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Waldenstrom macroglobulinemia, lymphoplasmacytic lymphoma, including Hilmo

Endpoint Browser PheWeb

C3_MACROGLOBULINEMIA_WIDE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C88.0
  • Hospital discharge: ICD-9 — 2733A
  • Cause of death: ICD-10 — C88.0
  • Cause of death: ICD-9 — 2733A
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 9761|9671
  • Cancer registry: Behaviour codes — 3

3 out of 7 registries used, show all original rules.

354

4. Check minimum number of events

None

354

5. Include endpoints

None

354

6. Filter based on genotype QC (FinnGen only)

274

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 274 108 166
Unadjusted period prevalence (%) 0.06 0.04 0.08
Median age at first event (years) 69.50 67.11 71.05

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
286
Matched controls
2860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C88.0
ICD-10 Finland
Waldenström macroglobulinaemia
+∞
307.7
266
*
XW000
NOMESCO Finland
Bone marrow biopsy
108.0
285.9
155
31
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
139.5
186.1
94
10
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3487.9
184.4
158
*
A04AA01
ATC
ondansetron; systemic, rectal
44.2
138.6
87
28
9761/3-C42.0
ICD-O-3
Waldenstrom macroglobulinemia of blood
+∞
128.0
113
*
H02AB02
ATC
dexamethasone; systemic
75.5
125.9
69
12
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
25.4
89.7
67
34
WW500
NOMESCO Finland
Blood transfusion
23.6
61.2
46
23
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
192.8
60.6
61
*
L03AA02
ATC
filgrastim; parenteral
+∞
58.4
54
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
57.2
53
*
9671/3-C42.1
ICD-O-3
Lymphoplasmacytic lymphoma of bone marrow
+∞
52.8
49
*
JN4BD
NOMESCO Finland
Extensive body CT
10.3
48.1
60
72
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
47.2
44
*
L03AA13
ATC
pegfilgrastim; parenteral
527.7
46.7
45
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.8
46.5
91
183
JN4AD
NOMESCO Finland
Body CT examination
8.1
44.5
69
108
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
445.5
40.1
39
*
ZX120
NOMESCO Finland
Intravenous
7.8
36.9
57
88
M04AA01
ATC
allopurinol; systemic
4.9
34.8
104
298
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
8.3
32.8
47
66
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
31.9
30
*
R50.9
ICD-10 Finland
Fever, unspecified
4.9
30.1
84
225
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
29.7
28
*
WZC00
NOMESCO Finland
Treatment plan or consultation
4.0
28.7
125
465
390
Kela drug reimbursment
Ibrutinib
+∞
28.6
27
*
1512
Kela drug reimbursment
Ibrutinib
+∞
28.6
27
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
27.5
26
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
27.5
26
*
D64.9
ICD-10 Finland
Anaemia, unspecified
4.6
26.7
78
215
JN6AD
NOMESCO Finland
CT of torso and neck
44.7
26.4
32
8
A03FA01
ATC
metoclopramide; systemic, rectal
4.7
25.6
72
192
C83.01
ICD-10 Finland
Lymphoplasmacytic lymphoma
+∞
25.4
24
*
C90.0
ICD-10 Finland
Multiple myeloma
+∞
24.3
23
*
L01EL01
ATC
ibrutinib; oral
+∞
23.2
22
*
J05AB01
ATC
aciclovir; systemic
3.7
23.1
103
381
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
22.2
21
*
L01AA02
ATC
chlorambucil; oral
+∞
22.2
21
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
22.2
21
*
B03XA01
ATC
erythropoietin; parenteral
124.6
21.9
23
*
J05AB11
ATC
valaciclovir; oral
3.9
20.8
74
233
EP1AE
NOMESCO Finland
Neck ultrasound examination
7.1
20.1
32
50
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
20.0
19
*
B03XA02
ATC
darbepoetin alfa; parenteral
24.8
18.1
25
11
C88.9
ICD-10 Finland
Malignant immunoproliferative disease, unspecified
+∞
17.9
17
*
130
Kela drug reimbursment
Malignant tumour
+∞
16.8
16
*
N08.1*C88.0
ICD-10 Finland
Glomerular disorders in Waldenström's macroglobulinaemia
+∞
16.8
16
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.2
16.1
35
74
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
15.8
15
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
15.8
15
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
60.0
14.9
17
*
1XC02, ,
NOMESCO Finland
60.0
14.9
17
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
84.6
14.7
16
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
14.5
180
1107
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
14.2
58
197
H02AB06
ATC
prednisolone; systemic
2.6
13.8
166
997
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
13.8
86
374
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
13.6
13
*
115
Kela drug reimbursment
Breast cancer
+∞
13.6
13
*
116
Kela drug reimbursment
Prostate cancer
+∞
13.6
13
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
6.0
13.1
24
43
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
10.8
12.8
24
24
L01AA01
ATC
cyclophosphamide; systemic
73.2
12.7
14
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
12.6
12
*
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
12.6
12
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
12.6
12
*
J01MA12
ATC
levofloxacin; systemic
2.8
12.4
78
339
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
12.3
115
605
XX3DW
NOMESCO Finland
Time consuming IT work
5.0
12.2
27
58
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
48.8
12.0
14
*
WF002
NOMESCO Finland
Radical radiotherapy
48.8
12.0
14
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
67.8
11.7
13
*
GD1AD
NOMESCO Finland
Thorax CT examination
4.3
11.6
32
82
C83.1
ICD-10 Finland
Mantle cell lymphoma
+∞
11.5
11
*
L01XE27
ATC
[U] ibrutinib
+∞
11.5
11
*
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
+∞
11.5
11
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
11.5
11
*
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
124.8
11.5
12
*
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
124.8
11.5
12
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
11.4
124
694
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.8
