Malignant immunoproliferative diseases

C3_IMMUNOPROLIFERATIVE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C88
  • Cause of death: ICD-10 C88

2 out of 7 registries used, show all original rules.

452

4. Check minimum number of events

None

452

5. Include endpoints

None

452

6. Filter based on genotype QC (FinnGen only)

354

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
C81-C96
Name in latin
Morbi immunoproliferativi maligni

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 354 144 210
Unadjusted period prevalence (%) 0.08 0.05 0.10
Median age at first event (years) 69.47 67.51 70.82

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
369
Matched controls
3690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C88.0
ICD-10 Finland
Waldenström macroglobulinaemia
+∞
307.7
266
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
39.1
278.9
208
118
XW000
NOMESCO Finland
Bone marrow biopsy
35.3
247.9
184
101
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
67.9
171.6
96
19
9761/3-C42.0
ICD-O-3
Waldenstrom macroglobulinemia of blood
+∞
123.0
111
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
42.1
106.8
66
19
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
20.8
87.3
70
41
L03AA02
ATC
filgrastim; parenteral
15.4
81.2
77
62
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
16.7
78.9
71
52
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
26.8
77.3
55
24
C88.9
ICD-10 Finland
Malignant immunoproliferative disease, unspecified
+∞
69.0
64
*
A04AA01
ATC
ondansetron; systemic, rectal
7.9
65.8
109
185
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
19.1
54.0
44
26
WW500
NOMESCO Finland
Blood transfusion
9.1
52.4
71
94
9671/3-C42.1
ICD-O-3
Lymphoplasmacytic lymphoma of bone marrow
+∞
46.9
44
*
L03AA13
ATC
pegfilgrastim; parenteral
8.9
46.5
63
83
M04AA01
ATC
allopurinol; systemic
4.9
46.2
140
406
JN6AD
NOMESCO Finland
CT of torso and neck
14.2
45.1
43
34
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.0
42.3
120
327
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.0
42.2
72
123
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
132.6
34.3
36
*
R50.9
ICD-10 Finland
Fever, unspecified
4.3
33.9
115
354
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
7.2
32.5
52
82
1512
Kela drug reimbursment
Ibrutinib
315.6
29.2
29
*
390
Kela drug reimbursment
Ibrutinib
315.6
29.2
29
*
JN4BD
NOMESCO Finland
Extensive body CT
4.0
26.9
94
291
C88.7
ICD-10 Finland
Other malignant immunoproliferative diseases
+∞
26.4
25
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.8
25.4
94
302
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
5.5
25.0
52
106
JN4AD
NOMESCO Finland
Body CT examination
3.7
24.5
96
320
L01EL01
ATC
ibrutinib; oral
+∞
24.2
23
*
C88.4
ICD-10 Finland
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lyphoma]
+∞
24.2
23
*
ZX120
NOMESCO Finland
Intravenous
3.9
23.2
79
239
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
23.2
22.5
32
15
B03XA02
ATC
darbepoetin alfa; parenteral
7.9
21.1
30
41
J05AB01
ATC
aciclovir; systemic
2.9
19.5
122
532
J05AB11
ATC
valaciclovir; oral
3.2
19.4
93
348
L01AA02
ATC
chlorambucil; oral
48.8
19.4
23
5
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.4
17.9
49
125
WW200
NOMESCO Finland
Immunization
7.2
17.7
27
40
H02AB02
ATC
dexamethasone; systemic
3.3
17.6
78
277
1XC02, ,
NOMESCO Finland
30.5
17.6
23
8
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
16.8
84
320
N08.1*C88.0
ICD-10 Finland
Glomerular disorders in Waldenström's macroglobulinaemia
+∞
16.8
16
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
29.1
16.7
22
8
C83.01
ICD-10 Finland
Lymphoplasmacytic lymphoma
177.7
16.6
17
*
H02AB06
ATC
prednisolone; systemic
2.5
15.7
224
1422
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
7.4
15.4
23
33
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
5.5
15.1
30
58
B03XA01
ATC
erythropoietin; parenteral
13.2
15.1
26
21
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
11.6
14.2
26
24
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
13.7
152
849
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
26.9
13.5
18
7
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.6
13.4
47
143
A41.9
ICD-10 Finland
Sepsis, unspecified
4.4
13.1
34
83
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
12.2
13.0
23
20
C90.0
ICD-10 Finland
Multiple myeloma
12.2
13.0
23
20
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
51.9
12.9
15
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
12.8
117
598
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
12.7
233
1588
C83.1
ICD-10 Finland
Mantle cell lymphoma
20.9
12.6
18
9
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
12.5
147
835
