No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
228 |
4. Check minimum number of eventsNone |
228 |
5. Include endpointsNone |
228 |
6. Filter based on genotype QC (FinnGen only) |
204 |
Control definitions (FinnGen only)
- Control exclude
- AB1_INTESTINAL_INFECTIONS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Amoebiasis
based on the number of shared cases.
Similar with more cases:
- Amoebiasis, including avohilmo
- Intestinal infectious diseases
- Intestinal infectious diseases, including avohilmo, including avohilmo
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2264 | 1163 | 1084 |
| Only index persons | 1862 | 978 | 884 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 35.75 | 39.01 | 31.87 |
| Only index persons | 35.28 | 37.77 | 32.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 204 | 119 | 85 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 43.48 | 45.75 | 40.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 213
- Matched controls
- 2130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A06.9
ICD-10 Finland
Amoebiasis, unspecified
+∞
75.6
68
*
A06.0
ICD-10 Finland
Acute amoebic dysentery
+∞
53.4
49
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
6.8
33.3
65
130
A06.1
ICD-10 Finland
Chronic intestinal amoebiasis
+∞
31.0
29
*
A06.8
ICD-10 Finland
Amoebic infection of other sites
+∞
26.6
25
*
P01AB01
ATC
metronidazole; oral, rectal
3.5
18.5
118
554
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.0
14.4
108
538
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
13.3
44
131
UJF32
NOMESCO Finland
Coloscopy
3.0
11.7
71
308
Z2221
NOMESCO Finland
Medical doctor
2.8
11.3
78
362
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
11.1
113
637
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
11.0
77
359
A07.8
ICD-10 Finland
Other specified protozoal intestinal diseases
115.5
10.5
11
*
A06.4
ICD-10 Finland
Amoebic liver abscess
+∞
10.5
10
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
+∞
10.5
10
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.2
9.1
40
142
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
10.7
8.7
16
16
N02AX02
ATC
tramadol; systemic, rectal
2.3
8.5
103
608
00699
ICD-8 Finland
Amoebiasis, Without mention of liver abscess
+∞
8.4
8
*
A02BC05
ATC
esomeprazole; systemic
2.3
8.3
96
553
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
7.9
43
173
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
7.7
43
175
R50.9
ICD-10 Finland
Fever, unspecified
2.7
7.6
47
202
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
7.4
91
532
00920
ICD-8 Finland
Diarrhoeal disease, Gastroenteritis (acuta) (infectiosa)
+∞
7.3
7
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
6.9
64
331
R06.0
ICD-10 Finland
Dyspnoea
2.3
6.8
69
372
H02AB07
ATC
prednisone; oral
2.8
6.3
33
129
00690
ICD-8 Finland
Amoebiasis, Sine abscessu hepatis
+∞
6.3
6
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
6.2
66
360
A02BC02
ATC
pantoprazole; systemic
2.1
6.2
147
1085
A03FA02
ATC
cisapride; oral, rectal
3.4
6.1
23
74
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.5
6.0
21
64
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
64
9.65
36.91
3.7
1.8
—
—
—
0
0
49
194
2.98
9.32
2.1
3.6
4.49
7.06
umol/l
1.44
41
167
140
923
2.51
9.21
6.3
6.3
10.15
11.41
umol/l
1.57
131
873
65
301
2.67
9.20
3.4
2.7
0.99
0.75
e6/l
0.18
27
158
60
274
2.66
8.68
3.5
2.8
1.44
2.47
e6/l
0.44
22
131
118
734
2.36
8.66
6.4
4.5
36.24
36.21
g/l
0.02
109
696
29
93
3.45
7.75
1.9
1.5
—
—
—
0
0
34
123
3.10
7.48
1.1
1.0
—
—
—
0
0
121
804
2.17
7.06
9.4
7.0
1.21
1.22
mmol/l
0.66
116
748
41
179
2.60
6.36
2.1
1.7
—
—
—
0
0
9
5
18.70
6.32
3.6
1.2
—
—
—
0
0
85
511
2.10
6.25
4.5
2.9
0.21
0.28
e6/l
0.40
57
370
12
14
9.01
6.14
3.0
1.1
—
—
—
0
0
91
566
2.06
6.07
3.2
2.5
56.24
74.44
u/l
0.92
82
522
126
893
2.01
5.72
9.9
7.3
1.20
1.22
mmol/l
0.90
114
768
87
542
2.02
5.70
2.0
2.2
133.01
294.56
u/l
0.76
81
516
98
637
2.00
5.70
4.8
3.1
—
—
—
0
0
11
13
8.85
5.63
3.0
1.1
—
—
—
0
0
40
187
2.40
5.34
2.2
1.6
—
—
—
0
0
78
481
1.98
5.17
1.6
1.4
0.63
1.40
u/ml
1.47
15
135
16
45
3.76
5.15
1.4
1.1
—
—
—
0
0
17
50
3.61
5.14
1.9
1.3
245.60
364.51
ug/g
—
10
26
49
256
2.19
5.04
1.9
1.6
1029.33
1287.61
nmol/l
1.27
40
191
16
46
3.68
5.00
1.4
1.1
—
—
—
0
0
93
622
1.88
4.75
3.6
2.9
2.34
2.36
mmol/l
0.76
82
571
91
606
1.88
4.70
3.6
3.3
31.73
28.21
u/l
0.69
84
574
139
1059
1.90
4.68
12.3
10.5
4.01
3.99
e9/l
0.04
119
925
107
751
1.85
4.67
2.4
2.0
95.54
97.71
pmol/l
0.19
58
381
59
340
2.02
4.67
3.0
2.7
2.43
2.45
mmol/l
0.93
54
303
70
432
1.92
4.53
4.5
3.0
340.74
345.07
umol/l
0.13
58
378
23
89
2.78
4.48
1.5
1.3
—
—
—
0
0
128
964
1.82
4.32
5.7
3.7
0.00
0.00
estimate
0.50
24
212
21
79
2.84
4.30
2.1
1.4
—
—
—
0
0
166
1361
2.00
4.24
6.4
4.2
12.30
10.73
mm/h
0.57
161
1260
47
258
2.05
4.22
2.1
1.8
—
—
—
0
0
129
986
1.78
4.03
5.7
3.7
0.00
0.02
estimate
0.50
24
203
127
972
1.76
3.89
5.7
3.7
0.00
0.00
estimate
-0.00
25
215
14
45
3.26
3.72
1.4
1.9
—
—
—
0
0
53
329
1.81
3.26
3.7
3.1
101.08
223.43
ng/l
0.59
40
248
13
44
3.08
3.19
1.4
1.8
—
—
—
0
0
66
442
1.71
3.12
2.5
2.1
2.47
2.78
mg/l
0.74
55
379
5
5
10.19
2.99
1.2
1.0
—
—
—
0
0
167
1431
1.77
2.98
4.7
4.2
14.90
14.72
pmol/l
0.40
157
1306
12
38
3.28
2.90
1.3
1.8
—
—
—
0
0
40
236
1.86
2.88
13.2
8.6
104.18
104.14
mmol/l
0.01
40
236
11
35
3.26
2.68
1.4
1.9
—
—
—
0
0
9
25
3.71
2.60
1.4
1.8
—
—
—
0
0
74
532
1.60
2.60
1.8
1.6
21.92
21.53
nmol/l
0.08
65
447
12
44
2.83
2.59
2.9
3.5
45.09
198.49
mg/l
0.58
12
38
12
44
2.83
2.59
2.9
3.5
172.82
23.62
mg/l
0.54
12
38
5
7
7.28
2.56
1.2
1.6
—
—
—
0
0
5
8
6.37
2.38
3.0
2.4
—
—
—
0
0
24
128
1.99
2.33
9.9
10.9
23.81
24.84
mmol/l
0.44
24
128
29
166
1.86
2.30
4.9
5.5
4.24
4.46
kpa
0.46
29
160
30
174
1.84
2.28
3.6
3.2
—
—
—
0
0
59
414
1.59
2.26
2.8
2.3
—
—
—
0
0
10
