Meningococcal infection

AB1_MENINGOCOCCAL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A39
  • Hospital discharge: ICD-9 03[6]
  • Hospital discharge: ICD-8 03[6]
  • Cause of death: ICD-10 A39
  • Cause of death: ICD-9 03[6]
  • Cause of death: ICD-8 03[6]

2 out of 7 registries used, show all original rules.

323

4. Check minimum number of events

None

323

5. Include endpoints

None

323

6. Filter based on genotype QC (FinnGen only)

288

Control definitions (FinnGen only)

Control exclude
AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3391 1544 1828
Only index persons 2683 1246 1437
Unadjusted period prevalence (%)
Whole population 0.05 0.04 0.05
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 17.73 17.89 17.27
Only index persons 16.06 16.30 15.85

-FinnGen-

Key figures

All Female Male
Number of individuals 288 163 125
Unadjusted period prevalence (%) 0.06 0.06 0.06
Median age at first event (years) 18.26 17.92 18.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
300
Matched controls
3000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
03600
ICD-8 Finland
Meningococcal infection, Meningococcal meningitis
+∞
123.7
110
*
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
46.0
43
*
0360A
ICD-9 Finland
Meningococcal infection, Meningococcal meningitis
+∞
32.9
31
*
A39.2
ICD-10 Finland
Acute meningococcaemia
+∞
26.4
25
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
118.3
20.9
22
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
19.6
18.1
27
15
A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
15.8
15
*
03697
ICD-8 Finland
Meningococcal infection, Suspecta
+∞
15.8
15
*
A39.9
ICD-10 Finland
Meningococcal infection, unspecified
+∞
14.7
14
*
03610
ICD-8 Finland
Meningococcal infection, Meningococcaemia acuta sive non definita
+∞
13.6
13
*
A41.9
ICD-10 Finland
Sepsis, unspecified
135.4
12.5
13
*
Z2446
NOMESCO Finland
Social worker
4.0
10.9
32
86
A46
ICD-10 Finland
Erysipelas
4.2
10.9
30
77
0362A
ICD-9 Finland
Meningococcal infection, Meningococcaemia
+∞
8.4
8
*
A41.8
ICD-10 Finland
Other specified sepsis
+∞
8.4
8
*
G03.9
ICD-10 Finland
Meningitis, unspecified
46.2
7.8
9
*
WX730
NOMESCO Finland
Conventional respirator
14.2
6.9
11
8
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.6
6.4
21
61
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.4
6.3
23
72
A39.8
ICD-10 Finland
Other meningococcal infections
+∞
6.3
6
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
6.2
42
185
N06AB04
ATC
citalopram; systemic
2.1
6.2
68
369