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
22.2
12.1
17
8
WZC00
NOMESCO Finland
Treatment plan or consultation
2.2
12.0
160
954
D70.82
ICD-10 Finland
Drug-induced neutropenia
10.1
11.9
23
24
212
Kela drug reimbursment
Gout
5.8
11.8
22
40
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
17.1
11.8
18
11
L01XE27
ATC
[U] ibrutinib
123.7
11.5
12
*
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
11.4
110
572
J01MA12
ATC
levofloxacin; systemic
2.4
11.3
101
508
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.2
11.0
30
76
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
29.0
10.8
14
5
L01AA01
ATC
cyclophosphamide; systemic
22.3
10.8
15
7
C83.39
ICD-10 Finland
Diffuse non-Hodgkin's large cell lymphoma UNS
61.8
10.7
12
*
J01MA14
ATC
moxifloxacin; systemic
2.8
10.6
56
218
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.3
10.3
27
66
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
10.2
98
506
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
8.0
10.1
22
29
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
17.3
10.0
15
9
TAB00
NOMESCO Finland
Lumbar puncture
3.8
9.4
30
85
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.7
9.4
22
49
D70.89
ICD-10 Finland
Neutropenic splenomegaly
9.0
9.4
19
22
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
14.2
9.3
15
11
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
9.2
47
179
ZX108
NOMESCO Finland
Inhalation
13.0
8.9
15
12
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
8.9
159
1028
B02.9
ICD-10 Finland
Zoster without complication
2.8
8.8
46
177
C03CA01
ATC
furosemide; systemic
1.9
8.7
169
1122
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
8.7
67
313
L03AA14
ATC
lipegfilgrastim; parenteral
7.6
8.6
19
26
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
28.3
8.5
11
*
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
20.6
8.5
12
6
127
Kela drug reimbursment
Transplant complication
8.2
8.5
18
23
A02BC02
ATC
pantoprazole; systemic
2.1
8.4
278
2197
9689/3-C42.2
ICD-O-3
Splenic marginal zone B-cell lymphoma of spleen
+∞
8.4
8
*
GD1AD
NOMESCO Finland
Thorax CT examination
2.9
8.2
39
143
9591/3-C42.1
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of bone marrow
34.2
8.1
10
*
A04AA02
ATC
granisetron; systemic, transdermal
2.9
8.0
38
139
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
8.7
7.9
16
19
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.0
7.7
34
119
WW300
NOMESCO Finland
Transfer of autologic stem cells
18.8
7.6
11
6
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
7.4
7.6
17
24
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
7.4
7.6
17
24
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
7.5
97
555
L04AA06
ATC
mycophenolic acid; systemic
6.7
7.5
18
28
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.9
7.5
35
127
ZXE00
NOMESCO Finland
One hour or less
1.9
7.4
150
995
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
13.7
7.4
12
9
PJA10
NOMESCO Finland
Exploration of lymph nodes
7.1
7.4
17
25
ZX112
NOMESCO Finland
Subcutaneous
4.2
7.2
19
47
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.0
7.1
20
52
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.2
6.9
18
44
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
6.3
6.9
17
28
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.4
6.8
49
221
N02AA05
ATC
oxycodone; systemic
1.9
6.8
100
597
A07AA09
ATC
vancomycin; oral
7.4
6.8
15
21
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
71.0
6.4
7
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
71.0
6.4
7
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
6.7
6.4
15
23
UJF32
NOMESCO Finland
Coloscopy
1.8
6.4
117
748
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
11.3
6.3
11
10
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
6.3
25
82
9699/3-C16.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of stomach, NOS
+∞
6.3
6
*
C88.3
ICD-10 Finland
Immunoproliferative small intestinal disease
+∞
6.3
6
*
C82.00
ICD-10 Finland
Follicular nodular non-Hodgkin's lymphoma, ungraded
+∞
6.3
6
*
C83.00
ICD-10 Finland
Lymphocytic lymphoma
27.2
6.3
8
*
L01BB05
ATC
fludarabine; systemic
27.2
6.3
8
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
6.2
48
223
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
6.2
143
976
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.2
6.2
25
83
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.2
6.2
58
293
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
6.1
107
672
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
12.8
6.1
10
8
G62.8
ICD-10 Finland
Other specified polyneuropathies
8.8
6.1
12
14
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
8.8
6.1
12
14
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
6.9
6.1
14
21

