Acute hepatitis A, including avohilmo

AB1_HEPATITIS_A_WIDE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Primary healthcare outpatient: ICD-10 — B15 Hospital discharge: ICD-10 — B15 Hospital discharge: ICD-9 — 070[0-1] Cause of death: ICD-10 — B15 Cause of death: ICD-9 — 070[0-1] 3 out of 7 registries used, show all original rules.	192
4. Check minimum number of events None	192
5. Include endpoints None	192
6. Filter based on genotype QC (FinnGen only)	161

Control definitions (FinnGen only)

Control exclude: AB1_VIRAL_HEPATITIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: B15-B19
Name in latin: Hepatitis A acuta

NAME	AB1_HEPATITIS_A_WIDE
CONTROL_EXCLUDE	AB1_VIRAL_HEPATITIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD	B15
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B15
HD_ICD_9	070[0-1]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B15
COD_ICD_9	070[0-1]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acute hepatitis A, including avohilmo based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	161	83	78
Unadjusted period prevalence (%)	0.03	0.03	0.04
Median age at first event (years)	39.64	39.56	39.72

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
176: Matched controls
1760

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B15.9

ICD-10 Finland

Hepatitis A without hepatic coma

+∞

124.1

104

0701A

ICD-9 Finland

Viral hepatitis A without mention of hepatic coma

+∞

55.1

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

47.1

23.5

B18.2

ICD-10 Finland

Chronic viral hepatitis C

+∞

18.0

0700A

ICD-9 Finland

Viral hepatitis A with hepatic coma

+∞

10.5

B15

ICD-10 Finland

Acute hepatitis A

+∞

9.5

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.8

8.5

B19.9

ICD-10 Finland

Unspecified viral hepatitis without hepatic coma

+∞

8.4

WYA30

NOMESCO Finland

Treatment of a patient needing special arrangements

3.9

7.9

F15.2

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome

+∞

7.3

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.8

6.5

153

R17

ICD-10 Finland

Hyperbilirubinaemia, with or without jaundice, not elsewhere classified

11.6

6.4

B15.0

ICD-10 Finland

Hepatitis A with hepatic coma

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016650) Hepatitis A virus Ab [Presence] in Serum

