Environmental-pollution-related condition

VWXY20_ENVIRONMENTAL__CONDI

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Y97 Cause of death: ICD-10 — Y97 2 out of 7 registries used, show all original rules.	43
4. Check minimum number of events None	43
5. Include endpoints None	43
6. Filter based on genotype QC (FinnGen only)	39

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Y9[7-8]

NAME	VWXY20_ENVIRONMENTAL__CONDI
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Y97
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Y97
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Environmental-pollution-related condition based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	39	25	14
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	52.90	46.60	64.15

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3022217) INR in Platelet poor plasma by Coagulation assay

133

4.63

5.46

12.3

11.5

1.11

1.14

inr

—

(3019060) Gas panel - Arterial blood

7.80

4.99

8.2

5.2

—

(3023368) Bacteria identified in Blood by Culture

3.86

4.44

3.8

3.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

4.63

3.66

4.2

8.2

106.00

103.45

mmol/l

1.09

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

153

3.06

3.08

3.5

2.5

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

128

2.98

3.04

6.8

6.0

1.20

1.22

mmol/l

0.67

118

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.48

2.93

1.3

1.8

—

(3003694) ABO and Rh group [Type] in Blood

2.91

2.86

2.0

1.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

5.74

2.86

1.3

1.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

109

2.81

2.73

4.1

3.7

15.31

18.79

ng/l

0.31

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

5.61

2.49

9.5

6.7

—

(3042936) Bacteria identified in Isolate by Culture

3.02

2.48

3.4

2.6

—

(3045414) Leukocytes [Presence] in Urine

6.89

2.44

2.6

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.41

2.40

4.2

1.5

—

(3026008) Bacteria identified in Urine by Culture

2.65

2.39

3.7

2.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

141

2.59

2.36

8.0

4.1

35.53

35.91

g/l

0.14

133

(3018677) aPTT in Platelet poor plasma by Coagulation assay

3.08

2.29

1.5

1.6

28.99

29.45

0.19

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

179

2.62

2.29

7.5

6.6

8.50

9.88

umol/l

0.96

171

(3020891) Body temperature

4.79

2.23

5.8

5.6

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

111

2.50

2.18

4.8

2.4

52.30

54.82

u/l

0.14

106

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.98

2.00

2.0

7.1

26.44

24.86

mmol/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.74

1.89

2.7

2.4

13.50

92.19

ng/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.04

1.83

1.4

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

110

2.30

1.82

3.8

2.9

25.79

29.85

u/l

0.49

100

(3021601) Nitrite [Presence] in Urine by Test strip

177

2.19

1.64

8.5

4.4

0.00

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

178

2.17

1.61

6.4

3.3

0.00

estimate

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.78

1.52

1.4

1.3

—

(3037522) Nuclear Ab [Titer] in Serum

2.39

1.48

1.6

184.00

600.00

titre

—

(36660697) Celiac disease serology panel - Serum

0.00

1.42

0.0

1.1

—

(3044889) 12 lead EKG panel

234

2.16

1.41

4.4

3.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.38

1.41

15.3

5.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.18

1.40

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

112

2.04

1.38

3.9

2.4

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

2.14

1.37

3.2

1.8

3.59

3.60

mg/l

0.01

(3031040) Bacteria [#/volume] in Urine by Automated count

225

2.10

1.37

5.8

3.5

—

132.80

—

(3029937) Albumin [Presence] in Urine by Test strip

2.06

1.34

5.5

3.7

0.00

estimate

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.00

1.32

1.0

1.3

1.29

1.21

g/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

178

1.97

1.29

13.1

5.4

—

(3035350) Ketones [Presence] in Urine by Test strip

180

1.93

1.23

6.7

3.2

0.00

estimate

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.59

1.19

1.9

4.1

—

(3025941) Bacteria identified in Stool by Culture

2.69

1.18

1.2

1.3

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.50

1.17

7.1

4.9

223.00

250.26

u/l

—

(3018418) pH of Serum or Plasma

1.96

1.11

4.2

3.8

7.41

7.40

—

(3037467) Urinalysis macro (dipstick) panel - Urine

245

1.95

1.10

10.6

3.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

120

1.86

1.09

1.8

1.9

94.06

102.33

pmol/l

0.48

(36304419) Bacteria [Presence] in Urine

1.93

1.07

2.5

2.0

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

103

1.88

1.07

4.7

3.5

2.33

2.35

mmol/l

0.24

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.99

1.06

1.4

1.3

271.42

12.27

u/ml

—

(3015736) pH of Urine

149

1.80

1.03

5.8

2.9

—

6.00

—

(40761536) Microorganisms panel - Urine sediment

2.41

0.98

3.5

3.3

—

(3013115) Eosinophils [#/volume] in Blood

200

1.76

0.95

11.0

5.2

0.29

0.20

e9/l

0.32

185

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

143

1.75

0.94

6.7

3.3

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

2.16

0.91

4.2

3.9

4.47

4.74

pmol/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.83

0.86

4.8

3.7

172.75

1022.41

ng/l

3.39

(40758558) Short blood count panel - Blood

101

1.75

0.85

7.3

5.9

—

(3044640) Blood type and Crossmatch panel - Blood

101

1.75

0.85

2.7

2.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.76

0.81

1.3

1.8

—

(3012544) pH of Venous blood

2.13

0.75

9.4

2.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.77

0.74

2.6

2.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.72

0.72

5.3

3.2

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.75

0.71

4.6

2.4

2.67

2.50

g/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.70

0.69

2.4

1.6

—

(3000494) Fungus identified in Specimen by Culture

1.73

0.66

1.6

1.3

—

(1002224) Polysomnography panel

0.00

0.62

0.0

1.1

—

(40768797) Stomach Pathology biopsy report

1.66

0.52

1.1

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

106

1.48

0.47

6.6

3.0

—

(1761868) Lipid panel - Serum or Plasma

135

0.66

0.45

5.1

2.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.42

0.0

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.51

0.41

1.5

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.39

0.35

1.3

1.5

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.25

0.23

2.6

2.1

20.00

26.70

u/l

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.3

—

1.20

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

2.2

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.21

0.0

1.8

—

2.20

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.20

0.0

2.6

—

0.27

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.20

0.0

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.27

0.19

1.6

1.5

—

(3013512) EKG study

1.20

0.11

3.7

3.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

257

1.14

0.08

3.6

2.7

58.41

44.37

u/l

0.43

248

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.81

0.08

1.3

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

274

1.06

0.01

3.8

3.3

—

(40768804) Tissue Pathology biopsy report

155

0.95

0.00

2.2

1.9

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.04

-0.00

1.7

1.9

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3002256) Pathology report gross observation

1.05

-0.00

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

3.44

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.5

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

23.98

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.95

-0.00

2.1

2.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.7

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.5

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

2.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.92

-0.00

1.7

2.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

2.3

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

1.8

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.88

-0.00

2.4

1.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.5

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

12.08

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: VWXY20_ENVIRONMENTAL__CONDI – Environmental-pollution-related condition

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Environmental-pollution-related condition

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints