Phlebitis and thrombophlebitis of superficial vessels of lower extremities, drug-induced

PHLEBI_THROMBOP_SUPERF_VESSE_LOWER_EXTREMITI

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 I80.0#

1 out of 7 registries used, show all original rules.

114

4. Check minimum number of events

None

114

5. Include endpoints

None

114

6. Filter based on genotype QC (FinnGen only)

101

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Similar endpoints

List of similar endpoints to Phlebitis and thrombophlebitis of superficial vessels of lower extremities, drug-induced based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 101 65 36
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 54.13 53.37 55.52

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
104
Matched controls
1040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
+∞
120.1
104
30
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
8.6
22.5
36
60
B01AA03
ATC
warfarin; systemic
4.7
13.5
48
161
PHD99
NOMESCO Finland
Resection of other vein
8.7
10.2
22
31
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
9.2
9.7
20
26
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
4.2
9.2
30
91
PHD76
NOMESCO Finland
Resection of long saphenous vein
9.6
9.0
18
22
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
7.5
26
82
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
11.0
6.2
11
11
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
8.1
6.1
13
18

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
48
289
2.23
3.85
4.2
3.3
1.03
0.39
e6/l
0.48
39
204
58
377
2.22
3.85
4.9
4.3
97.19
56.75
e6/l
0.50
45
263
31
156
2.41
3.76
3.4
3.2
4.02
4.24
e6/l
0.03
18
74
53
341
2.13
3.51
3.9
3.5
26.68
40.17
e6/l
0.48
45
258
37
212
2.16
3.26
1.5
1.8
1.67
1.66
mg/l
0.00
27
178
35
199
2.14
3.13
3.6
3.4
542.77
514.27
mosm/kgh2o
0.33
30
172
5
5
10.41
3.01
1.0
1.4
—
—
—
0
0
53
387
1.75
2.08
12.6
12.5
0.00
0.00
e9/l
0.27
42
314
55
408
1.74
2.03
5.5
5.8
0.67
0.64
%
0.18
50
382
42
290
1.75
1.99
4.5
5.5
—
—
—
0
0
66
778
0.58
1.77
3.8
4.5
1.18
1.28
mmol/l
0.64
61
690
8
32
2.62
1.63
2.5
3.4
7.41
7.42
ph
—
8
32
16
86
2.02
1.61
1.7
2.5
0.20
0.21
g/l
0.13
16
78
44
324
1.62
1.57
4.8
3.8
—
—
—
0
0
58
463
1.57
1.44
6.5
5.8
1.73
1.75
e9/l
0.05
46
408
57
456
1.55
1.38
6.3
5.8
0.61
0.58
e9/l
0.43
42
388
0
37
0.00
1.37
0.0
1.9
—
24.89
—
0
37
13
69
2.01
1.35
1.2
2.8
11.54
9.94
g/l
0.27
13
61
57
459
1.54
1.32
6.3
5.8
0.04
0.04
e9/l
0.09
42
389
58
470
1.53
1.30
6.3
5.9
0.23
0.18
e9/l
1.15
47
408
14
78
1.92
1.28
3.4
3.1
69.19
66.46
g/l
0.70
14
71
25
167
1.65
1.28
1.2
1.5
2.27
2.60
g/l
0.25
15
91
73
820
0.63
1.25
4.7
5.3
1.46
1.52
mmol/l
0.40
68
735
78
680
1.59
1.21
30.1
22.8
14.00
13.94
%
0.12
78
673
8
39
2.14
1.18
3.0
2.5
—
—
—
0
0
37
278
1.51
1.15
5.2
4.8
—
—
—
0
0
15
90
1.78
1.11
3.5
8.9
—
—
—
0
0
9
45
2.09
1.08
1.1
1.2
—
—
—
0
0
9
46
2.05
1.07
2.0
1.8
—
—
—
0
0
5
22
2.33
1.04
1.8
3.6
5.20
4.93
kpa
—
5
22
5
22
2.33
1.04
1.8
3.6
8.50
8.30
kpa
—
5
22
54
449
1.42
0.97
2.6
2.1
91.16
96.84
pmol/l
0.33
28
222
6
27
2.29
0.95
1.2
1.2
—
—
—
0
0
81
878
0.65
0.95
32.0
24.6
75.91
78.33
umol/l
0.48
81
870
11
63
1.83
0.94
3.3
8.6
25.92
25.49
mmol/l
0.15
11
63
38
299
1.43
0.92
2.2
1.8
21.73
22.47
nmol/l
0.09
32
251
59
504
1.39
0.88
7.6
10.0
3.98
4.15
e9/l
0.25
44
441
31
237
1.44
0.87
2.9
2.3
2.46
2.88
mg/l
0.48
25
205
41
331
1.39
0.85
4.2
4.3
7.40
7.40
ph
0.18
30
236
44
360
1.39
0.84
1.9
2.0
1.13
1.31
mmol/l
1.40
36
284
6
32
1.93
0.83
1.0
1.2
—
—
—
0
0
12
75
1.68
0.79
3.6
2.9
—
—
—
0
0
27
345
0.71
0.78
4.3
3.8
—
—
—
0
0
78
844
0.70
0.78
20.2
16.0
—
—
—
0
0
18
127
1.50
0.74
1.3
1.3
—
—
—
0
0
83
885
0.69
0.70
34.1
27.7
30.33
30.41
pg
0.16
83
876
83
885
0.69
0.70
34.7
28.4
38.98
39.56
%
0.42
83
875
83
885
0.69
0.70
34.5
28.0
129.64
132.21
g/l
0.88
83
875
83
884
0.70
0.68
34.2
27.7
92.14
91.80
fl
0.26
83
875
5
28
1.82
0.67
35.6
15.4
—
—
—
0
0
81
865
0.71
0.66
29.6
22.4
3.96
3.98
mmol/l
0.20
81
849
5
29
1.76
0.64
1.2
1.1
—
—
—
0
0
81
864
0.72
0.64
29.0
22.4
140.02
139.67
mmol/l
0.65
81
848
44
375
1.30
0.61
3.5
2.9
93.89
134.53
ug/l
1.56
37
342
37
309
1.31
0.59
3.4
6.4
—
—
—
0
0
55
486
1.28
0.56
5.0
4.6
0.00
16.08
estimate
0.50
12
101
6
99
0.58
0.55
4.7
2.5
3.61
4.58
e9/l
—
6
85
10
66
1.57
0.55
1.8
1.4
—
—
—
0
0
55
490
1.26
0.51
5.0
4.6
0.00
0.00
estimate
-0.00
12
96
22
272
0.76
0.50
6.1
4.8
0.00
0.00
estimate
—
10
89
5
82
0.59
0.48
8.0
3.1
—
—
—
0
0
14
105
1.39
0.44
1.6
1.8
—
—
—
0
0
43
378
1.23
0.43
4.5
4.3
6.15
6.30
ph
0.29
20
206
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
27
318
0.80
0.41
3.5
3.1
13.17
33.49
mg/l
2.05
18
202
53
479
1.22
0.40
4.8
4.6
0.00
0.00
estimate
—
9
97
12
89
1.39
0.40
1.1
1.3
—
—
—
0
0
6
41
1.49
0.37
1.0
1.2
—
—
—
0
0
24
281
0.81
0.34
3.7
3.7
—
—
—
0
0
19
228
0.80
0.34
1.5
1.3
—
—
—
0
0
57
528
1.18
0.31
4.1
6.2
9.92
12.04
umol/l
1.93
57
501
25
215
1.21
0.30
5.4
5.0
1.02
1.02
kg/l
0.27
18
143
13
103
1.30
0.30
4.0
3.0
7.40
7.39
ph
—
7
60
29
327
0.84
0.28
4.3
3.7
2.40
6.47
mg/mmol
1.72
19
192
5
70
0.70
0.27
1.2
1.6
—
—
—
0
0
9
72
1.27
0.26
3.1
4.4
—
—
—
0
0
76
791
0.85
0.24
7.0
5.6
1.88
1.94
mu/l
0.16
71
711
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
19.46
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
5.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
8.61
—
0
13
6
48
1.27
0.20
2.3
2.4
—
—
—
0
0
34
312
1.13
0.19
2.8
2.4
—
—
—
0
0
14
120
1.19
0.17
2.3
3.7
1.61
1.88
%
1.02
14
109
5
69
0.71
0.17
7.0
5.3
23.22
24.68
mmol/l
—
5
64
15
131
1.17
0.15
1.2
1.2
—
—
—
0
0
13
112
1.18
0.15
1.3
1.4
—
—
—
0
0
14
123
1.16
0.13
3.6
7.6
13.31
11.77
kpa
0.29
14
116
14
123
1.16
0.13
3.6
7.6
4.82
5.12
kpa
0.78
14
116
10
116
0.85
0.12
4.6
7.7
97.93
95.70
%
—
10
111
11
95
1.18
0.12
1.5
2.1
333.45
374.57
nmol/l
0.32
11
87
5
46
1.09
0.10
1.6
2.0
10.58
12.01
nmol/l
—
5
40
6
57
1.06
0.08
1.2
1.1
—
—
—
0
0
8
78
1.03
0.07
1.1
1.5
—
—
—
0
0
8
91
0.87
0.07
1.1
1.3
—
—
—
0
0
37
384
0.94
0.06
5.2
4.3
24.93
51.83
ng/l
1.41
27
302
25
262
0.94
0.05
3.9
4.1
0.00
0.00
estimate
—
6
76
18
191
0.93
0.05
8.4
5.2
—
—
—
0
0
39
379
1.05
0.04
2.3
2.2
—
—
—
0
0
13
137
0.94
0.01
2.8
3.1
0.77
1.00
ug/l
—
8
97
22
226
0.97
0.00
5.6
5.2
1.70
2.60
ug/l
0.70
17
196
42
422
0.99
0.00
2.8
2.7
—
—
estimate
—
0
0
36
361
1.00
0.00
4.8
4.7
0.11
0.01
estimate
—
9
77
14
135
1.04
0.00
2.9
2.0
—
—
—
0
0
16
155
1.04
0.00
2.2
1.7
35.78
29.63
s
0.86
16
148
10
96
1.05
0.00
1.5
1.3
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
43.67
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
3.3
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.90
-0.00
1.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.4
—
43.30
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
17.10
—
0
7
31
310
1.00
-0.00
1.9
2.2
110.45
217.08
u/l
3.30
31
297
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
-0.52
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
371.00
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
8.43
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.95
—
0
5

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: PHLEBI_THROMBOP_SUPERF_VESSE_LOWER_EXTREMITI – Phlebitis and thrombophlebitis of superficial vessels of lower extremities, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).