8.40

17.87

1.2

1.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

10.60

13.00

1.1

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

16.76

9.20

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

12.77

7.19

2.1

1.1

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

13.46

5.64

1.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

13.46

5.64

1.0

—

(37021073) Hepatitis C virus genotype in Serum or Plasma by Sequencing

+∞

5.23

1.2

0.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

7.74

5.23

1.2

1.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

161

2.47

4.91

2.1

2.5

25.00

30.84

u/l

1.44

134

(3021879) Hepatitis B virus core Ab [Presence] in Serum

157

2.44

4.72

1.8

1.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

676

1.97

4.64

6.4

5.2

34.93

36.08

g/l

1.10

650

(3034770) Mitochondria Ab [Titer] in Serum

3.31

4.50

1.3

1.2

—

(3006504) Eosinophils/Leukocytes in Blood

105

763

1.93

4.32

8.1

6.8

3.27

2.78

1.38

100

719

(3019069) Monocytes/Leukocytes in Blood

105

766

1.92

4.24

8.1

6.9

8.97

8.71

0.39

100

725

(3022096) Basophils/Leukocytes in Blood

104

762

1.89

4.09

8.5

6.8

0.72

0.69

0.27

716

(3019198) Lymphocytes [#/volume] in Blood

112

854

1.86

3.74

8.4

6.8

2.35

1.81

e9/l

0.66

101

766

(3006315) Basophils [#/volume] in Blood

110

835

1.85

3.72

8.5

6.8

0.05

0.04

e9/l

1.07

720

(3013115) Eosinophils [#/volume] in Blood

112

862

1.82

3.55

8.6

7.0

0.21

0.19

e9/l

0.89

100

765

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.50

3.50

4.2

2.7

—

(3037522) Nuclear Ab [Titer] in Serum

247

1.98

3.46

1.3

1.4

376.00

397.29

titre

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.65

3.43

4.6

2.8

—

(3021589) Normoblasts [#/volume] in Blood

725

1.75

3.30

14.6

11.8

0.00

e9/l

0.53

586

(3001604) Monocytes [#/volume] in Blood

108

833

1.77

3.29

8.6

6.8

0.58

0.57

e9/l

0.10

720

(3028707) Methadone [Presence] in Urine by Screen method

3.71

3.27

1.8

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

238

1.94

3.18

2.3

1.7

—

(3032080) INR in Blood by Coagulation assay

683

1.73

3.16

11.7

11.6

1.17

1.19

inr

0.15

567

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

193

2.02

3.14

2.7

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

201

1.99

3.12

2.7

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

288

1.86

3.10

1.6

1.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.65

2.97

1.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

359

1.77

2.94

2.9

2.2

2.83

3.01

mg/l

0.24

308

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

4.25

2.92

1.0

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

114

920

1.68

2.70

14.4

11.0

3.82

4.15

e9/l

1.23

102

810

(3011288) Drugs identified in Urine by Screen method Nominal

2.67

2.50

11.4

1.5

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

135

1154

1.73

2.43

5.4

4.6

12.84

10.87

mm/h

0.74

128

1081

(3001122) Ferritin [Mass/volume] in Serum or Plasma

735

1.60

2.42

3.2

3.1

133.20

111.75

ug/l

0.31

690

(3026782) Osmolality of Urine

295

1.71

2.32

2.9

2.8

526.07

529.65

mosm/kgh2o

0.04

253

(40758558) Short blood count panel - Blood

478

1.61

2.32

8.2

7.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.86

2.32

1.3

—

(3018095) Leukocytes [#/volume] in Urine

589

1.58

2.30

4.4

4.0

28.96

98.08

e6/l

1.32

394

(3000764) Benzodiazepines [Presence] in Urine

2.31

2.29

1.8

1.2

—

(3002582) Erythrocytes [#/volume] in Urine

517

1.59

2.26

3.5

3.2

109.79

163.35

e6/l

0.13

378

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.22

2.21

2.1

1.5

0.43

0.33

mg/l

—

(3044290) Cell count panel - Cerebral spinal fluid

3.11

2.18

2.6

1.3

—

(3023368) Bacteria identified in Blood by Culture

404

1.61

2.17

6.5

4.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

4.40

2.17

3.8

1.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

4.40

2.17

1.0

1.1

—

(3000494) Fungus identified in Specimen by Culture

203

1.77

2.12

1.2

1.5

—

(3027944) Amphetamines [Presence] in Urine

2.22

2.10

1.9

1.3

—

(3027008) Opiates [Presence] in Urine

2.22

2.10

1.8

1.2

—

(3028300) Cannabinoids [Presence] in Urine

2.22

2.10

1.8

1.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

2.08

0.0

2.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

3.60

2.07

1.1

1.3

—

(21494815) CD4 cells/Lymphocytes in Specimen

4.10

2.05

3.8

2.1

31.92

39.63

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.73

2.04

1.0

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.29

2.00

2.2

2.3

—

(3016879) Cocaine [Presence] in Urine

2.22

1.99

1.8

1.2

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.82

1.96

2.3

4.9

—

4606.17

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

268

1.64

1.89

2.8

2.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

2.15

1.87

1.5

1.3

48.80

23.31

iu/l

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

144

1287

1.65

1.80

29.1

19.9

13.78

13.58

0.88

144

1277

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.01

1.77

1.9

1.6

—

(3037756) Immunofixation for Serum or Plasma

2.65

1.68

1.0

1.8

—

(3030467) Casts [#/volume] in Urine by Automated count

444

1.49

1.67

3.3

3.1

0.40

0.38

e6/l

0.04

306

(42870588) Differential panel, method unspecified - Blood

555

1.47

1.67

8.2

6.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.23

1.65

2.0

1.2

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.91

1.64

1.7

3.3

24.49

24.60

mmol/l

0.04

(3018418) pH of Serum or Plasma

465

1.48

1.62

2.8

4.5

7.41

7.40

0.80

340

(3007164) IgA [Mass/volume] in Serum or Plasma

385

1.50

1.59

1.6

1.4

2.69

2.42

g/l

0.36

237

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

1.54

0.0

1.4

—

(3048689) Calprotectin [Mass/mass] in Stool

222

1.60

1.53

2.6

2.3

131.82

129.28

ug/g

0.02

176

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.05

1.47

3.4

2.8

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.11

1.47

1.1

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

2.79

1.44

1.3

1.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

303

1.51

1.44

1.4

1.3

15.21

8.50

u/ml

0.19

121

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

185

1.61

1.40

3.4

2.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

279

1.51

1.39

2.9

11.07

0.84

e6/l

0.50

136

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.26

1.39

1.4

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

351

1.46

1.36

1.9

1.8

1.56

1.22

mg/l

0.13

281

(3012544) pH of Venous blood

162

1.63

1.35

2.4

3.9

7.39

0.10

(3015736) pH of Urine

689

1.39

1.33

3.8

3.5

6.21

6.19

0.08

395

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

2.55

1.31

1.2

1.3

—

(3016018) Differential panel - Cerebral spinal fluid

2.83

1.29

1.8

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.35

1.28

1.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.35

1.28

1.0

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

124

1.69

1.27

3.4

1.5

—

(3026008) Bacteria identified in Urine by Culture

438

1.41

1.26

3.4

3.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

127

1139

1.41

1.24

5.0

3.3

59.79

44.88

u/l

0.80

121

1090

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

385

1.42

1.23

2.0

2.5

—

(3018333) Ribosomal P Ab [Presence] in Serum

2.68

1.22

1.2

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

2.68

1.22

1.2

1.3

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

2.35

1.19

1.5

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

128

1155

1.40

1.16

4.3

14.35

14.72

pmol/l

0.88

116

1061

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

2.54

1.16

1.2

1.3

—

(3000850) Epithelial cells [#/volume] in Urine

346

1.40

1.11

2.6

4.18

5.16

e6/l

0.40

309

(3004588) Protein electrophoresis panel - Serum or Plasma

105

1.69

1.11

1.6

2.9

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.00

1.10

1.0

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

205

1.50

1.10

3.5

2.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

2.42

1.10

1.2

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

2.42

1.10

1.2

1.3

—

(3002179) Metamyelocytes/Leukocytes in Blood

146

1.58

1.10

3.9

4.5

0.56

0.61

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.24

1.09

1.4

1.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.98

1.08

1.0

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

854

1.33

1.08

4.0

3.9

0.00

estimate

-0.00

173

(40759836) Histone Ab [Presence] in Serum by Immunoblot

2.31

1.04

1.2

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

341

1.39

1.03

2.5

2.1

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

149

1390

1.47

1.03

5.3

1.85

1.88

mu/l

0.13

141

1287

(3042936) Bacteria identified in Isolate by Culture

243

1.44

1.03

2.1

2.0

—

(1761868) Lipid panel - Serum or Plasma

677

0.75

1.01

3.6

3.1

—

(3025159) Blasts/Leukocytes in Blood

150

1.53

0.99

3.7

5.1

0.00

0.22

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

2.21

0.98

1.6

4.0

2.40

2.58

nmol/l

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.84