35
2.95
2.24
1.7
1.1
—
—
—
0
0
28
164
1.81
2.07
3.3
2.6
0.21
0.22
g/l
0.41
23
154
10
38
2.71
2.03
1.0
1.2
—
—
—
0
0
141
1211
1.49
1.98
3.5
3.3
—
—
—
0
0
59
426
1.53
1.97
5.1
3.7
1.02
1.02
kg/l
0.51
37
271
29
175
1.76
1.95
12.8
12.1
-1.47
1.10
mmol/l
0.97
22
155
72
545
1.49
1.92
5.9
3.8
0.00
0.02
estimate
0.74
22
199
194
1801
1.87
1.85
24.0
13.7
25.02
22.37
mg/l
0.49
170
1423
5
12
4.24
1.83
1.2
1.8
92.20
100.58
%
—
5
12
8
31
2.64
1.67
1.5
2.0
—
—
—
0
0
51
370
1.50
1.66
1.5
1.3
31.17
24.09
iu/ml
—
10
122
5
14
3.63
1.62
1.2
1.0
—
—
—
0
0
49
355
1.49
1.60
1.7
1.7
435.79
468.46
pmol/l
0.31
43
299
7
26
2.75
1.59
1.0
1.5
—
—
—
0
0
7
26
2.75
1.59
1.0
1.5
—
—
—
0
0
8
33
2.48
1.55
1.5
1.5
—
135.80
—
0
10
22
132
1.74
1.53
3.2
3.0
63.64
67.11
ml/min/173m2
0.16
11
57
6
21
2.91
1.51
1.8
1.3
—
—
—
0
0
182
1682
1.56
1.50
6.3
5.2
1.76
1.88
mu/l
0.87
174
1545
9
39
2.36
1.45
1.4
1.2
—
—
—
0
0
89
732
1.37
1.43
5.7
3.6
0.05
0.04
estimate
0.05
19
182
142
1258
1.39
1.43
3.4
3.2
52.66
47.02
u/l
0.28
134
1192
46
337
1.47
1.42
1.5
1.3
3.40
10.73
u/ml
1.31
18
131
12
60
2.06
1.41
5.5
10.2
1.72
1.34
mg/l
0.58
12
52
98
823
1.35
1.37
3.5
2.7
—
—
estimate
—
0
0
69
548
1.38
1.37
4.7
3.9
14.42
6.93
mg/mmol
0.71
44
340
53
402
1.42
1.37
1.9
1.9
0.89
1.25
mg/l
0.57
35
318
11
54
2.09
1.35
1.1
1.3
—
—
—
0
0
17
99
1.78
1.31
5.2
5.5
0.62
0.62
%
0.00
17
99
178
1650
1.48
1.31
4.1
4.2
1.26
1.26
mmol/l
0.01
168
1517
14
77
1.88
1.29
1.9
1.6
11.17
11.99
u/ml
—
6
14
17
100
1.76
1.28
5.2
5.5
1.06
1.33
%
0.63
17
100
6
25
2.44
1.25
1.5
2.1
—
—
—
0
0
89
745
1.33
1.24
2.1
1.9
1.40
1.38
mmol/l
0.10
77
639
11
56
2.02
1.24
1.4
1.3
—
—
—
0
0
52
401
1.39
1.22
1.6
1.8
—
—
—
0
0
81
672
1.33
1.20
4.3
3.3
27.14
41.43
ng/l
0.82
63
466
6
26
2.34
1.19
2.5
5.3
—
—
—
0
0
8
39
2.09
1.16
4.1
3.9
11.34
8.74
pmol/l
—
8
39
12
65
1.90
1.16
1.7
1.7
10.83
4.82
ug/l
0.26
12
59
7
30
2.38
1.13
3.6
1.3
—
—
—
0
0
19
121
1.63
1.10
18.3
10.9
1.28
1.35
%
0.12
19
121
176
1652
1.38
0.98
6.9
6.0
38.77
38.78
mmol/mol
0.00
166
1541
18
118
1.57
0.94
19.0
11.4
0.62
0.68
%
0.29
18
118
22
152
1.50
0.92
1.5
1.4
—
—
—
0
0
6
29
2.10
0.90
1.8
2.1
—
—
—
0
0
8
42
1.94
0.89
1.5
1.5
—
—
—
0
0
58
479
1.29
0.86
3.5
3.4
1406.14
1219.35
ng/l
0.16
48
397
11
65
1.73
0.84
4.2
3.6
8.73
8.44
kpa
0.16
11
65
20
140
1.47
0.80
2.0
1.8
—
—
—
0
0
31
238
1.35
0.76
1.7
1.8
1.57
1.42
%
0.36
25
212
5
24
2.11
0.75
1.0
1.1
—
—
—
0
0
5
24
2.11
0.75
1.6
2.0
—
—
—
0
0
17
121
1.44
0.64
1.5
1.3
198.10
263.65
u/ml
0.15
17
114
5
29
1.74
0.64
1.6
1.1
—
—
—
0
0
8
49
1.66
0.63
2.0
2.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
14
97
1.47
0.60
1.6
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
4.1
—
75.57
—
0
21
17
123
1.42
0.60
1.9
1.7
—
—
—
0
0
19
141
1.38
0.59
1.6
2.3
5.59
5.78
ug/l
0.03
19
125
12
82
1.49
0.55
1.3
2.1
5.70
5.01
mg/l
—
7
64
181
1745
1.25
0.51
5.3
4.9
4.56
4.62
mmol/l
0.42
173
1623
178
1716
1.23
0.48
5.0
4.8
5.97
5.84
mmol/l
0.54
162
1574
31
257
1.24
0.46
2.3
2.4
—
—
—
0
0
180
1739
1.23
0.46
5.2
4.8
1.45
1.46
mmol/l
0.16
173
1605
8
57
1.42
0.42
2.0
3.9
150.88
173.96
%
—
8
57
5
32
1.58
0.42
1.0
1.2
—
—
—
0
0
8
58
1.39
0.42
1.0
1.1
—
14.62
—
0
13
11
79
1.41
0.41
3.6
3.8
1.01
1.02
ratio
1.83
11
74
0
16
0.00
0.41
0.0
5.3
—
175.27
—
0
11
8
60
1.35
0.40
3.9
2.8
25.32
25.42
mmol/l
—
8
60
29
243
1.22
0.40
2.2
2.2
—
—
—
0
0
182
1767
1.21
0.39
6.0
5.6
2.68
2.71
mmol/l
0.22
177
1641
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
175
1703
1.15
0.30
22.4
13.3
84.32
83.55
ml/min/173m2
0.18
166
1560
10
76
1.33
0.28
2.1
2.2
51.20
40.78
u/l
—
10
67
60
552
1.12
0.28
5.0
3.2
0.09
0.01
estimate
0.40
22
169
31
273
1.16
0.27
1.5
1.6
—
—
—
0
0
34
302
1.15
0.26
3.9
3.0
0.65
0.70
ug/l
0.23
25
188
5
73
0.68
0.26
1.0
1.1
1.58
1.59
g/l
—
5
73
5
74
0.67
0.26
1.0
1.1
0.86
0.90
g/l
—
5
74
18
211
0.84
0.24
1.8
2.1
3.13
3.51
ratio
0.70
12
175
0
10
0.00
0.21
0.0
2.3
—
48.06
—
0
10
0
10
0.00
0.21
0.0
3.8
—
211.10
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
199.98
—
0
10
0
12
0.00
0.21
0.0
4.0
—
0.92
—
0
12
23
207
1.12
0.15
4.7
4.7
27.50
32.02
%
1.21
16
128
198
1962
1.13
0.12
34.0
21.5
90.68
90.70
fl
0.02
198
1943
15
134
1.13
0.11
1.7
1.2
30.20
169.26
u/ml
—
5
52
198
1963
1.12
0.11
35.5
22.1
40.00
40.66
%
1.34
198
1941
198
1965
1.11
0.09
34.5
21.6
133.08
136.17
g/l
2.17
198
1945
6
57
1.05
0.08
1.3
2.0
—
—
—
0
0
5
64
0.78
0.08
1.0
2.2
—
—
—
0
0
9
84
1.07
0.07
3.0
1.5
417.00
325.65
mu/l
—
9
79
20
188
1.07
0.05
13.8
6.1
—
—
—
0
0
15
160
0.93
0.04
1.6
1.9
3.62
3.52
mmol/l
—
10
120
41
398
1.04
0.04
4.5
4.3
22.66
22.66
%
0.00
19
183
51
503
1.02
0.01
6.4
4.9
1.44
1.76
ug/l
0.53
45
438
0
6
0.00
0.00
0.0
4.5
—
138.15
—
0
6
6
63
0.95
0.00
1.5
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
53
0.94
-0.00
1.2
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
53.81
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
11.2
5.2
3.90
3.99
mmol/l
—
5
54
Mortality – FinRegistry
↥Association
Association between endpoint AB1_AMOEBIASIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_AMOEBIASIS | 1.655 [1.34, 2.04] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.218 |
During the follow-up period (1.1.1998 — 31.12.2019), 241 out of 965 females with AB1_AMOEBIASIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_AMOEBIASIS | 1.981 [1.42, 2.76] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 202 out of 870 males with AB1_AMOEBIASIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_AMOEBIASIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.174% | 0.37% |
| 5 | 0.862% | 2.264% |
| 10 | 2.187% | 5.55% |
| 15 | 4.515% | 10.558% |
| 20 | 7.752% | 17.621% |
Relationships between endpoints
↥Index endpoint: AB1_AMOEBIASIS – Amoebiasis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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