11.4
38
112
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.3
11.1
47
162
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
11.0
51
186
Z51.5
ICD-10 Finland
Palliative care
4.3
10.8
29
73
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
+∞
10.5
10
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
10.5
10
*
L02BG04
ATC
letrozole; oral
+∞
10.5
10
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
+∞
10.5
10
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
10.5
10
*
A04AD12
ATC
aprepitant; systemic
+∞
10.5
10
*
B02.9
ICD-10 Finland
Zoster without complication
3.5
10.4
38
119
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.7
10.1
34
101
WZC30
NOMESCO Finland
Teaching
2.9
10.0
52
202
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
9.7
76
363
L02AE02
ATC
leuprorelin; implant, parenteral
103.3
9.5
10
*
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
9.4
9
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
9.4
9
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
+∞
9.4
9
*
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
+∞
9.4
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
9.3
109
620
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
8.8
80
408
NK6AN
NOMESCO Finland
Total body bone isotope imaging
51.6
8.7
10
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.9
8.7
26
71
A02BC02
ATC
pantoprazole; systemic
2.3
8.7
214
1611
D70.89
ICD-10 Finland
Neutropenic splenomegaly
28.5
8.5
11
*
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
20.8
8.5
12
6
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
8.4
8
*
A79
ICPC
Malignancy NOS
+∞
8.4
8
*
9591/3-C42.1
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of bone marrow
+∞
8.4
8
*
C83.0
ICD-10 Finland
Small cell B-cell lymphoma
+∞
8.4
8
*
N02AA05
ATC
oxycodone; systemic
2.5
8.4
64
301
B01AB10
ATC
tinzaparin; parenteral
3.1
8.3
37
131
L57.0
ICD-10 Finland
Actinic keratosis
2.9
8.1
41
156
PJA10
NOMESCO Finland
Exploration of lymph nodes
34.4
8.1
10
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
34.4
8.1
10
*
TAB00
NOMESCO Finland
Lumbar puncture
4.2
8.0
22
56
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
4.1
7.9
22
57
HAB40
NOMESCO Finland
Wedge excision of mammary gland
46.3
7.8
9
*
UJF32
NOMESCO Finland
Coloscopy
2.2
7.7
87
482
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
12.3
7.7
13
11
ZX108
NOMESCO Finland
Inhalation
25.8
7.6
10
*
WW200
NOMESCO Finland
Immunization
7.5
7.6
17
24
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
82.1
7.5
8
*
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
7.2
7.4
17
25
A41.9
ICD-10 Finland
Sepsis, unspecified
4.0
7.4
21
55
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.4
7.4
19
46
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
+∞
7.3
7
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
7.3
7
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
7.3
7
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
7.3
7
*
WW300
NOMESCO Finland
Transfer of autologic stem cells
+∞
7.3
7
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
7.3
7
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
7.3
7
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
7.3
7
*
L01BB05
ATC
fludarabine; systemic
+∞
7.3
7
*
C83.00
ICD-10 Finland
Lymphocytic lymphoma
+∞
7.3
7
*
WX402
NOMESCO Finland
General anaesthesia
2.3
7.2
60
292
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
30.9
7.2
9
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.7
7.2
23
66
J01CA04
ATC
amoxicillin; systemic
2.2
7.0
228
1824
B01AB04
ATC
dalteparin; parenteral
4.2
7.0
19
48
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
14.2
6.9
11
8
B01AB05
ATC
enoxaparin; parenteral
2.0
6.9
97
580
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
23.1
6.7
9
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.2
6.7
27
90
J01MA14
ATC
moxifloxacin; systemic
2.8
6.7
35
136
C03CA01
ATC
furosemide; systemic
1.9
6.6
125
825
WZC15, ,
NOMESCO Finland
71.4
6.5
7
*
Y77
ICPC
Malignant neoplasm prostate
71.4
6.5
7
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.8
6.4
17
31
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.9
6.4
145
1012
AA1AA
NOMESCO Finland
Head X-ray examination
11.4
6.3
11
10
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
11.4
6.3
11
10
ZX112
NOMESCO Finland
Subcutaneous
11.4
6.3
11
10
UJF30
NOMESCO Finland
Ileoscopy through colon
2.6
6.3
37
152
JN4CD
NOMESCO Finland
Very extensive body CT
7.3
6.3
14
20
153
Kela drug reimbursment
Lenalidomid
+∞
6.3
6
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
L04AX04
ATC
lenalidomide; oral
+∞
6.3
6
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
6.3
6
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
6.3
6
*
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
+∞
6.3
6
*
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
+∞
6.3
6
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
6.3
6
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
6.3
6
*
329
Kela drug reimbursment
Lenalidomide
+∞
6.3
6
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
8.0
6.2
13
17
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.8
6.1
19
53
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.8
6.1
31
118
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
10.3
6.1
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
184
39
130.48
307.65
2.2
1.3
—
—
—
0
0
237
126
104.95
307.65
14.8
1.3
14.46
1.13
g/l
37.81
228
119
194
78
75.21
302.86
8.4
1.3
110.19
44.48
mg/l
4.40
180
69
194
79
74.23
301.54
8.3
1.3
55.41
32.57
mg/l
0.69
180
71
180
68
69.72
284.99
8.0
1.3
19.44
1.35
ratio
3.99
122
39
223
178
53.33
261.56
12.9
1.3
—
—
—
0
0
195
157
36.89
223.54
6.6
1.9
8.03
11.16
g/l
6.49
190
144
120
24
85.42
218.11
1.6
1.3
—
—
—
0
0
129
92
24.72
151.80
11.7
1.2
15.91
10.40
g/l
6.07
121
81
90
24
54.26
151.29
1.8
1.0
—
—
—
0
0
76
12
85.89
141.46
1.2
1.0
—
—
—
0
0
93
53
25.52
119.93
1.8
1.3
—
—
—
0
0
114
7
268.91
118.61
1.5
1.0
—
—
—
0
0
171
276
13.92
117.01
5.6
1.9
62.78
65.16
e9/l
0.33
132
207
187
357
13.24
111.13
5.6
1.8
1.68
1.70
%
0.11
179
318
118
125
15.37
108.11
2.7
1.6
1.43
1.61
g/l
1.08
105
113
101
92
16.43
101.24
1.5
1.3
—
—
—
0
0
130
176
12.71
99.77
2.0
1.3
—
—
—
0
0
140
220
11.51
95.38
1.9
1.4
—
—
—
0
0
184
412
10.72
92.37
4.7
1.3
1.58
2.95
g/l
5.97
167
238
120
167
11.66
89.30
1.9
1.4
—
—
—
0
0
61
26
29.55
87.30
2.3
2.1
1.05
1.51
g/24h
0.23
40
17
46
11
49.64
77.69
1.8
2.0
33.44
51.80
%
2.27
46
11
199
673
7.43
60.58
6.4
2.5
332.82
362.95
umol/l
3.57
190
574
139
336
7.10
60.51
8.9
4.6
1.05
1.02
mmol/l
0.64
133
306
210
763
7.59
58.59
17.1
5.1
—
—
—
0
0
44
23
22.43
57.38
2.2
1.5
450.05
852.74
mg
0.67
44
23
60
8
94.30
55.53
1.4
1.0
—
—
—
0
0
247
1165
9.21
48.39
17.5
5.1
0.68
0.61
e9/l
2.71
231
986
248
1175
9.36
48.32
17.4
5.1
0.04
0.04
e9/l
0.13
232
999
249
1186
9.50
48.18
17.5
5.2
1.94
1.79
e9/l
0.47
236
1030
250
1208
9.50
47.20
18.3
5.1
0.16
0.21
e9/l
4.39
236
1036
251
1229
9.52
46.33
29.7
5.8
3.54
4.35
e9/l
8.80
234
1060
88
186
6.39
42.39
8.7
3.5
0.72
0.87
%
0.30
58
42
247
1286
7.75
39.59
20.5
6.1
1.22
1.21
mmol/l
1.63
227
1108
80
175
5.96
36.77
9.1
3.4
0.48
0.37
%
0.30
51
38
178
742
4.70
36.77
15.1
3.1
7.40
7.40
ph
0.78
144
515
79
179
5.72
34.81
9.1
3.5
0.04
0.09
%
0.37
49
35
166
697
4.29
32.97
3.2
2.4
2.92
2.91
mg/l
0.02
149
589
222
1162
5.07
32.21
17.6
5.6
1.22
1.21
mmol/l
2.07
217
1045
36
7
58.53
31.14
3.0
1.4
44.78
179.43
e6/l
—
36
7
32
29
12.30
30.76
2.9
1.4
32.91
32.55
pg
0.13
32
29
121
429
4.16
29.94
3.1
1.9
30.83
29.76
s
0.90
115
415
34
36
10.58
29.43
1.2
1.2
—
—
—
0
0
31
29
11.87
29.16
1.6
1.1
—
—
—
0
0
38
14
31.04
28.84
3.8
1.0
42.14
39.64
g/l
0.73
38
14
200
1050
4.01
26.85
5.3
2.9
223.92
137.16
ug/l
2.49
195
961
71
188
4.69
25.50
9.9
3.6
0.00
0.00
%
-0.00
41
32
29
6
53.54
24.79
1.3
1.0
—
—
—
0
0
61
147
5.00
24.52
2.7
1.4
2.67
2.81
ug/l
0.14
46
114
32
14
25.56
23.16
1.5
1.2
—
—
—
0
0
115
458
3.53
22.94
13.4
4.0
—
—
—
0
0
162
814
3.28
21.76
5.7
2.0
2.35
2.35
mmol/l
0.13
148
707
148
717
3.21
20.95
6.4
2.2
—
—
—
0
0
147
719
3.15
20.31
10.1
4.0
—
—
—
0
0
180
1020
3.06
18.61
6.0
2.5
—
—
estimate
—
0
0
136
663
3.00
18.48
2.7
1.6
—
—
—
0
0
37
73
5.67
18.44
1.4
1.3
—
—
—
0
0
74
257
3.54
17.76
3.9
2.3
5.41
7.78
umol/l
1.68
69
229
58
172
3.98
17.55
1.4
1.1
—
—
—
0
0
22
7
33.87
17.30
1.5
1.0
—
—
—
0
0
116
548
2.88
16.27
6.8
2.2
—
—
—
0
0
39
91
4.80
16.03
2.0
2.4
1137.58
252.07
mg/l
0.48
24
27
79
303
3.22
16.02
1.5
1.3
870.00
518.97
titre
—
8
78
76
285
3.27
16.00
4.4
2.6
3.31
5.13
e9/l
3.00
62
235
116
560
2.80
15.48
7.0
3.9
82.91
83.65
%
0.11
111
554
25
41
6.59
14.93
5.5
1.6
49.92
59.88
%
1.84
25
41
155
889
2.62
14.38
2.4
1.7
22.67
19.45
nmol/l
1.60
143
742
24
41
6.30
13.76
1.2
1.1
—
—
—
0
0
107
523
2.67
13.63
1.9
1.8
1112.79
1209.69
nmol/l
0.47
85
401
25
45
5.99
13.61
1.5
1.1
—
—
—
0
0
20
12
17.80
13.18
4.2
1.9
0.50
0.98
e9/l
1.17
20
12
167
1030
2.49
12.76
33.1
10.2
0.00
0.00
e9/l
0.55
146
845
19
12
16.85
12.32
2.5
2.6
39.13
53.00
%
—
8
6
37
104
3.94
11.90
1.0
1.3
—
—
—
0
0
189
1265
2.46
11.61
2.9
2.2
93.16
95.44
pmol/l
0.26
125
658
23
26
9.52
11.50
1.6
1.2
165.45
171.55
au/ml
—
11
8
20
19
11.22
10.96
9.8
4.2
—
—
—
0
0
81
379
2.59
10.95
2.2
1.8
—
—
—
0
0
30
77
4.24
10.88
2.0
1.4
0.89
1.14
g/l
3.10
30
71
29
76
4.13
10.22
2.0
1.3
0.16
0.22
g/l
2.92
24
71
221
1635
2.55
10.18
6.5
4.3
—
3.91
—
0
5
52
202
2.92
10.00
4.5
3.6
92.33
88.13
ng/l
0.10
43
171
137
836
2.23
9.94
5.7
3.2
12.38
136.35
e6/l
0.88
111
613
22
31
7.59
9.71
4.7
1.7
2.90
4.65
e9/l
2.55
22
31
21
44
5.07
9.70
1.5
1.1
—
—
—
0
0
121
710
2.22
9.59
5.6
3.0
0.69
0.46
e6/l
0.34
98
493
9
0
+∞
9.42
1.3
0.0
—
—
—
0
0
185
1301
2.19
9.08
19.8
17.7
1.30
1.35
inr
0.49
160
1085
91
485
2.29
9.02
4.1
2.8
506.48
530.01
mosm/kgh2o
0.58
77
406
153
1004
2.13
8.94
4.0
3.4
1752.04
1477.82
ng/l
0.38
136
866
64
293
2.53
8.89
1.8
1.7
—
—
—
0
0
96
531
2.22
8.64
2.2
1.7
2.12
1.26
mg/l
0.43
82
418
16
16
10.52
8.64
1.4
1.1
—
—
—
0
0
143
924
2.10
8.60
7.0
3.8
60.77
129.17
e6/l
1.01
110
631
95
528
2.20
8.42
4.2
2.1
2.53
2.44
mmol/l
6.05
83
467
46
184
2.79
8.33
16.0
3.1
1.24
1.22
mmol/l
1.54
46
150
101
578
2.16
8.30
4.3
2.4
3.60
4.85
e6/l
1.09
89
512
70
347
2.35
8.12
1.2
1.2
—
—
—
0
0
11
5
22.79
8.07
1.4
1.0
—
—
—
0
0
98
560
2.14
8.04
1.6
1.3
—
—
—
0
0
19
30
6.70
7.86
1.4
1.3
—
—
—
0
0
19
30
6.70
7.86
1.4
1.3
—
—
—
0
0
19
30
6.70
7.86
1.4
1.3
—
—
—
0
0
19
30
6.70
7.86
1.4
1.3
—
—
—
0
0
158
1083
2.03
7.84
3.3
2.4
83.06
79.55
nmol/l
0.68
147
941
18
30
6.33
7.20
1.0
1.0
—
—
—
0
0
75
403
2.17
7.09
1.5
1.3
62.96
35.87
iu/ml
0.39
20
121
174
1263
1.96
7.02
5.0
3.9
0.00
0.00
estimate
-0.00
42
253
62
310
2.28
6.98
2.0
1.5
—
—
—
0
0
70
369
2.19
6.93
1.3
1.3
4.46
9.94
u/ml
0.66
22
129
15
21
7.47
6.79
1.3
1.2
—
—
—
0
0
46
205
2.48
6.68
2.7
2.1
0.16
0.20
g/l
2.59
39
183
123
806
1.92
6.64
3.8
2.2
58.69
64.22
u/l
0.34
114
743
176
1297
1.93
6.63
5.0
4.0
0.00
0.03
estimate
0.93
42
240
15
22
7.13
6.61
1.3
1.2
0.43
0.32
g/l
—
10
17
16
26
6.45
6.57
1.8
1.2
—
—
—
0
0
106
665
1.94
6.48
13.8
4.3
—
—
—
0
0
174
1283
1.91
6.48
5.0
4.0
0.00
0.00
estimate
-0.00
43
258
36
145
2.70
6.41
2.3
2.5
—
—
—
0
0
146
1028
1.86
6.18
4.2
3.5
6.33
6.25
ph
0.42
72
551
17
33
5.41
6.12
1.4
1.1
313.00
187.82
u/ml
—
9
11
15
25
6.27
6.08
2.1
1.2
—
—
—
0
0
21
64
3.46
5.99
1.5
1.2
10.15
79.51
e6/l
0.44
13
53
74
420
2.03
5.96
5.1
3.0
1.93
2.02
e6/l
0.04
41
196
21
65
3.41
5.85
1.5
1.3
32.79
1786.29
e6/l
0.56
14
55
47
230
2.25
5.51
2.0
2.0
158.06
135.88
ug/g
0.24
35
174
117
799
1.79
5.24
3.7
3.2
—
—
—
0
0
26
98
2.82
5.24
1.7
2.1
12.59
9.60
iu/ml
—
7
23
5
0
+∞
5.22
1.4
0.0
—
—
—
0
0
16
36
4.64
5.14
1.7
2.1
1.42
1.20
g/l
0.09
11
31
67
389
1.94
4.99
9.4
6.4
104.76
104.38
mmol/l
0.24
67
389
16
46
3.63
4.97
5.9
2.7
8.65
11.71
pmol/l
0.44
16
46
41
198
2.25
4.95
5.8
4.1
7.42
7.42
ph
0.29
35
162
17
52
3.41
4.83
5.1
3.2
—
—
—
0
0
57
317
2.00
4.79
5.9
3.1
7.37
7.39
ph
0.84
34
192
11
18
6.31
4.65
1.3
1.2
—
—
—
0
0
98
655
1.75
4.62
3.7
3.3
0.00
0.10
—
7
21
7
5
14.30
4.60
4.0
1.0
—
—
—
0
0
46
242
2.07
4.49
12.3
7.8
—
—
—
0
0
45
238
2.06
4.33
1.4
1.3
—
—
—
0
0
11
22
5.16
4.04
1.3
1.2
—
—
—
0
0
39
202
2.08
3.96
3.7
2.1
32.26
37.24
u/l
0.35
31
164
255
2278
2.10
3.83
53.5
15.8
21.88
25.68
mg/l
1.57
246
1856
11
24
4.72
3.78
2.1
1.2
—
—
—
0
0
10
20
5.14
3.72
1.9
1.1
—
—
—
0
0
42
229
1.98
3.71
2.1
2.1
0.00
0.00
estimate
—
5
46
58
352
1.81
3.71
8.7
7.0
0.82
1.20
mmol/l
0.41
51
292
14
40
3.63
3.66
2.6
3.0
—
—
—
0
0
7
9
7.94
3.58
1.3
1.2
—
—
—
0
0
34
176
2.06
3.46
6.3
3.4
—
—
—
0
0
10
22
4.67
3.46
1.3
1.0
—
—
—
0
0
81
553
1.65
3.39
4.3
4.5
240.34
388.99
ng/l
0.37
68
475
42
237
1.91
3.37
2.9
1.6
355.69
379.33
nmol/l
0.36
42
217
43
245
1.89
3.35
9.7
7.1
1.03
1.42
mmol/l
3.85
43
240
57
357
1.75
3.27
9.1
7.0
7.42
7.41
ph
0.46
30
220
12
35
3.53
3.14
1.5
1.1
—
—
—
0
0
32
170
1.99
3.05
11.0
9.0
24.31
24.44
mmol/l
0.10
32
164
5
5
10.14
2.99
1.0
2.0
—
—
—
0
0
20
89
2.34
2.94
2.3
1.8
—
—
—
0
0
8
17
4.81
2.94
1.3
1.1
—
—
—
0
0
15
58
2.67
2.92
1.1
1.3
333.60
325.96
ug/g
—
10
38
50
312
1.73
2.90
6.3
3.0
1.46
1.95
mmol/l
0.37
43
275
70
478
1.61
2.89
1.4
1.3
0.34
1.63
u/ml
—
9
134
6
9
6.78
2.88
1.0
1.1
—
—
—
0
0
14
53
2.73
2.84
3.1
2.9
—
—
—
0
0
171
1438
1.47
2.58
4.3
3.3
56.12
53.36
u/l
0.15
161
1327
9
26
3.54
2.50
1.3
1.0
—
—
—
0
0
21
104
2.10
2.43
1.4
1.3
—
—
—
0
0
6
13
4.69
2.28
1.0
1.2
—
—
—
0
0
6
13
4.69
2.28
1.0
1.2
—
—
—
0
0
139
1142
1.42
2.27
6.0
4.3
47.72
87.95
ng/l
0.42
116
906
5
9
5.63
2.22
1.0
1.1
—
—
—
0
0
8
24
3.40
2.19
2.1
1.3
—
—
—
0
0
32
191
1.76
2.18
1.5
1.5
—
—
—
0
0
27
153
1.84
2.17
1.2
1.3
—
—
—
0
0
20
102
2.03
2.16
1.1
1.3
—
—
—
0
0
9
31
2.96
2.09
3.3
2.2
-0.23
1.12
mmol/l
—
9
31
25
141
1.85
2.04
6.2
4.3
—
—
—
0
0
200
1772
1.43
2.02
4.1
3.9
14.83
15.08
pmol/l
0.75
183
1588
5
12
4.22
1.83
1.4
1.1
—
—
—
0
0
9
35
2.62
1.81
1.0
1.1
—
—
—
0
0
13
60
2.22
1.80
1.2
1.2
—
—
—
0
0
83
651
1.39
1.68
4.4
3.7
0.00
0.00
estimate
-0.00
33
196
7
25
2.84
1.66
2.3
1.8
6.69
11.10
%
—
7
25
13
63
2.11
1.62
1.2
1.4
—
—
—
0
0
5
14
3.61
1.62
1.0
1.3
56.40
80.86
pmol/l
—
5
14
5
14
3.61
1.62
1.2
1.0
—
—
—
0
0
8
32
2.54
1.61
2.5
1.5
89.79
90.46
%
—
8
32
7
26
2.73
1.59
1.6
1.3
—
—
—
0
0
11
50
2.25
1.59
1.2
1.4
—
—
—
0
0
10
44
2.32
1.57
1.1
1.2
—
—
—
0
0
8
33
2.46
1.55
1.1
1.0
996.50
576.04
ng/l
—
8
23
8
33
2.46
1.55
1.1
1.0
337.88
258.26
ng/l
—
8
23
6
22
2.76
1.44
2.0
2.2
—
—
—
0
0
89
725
1.33
1.40
5.6
3.9
0.00
0.01
estimate
0.50
33
228
10
47
2.17
1.35
1.2
1.2
—
—
—
0
0
86
1032
0.76
1.30
1.9
2.0
1.28
1.30
mmol/l
0.08
70
841
12
62
1.98
1.29
3.9
3.8
0.71
1.50
index
—
7
36
5
18
2.81
1.29
1.2
1.1
—
—
—
0
0
112
955
1.28
1.24
5.3
4.0
0.00
0.02
estimate
0.80
38
197
30
209
1.49
1.16
3.2
3.0
6.30
6.03
ph
1.07
22
147
0
35
0.00
1.16
0.0
4.3
—
357.79
—
0
29
28
196
1.48
1.07
5.6
4.4
—
—
—
0
0
134
1184
1.25
1.07
5.3
4.5
2.24
2.01
ug/l
0.32
121
1052
7
33
2.15
1.06
3.4
1.8
11.43
10.12
mmol/l
—
7
33
64
779
0.77
1.05
3.0
3.9
—
—
—
0
0
13
75
1.77
1.04
3.6
4.4
—
—
—
0
0
5
23
2.19
0.98
1.0
1.3
—
—
—
0
0
12
69
1.77
0.98
4.5
3.3
0.82
0.87
nmol/l
—
6
56
7
36
1.97
0.97
3.4
4.9
6.40
6.52
mmol/l
—
7
30
21
142
1.52
0.95
3.6
3.8
1.02
1.02
ratio
0.70
21
132
24
168
1.47
0.93
3.7
2.5
0.57
0.60
%
0.32
24
168
229
2167
1.28
0.92
5.5
5.1
1.94
2.00
mu/l
0.26
217
1958
24
173
1.42
0.82
3.4
2.5
1.35
1.11
%
0.66
24
173
5
96
0.51
0.79
3.6
10.6
—
—
—
0
0
22
157
1.43
0.79
3.8
2.9
24.72
25.45
mmol/l
0.38
22
152
5
24
2.10
0.75
1.2
1.1
—
—
—
0
0
5
24
2.10
0.75
1.0
1.1
—
13.02
—
0
5
72
621
1.21
0.69
1.5
1.8
487.86
423.11
pmol/l
1.10
58
504
5
27
1.87
0.68
1.4
2.7
—
—
—
0
0
17
236
0.70
0.68
1.6
1.4
—
—
—
0
0
243
2340
1.26
0.67
38.2
14.7
—
—
—
0
0
255
2475
1.28
0.61
72.3
23.8
3.93
4.48
e12/l
35.13
248
2396
255
2475
1.28
0.61
72.3
23.8
6.73
6.80
e9/l
0.16
248
2400
36
292
1.27
0.60
2.7
2.8
6.21
8.41
ug/l
0.26
30
255
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
221
2282
0.86
0.45
6.7
7.6
37.53
40.45
mmol/mol
9.11
204
2113
28
230
1.24
0.44
4.3
2.5
0.58
0.36
e6/l
0.36
28
214
6
92
0.64
0.43
1.7
1.4
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
nmol/l
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
86.19
—
0
16
12
88
1.38
0.40
1.8
1.5
59.45
14.72
u/ml
—
6
13
7
103
0.67
0.40
1.0
1.2
—
94.75
—
0
38
5
35
1.44
0.39
2.2
3.0
—
—
—
0
0
15
116
1.31
0.38
2.0
1.8
—
—
—
0
0
222
2282
0.88
0.37
4.7
5.7
1.37
1.44
mmol/l
1.43
202
2069
6
43
1.40
0.35
3.8
2.8
1.21
1.20
mmol/l
—
6
43
6
45
1.34
0.34
3.8
2.7
105.83
105.80
mmol/l
—
6
45
6
45
1.34
0.34
3.8
2.7
4.35
4.12
mmol/l
—
6
45
73
672
1.12
0.31
3.2
3.0
0.71
0.78
ug/l
0.42
57
468
230
2352
0.89
0.31
5.4
6.7
2.28
2.51
mmol/l
4.38
211
2141
11
85
1.31
0.28
1.5
1.3
—
—
—
0
0
5
73
0.68
0.26
1.0
1.1
—
—
—
0
0
214
2189
0.91
0.25
4.3
4.8
1.13
1.27
mmol/l
1.56
192
1969
6
83
0.72
0.24
2.3
2.0
32.83
44.78
nmol/l
—
6
78
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
226
2301
0.92
0.21
4.6
5.8
4.10
4.39
mmol/l
3.85
209
2106
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
104
994
1.07
0.20
4.6
3.6
75.62
46.35
mg/l
0.53
80
650
21
194
1.09
0.09
1.9
2.6
13.77
15.50
nmol/l
0.64
21
172
58
602
0.95
0.09
5.6
4.1
1.02
1.02
kg/l
0.09
45
395
102
1000
1.03
0.06
4.3
3.5
6.71
7.60
mmol/l
1.24
89
822
10
90
1.12
0.05
1.2
1.1
—
—
—
0
0
14
151
0.92
0.05
1.2
1.3
—
—
—
0
0
230
2315
0.97
0.05
5.6
5.8
5.87
6.14
mmol/l
4.03
212
2083
103
1017
1.02
0.03
5.0
4.3
16.75
7.59
mg/mmol
0.89
71
648
184
1845
0.99
0.00
59.6
20.8
328.41
331.99
g/l
5.28
184
1834
0
7
0.00
0.00
0.0
11.7
—
981.71
—
0
7
0
8
0.00
0.00
0.0
1.3
—
76.45
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
8.3
—
0.70
—
0
7
5
59
0.84
-0.00
1.6
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
120.83
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
11.64
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
53.33
—
0
6

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: C3_MACROGLOBULINEMIA_WIDE – Waldenstrom macroglobulinemia, lymphoplasmacytic lymphoma, including Hilmo

GWS hits: 5

This endpoint is excluded (different definition than used in FinnGen).