0.98

1.4

1.3

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.84

0.98

1.2

1.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

2.26

0.94

1.3

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

257

1.40

0.92

3.1

7.28

2.45

e6/l

0.48

116

(3022145) Colonoscopy Study observation

206

1.43

0.88

1.1

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

155

1.48

0.86

4.6

3.5

—

(4035726) Immunohistochemistry procedure

131

1.50

0.82

1.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

157

1.46

0.81

2.9

2.1

331.00

405.76

nmol/l

1.23

148

(3017181) Myelocytes/Leukocytes in Blood

157

1.46

0.81

4.0

4.6

0.38

0.95

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

310

1.33

0.79

4.1

3.7

99.11

265.76

ng/l

0.70

242

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

155

1474

1.43

0.78

5.3

4.9

6.07

5.90

mmol/l

0.68

149

1369

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.78

0.0

1.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

710

1.26

0.78

2.5

2.6

76.11

75.55

nmol/l

0.05

642

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.77

0.0

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

108

1.53

0.76

10.4

9.1

23.38

25.20

mmol/l

0.81

108

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

2.11

0.75

1.2

1.3

—

(3021788) Differential panel - Synovial fluid

2.11

0.75

1.8

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

742

1.25

0.75

7.9

8.9

1.22

1.21

mmol/l

0.19

643

(3035350) Ketones [Presence] in Urine by Test strip

861

1.25

0.75

4.1

3.9

0.00

9.07

estimate

0.50

179

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

664

1.25

0.74

1.9

2.0

1.43

1.41

mmol/l

0.07

560

(3009261) Glucose [Presence] in Urine by Test strip

873

1.25

0.72

4.1

3.9

0.00

estimate

-0.00

165

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.61

0.72

1.2

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

170

1.41

0.72

2.7

1.9

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.55

0.72

1.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

324

1.30

0.71

1.4

1.3

31.34

32.58

iu/ml

0.04

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.74

0.71

1.7

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.68

0.70

2.5

1.4

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.68

0.70

4.2

3.6

56.80

2871.13

u/ml

—

(3021440) Promyelocytes/Leukocytes in Blood

145

1.43

0.69

4.3

4.7

0.00

0.17

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

1.81

0.66

4.8

1.4

804.30

137.74

u/ml

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

497

1.25

0.66

2.4

2.2

154.25

167.63

u/l

0.16

473

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

112

1.47

0.66

2.6

4.0

69.45

87.92

ng/l

0.70

100

(1616796) Gas panel - Central venous blood

1.74

0.64

6.8

3.2

—

(21494755) Public health laboratory ask at order entry panel

197

0.69

0.63

1.6

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.63

0.62

1.3

1.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.52

0.58

2.6

2.7

0.46

0.62

1.49

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.58

0.0

1.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

1.69

0.57

1.2

1.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.50

0.56

2.6

2.7

2.11

1.42

0.47

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

409

0.79

0.56

4.7

4.3

25.60

22.84

0.29

187

(3014576) Chloride [Moles/volume] in Serum or Plasma

224

1.30

0.55

9.1

8.4

104.11

104.06

mmol/l

0.02

224

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

1.60

0.55

1.3

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

167

0.70

0.52

6.9

6.8

—

(3003694) ABO and Rh group [Type] in Blood

452

1.21

0.51

1.3

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

455

1.20

0.48

3.7

3.9

0.00

0.02

estimate

0.50

165

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

317

0.79

0.48

2.9

3.0

0.74

0.78

ug/l

0.07

178

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

313

1.23

0.47

1.8

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

681

1.18

0.46

2.4

2.0

102.27

98.46

pmol/l

0.30

351

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.63

0.43

1.0

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.63

0.43

1.0

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

714

1.17

0.42

3.0

—

estimate

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

157

1523

1.29

0.42

23.2

16.0

25.46

22.05

mg/l

0.58

137

1248

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.41

0.0

2.8

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

1.48

0.40

3.0

3.5

6.36

7.60

mmol/l

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.7

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

149

1440

1.23

0.39

6.9

6.2

38.93

39.32

mmol/mol

0.21

144

1355

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.39

0.0

3.9

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.39

0.0

1.3

—

52.68

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.39

0.0

1.5

—

17.14

—

(3003129) Base excess in Capillary blood by calculation

0.00

0.39

0.0

1.4

—

0.79

—

(3044640) Blood type and Crossmatch panel - Blood

523

1.16

0.38

2.2

2.4

—

(36660697) Celiac disease serology panel - Serum

144

1.28

0.37

1.3

1.2

—

(3019977) pH of Arterial blood

172

1.25

0.36

13.4

12.8

7.44

7.42

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

153

1486

1.23

0.35

18.3

15.1

85.75

83.86

ml/min/173m2

0.54

144

1383

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.38

0.35

2.5

1.3

—

(40768804) Tissue Pathology biopsy report

606

1.14

0.33

2.0

2.1

—

(3022621) pH of Urine by Test strip

132

0.74

0.33

3.2

2.1

5.80

6.03

—

(3027801) Oxygen [Partial pressure] in Arterial blood

174

1.23

0.33

13.4

12.6

12.64

11.96

kpa

0.19

167

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

174

1.23

0.33

13.4

12.6

5.00

5.13

kpa

0.24

166

(3005322) IgE [Units/volume] in Serum or Plasma

110

1.30

0.33

1.1

1.2

104.41

362.82

u/ml

0.98

103

(4034850) Laboratory test

1.29

0.32

3.7

8.7

—

(3013512) EKG study

510

0.87

0.32

4.0

3.7

—

(40768797) Stomach Pathology biopsy report

214

1.20

0.30

1.2

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.26

0.30

2.3

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.24

0.29

2.4

1.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

104

1.27

0.27

1.1

1.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

157

1536

1.21

0.27

5.8

2.80

2.77

mmol/l

0.13

149

1444

(3009508) Creatinine [Moles/volume] in Urine

527

1.12

0.25

3.8

3.2

8.35

8.24

mmol/l

0.05

449

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

410

1.13

0.25

1.5

1.3

1.26

1.79

u/ml

0.25

107

(40760892) CBC W Ordered Manual Differential panel - Blood

382

1.13

0.24

6.2

5.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

200

0.83

0.24

2.1

1.5

—

(3019150) Specific gravity of Urine by Refractometry

363

1.13

0.24

4.3

3.8

1.02

kg/l

0.31

236

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

162

1.19

0.24

1.9

1.8

—

(3028626) Oxygen [Partial pressure] in Capillary blood

1.29

0.23

2.4

2.6

8.72

8.38

kpa

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.26

0.22

1.6

1.7

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

2.5

—

(4027681) Cerebrospinal fluid IgG ratio and IgG index

0.00

0.21

0.0

1.2

—

0.45

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

1.6

—

7.64

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

212

1.15

0.21

1.3

1.5

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

2.9

—

0.77

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.4

—

1.00

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

603

1.10

0.20

4.7

3.7

26.83

31.69

ng/l

0.21

401

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

164

1618

1.20

0.18

17.2

12.5

32.12

27.30

u/l

1.91

159

1587

(3000492) Spirometry study

194

0.86

0.17

1.4

1.5

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.13

0.17

1.1

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.13

0.17

1.1

1.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.23

0.17

3.3

3.9

47.81

49.20

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

107

1036

1.08

0.17

3.6

3.4

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

139

1.17

0.17

13.1

10.4

1.62

1.26

mmol/l

0.82

139

(4024509) Urine culture

1.15

0.16

1.4

1.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.21

0.16

22.2

16.6

15.60

15.82

0.14

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.16

0.15

1.6

1.3

—

(3000991) Gas panel - Venous blood

142

1.14

0.13

13.2

11.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

485

0.93

0.12

3.8

3.2

0.00

estimate

-0.00

141

(40761536) Microorganisms panel - Urine sediment

126

0.86

0.11

5.7

3.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

182

1.11

0.11

2.0

1.6

—

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

164

1655

0.87

0.11

34.7

24.7

40.09

40.88

0.97

164

1643

(3024731) MCV [Entitic mean volume] in Red Blood Cells

164

1655

0.87

0.11

33.6

24.0

90.05

90.78

1.02

164

1643

(3035941) MCH [Entitic mass]