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
195
89
45.34
284.70
2.1
1.8
—
—
—
0
0
254
233
32.77
270.03
13.8
1.4
13.53
1.12
g/l
36.32
244
209
205
143
31.01
248.40
7.8
3.5
50.32
47.05
mg/l
0.06
192
123
205
143
31.01
248.40
7.9
3.5
104.80
98.57
mg/l
0.05
192
121
189
131
28.53
228.11
7.7
3.1
17.92
2.95
ratio
3.27
133
70
248
287
24.30
225.31
11.6
2.4
—
—
—
0
0
131
56
35.72
191.32
1.5
1.3
—
—
—
0
0
223
290
17.91
182.88
6.2
2.4
7.89
10.64
g/l
7.96
218
263
133
84
24.19
164.22
1.6
1.7
—
—
—
0
0
143
154
14.53
128.82
10.5
2.2
15.08
10.63
g/l
4.91
133
138
125
117
15.64
122.77
2.5
1.6
—
—
—
0
0
90
45
26.13
121.54
1.8
2.4
—
—
—
0
0
83
49
21.56
103.69
1.2
1.1
—
—
—
0
0
217
510
8.90
101.03
5.8
2.8
1.70
1.81
%
0.73
206
462
191
402
8.78
98.23
5.2
2.8
64.88
66.99
e9/l
0.30
152
294
137
197
10.47
97.99
1.5
1.5
—
—
—
0
0
183
369
8.85
97.88
1.8
1.6
—
—
—
0
0
135
197
10.23
95.21
2.9
2.1
1.48
1.50
g/l
0.06
118
176
59
21
33.25
89.32
1.4
1.4
—
—
—
0
0
169
343
8.25
88.74
1.9
1.5
—
—
—
0
0
155
307
7.98
82.61
1.9
1.5
—
—
—
0
0
209
620
6.47
71.95
4.0
1.4
1.31
2.74
g/l
15.68
186
364
53
28
21.94
68.78
1.8
1.9
33.36
39.75
%
0.85
53
28
61
46
15.69
66.35
2.3
2.7
1.03
1.30
g/24h
0.17
39
31
249
934
6.12
63.61
7.1
3.2
326.88
362.62
umol/l
5.78
240
805
50
34
16.85
57.28
2.1
2.9
481.36
1202.29
mg
1.44
50
34
170
516
5.25
54.20
11.1
6.1
1.05
1.04
mmol/l
0.19
165
481
260
1153
5.25
50.26
17.2
6.3
—
—
—
0
0
123
310
5.45
48.22
2.0
1.5
—
—
—
0
0
298
1555
5.76
44.70
16.9
6.4
55.13
58.24
%
3.91
292
1480
312
1691
6.47
44.62
17.1
6.2
0.04
0.04
e9/l
0.39
287
1443
311
1685
6.38
44.38
17.2
6.2
0.65
0.62
e9/l
1.36
286
1435
315
1732
6.59
43.94
18.5
6.4
0.16
0.20
e9/l
3.89
294
1500
313
1713
6.45
43.88
17.3
6.3
1.87
1.91
e9/l
0.09
293
1502
297
1622
5.26
39.91
16.4
5.3
34.40
35.01
g/l
0.92
292
1528
115
317
4.82
39.74
8.7
4.4
0.80
0.83
%
0.07
80
115
43
42
11.46
39.40
1.6
1.2
—
—
—
0
0
319
1874
6.18
38.21
30.7
10.0
3.48
4.24
e9/l
10.26
294
1634
33
22
16.38
37.84
1.3
2.0
—
—
—
0
0
49
63
8.82
36.63
6.9
4.3
1.35
1.04
%
0.42
44
57
310
1845
5.25
34.73
21.1
7.8
1.21
1.21
mmol/l
0.87
288
1586
104
299
4.45
33.55
9.1
4.2
0.69
0.39
%
1.32
70
104
103
299
4.39
32.74
9.2
4.5
0.04
0.13
%
1.27
68
96
160
651
3.57
30.96
8.3
3.7
0.81
0.81
mmol/l
0.42
155
621
39
14
30.95
29.57
3.8
2.1
41.68
40.89
g/l
0.19
39
14
201
969
3.36
29.12
3.1
2.2
3.04
2.94
mg/l
0.23
180
831
221
1136
3.36
28.60
14.7
4.4
7.40
7.40
ph
0.98
183
820
154
641
3.41
28.27
4.3
2.2
30.77
29.59
s
1.24
147
620
33
9
40.06
26.63
1.4
1.8
39.88
25.89
%
—
33
9
30
5
65.05
26.39
1.9
1.6
—
—
—
0
0
41
68
6.66
24.30
2.0
1.5
—
—
—
0
0
243
1412
3.11
23.82
5.4
3.0
253.58
151.04
ug/l
2.55
235
1293
92
306
3.67
23.51
9.5
4.8
0.05
0.17
%
0.55
58
90
30
11
29.53
22.63
1.3
2.7
—
—
—
0
0
37
60
6.74
22.36
1.2
1.2
—
—
—
0
0
35
54
7.06
22.15
2.5
2.4
33.11
33.06
pg
0.03
35
54
144
659
2.94
21.36
13.9
5.3
—
—
—
0
0
37
67
6.03
20.04
1.4
1.3
8.04
20.02
e6/l
0.45
23
46
27
35
8.24
19.80
1.3
1.2
—
—
—
0
0
34
58
6.36
19.53
1.4
1.3
—
—
—
0
0
37
69
5.85
19.43
1.5
1.4
117.96
1914.18
e6/l
0.51
25
50
27
36
8.01
19.35
2.9
2.4
13.75
11.66
iu/ml
—
11
5
193
1089
2.62
18.34
11.4
4.5
—
—
—
0
0
30
49
6.58
17.94
9.1
4.1
—
—
—
0
0
195
1128
2.55
17.27
6.7
2.7
—
—
—
0
0
38
83
4.99
16.75
1.8
1.3
—
—
—
0
0
48
127
4.20
16.69
2.0
3.3
1013.03
254.35
mg/l
0.53
30
54
45
114
4.36
16.56
1.3
1.4
—
—
—
0
0
31
58
5.74
16.18
2.2
1.6
168.47
157.62
au/ml
0.15
15
12
98
419
2.82
15.87
1.5
1.3
1053.33
486.06
titre
0.49
12
99
28
24
12.53
15.83
2.9
2.9
36.07
42.69
%
0.61
14
13
58
184
3.55
15.57
2.8
1.8
3.06
3.22
ug/l
0.03
52
161
46
126
4.03
15.24
1.1
1.2
—
—
—
0
0
201
1241
2.36
14.62
6.6
3.7
2.34
2.35
mmol/l
0.49
186
1117
26
47
5.88
14.04
1.2
1.1
—
—
—
0
0
26
47
5.88
14.04
1.1
1.0
—
—
—
0
0
30
63
5.09
13.80
1.8
1.2
269.94
300.77
u/ml
0.13
17
30
73
287
2.92
13.66
4.6
4.2
91.60
85.13
ng/l
0.22
63
253
27
52
5.52
13.65
2.4
1.6
—
—
—
0
0
27
52
5.52
13.65
2.4
1.6
—
—
—
0
0
27
52
5.52
13.65
2.4
1.6
—
—
—
0
0
27
52
5.52
13.65
2.4
1.6
—
—
—
0
0
27
53
5.42
13.37
4.4
2.4
2.98
4.74
e9/l
4.21
27
53
152
857
2.32
13.36
7.1
2.6
—
—
—
0
0
230
1542
2.30
13.30
6.4
3.0
—
—
estimate
—
0
0
130
689
2.37
13.16
1.9
1.7
1126.18
1201.78
nmol/l
0.38
103
523
92
416
2.61
13.12
7.5
3.0
7.43
9.06
umol/l
0.44
87
376
219
1457
2.24
12.65
31.4
12.5
0.00
0.00
e9/l
0.29
192
1200
91
419
2.56
12.45
4.3
3.1
3.40
4.93
e9/l
1.86
76
353
31
76
4.36
11.84
5.1
2.4
52.48
60.06
%
1.63
31
76
20
17
12.36
11.47
1.4
1.2
—
—
—
0
0
149
876
2.18
11.44
9.2
4.8
83.80
85.29
%
0.31
142
868
109
565
2.32
11.37
2.4
2.0
—
—
—
0
0
198
1325
2.07
