Cholera, including avohilmo

AB1_CHOLERA_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 A00
  • Hospital discharge: ICD-10 A00
  • Hospital discharge: ICD-9 00[1]
  • Hospital discharge: ICD-8 00001|00010|00097|00099
  • Cause of death: ICD-10 A00
  • Cause of death: ICD-9 00[1]
  • Cause of death: ICD-8 00001|00010|00097|00099

3 out of 7 registries used, show all original rules.

82

4. Check minimum number of events

None

82

5. Include endpoints

None

82

6. Filter based on genotype QC (FinnGen only)

75

Control definitions (FinnGen only)

Control exclude
AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF13

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 75 37 38
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 53.51 43.33 63.41

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
77
Matched controls
770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A00.0
ICD-10 Finland
Cholera due to Vibrio cholerae 01, biovar cholerae
+∞
26.6
24
*
A00
ICD-10 Finland
Cholera
+∞
25.4
23
*
A00.9
ICD-10 Finland
Cholera, unspecified
+∞
21.9
20
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
160
3.01
5.19
10.7
3.7
—
—
—
0
0
39
214
2.67
4.29
5.5
3.1
10.43
349.08
e6/l
0.54
31
156
34
178
2.63
4.06
4.2
2.8
—
—
estimate
—
0
0
41
239
2.53
3.88
7.0
3.8
45.90
17.94
e6/l
0.42
32
158
34
182
2.55
3.84
5.1
3.0
2.25
0.31
e6/l
0.45
25
125
35
205
2.30
3.11
4.9
3.4
2.31
2.36
mmol/l
1.36
30
186
45
293
2.29
3.11
20.8
12.0
0.00
0.00
e9/l
-0.00
37
239
16
65
2.84
3.03
1.9
1.8
—
—
—
0
0
8
17
5.12
3.01
4.8
3.7
7.43
7.41
ph
—
8
17
64
498
2.69
2.77
5.1
4.3
14.99
14.83
pmol/l
0.18
57
454
36
225
2.13
2.64
5.2
3.4
19.77
28.10
ng/l
0.58
22
151
33
203
2.09
2.49
8.8
5.3
—
—
—
0
0
6
12
5.32
2.45
5.5
2.8
5.13
4.92
kpa
—
6
12
6
12
5.32
2.45
5.5
2.8
8.22
8.65
kpa
—
6
12
24
132
2.19
2.39
1.7
1.5
1.38
1.44
mg/l
0.03
13
106
43
297
2.01
2.33
16.7
12.1
1.15
1.20
inr
0.33
38
246
13
55
2.64
2.26
3.9
2.9
1.05
0.21
e6/l
0.72
13
49
11
42
2.88
2.25
13.5
10.0
26.46
23.99
mmol/l
0.85
11
42
8
24
3.60
2.25
1.4
1.7
—
—
—
0
0
49
360
1.99
2.17
9.3
5.8
0.16
0.18
e9/l
0.33
40
319
33
212
1.97
2.15
4.0
2.1
—
—
—
0
0
5
10
5.26
2.10
2.8
1.4
89.44
90.43
%
—
5
10
10
38
2.87
2.09
1.4
1.2
—
—
—
0
0
8
26
3.31
2.08
3.4
3.3
—
—
—
0
0
16
80
2.26
1.97
1.5
1.3
—
—
—
0
0
69
598
2.48
1.89
6.0
5.2
1.90
1.83
mu/l
0.16
64
547
44
321
1.87
1.89
9.3
5.5
0.57
0.66
%
0.55
37
301
44
321
1.87
1.89
9.2
5.3
2.02
2.66
%
1.54
37
304
44
322
1.86
1.87
9.4
5.5
8.47
8.78
%
0.35
37
308
5
12
4.37
1.85
6.8
4.4
—
—
—
0
0
72
640
2.92
1.85
33.9
14.0
33.87
22.60
mg/l
1.52
65
536
31
204
1.87
1.83
8.0
5.3
—
—
—
0
0
46
346
1.82
1.74
9.5
5.5
0.04
0.04
e9/l
0.09
37
299
14
70
2.22
1.72
19.1
10.5
0.63
0.01
mmol/l
—
9
58
46
347
1.81
1.72
9.4
5.5
0.60
0.58
e9/l
0.30
37
303
42
309
1.79
1.70
12.4
7.3
1.22
1.21
mmol/l
0.61
35
267
14
71
2.19
1.66
19.6
10.4
7.44
7.42
ph
—
6
37
14
71
2.19
1.66
2.5
1.4
—
—
—
0
0
47
359
1.79
1.66
9.8
5.5
1.80
1.77
e9/l
0.11
42
321
12
57
2.31
1.65
1.3
1.5
—
—
—
0
0
29
193
1.81
1.62
5.9
2.8
—
—
—
0
0
44
334
1.74
1.55
9.3
5.2
61.16
58.00
%
1.21
39
320
44
334
1.74
1.55
9.7
5.3
22.93
27.62
%
2.47
39
323
64
545
2.03
1.52
33.3
17.6
13.98
13.59
%
1.32
64
538
36
263
1.69
1.43
3.2
3.0
—
—
—
0
0
11
55
2.17
1.35
15.2
6.7
9.55
9.23
mmol/l
0.05
11
55
16
93
1.91
1.34
3.9
2.9
24.94
24.69
%
0.02
16
87
28
195
1.68
1.30
2.3
2.3
165.39
280.82
u/l
0.62
23
188
11
56
2.13
1.29
19.4
13.5
—
—
—
0
0
11
56
2.13
1.29
15.1
11.6
1.15
1.45
mmol/l
0.48
11
56
29
206
1.65
1.25
6.8
3.8
0.00
0.00
estimate
-0.00
15
75
17
104
1.81
1.22
3.9
2.9
12.72
14.93
umol/l
0.64
17
96
6
26
2.41
1.21
2.2
1.2
—
—
—
0
0
71
645
2.29
1.17
40.8
16.6
3.91
3.98
mmol/l
1.27
71
628
5
20
2.60
1.17
1.0
1.6
0.18
0.24
g/l
—
5
20
8
41
2.06
1.12
3.3
2.5
—
—
—
0
0
5
21
2.47
1.11
1.0
1.2
—
—
—
0
0
5
21
2.47
1.11
1.0
1.5
1.05
1.19
g/l
—
5
21
45
365
1.56
1.08
6.0
3.9
0.13
0.00
estimate
0.48
15
85
69
627
1.97
1.07
5.6
4.9
4.39
4.56
mmol/l
0.68
64
590
39
307
1.55
1.06
4.2
2.6
—
—
estimate
—
0
0
7
34
2.16
1.06
8.6
4.6
23.13
23.89
mmol/l
—
7
34
44
357
1.54
1.04
6.1
3.9
0.00
0.00
estimate
-0.00
15
87
34
262
1.53
1.01
2.9
2.1
87.85
95.60
pmol/l
0.58
16
137
36
281
1.53
1.00
5.4
3.8
0.00
0.01
estimate
0.49
13
72
11
62
1.90
1.00
6.5
3.5
—
—
—
0
0
7
36
2.04
1.00
7.4
3.8
—
—
—
0
0
15
95
1.72
0.96
1.8
1.7
1269.11
1267.68
nmol/l
—
9
73
30
227
1.53
0.96
4.0
3.2
6.94
8.15
mmol/l
0.87
21
195
28
209
1.53
0.95
5.4
4.2
18.48
15.50
mg/mmol
0.08
19
133
6
28
2.24
0.94
1.2
1.1
—
—
—
0
0
27
202
1.52
0.90
4.2
3.5
—
—
—
0
0
27
204
1.50
0.85
3.3
3.4
102.23
111.85
mg/l
0.05
17
132
28
214
1.48
0.84
5.0
3.4
0.07
0.00
estimate
0.48
15
70
46
388
1.46
0.83
10.9
4.9
6.56
6.60
mmol/l
0.05
41
360
69
636
1.82
0.83
6.0
5.5
2.54
2.68
mmol/l
0.60
62
594
14
91
1.66
0.82
2.4
1.9
—
—
—
0
0
23
170
1.50
0.80
3.3
2.0
2.33
2.70
mg/l
0.55
15
152
0
26
0.00
0.80
0.0
1.2
—
1.51
—
0
26
0
26
0.00
0.80
0.0
1.2
—
0.83
—
0
26
43
360
1.44
0.79
6.2
3.9
0.00
0.00
estimate
-0.00
15
86
35
282
1.44
0.79
4.1
3.5
6.39
6.15
ph
0.57
18
151
9
54
1.75
0.78
1.8
1.5
—
—
—
0
0
65
592
1.63
0.77
7.7
5.9
38.99
38.83
mmol/mol
0.06
60
562
23
172
1.48
0.76
6.4
4.6
—
—
—
0
0
5
25
2.07
0.74
1.2
1.2
—
—
—
0
0
9
58
1.62
0.73
1.1
1.1
—
—
—
0
0
13
86
1.62
0.71
23.8
9.3
103.46
105.02
mmol/l
0.41
13
86
46
395
1.41
0.71
14.8
10.3
4.66
4.15
e9/l
0.48
38
351
13
88
1.57
0.66
1.5
1.3
—
—
—
0
0
8
49
1.70
0.64
1.4
1.3
2.61
1.14
g/l
—
8
44
18
133
1.46
0.62
1.3
1.3
13.51
24.77
iu/ml
—
8
38
67
623
1.58
0.61
5.6
4.9
1.33
1.44
mmol/l
1.32
60
578
17
125
1.46
0.60
1.3
1.3
38.96
11.84
u/ml
—
9
52
0
23
0.00
0.59
0.0
8.8
—
—
—
0
0
9
62
1.51
0.55
5.3
2.0
0.23
0.23
g/l
—
9
56
7
46
1.57
0.50
22.1
13.5
1.10
1.36
%
—
7
46
12
86
1.47
0.48
1.8
1.4
—
—
—
0
0
29
243
1.31
0.48
2.7
2.0
—
—
—
0
0
8
55
1.51
0.45
1.1
1.2
—
—
—
0
0
19
151
1.34
0.44
1.7
1.4
2.73
2.48
g/l
0.28
14
97
8
58
1.42
0.43
2.0
2.5
9.19
10.46
g/l
—
8
53
23
192
1.28
0.38
2.1
1.8
25.37
21.41
nmol/l
0.36
18
164
20
164
1.30
0.38
2.5
2.0
—
—
—
0
0
6
42
1.46
0.36
4.5
3.3
—
—
—
0
0
6
45
1.36
0.34
25.0
13.6
0.58
0.63
%
—
6
45
10
74
1.40
0.34
3.3
2.0
8.10
5.55
umol/l
—
10
63
10
74
1.40
0.34
2.0
1.2
—
—
—
0
0
63
597
1.30
0.33
6.0
4.1
1.47
1.26
mmol/l
0.94
57
549
17
139
1.29
0.32
2.3
1.6
—
—
—
0
0
29
259
1.19
0.25
2.7
2.0
1.10
1.41
mmol/l
1.39
20
226
11
135
0.78
0.24
3.2
2.9
0.98
0.68
ug/l
—
6
84
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
270.00
—
0
6
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
10
86
1.19
0.11
1.3
1.7
—
—
—
0
0
5
60
0.82
0.08
1.4
4.8
8.96
6.16
ug/l
—
5
50
8
77
1.04
0.07
1.5
1.4
—
—
—
0
0
17
161
1.07
0.03
4.9
3.7
1.02
1.02
kg/l
—
9
91
19
199
0.94
0.03
1.8
1.6
—
—
—
0
0
10
93
1.09
0.02
2.5
1.5
—
—
—
0
0
10
94
1.07
0.01
2.3
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
4.8
—
0.68
—
0
6
0
6
0.00
0.00
0.0
5.8
—
0.60
—
0
6
0
6
0.00
0.00
0.0
9.3
—
708.50
—
0
6
0
6
0.00
0.00
0.0
1.5
—
182.00
—
0
6
0
6
0.00
0.00
0.0
14.2
—
1001.67
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
14.20
—
0
5
0
7
0.00
-0.00
0.0
2.0
—
14.10
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
275.29
—
0
7
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
7.54
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.3
—
1.57
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
71.40
—
0
5
0
7
0.00
-0.00
0.0
2.0
—
42.33
—
0
7
0
8
0.00
-0.00
0.0
1.6
—
0.48
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: AB1_CHOLERA_WIDE – Cholera, including avohilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).