1.8
—
—
—
0
0
9
106
0.83
0.13
4.4
1.9
—
—
—
0
0
9
107
0.83
0.13
4.2
1.9
—
—
—
0
0
9
107
0.83
0.13
4.4
1.9
—
—
—
0
0
15
166
0.89
0.10
3.5
2.7
1.02
1.02
kg/l
—
7
108
5
44
1.14
0.10
2.0
1.3
—
—
—
0
0
6
57
1.06
0.08
1.3
1.3
—
—
—
0
0
6
72
0.82
0.08
7.3
2.4
—
—
—
0
0
9
100
0.89
0.06
4.4
2.0
—
—
—
0
0
21
223
0.93
0.06
3.6
2.3
0.71
0.73
ug/l
0.04
16
111
16
166
0.96
0.00
1.4
1.6
—
—
—
0
0
75
747
1.02
0.00
3.8
3.7
6.03
5.91
mmol/l
0.34
70
702
83
826
1.03
0.00
4.1
4.1
1.23
1.27
mmol/l
0.64
78
796
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
53.89
—
0
9
0
5
0.00
-0.00
0.0
3.8
—
11.40
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
7.46
—
0
5
0
5
0.00
-0.00
0.0
4.0
—
803.60
—
0
5
0
5
0.00
-0.00
0.0
4.2
—
70.40
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1193.00
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
34.00
—
0
5
5
50
1.00
-0.00
1.4
3.6
25.80
24.52
mmol/l
—
5
50
0
6
0.00
-0.00
0.0
2.8
—
0.41
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
41.56
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
1.57
—
0
7
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
178.40
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
95.71
—
0
7

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_TESTIS_NONSEMINOMA – Non-seminoma of testis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).