10.56
4.1
3.7
1946.60
1487.15
ng/l
0.71
178
1154
178
1154
2.05
10.27
2.3
1.8
22.64
20.41
nmol/l
0.81
162
942
84
430
2.23
8.80
10.2
4.0
7.38
7.38
ph
0.20
57
246
282
2227
2.13
8.71
6.6
4.9
—
2.94
—
0
7
84
438
2.19
8.38
2.0
1.5
—
—
—
0
0
21
50
4.39
8.31
1.7
1.4
—
—
—
0
0
220
1618
1.89
8.05
2.9
2.2
93.37
94.63
pmol/l
0.15
145
858
86
461
2.13
7.97
1.4
1.3
—
—
—
0
0
127
784
1.95
7.96
4.9
3.2
2.51
2.46
mmol/l
3.43
115
712
45
181
2.69
7.93
2.4
2.6
—
—
—
0
0
37
134
2.96
7.91
1.7
2.1
9.98
11.04
iu/ml
—
9
36
71
354
2.25
7.88
12.8
11.1
—
—
—
0
0
18
27
6.95
7.68
1.6
1.1
—
—
—
0
0
13
11
12.20
7.63
1.0
1.0
—
—
—
0
0
202
1467
1.83
7.48
3.4
2.4
80.57
78.86
nmol/l
0.30
188
1288
177
1236
1.83
7.44
5.4
3.7
26.78
115.01
e6/l
0.97
147
956
123
766
1.91
7.43
3.0
1.8
2.23
1.52
mg/l
0.45
109
611
18
30
6.25
7.17
1.3
1.3
—
—
—
0
0
236
1812
1.84
7.14
18.5
17.1
1.29
1.31
inr
0.25
204
1507
180
1278
1.80
7.04
2.7
2.2
—
—
—
0
0
18
31
6.05
7.00
1.7
1.4
—
—
—
0
0
77
416
2.08
6.93
9.9
3.9
1.82
1.74
mmol/l
0.06
66
357
77
416
2.08
6.93
1.9
1.8
—
—
—
0
0
12
11
11.23
6.84
1.7
1.5
—
—
—
0
0
12
11
11.23
6.84
1.1
1.1
—
—
—
0
0
156
1069
1.80
6.82
5.4
3.6
0.59
0.39
e6/l
0.41
129
794
158
1092
1.78
6.67
3.6
3.6
—
—
—
0
0
189
1378
1.76
6.62
4.4
3.8
6.24
6.19
ph
0.21
98
740
186
1353
1.76
6.54
6.6
4.4
66.45
108.59
e6/l
0.65
146
988
115
735
1.82
6.23
4.1
3.2
497.86
544.52
mosm/kgh2o
2.02
100
648
57
291
2.13
5.91
14.3
3.9
1.23
1.22
mmol/l
0.20
57
249
156
1105
1.71
5.85
4.2
2.6
58.34
66.29
u/l
0.57
145
1024
74
419
1.96
5.79
2.7
4.4
7.62
39.95
ug/l
0.96
52
355
129
872
1.74
5.69
4.2
2.8
3.71
4.30
e6/l
0.51
116
801
56
288
2.11
5.69
7.9
4.5
7.42
7.42
ph
0.05
47
240
11
13
8.68
5.59
3.5
1.5
—
—
—
0
0
23
78
3.08
5.52
5.5
3.3
—
—
—
0
0
63
345
2.00
5.40
10.3
4.3
7.39
7.34
ph
3.12
57
239
142
997
1.69
5.40
19.4
6.5
—
—
—
0
0
18
53
3.52
5.37
2.1
1.7
—
—
—
0
0
18
53
3.52
5.37
1.9
1.3
677.08
1861.71
e6/l
1.94
12
34
18
53
3.52
5.37
1.1
1.1
—
—
—
0
0
9
8
11.49
5.31
1.2
1.3
—
—
—
0
0
220
1736
1.66
5.28
5.2
4.2
0.00
0.00
estimate
-0.00
48
362
99
635
1.76
5.18
4.8
3.4
1.70
1.54
e6/l
0.12
60
323
265
2202
1.72
5.16
7.2
5.2
438.60
2026.30
e6/l
—
5
40
64
360
1.94
5.08
3.3
2.4
0.17
0.21
g/l
4.05
54
333
9
9
10.21
5.05
1.3
1.7
—
—
—
0
0
112
750
1.71
5.01
4.6
4.4
928.52
395.47
ng/l
0.35
95
649
86
534
1.80
5.01
1.4
1.3
55.33
34.19
iu/ml
0.36
24
177
16
37
4.47
5.00
1.2
1.2
—
—
—
0
0
221
1761
1.64
4.97
5.2
4.2
0.00
9.34
estimate
0.80
50
375
80
491
1.80
4.83
1.3
1.3
3.96
12.85
u/ml
1.37
26
179
20
68
3.05
4.79
5.6
3.2
9.02
9.83
pmol/l
0.12
20
68
221
1772
1.62
4.76
5.2
4.3
0.00
0.88
estimate
0.51
49
344
123
861
1.64
4.59
1.5
1.3
—
—
—
0
0
8
8
10.19
4.54
1.4
1.0
—
—
—
0
0
19
65
3.03
4.51
2.5
2.8
—
—
—
0
0
11
20
5.63
4.32
1.7
1.1
84.43
64.59
mg/l
0.37
11
15
14
35
4.12
4.14
1.2
1.0
—
—
—
0
0
9
14
6.56
4.00
1.1
1.1
—
—
—
0
0
15
48
3.22
3.97
1.9
1.4
613345.50
28754.71
e6/l
—
10
24
12
27
4.56
3.97
1.2
1.2
—
—
—
0
0
58
343
1.82
3.93
2.8
2.1
380.98
394.44
nmol/l
0.13
58
321
8
11
7.40
3.88
6.3
5.1
—
—
—
0
0
70
443
1.72
3.76
1.4
1.3
—
—
—
0
0
24
103
2.42
3.75
3.7
2.5
114.89
126.00
g/l
0.97
18
80
60
365
1.77
3.70
12.0
9.7
1.34
1.35
mmol/l
0.02
60
359
14
40
3.60
3.64
1.4
1.2
—
—
—
0
0
55
329
1.79
3.59
3.6
2.6
39.91
33.85
u/l
0.20
45
279
74
483
1.67
3.54
9.6
9.0
1.01
0.91
mmol/l
0.08
62
401
73
485
1.63
3.25
10.1
9.0
7.42
7.41
ph
0.60
40
286
21
91
2.39
3.23
1.5
1.2
—
—
—
0
0
7
11
6.46
3.20
1.0
1.3
—
—
—
0
0
119
891
1.50
3.12
3.7
3.2
0.00
0.07
—
7
28
11
30
3.75
3.11
1.2
1.0
—
—
—
0
0
10
25
4.08
3.10
1.3
1.1
—
—
—
0
0
13
45
2.96
3.05
1.9
1.4
—
—
—
0
0
55
345
1.70
3.05
2.7
2.8
12.11
6.94
ug/l
0.30
47
305
37
206
1.88
3.04
8.9
4.8
—
—
—
0
0
179
1465
1.43
2.91
6.1
4.5
51.77
39.23
ng/l
0.45
151
1175
140
1096
1.45
2.89
5.7
3.2
32.31
35.85
u/l
0.49
134
1037
328
3034
1.73
2.81
54.4
19.5
24.06
25.96
mg/l
0.58
314
2583
45
274
1.73
2.78
1.6
1.6
—
—
—
0
0
6
10
6.08
2.71
2.3
6.9
42.83
40.60
%
—
6
10
22
106
2.14
2.69
1.4
1.4
265.19
283.51
ug/g
0.15
16
65
30
163
1.91
2.67
1.6
1.3
—
—
—
0
0
51
328
1.64
2.58
2.0
2.2
158.03
150.83
ug/g
0.07
40
270
12
44
2.79
2.57
4.7
2.0
0.25
0.86
mmol/l
0.22
12
44
6
11
5.52
2.55
4.3
1.6
0.62
0.59
mmol/l
—
6
11
6
12
5.06
2.41
1.2
1.1
—
—
—
0
0
16
71
2.31
2.38
2.9
2.6
—
—
—
0
0
33
193
1.78
2.35
4.6
3.4
24.98
24.91
mmol/l
0.03
33
185
89
662
1.45
2.35
1.4
1.2
0.48
1.25
u/ml
1.94
13
172
140
1141
1.37
2.17
2.7
2.2
101.86
279.54
u/l
2.07
133
1079
220
1923
1.36
2.16
6.2
3.5
58.09
57.65
u/l
0.03
205
1781
15
68
2.26
2.14
1.3
1.5
—
—
—
0
0
5
10
5.05
2.07
17.8
7.3
6.04
4.82
kpa
—
5
10
104
1290
0.73
1.97
2.2
2.0
1.29
1.31
mmol/l
0.06
87
1050
8
27
3.00
1.94
1.8
1.1
—
—
—
0
0
9
33
2.77
1.94
1.1
1.0
315.00
290.75
ng/l
—
9
20
9
33
2.77
1.94
1.1
1.0
983.00
580.60
ng/l
—
9
20
48
329
1.53
1.89
2.5
2.1
0.00
0.00
estimate
—
6
67
8
28
2.90
1.87
1.0
1.1
—
—
—
0
0
8
28
2.90
1.87
1.0
1.1
—
—
—
0
0
19
102
1.91
1.79
3.5
3.7
4.00
2.02
index
0.38
13
64
38
251
1.57
1.77
5.6
4.5
—
—
—
0
0
9
36
2.54
1.75
1.9
2.1
—
—
—
0
0
39
260
1.56
1.74
11.8
12.0
24.43
24.37
mmol/l
0.05
39
255
39
260
1.56
1.74
6.1
4.0
—
—
—
0
0
28
172
1.68
1.73
1.2
1.3
—
—
—
0
0
5
13
3.88
1.72
1.0
1.5
—
—
—
0
0
52
381
1.42
1.50
1.4
1.3
—
—
—
0
0
7
28
2.53
1.46
1.0
1.3
67.14
94.75
pmol/l
—
7
28
32
214
1.54
1.44
1.2
1.2
—
—
—
0
0
8
34
2.38
1.30
1.0
1.3
—
—
—
0
0
5
18
2.80
1.29
1.2
1.1
—
—
—
0
0
10
48
2.11
1.29
1.0
1.1
2.40
3.74
u/ml
—
5
19
17
101
1.72
1.22
3.3
4.8
—
—
—
0
0
13
71
1.86
1.21
1.3
1.2
—
—
—
0
0
148
1296
1.24
1.19
5.3
4.3
0.00
0.01
estimate
0.69
44
299
251
2326
1.25
1.18
4.3
4.1
14.73
15.06
pmol/l
1.33
228
2063
85
1008
0.80
1.06
3.5
3.6
—
—
—
0
0
107
919
1.23
1.02
4.3
3.7
0.00
0.09
estimate
0.52
41
283
9
51
1.78
0.95
8.9
2.0
11.00
9.84
mmol/l
—
9
51
6
27
2.24
0.94
2.3
3.2
1.17
0.81
index
—
6
27
6
29
2.09
0.89
1.2
1.0
—
—
—
0
0
8
42
1.92
0.89
20.0
3.5
6.90
10.79
%
—
8
42
8
44
1.84
0.86
2.4
1.8
90.16
89.73
%
—
8
44
114
1002
1.20
0.85
6.0
4.4
0.00
0.01
estimate
0.50
40
329
8
45
1.79
0.84
1.0
1.1
—
8.89
—
0
11
6
31
1.95
0.84
1.3
1.1
—
—
—
0
0
6
31
1.95
0.84
1.0
1.4
—
—
nmol/l
—
0
0
8
141
0.56
0.84
1.4
1.5
—
—
—
0
0
25
181
1.41
0.82
2.0
3.0
—
—
—
0
0
6
32
1.89
0.82
1.2
1.0
—
—
—
0
0
6
33
1.83
0.79
1.3
1.2
—
—
—
0
0
6
109
0.54
0.73
3.2
12.8
—
—
—
0
0
7
39
1.81
0.73
1.1
1.4
0.56
0.53
nmol/l
—
7
34
5
26
1.94
0.71
2.4
2.6
—
—
—
0
0
5
91
0.54
0.68
1.0
1.1
—
—
—
0
0
142
1296
1.16
0.66
5.2
4.1
—
0.60
—
0
5
5
29
1.73
0.64
1.4
1.1
—
—
—
0
0
8
50
1.61
0.61
3.0
6.6
6.26
6.56
mmol/l
—
8
42
88
779
1.17
0.61
1.6
1.8
475.20
443.01
pmol/l
0.46
71
632
6
36
1.68
0.57
1.3
2.1
—
—
—
0
0
24
186
1.31
0.56
3.5
3.8
1.02
1.02
ratio
0.79
24
176
6
38
1.59
0.54
2.0
2.8
—
—
—
0
0
6
38
1.59
0.54
2.3
1.2
15.17
35.17
ng/l
—
6
38
284
2931
0.87
0.53
6.7
7.4
38.51
40.31
mmol/mol
3.56
260
2706
162
1511
1.13
0.53
5.4
6.2
1.94
2.67
ug/l
1.36
144
1351
10
66
1.53
0.53
1.2
1.4
—
—
—
0
0
14
100
1.42
0.52
4.0
3.2
0.83
0.90
nmol/l
—
7
81
6
40
1.51
0.52
1.7
1.3
—
—
—
0
0
24
301
0.78
0.51
1.6
1.5
—
—
—
0
0
7
45
1.57
0.49
2.6
2.9
2.79
7.06
nmol/l
—
7
45
33
273
1.23
0.48
3.2
2.8
6.23
6.06
ph
0.57
26
192
329
3221
1.20
0.47
74.3
29.4
6.69
6.89
e9/l
0.48
321
3151
329
3221
1.20
0.47
74.2
29.3
3.95
4.43
e12/l
34.90
321
3148
329
3221
1.20
0.47
74.2
29.4
232.08
239.08
e9/l
0.80
324
3159
313
3059
1.15
0.41
37.4
17.2
—
—
—
0
0
9
67
1.35
0.38
1.1
1.2
—
—
—
0
0
287
2940
0.89
0.37
5.0
5.6
1.36
1.43
mmol/l
1.81
259
2659
11
146
0.75
0.36
1.5
1.4
—
—
—
0
0
83
761
1.12
0.36
5.6
4.5
1.02
1.02
kg/l
0.12
64
517
289
2958
0.89
0.36
5.0
5.7
4.10
4.41
mmol/l
5.24
264
2698
296
3022
0.90
0.33
5.6
6.6
2.28
2.53
mmol/l
5.86
268
2744
288
2813
1.11
0.33
5.6
5.3
2.03
2.01
mu/l
0.08
270
2525
132
1254
1.08
0.28
4.8
4.2
17.19
9.12
mg/mmol
0.83
89
798
15
122
1.24
0.27
1.7
1.6
69.14
11.91
u/ml
—
5
18
8
66
1.22
0.27
1.4
1.4
—
—
—
0
0
5
71
0.70
0.26
1.0
1.7
—
4.32
—
0
24
244
2379
1.08
0.25
63.8
26.1
328.87
331.74
g/l
4.83
244
2371
37
332
1.13
0.24
3.8
2.8
0.48
0.35
e6/l
0.25
37
321
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
4.01
—
0
10
0
10
0.00
0.21
0.0
1.2
—
0.00
—
0
10
8
103
0.77
0.21
1.4
1.2
—
—
—
0
0
128
1228
1.06
0.20
4.4
3.5
81.55
53.83
mg/l
0.53
95
817
10
123
0.81
0.20
1.2
1.1
—
—
—
0
0
85
894
0.94
0.18
3.2
3.4
0.72
0.77
ug/l
0.33
63
621
17
147
1.16
0.18
1.0
1.2
23.37
125.56
u/ml
—
6
52
22
195
1.14
0.18
1.2
1.3
—
—
—
0
0
28
309
0.90
0.17
2.0
2.4
11.95
12.95
nmol/l
0.34
28
273
129
1249
1.05
0.15
4.2
3.5
6.65
7.46
mmol/l
1.37
110
1031
280
2829
0.96
0.11
4.5
4.7
1.19
1.27
mmol/l
0.78
249
2540
296
2975
0.97
0.04
5.6
5.8
5.92
6.10
mmol/l
1.97
268
2693
16
154
1.04
0.00
2.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
51.50
—
0
8
9
97
0.93
-0.00
2.1
1.9
33.11
44.12
nmol/l
—
9
89
0
9
0.00
-0.00
0.0
10.6
—
957.78
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
64.00
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
85.89
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
150.50
—
0
8
0
9
0.00
-0.00
0.0
1.4
—
9.55
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_IMMUNOPROLIFERATIVE – Malignant immunoproliferative diseases

GWS hits: 2

This endpoint is excluded (different definition than used in FinnGen).