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
81
465
2.02
6.31
5.2
2.9
—
—
—
0
0
28
113
2.63
4.96
14.3
7.3
25.77
24.62
mmol/l
0.74
28
113
13
42
3.19
3.41
1.4
1.1
—
—
—
0
0
55
341
1.75
3.25
3.5
2.9
0.80
0.82
mmol/l
0.42
49
326
148
1174
1.51
3.13
7.1
5.7
28.54
28.92
%
0.13
140
1124
25
120
2.18
3.08
16.8
11.0
91.54
93.52
%
0.47
25
120
18
76
2.46
2.95
1.2
1.2
—
—
—
0
0
84
598
1.56
2.88
2.5
2.3
327.61
339.12
umol/l
0.52
74
537
143
1144
1.48
2.81
7.1
5.8
8.33
8.71
%
0.98
134
1087
9
23
4.00
2.79
1.3
1.0
—
—
—
0
0
119
928
1.47
2.62
12.7
10.4
1.21
1.16
inr
0.35
95
762
7
15
4.75
2.61
1.3
1.4
—
—
—
0
0
141
1143
1.44
2.50
7.2
5.7
3.00
2.87
%
0.23
132
1081
79
573
1.51
2.46
4.7
3.4
96.34
94.50
%
0.30
79
564
10
32
3.20
2.46
1.2
2.0
29.10
36.81
umol/l
—
10
26
141
1146
1.43
2.45
7.2
5.7
0.63
0.72
%
1.22
131
1076
23
118
2.03
2.43
17.9
11.1
0.55
0.68
%
1.17
23
118
141
1163
1.40
2.18
7.1
5.6
56.52
56.64
%
0.04
136
1117
23
123
1.94
2.18
18.1
10.6
1.56
1.49
%
0.08
23
123
6
14
4.35
2.16
1.5
1.1
—
—
—
0
0
30
177
1.77
2.12
15.4
8.3
—
—
—
0
0
17
83
2.11
2.05
5.5
2.6
—
—
—
0
0
100
785
1.41
2.03
7.3
5.6
—
—
—
0
0
152
1282
1.38
2.01
6.9
5.7
2.00
1.88
e9/l
0.72
124
1129
121
986
1.38
1.96
4.4
3.9
35.47
37.24
g/l
1.87
107
938
15
71
2.17
1.95
1.9
1.5
—
—
—
0
0
91
710
1.40
1.90
2.2
1.9
—
—
—
0
0
6
17
3.58
1.84
1.2
1.7
—
—
—
0
0
5
12
4.22
1.83
1.2
1.3
7.28
1.74
mmol/l
—
5
12
25
404
0.58
1.82
1.3
1.6
—
—
—
0
0
38
250
1.60
1.82
1.6
1.5
—
—
—
0
0
49
674
0.67
1.76
1.4
1.3
0.64
1.71
u/ml
1.01
14
191
8
30
2.71
1.73
2.3
1.3
—
—
—
0
0
5
13
3.89
1.72
3.8
3.3
22.42
16.35
mu/l
—
5
13
71
540
1.41
1.70
1.7
1.7
1.33
1.12
mg/l
0.25
54
411
147
1256
1.33
1.69
7.2
5.7
0.58
0.55
e9/l
0.66
120
1084
24
143
1.74
1.67
2.2
2.7
70.78
70.50
e9/l
0.01
17
95
147
1259
1.33
1.65
7.2
5.7
0.04
0.04
e9/l
0.38
119
1087
32
210
1.59
1.56
14.0
8.0
7.43
7.42
ph
0.21
12
117
150
1298
1.31
1.53
7.2
5.9
0.20
0.19
e9/l
0.32
123
1137
0
43
0.00
1.53
0.0
2.0
—
133.55
—
0
31
5
15
3.37
1.53
4.0
2.9
—
—
—
0
0
7
27
2.63
1.52
1.1
1.2
—
—
—
0
0
12
58
2.11
1.51
1.0
1.1
—
—
—
0
0
12
58
2.11
1.51
1.0
1.1
—
—
—
0
0
9
38
2.41
1.47
1.4
1.2
—
—
—
0
0
7
28
2.53
1.46
1.6
1.1
—
—
—
0
0
130
1110
1.30
1.44
9.8
9.5
0.00
0.00
e9/l
0.66
98
908
27
174
1.61
1.43
5.1
3.8
7.32
7.36
ph
0.27
12
125
7
29
2.45
1.40
4.1
2.1
5.26
4.78
kpa
—
7
29
7
29
2.45
1.40
4.1
2.1
7.94
9.29
kpa
—
7
29
117
989
1.30
1.39
9.5
5.1
1.21
1.22
mmol/l
0.72
102
909
5
17
2.97
1.36
1.2
1.4
—
—
—
0
0
0
40
0.00
1.33
0.0
3.5
—
105.53
—
0
34
0
40
0.00
1.33
0.0
3.5
—
10.88
—
0
34
28
186
1.56
1.32
15.1
8.6
94.72
95.74
%
0.47
28
180
94
779
1.30
1.28
3.4
2.8
2.37
2.36
mmol/l
0.27
84
723
157
1389
1.27
1.28
9.7
8.3
4.09
3.91
e9/l
0.49
132
1202
29
198
1.51
1.22
3.0
2.5
7.38
7.39
ph
0.68
17
106
100
1171
0.78
1.21
2.7
2.9
—
—
—
0
0
27
183
1.52
1.18
15.6
7.4
128.00
125.38
g/l
0.28
27
177
40
295
1.41
1.16
1.7
1.6
1140.41
1171.27
nmol/l
0.07
31
230
96
1123
0.79
1.14
1.8
1.9
1.50
1.42
mmol/l
0.34
83
986
61
755
0.76
1.12
2.8
2.8
0.00
0.00
estimate
0.50
23
213
35
254
1.43
1.11
8.3
4.1
1.07
1.04
mmol/l
0.27
28
232
5
22
2.29
1.04
1.4
1.3
—
—
—
0
0
9
47
1.94
1.03
5.6
2.1
7.41
7.42
ph
—
9
47
65
528
1.29
1.02
2.4
2.0
2.85
2.70
mg/l
0.18
55
452
199
1838
1.25
1.01
7.9
6.6
77.47
74.99
u/l
0.42
193
1753
7
36
1.97
0.97
1.7
3.4
4.45
3.84
e9/l
—
7
36
148
1330
1.22
0.96
6.4
4.2
6.56
6.48
mmol/l
0.20
138
1244
17
109
1.59
0.96
2.8
1.7
—
—
—
0
0
0
32
0.00
0.95
0.0
1.4
—
—
—
0
0
6
27
2.25
0.94
1.2
1.1
0.55
0.28
g/l
—
6
22
6
27
2.25
0.94
1.2
1.1
—
—
—
0
0
6
27
2.25
0.94
1.2
1.1
3.38
2.62
g/l
—
6
21
6
27
2.25
0.94
1.2
1.1
7.21
6.39
g/l
—
6
22
22
152
1.48
0.91
1.6
1.7
—
—
—
0
0
72
602
1.26
0.90
2.8
2.6
—
—
—
0
0
16
103
1.58
0.89
1.8
2.2
—
—
—
0
0
8
42
1.93
0.89
1.1
1.3
5.67
8.22
ug/l
—
8
37
18
120
1.53
0.87
5.3
2.5
7.39
7.42
ph
1.58
12
103
124
1104
1.21
0.86
10.5
5.4
1.21
1.22
mmol/l
0.19
99
950
19
129
1.50
0.85
1.5
1.4
—
—
—
0
0
118
1318
0.83
0.85
3.8
3.4
0.00
0.02
estimate
0.50
23
251
48
591
0.78
0.85
1.7
1.4
2.05
2.36
g/l
1.04
36
374
12
189
0.62
0.84
2.9
4.6
0.00
0.38
%
—
5
32
23
165
1.43
0.80
1.7
1.6
—
—
—
0
0
62
735
0.80
0.80
1.8
1.5
—
—
—
0
0
116
1292
0.83
0.80
3.8
3.4
0.00
0.00
estimate
-0.00
25
269
6
33
1.83
0.79
3.7
2.7
—
—
—
0
0
88
1005
0.82
0.79
3.4
3.2
0.17
0.00
estimate
0.47
24
226
23
166
1.42
0.78
1.7
1.6
—
—
—
0
0
23
166
1.42
0.78
1.7
1.6
—
—
—
0
0
0
27
0.00
0.78
0.0
3.1
—
17.04
—
0
5
111
991
1.19
0.73
2.1
1.9
98.91
96.84
pmol/l
0.16
56
517
5
25
2.02
0.73
2.8
2.7
—
—
—
0
0
64
544
1.22
0.70
2.0
2.1
—
—
—
0
0
7
117
0.59
0.69
10.9
5.8
27.47
24.59
mmol/l
—
7
111
7
42
1.68
0.69
1.3
1.3
—
—
—
0
0
51
606
0.81
0.67
3.0
3.9
—
—
—
0
0
17
120
1.44
0.66
2.9
2.2
—
—
—
0
0
54
454
1.23
0.66
1.8
1.6
—
—
—
0
0
30
378
0.77
0.65
1.4
1.4
—
—
—
0
0
42
344
1.26
0.64
1.6
1.6
—
—
—
0
0
34
420
0.79
0.63
1.4
1.7
505.18
32143290.36
pmol/l
0.50
28
364
10
63
1.61
0.62
1.4
1.4
—
—
—
0
0
120
1308
0.86
0.59
3.8
3.4
0.00
5.95
estimate
0.50
25
273
79
697
1.18
0.59
5.8
3.2
7.40
7.40
ph
0.59
50
484
22
167
1.34
0.58
1.7
1.6
—
—
—
0
0
6
35
1.73
0.58
1.0
1.2
—
—
—
0
0
13
183
0.70
0.57
2.6
4.1
0.00
0.06
%
—
5
34
132
1216
1.15
0.57
3.1
2.9
105.24
95.35
ug/l
0.25
124
1152
247
2385
1.20
0.56
4.4
4.6
5.89
5.80
mmol/l
0.52
230
2234
19
142
1.36
0.56
1.2
1.2
—
—
—
0
0
13
181
0.71
0.54
1.2
1.2
—
—
—
0
0
35
288
1.24
0.53
2.1
1.9
—
—
—
0
0
26
206
1.29
0.53
3.5
2.0
6.03
6.07
ph
0.09
17
130
6
99
0.60
0.53
1.0
2.1
225.50
239.29
pmol/l
—
6
94
132
1223
1.14
0.51
5.7
5.1
9.78
10.76
umol/l
0.92
127
1161
199
1896
1.15
0.51
3.5
3.1
46.74
41.15
u/l
0.64
189
1833
14
189
0.73
0.50
2.5
4.1
1.00
0.65
%
—
6
39
7
48
1.47
0.47
1.1
1.3
0.70
0.66
g/l
—
7
43
50
434
1.18
0.46
2.9
2.3
2.44
2.43
mmol/l
0.13
43
394
50
435
1.18
0.45
3.7
3.6
50.69
337.19
ng/l
1.77
36
299
37
434
0.83
0.45
2.9
2.7
0.68
0.67
ug/l
0.05
19
226
81
733
1.14
0.44
8.0
5.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
1816.07
—
0
15
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
239
2320
1.15
0.40
5.0
5.1
1.69
1.84
mu/l
0.81
225
2188
0
19
0.00
0.39
0.0
1.1
—
0.21
—
0
12
9
66
1.37
0.38
1.1
1.2
—
—
—
0
0
61
547
1.14
0.38
1.4
1.3
38.70
27.72
iu/ml
0.30
16
177
11
147
0.74
0.38
1.0
1.1
0.95
0.92
g/l
0.22
11
147
13
98
1.34
0.38
2.0
1.7
—
—
—
0
0
9
68
1.33
0.38
2.3
2.6
—
—
—
0
0
5
37
1.36
0.37
1.4
2.3
—
—
—
0
0
22
180
1.24
0.37
2.5
3.3
—
—
—
0
0
11
146
0.74
0.37
1.0
1.1
1.60
1.54
g/l
0.52
11
146
89
821
1.12
0.36
3.6
3.2
67.00
110.86
ng/l
0.21
60
492
96
890
1.12
0.36
3.8
3.4
28.83
107.14
e6/l
1.48
66
588
23
190
1.23
0.36
1.1
1.1
—
—
—
0
0
36
312
1.17
0.35
1.8
2.0
—
—
—
0
0
6
43
1.40
0.35
1.2
1.0
—
—
—
0
0
37
324
1.16
0.32
1.3
1.2
—
—
—
0
0
7
52
1.35
0.31
1.7
2.8
59.00
58.40
%
—
7
52
114
1077
1.09
0.29
2.6
2.4
—
—
estimate
—
0
0
8
107
0.74
0.29
3.3
2.2
0.80
0.61
%
—
8
107
8
109
0.73
0.29
3.3
2.2
3.14
1.40
%
—
8
109
8
62
1.30
0.28
5.0
4.4
1.25
1.36
mmol/l
—
8
62
33
291
1.15
0.27
1.8
1.7
—
—
—
0
0
13
104
1.26
0.27
13.5
9.8
16.12
16.38
%
0.13
13
98
17
203
0.83
0.26
1.2
1.3
49.67
151.10
u/ml
—
6
90
161
1670
0.92
0.26
4.7
