Acute hepatitis A

AB1_HEPATITIS_A

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B15 Hospital discharge: ICD-9 — 070[0-1] Cause of death: ICD-10 — B15 Cause of death: ICD-9 — 070[0-1] 2 out of 7 registries used, show all original rules.	177
4. Check minimum number of events None	177
5. Include endpoints None	177
6. Filter based on genotype QC (FinnGen only)	148

Control definitions (FinnGen only)

Control exclude: AB1_VIRAL_HEPATITIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: B15-B19
Name in latin: Hepatitis A acuta

NAME	AB1_HEPATITIS_A
CONTROL_EXCLUDE	AB1_VIRAL_HEPATITIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B15
HD_ICD_9	070[0-1]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B15
COD_ICD_9	070[0-1]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acute hepatitis A based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1602	688	896
Only index persons	1328	598	730
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.03
Only index persons	0.03	0.02	0.03
Median age at first event (years)
Whole population	36.85	37.94	35.93
Only index persons	34.38	35.37	33.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	148	74	74
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	39.62	38.88	40.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
161: Matched controls
1610

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B15.9

ICD-10 Finland

Hepatitis A without hepatic coma

+∞

114.7

0701A

ICD-9 Finland

Viral hepatitis A without mention of hepatic coma

+∞

55.5

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

64.3

23.9

B18.2

ICD-10 Finland

Chronic viral hepatitis C

+∞

17.0

0700A

ICD-9 Finland

Viral hepatitis A with hepatic coma

+∞

10.5

B19.9

ICD-10 Finland

Unspecified viral hepatitis without hepatic coma

+∞

8.4

WYA30

NOMESCO Finland

Treatment of a patient needing special arrangements

4.0

7.5

F15.2

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome

+∞

7.3

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.6

6.9

R17

ICD-10 Finland

Hyperbilirubinaemia, with or without jaundice, not elsewhere classified

11.7

6.4

N05BA02

ATC

chlordiazepoxide; systemic

11.7

6.4

B15.0

ICD-10 Finland

Hepatitis A with hepatic coma

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

16.07

7.85

2.1

1.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

7.60

7.20

1.1

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

13.22

6.17

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

5.61

5.88

1.1

—

(37021073) Hepatitis C virus genotype in Serum or Plasma by Sequencing

+∞

5.23

1.2

0.0

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

623

1.86

3.67

6.6

5.0

34.86

36.09

g/l

1.13

597

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

10.32

3.52

1.0

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

10.32

3.52

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.51

3.23

4.0

2.7

—

(3028707) Methadone [Presence] in Urine by Screen method

3.86

3.15

1.9

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

179

2.06

3.12

2.8

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

187

2.04

3.10

2.8

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.60

2.99

4.5

2.9

—

(3032080) INR in Blood by Coagulation assay

630

1.74

2.99

12.4

11.9

1.18

1.20

inr

0.17

523

(3028026) IgM [Mass/volume] in Serum or Plasma

105

2.27

2.85

1.3

1.6

1.27

1.13

g/l

0.21

(3019198) Lymphocytes [#/volume] in Blood

100

783

1.73

2.83

8.4

6.8

2.31

1.82

e9/l

0.51

701

(3006315) Basophils [#/volume] in Blood

765

1.72

2.79

8.5

6.9

0.05

0.04

e9/l

1.14

660

(3044290) Cell count panel - Cerebral spinal fluid

3.91

2.71

2.6

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

143

2.07

2.71

1.7

—

(3013115) Eosinophils [#/volume] in Blood

100

789

1.71

2.70

8.6

7.1

0.21

0.19

e9/l

0.77

701

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

4.83

2.62

1.1

1.0

—

(3005719) IgG [Mass/volume] in Serum or Plasma

124

2.10

2.57

2.6

2.4

12.31

10.41

g/l

0.89

115

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

193

1.89

2.51

2.0

1.8

1.56

1.43

0.29

174

(3018010) Neutrophils/Leukocytes in Blood

713

1.64

2.41

9.3

6.7

57.34

58.09

0.23

683

(3000764) Benzodiazepines [Presence] in Urine

2.44

2.40

1.9

1.2

—

(3001604) Monocytes [#/volume] in Blood

764

1.64

2.38

8.6

6.9

0.58

0.57

e9/l

0.14

661

(3011288) Drugs identified in Urine by Screen method Nominal

2.68

2.33

12.2

1.5

—

(3026389) Candida sp identified in Specimen by Organism specific culture

4.75

2.29

3.8

1.3

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

2.37

2.25

1.5

1.3

48.80

22.34

iu/l

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

334

1.67

2.22

3.1

2.1

3.03

2.95

mg/l

0.09

288

(3028300) Cannabinoids [Presence] in Urine

2.33

2.19

1.9

1.2

—

(3027008) Opiates [Presence] in Urine

2.33

2.19

1.9

1.2

—

(3027944) Amphetamines [Presence] in Urine

2.33

2.19

1.9

1.3

—

(3021589) Normoblasts [#/volume] in Blood

666

1.59

2.18

15.3

12.1

0.00

e9/l

0.53

538

(21494815) CD4 cells/Lymphocytes in Specimen

4.41

2.17

3.8

2.1

31.92

40.88

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

2.11

0.0

1.9

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.20

2.04

2.2

1.5

0.43

0.34

mg/l

—

(3016879) Cocaine [Presence] in Urine

2.30

2.01

1.9

1.2

—

(3000494) Fungus identified in Specimen by Culture

184

1.77

1.96

1.2

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.31

1.90

3.4

2.8

—

(3037522) Nuclear Ab [Titer] in Serum

227

1.69

1.89

1.3

1.4

285.71

408.57

titre

—

(3037756) Immunofixation for Serum or Plasma

2.95

1.89

1.0

1.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.08

1.82

1.9

1.6

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

675

1.51

1.81

3.3

3.0

128.41

111.09

ug/l

0.21

633

(3013650) Neutrophils [#/volume] in Blood by Automated count

101

844

1.53

1.81

15.2

11.1

3.83

4.17

e9/l

1.12

746

(3002032) Base excess in Venous blood by calculation

143

1.80

1.73

2.5

3.7

1.07

1.87

mmol/l

0.50

120

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

259

1.61

1.70

1.6

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

251

1.62

1.68

2.9

1.9

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.66

1.68

1.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.66

1.68

1.0

1.1

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

3.24

1.67

1.0

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

2.34

1.67

1.4

1.2

—

(40758558) Short blood count panel - Blood

439

1.50

1.63

8.6

7.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

3.65

1.62

1.0

1.1

—

(3023368) Bacteria identified in Blood by Culture

367

1.53

1.62

7.0

4.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.36

1.59

1.0

1.2

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.93

1.58

1.8

3.2

24.64

24.47

mmol/l

0.08

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.50

1.56

1.4

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.24

1.54

2.1

1.2

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

120

1058

1.53

5.5

4.7

12.95

11.04

mm/h

0.63

115

992

(3012544) pH of Venous blood

150

1.71

1.48

2.5

3.7

7.39

0.01

(42870588) Differential panel, method unspecified - Blood

508

1.43

1.38

8.7

6.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.05

1.37

2.2

2.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

162

1.64

1.36

3.4

2.2

—

(3026008) Bacteria identified in Urine by Culture

390

1.45

1.33

3.4

3.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

1.33

0.0

1.5

—

(3002179) Metamyelocytes/Leukocytes in Blood

131

1.69

1.31

4.0

4.6

0.63

0.61

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

216

1.54

1.26

2.4

1.7

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

2.45

1.25

1.3

1.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.22

1.23

1.0

1.3

—

(3018095) Leukocytes [#/volume] in Urine

545

1.39

1.23

4.0

27.36

98.57

e6/l

1.23

362

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.16

1.20

1.5

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.00

1.20

1.3

—

(3048689) Calprotectin [Mass/mass] in Stool

202

1.53

1.18

2.6

2.4

142.04

135.04

ug/g

0.05

162

(3018418) pH of Serum or Plasma

427

1.40

1.16

2.9

4.4

7.41

7.40

0.51

312

(3004588) Protein electrophoresis panel - Serum or Plasma

1.74

1.15

1.7

3.0

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

129

1179

1.47

1.15

30.2

19.9

13.81

13.57

1.07

129

1171

(3002582) Erythrocytes [#/volume] in Urine

475

1.38

1.14

3.2

130.27

176.75

e6/l

0.10

345

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

274

1.45

1.13

1.4

1.3

17.42

7.45

u/ml

0.26

105

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

348

1.41

1.09

2.0

2.3

—

(1761868) Lipid panel - Serum or Plasma

626

0.73

1.06

3.7

3.1

—

(3021788) Differential panel - Synovial fluid

2.31

1.04

1.8

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

2.31

1.04

1.2

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

2.31

1.04

1.2

1.1

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

2.21

0.98

1.6

1.3

—

(3025159) Blasts/Leukocytes in Blood

135

1.55

0.94

3.9

5.2

0.00

0.24

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

116

1056

1.35

0.93

4.2