164

1655

0.87

0.11

33.6

23.9

29.96

30.28

1.15

164

1643

(3000963) Hemoglobin [Mass/volume] in Blood

164

1655

0.87

0.11

33.9

24.2

134.50

136.95

g/l

1.30

164

1642

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

154

1521

1.10

0.11

5.0

5.2

4.67

4.68

mmol/l

0.04

145

1433

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

115

0.86

0.11

1.8

2.5

—

15.79

—

(1002224) Polysomnography panel

106

1.14

0.10

1.2

1.1

—

(3010421) pH of Blood

1.14

0.10

8.0

3.3

7.39

7.43

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.07

0.09

2.6

1.7

—

(3049717) Cytology report of Urine Cyto stain

1.09

0.09

1.8

2.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

153

1514

1.08

0.08

4.9

5.1

1.41

1.45

mmol/l

0.44

145

1416

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.83

0.08

13.2

10.5

1.28

1.47

—

(3008898) HLA-B27 [Presence]

0.83

0.07

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.09

0.07

2.6

1.8

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

122

0.90

0.07

1.2

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

493

1.05

0.07

4.1

4.0

6.19

9.98

mg/mmol

0.47

313

(3025941) Bacteria identified in Stool by Culture

100

1.11

0.05

2.0

1.3

—

(3016502) Oxygen saturation in Arterial blood

159

1.08

0.05

16.0

13.4

96.07

95.46

0.25

154

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

643

0.97

0.04

4.4

3.7

0.00

estimate

-0.00

144

(3012516) Albumin [Mass/volume] in Urine

482

0.97

0.04

3.6

3.4

38.12

64.70

mg/l

0.43

312

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

449

1.03

0.03

2.5

3.2

1345.37

929.96

ng/l

0.34

372

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.09

0.03

1.7

1.3

—

(3002256) Pathology report gross observation

192

1.05

0.02

1.6

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

145

1457

0.97

0.01

4.2

4.3

1.31

1.30

mmol/l

0.05

134

1352

(40761511) CBC panel - Blood by Automated count

158

1579

1.01

0.00

19.9

13.6

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

105

0.95

0.00

1.1

1.3

—

23.91

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.5

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

1.1

—

124.00

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.98

0.00

13.2

11.9

0.80

0.86

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

2.5

—

44.07

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.5

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.1

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.9

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

0.0

1.1

—

223.83

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

8.90

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.5

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3009876) Amylase isoenzyme 3 panel - Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3015479) Mycobacterium sp identified in Blood by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3014043) Spermatozoa Nonprogressive/Spermatozoa in Semen

0.00

-0.00

0.0

5.6

—

8.40

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

1.7

—

17.14

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.00

-0.00

2.0

1.6

—

9.26

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.2

—

122.44

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.4

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.96

-0.00

11.8

12.9

25.29

24.88

mmol/l

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

-0.00

0.0

1.2

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.4

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.97

-0.00

1.2

—

(3019060) Gas panel - Arterial blood

0.97

-0.00

9.6

10.3

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

112.14

—

(3000213) Normetanephrine [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.2

—

2.14

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.4

—

8.10

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.4

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

10.16

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.6

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(4133840) Spirometry

0.00

-0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3020650) Glucose [Presence] in Urine

0.00

-0.00

0.0

1.6

—

0.00

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

-0.00

0.0

2.8

—

39.20

—

(3036489) Thrombin time

0.88

-0.00

2.3

2.0

24.00

21.18

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

12.67

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.8

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.4

—

(3042299) inFLIXimab [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

5.2

—

6.68

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.94

-0.00

1.7

2.1

—

(3028009) Chlamydia trachomatis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

5.10

—

(3026250) Tacrolimus [Mass/volume] in Blood

0.00

-0.00

0.0

26.3

—

6.18

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.7

—

4.58

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.7

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.0

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

2.3

—

44.07

—

(3036035) von Willebrand factor (vWf) Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.8

—

162.50

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.5

—

0.63

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.7

—

9.72

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.8

—

82.72

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: AB1_HEPATITIS_A_WIDE – Acute hepatitis A, including avohilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Acute hepatitis A, including avohilmo

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Acute hepatitis A, including avohilmo (AB1_HEPATITIS_A_WIDE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints