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This is a non-core endpoint: only basic statistics are computed.

Malignant neoplasm of peripheral nerves and autonomic nervous system

C3_PERIPHERAL_NERVES_AUTONOMIC3_NERVESYSTEM

tumour of cranial and spinal nerves: ['A benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths.', 'Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C47
  • Cause of death: ICD-9 1928
  • Cause of death: ICD-8 192[4-5]
  • Cancer registry: Topography ICD-O-3 C47
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

45

4. Check minimum number of events

None

45

5. Include endpoints

None

45

6. Filter based on genotype QC (FinnGen only)

43

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 43 22 21
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 17.12 15.06 19.29

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
106
4.06
5.09
2.5
1.5
—
—
—
0
0
9
11
9.88
4.82
1.4
1.2
—
—
—
0
0
9
15
7.19
4.05
8.4
8.3
23.89
24.19
mmol/l
—
9
15
21
90
3.50
4.02
3.6
2.0
—
—
—
0
0
20
85
3.44
3.85
5.7
1.8
2.39
2.37
mmol/l
0.37
15
71
11
27
5.04
3.70
9.0
10.4
—
—
—
0
0
10
23
5.27
3.56
7.8
6.4
1.04
1.36
mmol/l
—
10
23
10
25
4.83
3.33
1.3
1.0
—
—
—
0
0
16
69
3.05
2.90
4.9
3.4
—
—
—
0
0
9
24
4.42
2.85
9.1
16.1
24.11
24.70
mmol/l
—
9
24
25
148
2.55
2.40
4.3
6.6
0.61
0.63
%
0.06
25
139
10
35
3.38
2.39
9.6
6.5
107.20
104.74
mmol/l
—
10
35
7
18
4.40
2.36
10.4
9.9
96.29
91.81
%
—
7
18
25
151
2.48
2.26
4.4
6.6
3.09
2.79
%
0.29
25
144
7
19
4.16
2.25
10.4
9.4
0.59
0.79
%
—
7
19
25
152
2.45
2.22
4.5
6.8
7.49
8.38
%
0.73
25
145
7
20
3.94
2.15
10.3
9.1
1.06
2.16
%
—
7
20
25
157
2.33
2.00
4.4
6.7
26.52
29.07
%
0.47
25
151
5
11
4.96
1.99
2.4
2.0
—
—
—
0
0
15
75
2.50
1.98
9.6
5.5
—
—
—
0
0
28
190
2.25
1.81
11.2
7.3
3.85
4.37
e9/l
0.80
28
157
24
154
2.20
1.77
4.0
7.9
—
—
—
0
0
24
154
2.20
1.77
4.5
6.6
57.18
57.48
%
0.03
24
148
6
20
3.30
1.64
4.5
8.0
24.17
24.77
mmol/l
—
6
20
24
165
1.97
1.38
9.2
3.3
13.00
9.96
umol/l
0.76
24
157
10
50
2.29
1.28
1.4
1.6
463.80
907.67
nmol/l
—
5
38
8
38
2.34
1.26
2.3
2.0
—
—
—
0
0
5
22
2.43
1.06
2.8
2.3
—
—
—
0
0
6
30
2.15
0.91
1.7
2.1
407.00
396.92
nmol/l
—
6
25
21
155
1.67
0.85
6.9
7.3
0.00
0.00
e9/l
-0.00
16
115
29
234
1.67
0.82
6.3
4.1
—
—
—
0
0
5
26
2.03
0.73
6.6
5.7
4.64
5.26
kpa
—
5
26
5
26
2.03
0.73
1.2
1.5
—
—
—
0
0
12
80
1.68
0.68
4.8
3.8
—
—
—
0
0
30
251
1.59
0.67
3.0
3.8
9.42
10.45
mm/h
0.23
24
231
8
121
0.59
0.67
2.5
2.9
—
—
—
0
0
5
29
1.81
0.66
1.2
1.2
—
—
—
0
0
5
88
0.51
0.64
5.8
2.9
—
—
—
0
0
12
82
1.63
0.62
2.8
2.2
109.00
159.57
u/l
0.51
12
77
16
121
1.50
0.54
1.4
1.8
67.00
87.16
pmol/l
—
5
55
25
210
1.43
0.49
3.8
3.2
—
—
—
0
0
5
32
1.63
0.44
1.2
1.4
—
—
—
0
0
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
0
15
0.00
0.42
0.0
1.3
—
129.00
—
0
5
0
16
0.00
0.42
0.0
2.2
—
0.51
—
0
16
0
16
0.00
0.42
0.0
2.2
—
1.19
—
0
16
34
311
1.38
0.33
4.2
5.1
37.16
39.70
mmol/mol
0.91
28
287
11
85
1.39
0.32
4.7
3.2
—
—
—
0
0
5
71
0.67
0.29
1.8
1.7
—
—
—
0
0
10
79
1.34
0.25
2.6
3.9
—
—
—
0
0
5
37
1.39
0.24
1.4
1.6
—
—
—
0
0
10
80
1.32
0.23
3.0
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
6.4
—
1.16
—
0
10
0
10
0.00
0.21
0.0
6.4
—
3.80
—
0
10
0
12
0.00
0.21
0.0
4.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
37
379
0.87
0.17
17.0
8.4
—
—
—
0
0
39
376
1.28
0.17
26.2
11.1
78.03
75.78
umol/l
0.18
39
376
12
105
1.19
0.12
4.6
3.4
6.31
7.27
mmol/l
0.48
12
89
8
92
0.84
0.07
1.5
1.9
—
—
—
0
0
9
102
0.85
0.07
2.0
1.6
—
—
—
0
0
12
116
1.05
0.00
3.1
3.3
55.33
35.44
ng/l
—
6
74
14
142
0.98
0.00
4.4
3.6
—
5.75
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
106.33
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
4.09
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
4.22
—
0
6
0
6
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
68.25
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.86
-0.00
1.6
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
211.60
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
5.30
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
40.90
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
220.71
—
0
7
0
5
0.00
-0.00
0.0
4.6
—
56.80
—
0
5
7
68
1.03
-0.00
2.9
2.5
339.29
343.43
umol/l
—
7
60
0
6
0.00
-0.00
0.0
3.0
—
7.13
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_PERIPHERAL_NERVES_AUTONOMIC3_NERVESYSTEM – Malignant neoplasm of peripheral nerves and autonomic nervous system

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).