3.8
—
4.90
—
0
5
80
747
1.10
0.26
3.5
2.8
32.83
58.31
e6/l
0.57
65
550
77
718
1.10
0.26
2.5
2.2
81.79
71.18
u/l
0.13
67
669
178
1721
1.08
0.26
3.6
3.5
—
0.17
—
0
6
9
75
1.21
0.25
1.0
1.2
—
—
—
0
0
249
2533
0.90
0.24
4.6
4.8
4.78
4.75
mmol/l
0.21
236
2409
6
83
0.72
0.24
3.3
8.2
—
—
—
0
0
31
275
1.14
0.24
15.3
5.8
103.68
104.10
mmol/l
0.20
31
275
84
790
1.09
0.24
3.5
3.1
7.35
8.23
mmol/l
1.21
77
684
235
2396
0.91
0.24
4.0
4.0
1.35
1.31
mmol/l
0.42
222
2253
5
38
1.32
0.23
3.4
1.5
—
—
—
0
0
270
2664
1.14
0.23
11.2
9.9
27.59
27.81
u/l
0.08
262
2618
5
40
1.25
0.22
2.4
2.3
—
—
—
0
0
5
40
1.25
0.22
1.6
2.6
8.44
6.99
pmol/l
—
5
40
58
624
0.91
0.22
1.7
1.6
21.11
22.07
nmol/l
0.18
48
540
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
7.47
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
51.17
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
64.40
—
0
10
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
27
302
0.88
0.20
1.4
1.4
—
—
—
0
0
6
49
1.23
0.20
2.5
1.4
—
—
—
0
0
214
2183
0.93
0.19
19.9
14.4
13.46
13.41
%
0.25
209
2165
14
119
1.19
0.18
1.1
1.2
—
1.47
—
0
7
249
2524
0.92
0.17
4.6
4.7
1.45
1.46
mmol/l
0.13
237
2393
68
644
1.07
0.17
3.6
2.6
0.31
0.39
e6/l
0.21
53
454
268
2652
1.10
0.16
19.2
14.4
74.88
74.09
umol/l
0.12
268
2627
94
977
0.94
0.15
2.0
2.0
—
—
—
0
0
16
181
0.88
0.14
1.9
2.2
0.11
0.67
e6/l
0.61
16
172
10
84
1.20
0.14
1.0
1.1
—
—
—
0
0
65
681
0.94
0.13
3.9
3.6
0.05
0.00
estimate
0.43
22
251
39
366
1.08
0.12
3.5
2.6
2.24
1.78
e6/l
0.16
21
161
11
95
1.16
0.12
1.1
1.1
—
—
—
0
0
31
289
1.08
0.11
1.8
1.8
4.24
3.53
mmol/l
1.84
20
217
259
2612
0.94
0.10
12.4
10.1
—
—
—
0
0
5
47
1.06
0.09
1.2
1.1
—
—
—
0
0
6
55
1.09
0.09
1.0
1.1
—
19.04
—
0
24
5
65
0.77
0.08
1.0
1.3
—
—
—
0
0
6
70
0.85
0.07
1.5
1.6
—
—
—
0
0
248
2499
0.96
0.07
17.5
11.1
25.23
20.30
mg/l
1.60
217
1963
15
137
1.10
0.07
1.7
1.6
0.21
0.32
mg/l
—
10
62
16
147
1.09
0.07
1.9
2.4
2.76
8.51
ug/l
—
10
132
7
83
0.84
0.07
1.1
1.1
—
—
—
0
0
9
84
1.07
0.07
1.2
1.3
—
—
—
0
0
9
102
0.88
0.06
4.7
3.4
—
—
—
0
0
24
228
1.06
0.05
1.0
1.2
—
—
—
0
0
29
302
0.96
0.04
1.2
1.2
—
—
—
0
0
56
574
0.97
0.04
3.9
3.5
1.02
1.02
kg/l
0.22
38
370
197
1958
1.02
0.03
4.2
4.2
14.59
14.63
pmol/l
0.10
185
1833
255
2559
0.98
0.02
5.1
5.3
2.82
2.83
mmol/l
0.11
244
2424
41
402
1.02
0.01
1.4
1.4
600.00
633.71
titre
—
10
89
36
367
0.98
0.01
2.5
2.5
92.08
94.24
ug/g
0.03
30
304
50
493
1.02
0.01
1.5
1.3
5.44
8.59
u/ml
0.32
19
198
14
142
0.99
0.00
1.1
1.1
—
—
—
0
0
17
171
0.99
0.00
1.7
1.4
—
—
—
0
0
21
209
1.01
0.00
1.2
1.5
—
—
—
0
0
276
2761
1.00
0.00
23.9
17.8
257.53
254.74
e9/l
0.26
270
2725
30
301
1.00
0.00
1.2
1.4
—
—
—
0
0
234
2343
0.99
0.00
5.6
5.5
38.64
38.43
mmol/mol
0.13
225
2249
70
696
1.01
0.00
4.4
3.9
18.55
6.69
mg/mmol
0.46
47
442
18
176
1.02
0.00
1.2
1.8
—
—
—
0
0
276
2764
0.98
0.00
23.8
17.7
4.51
4.61
e12/l
2.50
270
2721
276
2764
0.98
0.00
23.8
17.8
6.80
6.54
e9/l
1.45
270
2719
29
286
1.02
0.00
1.6
1.4
—
—
—
0
0
69
695
0.99
0.00
3.8
3.3
66.99
39.02
mg/l
0.33
46
454
7
75
0.93
0.00
3.7
2.9
9.14
725.32
u/ml
—
7
70
0
7
0.00
-0.00
0.0
6.9
—
8.57
—
0
7
106
1060
1.00
-0.00
3.3
3.1
6.23
6.17
ph
0.22
64
625
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.48
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
0.00
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
29.25
—
0
8
9
89
1.01
-0.00
2.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
60.14
—
0
7
0
7
0.00
-0.00
0.0
3.4
—
47.14
—
0
7
0
9
0.00
-0.00
0.0
1.3
—
12.61
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
0.35
—
0
5
5
50
1.00
-0.00
1.8
2.6
7.98
8.68
kpa
—
5
50
11
110
1.00
-0.00
1.0
1.3
47.33
274.42
miu/ml
—
6
60
5
53
0.94
-0.00
7.2
3.5
4.06
3.85
mmol/l
—
5
53
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
52
0.96
-0.00
1.6
1.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_MENINGOCOCCAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_MENINGOCOCCAL 2.491 [1.73, 3.59] < 0.001
Birth year 0.997 [0.99, 1.01] 0.475

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 463 females with AB1_MENINGOCOCCAL died.

Males

Parameter HR [95% CI] p-value
AB1_MENINGOCOCCAL 2.574 [1.72, 3.86] < 0.001
Birth year 0.989 [0.98, 1.0] 0.054

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 513 males with AB1_MENINGOCOCCAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MENINGOCOCCAL.

N-year risk Females Males
1 0.184% 0.429%
5 1.429% 2.889%
10 3.829% 7.419%
15 7.655% 14.077%
20 13.33% 23.471%

Relationships between endpoints

Index endpoint: AB1_MENINGOCOCCAL – Meningococcal infection

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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