4.3

14.44

14.69

pmol/l

0.45

105

971

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.11

0.90

1.3

1.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

608

1.30

0.87

1.8

2.0

1.45

1.42

mmol/l

0.09

512

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

181

1.45

0.86

3.6

2.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

455

1.32

0.86

2.5

2.2

159.35

167.83

u/l

0.09

433

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.80

0.85

4.2

3.6

56.80

722.43

u/ml

—

(4035726) Immunohistochemistry procedure

122

1.54

0.84

1.3

1.4

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

1.78

0.84

1.9

1.4

263.75

278.85

ug/g

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

318

1.34

0.82

1.8

1.71

1.17

mg/l

0.20

259

(3017181) Myelocytes/Leukocytes in Blood

140

1.49

0.81

4.2

4.7

0.43

0.91

—

(3007164) IgA [Mass/volume] in Serum or Plasma

346

1.33

0.81

1.4

2.70

2.45

g/l

0.28

208

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.79

0.0

1.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

202

1.40

0.79

9.2

8.1

104.07

103.99

mmol/l

0.03

202

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.79

0.0

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.57

0.79

11.0

8.8

23.57

25.18

mmol/l

0.64

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.65

0.77

2.6

0.46

0.63

1.59

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

1.79

0.77

1.3

1.2

—

(3042936) Bacteria identified in Isolate by Culture

221

1.38

0.77

1.9

1.8

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.74

0.77

1.0

1.4

—

(3019977) pH of Arterial blood

151

1.45

0.76

13.4

9.8

7.44

7.43

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

304

1.33

0.75

2.4

2.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.63

0.74

2.6

2.11

1.44

0.45

(3027801) Oxygen [Partial pressure] in Arterial blood

152

1.44

0.74

13.4

9.6

12.64

11.88

kpa

0.21

147

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

152

1.44

0.74

13.4

9.7

5.00

5.10

kpa

0.18

146

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

135

1274

1.37

0.72

5.3

1.88

1.89

mu/l

0.04

127

1183

(3022145) Colonoscopy Study observation

188

1.39

0.72

1.1

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

111

1.49

0.69

4.0

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.88

0.69

1.0

1.3

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

1.88

0.69

4.8

1.4

804.30

142.76

u/ml

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.88

0.69

1.0

1.3

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

103

1.50

0.68

2.7

3.9

72.01

85.88

ng/l

0.48

(3036481) Cortisol [Moles/volume] in Serum or Plasma

146

1.42

0.68

3.0

2.1

321.85

399.44

nmol/l

1.16

138

(1616796) Gas panel - Central venous blood

1.81

0.66

6.8

3.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.62

0.66

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

784

1.24

0.65

3.9

0.00

estimate

-0.00

160

(3021440) Promyelocytes/Leukocytes in Blood

130

1.43

0.64

4.4

4.8

0.00

0.15

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

1.75

0.64

3.4

4.6

—

4987.40

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

676

1.24

0.63

8.6

8.0

1.22

1.21

mmol/l

0.37

585

(3015736) pH of Urine

638

1.23

0.62

3.8

3.4

6.28

6.18

0.32

365

(3042631) Mycobacterium sp identified in Specimen

0.00

0.61

0.0

3.9

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.61

0.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

620

1.23

0.60

2.4

2.1

103.31

97.64

pmol/l

0.47

322

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

258

1.30

0.60

2.3

2.9

13.44

0.77

e6/l

0.49

127

(3030467) Casts [#/volume] in Urine by Automated count

409

1.25

0.58

3.1

0.40

0.38

e6/l

0.03

279

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.69

0.57

1.0

1.2

—

(3022621) pH of Urine by Test strip

121

0.64

0.57

2.8

2.1

5.75

6.01

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

143

1.37

0.55

4.9

3.5

—

(3029937) Albumin [Presence] in Urine by Test strip

413

1.23

0.53

3.6

4.0

0.00

0.02

estimate

0.50

152

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

140

1343

1.33

0.53

5.4

5.0

6.09

5.92

mmol/l

0.67

134

1248

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.52

0.52

2.5

1.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

293

1.25

0.50

1.4

1.3

33.67

33.50

iu/ml

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

392

0.80

0.49

4.8

4.3

26.76

22.37

0.51

179

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.54

0.49

1.6

1.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

652

1.19

0.47

2.6

77.94

75.21

nmol/l

0.28

592

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.42

0.45

2.3

1.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

303

0.79

0.45

2.9

3.1

0.77

0.79

ug/l

0.04

169

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.39

0.44

2.4

1.7

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.39

0.44

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

288

1.23

0.44

1.8

1.7

—

(3038515) Glucose [Moles/volume] in Venous blood

1.58

0.42

3.0

3.6

6.36

7.75

mmol/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

150

1.30

0.42

1.9

1.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

1.53

0.41

1.0

1.5

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

55.34

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.41

0.0

3.9

—

(3000850) Epithelial cells [#/volume] in Urine

319

1.21

0.40

2.8

2.7

3.91

5.32

e6/l

0.73

283

(21494755) Public health laboratory ask at order entry panel

181

0.75

0.40

1.6

1.4

—

(3003129) Base excess in Capillary blood by calculation

0.00

0.40

0.0

1.4

—

0.85

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.40

0.0

1.5

—

17.14

—

(3035350) Ketones [Presence] in Urine by Test strip

790

1.16

0.38

4.1

3.9

0.00

9.78

estimate

0.50

166

(3009261) Glucose [Presence] in Urine by Test strip

800

1.16

0.38

4.0

3.9

0.00

estimate

-0.00

153

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

237

1.22

0.37

2.6

3.0

8.81

2.23

e6/l

0.55

108

(3044640) Blood type and Crossmatch panel - Blood

477

1.17

0.36

2.3

—

(4034850) Laboratory test

1.38

0.35

3.7

8.6

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

136

1316

1.22

0.35

7.0

6.4

39.24

39.40

mmol/mol

0.07

131

1243

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

143

0.75

0.33

7.5

7.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.32

0.33

1.2

—

(3000991) Gas panel - Venous blood

128

1.28

0.33

13.2

10.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.37

0.33

3.3

3.8

47.81

48.29

—

(3005322) IgE [Units/volume] in Serum or Plasma

101

1.31

0.33

1.2

111.92

378.17

u/ml

0.91

(3003694) ABO and Rh group [Type] in Blood

414

1.16

0.31

1.3

1.4

—

(3013512) EKG study

467

0.86

0.31

4.2

3.8

—

(3019150) Specific gravity of Urine by Refractometry

328

1.17

0.30

4.2

3.9

1.02

kg/l

0.18

216

(3003327) Ova and parasites identified in Stool by Light microscopy

1.26

0.30

1.7

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.32

0.29

1.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

182

0.81

0.28

2.1

1.5

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

122

1.25

0.28

13.9

9.8

1.65

1.29

mmol/l

0.72

122

(4024509) Urine culture

1.22

0.27

1.4

1.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.22

0.27

1.6

1.2

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

139

1356

1.18

0.26

18.6

15.3

85.63

83.62

ml/min/173m2

0.55

131

1263

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

559

1.12

0.24

4.9

3.7

27.70

33.19

ng/l

0.23

369

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

286

1.15

0.24

4.4

3.6

28.35

275.78

ng/l

1.48

222

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.36

0.24

1.6

—

(3028626) Oxygen [Partial pressure] in Capillary blood

1.36

0.24

2.4

2.5

8.72

8.37

kpa

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.36

0.24

1.8

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

142

1390

1.18

0.23

24.1

16.0

24.96

21.67

mg/l

0.51

124

1142

(40760892) CBC W Ordered Manual Differential panel - Blood

345

1.13

0.23

5.4

5.6

—

(1002224) Polysomnography panel

1.24

0.22

1.2

1.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

143

1402

1.18

0.21

5.8

5.9

2.78

2.77

mmol/l

0.06

135

1320

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

116.35

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.2

—

0.90

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

1.6

—

7.64

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3025941) Bacteria identified in Stool by Culture

1.25

0.21

2.0

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

3.0

—

0.75

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.21

0.0

2.7

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

0.21

0.0

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

155

1.18

0.21

2.7

1.9

—

(3024731) MCV [Entitic mean volume] in Red Blood Cells

149

1511

0.81

0.20

34.7

23.9

90.00

90.81

1.14

149

1499

(3000963) Hemoglobin [Mass/volume] in Blood

149

1511

0.81

0.20

35.0

24.1

134.14

136.99

g/l

1.53

149

1498

(3035941) MCH [Entitic mass]

149

1511

0.81

0.20

34.7

23.9

29.94

30.29

1.29

149

1499

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

149

1511

0.81

0.20

36.0

24.6

39.95

40.89

1.12

149

1499

(3001019) Free T4 and TSH panel - Serum or Plasma

1.15

0.15

2.6

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

660

1.08

0.15

3.0

2.8

—

estimate

—

(3041096) Erythrocytes [Presence] in Urine by Automated

447

0.92

0.14

3.9

3.3

0.00

estimate

-0.00

130

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

106

0.84

0.13

1.9

2.5

—

17.25

—

(3002256) Pathology report gross observation

178

0.89

0.12

1.5

1.2

—

(40761536) Microorganisms panel - Urine sediment

115

0.86

0.11

5.8

3.5

—

(3012516) Albumin [Mass/volume] in Urine

442

0.93

0.11

3.5

41.88

67.86

mg/l

0.35

289

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

131

1329

0.92

0.10

4.3

4.4

1.33

1.31

mmol/l

0.16

121

1236

(40768797) Stomach Pathology biopsy report

203

1.10

0.10

1.2

1.3

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

149

1475

1.14

0.10

17.3

12.6

29.52

27.40

u/l

0.71

144

1449

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.14

0.10

2.6

1.6

—

(40768804) Tissue Pathology biopsy report

559

1.06

0.09

2.1

—

(3000492) Spirometry study

175

0.90

0.09

1.4

1.5

—

(3036489) Thrombin time

0.83

0.08

1.6

2.1

25.00

20.96

—

(3019060) Gas panel - Arterial blood

1.09

0.07

9.6

4.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

196

1.08

0.07

1.3

1.5

—

(3009508) Creatinine [Moles/volume] in Urine

483

1.05

0.07

3.9

3.2

7.72

8.19

mmol/l

0.37

414

(40761511) CBC panel - Blood by Automated count

143

1443

0.92

0.07

20.9

13.6

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

111

0.89

0.06

1.2

1.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

140

1387

1.07

0.06

5.0

5.2

4.65

4.67

mmol/l

0.06

132

1308

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

139

1379

1.06

0.04

4.9

5.2

1.41

1.44

mmol/l

0.42

132

1291

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

948

1.03

0.04

3.7

3.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.09

0.03

1.1

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

162

1.06

0.02

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

589

0.98

0.02

4.4

3.8

0.00

estimate

-0.00

133

(3020682) Albumin/Creatinine [Ratio] in Urine

454

1.02

0.00

4.0

4.1

6.65

10.28

mg/mmol

0.40

293

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

376

1.01

0.00

1.4

1.3

1.23

1.81

u/ml

0.26

102

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

422

0.99

0.00

2.5

3.1

1479.62

930.52

ng/l

0.43

351

(36660697) Celiac disease serology panel - Serum

132

0.98

0.00

1.4

1.2

—

(3008898) HLA-B27 [Presence]

0.92

-0.00

1.1

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

12.67

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

8.89

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

135.67

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

44.37

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

88.53

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.4

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.8

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.87

-0.00

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.7

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

112.14

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.6

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.2

—

122.44

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

10.16

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

-0.00

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.8

—

82.72

—

(3042299) inFLIXimab [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

5.2

—

6.68

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.87

-0.00

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

3.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.97

-0.00

1.9

1.3

—

(3036035) von Willebrand factor (vWf) Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.8

—

162.50

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.94

-0.00

1.1

1.3

—

16.22

—

(4133840) Spirometry

0.00

-0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

1.7

—

17.14

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.7

—

4.58

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.02

-0.00

1.7

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

5.1

—

211.14

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.5

—

8.20

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

1.8

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

0.61

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.6

—

(3020650) Glucose [Presence] in Urine

0.00

-0.00

0.0

1.6

—

0.00

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.87

-0.00

1.2

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.6

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

2.3

—

44.07

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(3026250) Tacrolimus [Mass/volume] in Blood

0.00

-0.00

0.0

26.3

—

6.18

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.7

—

9.72

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.1

—

223.83

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_HEPATITIS_A and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_HEPATITIS_A	2.036 [1.4, 2.96]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.506

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 336 females with AB1_HEPATITIS_A died.

Males

Parameter	HR [95% CI]	p-value
AB1_HEPATITIS_A	3.07 [2.26, 4.18]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 473 males with AB1_HEPATITIS_A died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HEPATITIS_A.

N-year risk	Females	Males
1	0.231%	0.453%
5	1.239%	3.157%
10	3.161%	7.868%
15	6.288%	14.48%
20	11.069%	23.486%

Relationships between endpoints

↥

Index endpoint: AB1_HEPATITIS_A – Acute hepatitis A

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acute hepatitis A

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints