Phantom limb syndrome with pain

PHANTOMLIMB

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G54.6
  • Hospital discharge: ICD-9 3536
  • Cause of death: ICD-10 G54.6
  • Cause of death: ICD-9 3536

2 out of 7 registries used, show all original rules.

110

4. Check minimum number of events

None

110

5. Include endpoints

None

110

6. Filter based on genotype QC (FinnGen only)

101

Control definitions (FinnGen only)

Control exclude
PAIN

Extra metadata

First used in FinnGen datafreeze
DF3
Parent code in ICD-10
G54
Name in latin
Syndroma phantomatis membri dolorosum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 707 296 401
Only index persons 573 236 337
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 55.87 56.33 55.27
Only index persons 53.44 53.66 53.29

-FinnGen-

Key figures

All Female Male
Number of individuals 101 48 53
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 55.81 51.19 60.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
102
Matched controls
1020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.6
ICD-10 Finland
Phantom limb syndrome with pain
+∞
141.3
100
*
N03AX16
ATC
[U] pregabalin
32.1
73.4
72
71
N03AX12
ATC
[U] gabapentin; oral
22.2
56.4
55
51
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
20.8
45.4
41
32
N02AA05
ATC
oxycodone; systemic
12.1
36.0
52
81
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
10.9
30.3
43
64
N06AX21
ATC
duloxetine; oral
13.9
28.9
31
31
N02AX02
ATC
tramadol; systemic, rectal
9.2
26.8
73
219
NGQ20
NOMESCO Finland
Amputation of lower leg
90.5
25.2
27
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
11.3
24.9
31
38
L28
ICPC
Limited function/disability (L)
8.4
24.7
45
88
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
32.8
20.9
27
11
M79.6
ICD-10 Finland
Pain in limb
6.3
19.5
62
201
NFQ20
NOMESCO Finland
Amputation of femur
+∞
19.4
18
*
J01MA02
ATC
ciprofloxacin; systemic
6.2
18.7
65
226
R10.1
ICD-10 Finland
Pain localized to upper abdomen
8.6
17.5
26
39
J01FF01
ATC
clindamycin; systemic
5.4
16.4
53
169
N06AX16
ATC
venlafaxine; oral
7.0
16.3
30
57
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
8.2
16.2
25
39
S97
ICPC
Chronic ulcer skin
8.7
16.0
23
33
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
15.4
15.7
26
22
TPH07
NOMESCO Finland
Cathetrisation of artery
7.4
15.3
26
45
NHQ40
NOMESCO Finland
Amputation of toe
32.8
14.9
19
7
TPH04
NOMESCO Finland
Cathetrisation of vein
5.6
14.9
38
98
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
173.9
14.9
15
*
N06AA09
ATC
amitriptyline; systemic
13.5
14.8
26
25
J01MA12
ATC
levofloxacin; systemic
5.4
14.3
38
101
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
20.0
14.2
21
13
A46
ICD-10 Finland
Erysipelas
5.5
14.2
36
92
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
7.2
13.9
24
42
ZXE20
NOMESCO Finland
More than three and less than five hours
6.0
13.9
30
66
L17
ICPC
Foot/toe symptom/complaint
4.7
13.5
50
173
N03AE01
ATC
clonazepam; systemic
18.8
13.3
20
13
SPAT1148
SPAT
Treatment of chronic ulcer or burn
5.6
12.5
29
68
SPAT1229
SPAT
Assessment of need for aid
10.9
12.4
24
28
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.7
12.4
28
64
R52.2
ICD-10 Finland
Other chronic pain
53.5
12.2
14
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
6.5
12.2
23
44
A10AE04
ATC
insulin glargine; parenteral
6.3
11.9
23
45
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.8
11.7
25
54
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
134.6
11.7
12
*
WX213
NOMESCO Finland
Lower leg blockade
134.6
11.7
12
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
14.3
11.4
19
16
ZXD05
NOMESCO Finland
Urgent procedure
4.2
11.4
47
173
N02BF01
ATC
gabapentin; oral
11.2
11.2
21
23
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.6
11.1
35
105
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
32.0
11.1
14
5
R51.80
ICD-10 Finland
Headache
12.7
10.8
19
18
S18
ICPC
Laceration/cut
4.1
10.8
67
324
C03CA01
ATC
furosemide; systemic
4.0
10.7
51
206
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.9
10.7
29
77
N03AX09
ATC
lamotrigine; oral
15.4
10.6
17
13
Z01.8
ICD-10 Finland
Other specified special examinations
4.5
10.6
34
103
Z89.5
ICD-10 Finland
Acquired absence of leg at or below knee
+∞
10.6
10
*
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
+∞
10.6
10
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
26.7
10.6
14
6
A28
ICPC
Limited function/disability NOS
4.5
10.6
33
98
N06AX11
ATC
mirtazapine; oral
3.9
10.3
50
203
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.2
10.3
37
122
X59
ICD-10 Finland
Exposure to unspecified factor
4.5
10.2
32
95
G54.0
ICD-10 Finland
Brachial plexus disorders
61.0
9.9
11
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
61.0
9.9
11
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
61.0
9.9
11
*
X58
ICD-10 Finland
Exposure to other specified factors
4.7
9.8
27
72
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
24.5
9.6
13
6
PE1AT
NOMESCO Finland
Femoral artery PTA
109.8
9.6
10
*
A01
ICPC
Pain general/multiple sites
5.7
9.5
20
42
WX212
NOMESCO Finland
Femoral plexus blockade
15.7
9.5
15
11
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
5.1
9.5
23
55
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
9.5
41
153
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.0
9.3
35
118
A02BC03
ATC
lansoprazole; oral
3.8
9.1
38
138
N05BA04
ATC
oxazepam; oral
3.8
9.1
38
138
ZXA00
NOMESCO Finland
Right side
3.7
8.8
39
147
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.5
8.7
63
322
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
8.7
23
59
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.0
8.7
21
50
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.4
8.7
26
74
A06AD11
ATC
lactulose; oral
4.6
8.3
23
61
WX306
NOMESCO Finland
Lumbar epidural anesthesy
9.0
8.3
17
22
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
36.6
8.2
10
*
Z3231
NOMESCO Finland
Registered nurse
3.5
8.2
40
159
N02BF02
ATC
pregabalin; oral
9.8
8.2
16
19
N05CF01
ATC
zopiclone; oral
3.4
8.1
45
194
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.1
8.1
19
44
R07.4
ICD-10 Finland
Chest pain, unspecified
3.5
8.0
36
136
J45.9
ICD-10 Finland
Asthma, unspecified
4.0
7.9
27
84
Z3226
NOMESCO Finland
Physiotherapist
4.0
7.9
27
84
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
4.1
7.9
26
79
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.0
7.9
19
45
ZZA00
NOMESCO Finland
Split skin graft
13.3
7.8
13
11
R4120
NOMESCO Finland
Occupational therapy
11.4
7.8
14
14
ZXE10
NOMESCO Finland
More than one and less than three hours
3.2
7.7
47
213
TK800
NOMESCO Finland
Hemodialysis
27.4
7.7
10
*
N05CD07
ATC
temazepam; oral
4.5
7.7
21
55
JN3AD
NOMESCO Finland
Abdominal CT examination
5.0
7.6
18
42
N05AH04
ATC
quetiapine; oral
4.1
7.5
24
71
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.6
7.5
31
110
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
7.6
7.5
17
26
R06.0
ICD-10 Finland
Dyspnoea
3.3
7.5
38
154
M54.5
ICD-10 Finland
Low back pain
3.4
7.5
35
135
I79.2*E11.5
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic peripheral angiopathy
+∞
7.4
7
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
3.3
7.3
37
149
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.0
7.3
16
23
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.3
7.3
17
27
SPAT1301
SPAT
No procedures
3.1
7.3
45
205
A02BC01
ATC
omeprazole; systemic
3.3
7.2
35
138
M54.4
ICD-10 Finland
Lumbago with sciatica
4.4
7.0
20
54
R50.9
ICD-10 Finland
Fever, unspecified
3.8
7.0
25
80
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
7.4
7.0
16
25
205
Kela drug reimbursment
Chronic hypertension
3.2
6.9
37
154
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
43.0
6.9
8
*
M03BX01
ATC
baclofen; systemic
43.0
6.9
8
*
WZC00
NOMESCO Finland
Treatment plan or consultation
3.0
6.8
47
226
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.1
6.8
16
26
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
6.8
29
105
R02
ICPC
Shortness of breath/dyspnoea
4.1
6.7
21
61
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.0
6.7
62
350
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.8
6.6
16
27
B01AA03
ATC
warfarin; systemic
3.4
6.5
28
101
T36
ICD-10 Finland
Poisoning by systemic antibiotics
15.6
6.5
10
7
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
15.6
6.5
10
7
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
15.6
6.5
10
7
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
6.2
6.5
17
32
M79.0
ICD-10 Finland
Rheumatism, unspecified
74.3
6.5
7
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
74.3
6.5
7
*
M54.6
ICD-10 Finland
Pain in thoracic spine
10.3
6.5
12
13
ZXE30
NOMESCO Finland
More than five and less than seven hours
7.9
6.5
14
20
WX892
NOMESCO Finland
Monitored bed care
7.1
6.5
15
24
B01AC04
ATC
clopidogrel; oral
3.4
6.4
29
108
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.0
6.4
38
167
SPAT1262
SPAT
Handing over of treatment supplies
3.4
6.3
28
103
N06AA10
ATC
nortriptyline; systemic
28.6
6.3
8
*
L04AA01
ATC
[U] ciclosporin
+∞
6.3
6
*
NFQ48
NOMESCO Finland
Revision of exarticulation or amputation stump of hip or femur
+∞
6.3
6
*
T87.6
ICD-10 Finland
Other and unspecified complications of amputation stump
+∞
6.3
6
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
+∞
6.3
6
*
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
+∞
6.3
6
*
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
+∞
6.3
6
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.1
6.2
34
142
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.8
6.2
17
34
ZYC01
NOMESCO Finland
Remote contact by phone
7.2
6.1
14
22
WX725
NOMESCO Finland
Noninvasive ventilation
7.2
6.1
14
22
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.8
6.1
50
261
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
8.9
6.0
12
15
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
16.3
6.0
9
6
NF3AA
NOMESCO Finland
Femur X-ray examination
16.3
6.0
9
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
16.3
6.0
9
6
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.9
6.0
16
31

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
38
88
6.29
16.97
3.5
1.6
—
—
—
0
0
58
240
4.28
12.06
10.3
3.7
—
—
—
0
0
34
116
3.90
8.87
7.0
1.7
—
—
—
0
0
18
39
5.39
8.24
11.2
8.8
16.27
15.23
%
0.67
18
39
67
374
3.31
7.71
5.2
2.5
—
—
estimate
—
0
0
47
216
3.18
7.51
5.3
3.0
—
—
—
0
0
10
6
18.26
6.89
13.0
11.2
12.16
12.07
mg/l
—
10
6
65
376
3.01
6.68
23.2
14.3
1.32
1.27
inr
0.29
55
303
27
95
3.51
6.56
1.5
1.2
—
—
—
0
0
67
398
2.99
6.49
9.1
6.3
9.96
12.23
umol/l
1.48
67
383
61
349
2.86
6.26
2.5
2.1
95.16
93.99
pmol/l
0.07
32
178
27
99
3.35
6.13
10.8
7.3
7.43
7.42
ph
0.43
17
64
40
191
2.80
5.69
3.9
2.2
3.46
2.86
mg/l
0.53
35
163
47
244
2.72
5.69
3.5
2.1
106.83
691.80
u/l
1.18
47
228
65
405
2.67
5.34
10.3
5.6
1.89
1.78
e9/l
0.47
59
355
22
81
3.19
4.90
12.6
8.0
118.36
121.51
g/l
0.27
22
81
15
43
3.92
4.82
1.9
2.0
0.87
1.81
g/l
0.63
15
38
24
94
3.03
4.81
2.1
1.5
—
—
—
0
0
31
142
2.70
4.67
4.0
3.1
0.78
0.83
mmol/l
1.31
31
137
9
11
8.84
4.66
1.8
1.5
—
—
—
0
0
62
398
2.42
4.49
10.6
5.6
0.05
0.04
e9/l
1.43
56
341
17
56
3.44
4.48
6.7
5.4
—
—
—
0
0
28
124
2.73
4.48
6.8
3.5
340.32
680.96
ng/l
0.36
22
102
62
400
2.40
4.41
10.6
5.5
0.65
0.59
e9/l
0.98
55
344
17
57
3.38
4.36
2.4
3.1
10.31
10.83
g/l
0.17
17
49
46
263
2.36
4.29
9.5
5.3
—
—
—
0
0
63
414
2.36
4.23
10.7
5.9
0.23
0.18
e9/l
1.75
56
356
18
64
3.20
4.21
1.6
1.4
—
—
—
0
0
24
101
2.80
4.21
2.0
3.0
1.90
1.74
%
0.45
24
91
23
95
2.83
4.17
2.4
1.4
—
—
—
0
0
8
10
8.56
4.14
1.6
1.5
—
—
—
0
0
26
120
2.57
3.79
2.6
1.8
31.07
28.64
s
1.05
26
114
49
302
2.20
3.69
5.4
3.2
5.92
7.79
mmol/l
3.12
44
254
47
288
2.17
3.57
5.1
3.4
67.35
54.75
mg/l
0.22
39
193
41
238
2.21
3.56
8.5
3.7
7.39
7.40
ph
0.36
30
171
26
124
2.47
3.53
2.0
1.6
—
—
—
0
0
64
444
2.18
3.52
14.0
9.7
4.19
4.02
e9/l
0.28
58
393
43
257
2.16
3.45
5.4
2.0
—
—
—
0
0
21
92
2.62
3.38
1.4
1.2
586.67
476.19
titre
—
6
21
47
297
2.08
3.22
6.6
4.1
22.33
9.50
mg/mmol
0.84
35
191
16
64
2.78
3.05
13.6
6.8
—
—
—
0
0
14
55
2.79
2.75
1.3
1.1
18.12
128.76
u/ml
—
5
19
8
19
4.47
2.74
1.1
1.1
—
—
—
0
0
27
146
2.16
2.71
2.5
1.7
—
—
—
0
0
48
322
1.93
2.66
6.9
3.5
33.87
55.37
ng/l
1.00
37
246
13
51
2.78
2.56
11.1
6.2
25.15
24.56
mmol/l
0.26
13
51
31
182
2.01
2.50
8.2
3.2
1.02
1.02
kg/l
0.67
26
110
14
58
2.64
2.49
1.4
2.4
—
—
—
0
0
38
240
1.93
2.49
2.4
1.7
14.55
19.93
nmol/l
2.63
31
199
93
811
2.66
2.44
49.5
13.0
26.69
26.43
mg/l
0.03
85
648
23
122
2.14
2.41
11.3
5.8
105.30
104.43
mmol/l
0.57
23
122
11
40
2.96
2.36
1.4
1.3
—
—
—
0
0
20
101
2.22
2.35
1.4
1.2
19.35
6.47
u/ml
—
8
39
14
60
2.55
2.34
1.1
1.1
—
—
—
0
0
8
23
3.68
2.32
1.5
1.3
—
—
—
0
0
6
14
4.48
2.18
2.0
1.4
—
—
—
0
0
8
26
3.25
2.06
1.4
1.2
—
—
—
0
0
16
78
2.25
2.04
9.6
2.8
7.38
7.37
ph
—
7
45
22
351
0.52
1.92
3.8
3.1
—
—
—
0
0
11
46
2.56
1.92
10.8
2.4
23.71
24.23
mmol/l
0.23
11
46
7
22
3.34
1.91
1.6
1.1
0.19
0.23
g/l
—
7
22
27
166
1.85
1.86
1.5
1.2
1.37
1.08
u/ml
—
6
48
8
31
2.71
1.70
2.6
2.7
—
—
—
0
0
15
78
2.08
1.64
1.3
1.4
—
—
—
0
0
7
27
2.71
1.54
5.1
2.6
24.11
26.11
mmol/l
—
7
27
32
220
1.66
1.49
7.6
6.2
—
—
—
0
0
93
848
2.09
1.47
51.6
16.5
139.14
139.84
mmol/l
1.39
93
828
93
848
2.09
1.47
51.9
16.6
4.01
3.98
mmol/l
0.42
93
827
34
241
1.62
1.40
8.0
2.9
24.82
357.16
e6/l
0.67
28
187
24
155
1.72
1.39
1.9
1.5
3.10
2.58
g/l
0.45
17
99
5
17
3.04
1.37
1.0
1.0
—
—
—
0
0
79
687
1.66
1.32
48.7
17.2
14.17
13.56
%
2.95
79
680
5
18
2.87
1.30
16.0
5.3
—
—
—
0
0
5
18
2.87
1.30
1.4
2.4
—
—
—
0
0
5
19
2.71
1.23
16.4
5.6
3.90
2.84
mmol/l
—
5
9
5
19
2.71
1.23
6.2
1.7
85.58
54.40
%
—
5
19
5
19
2.71
1.23
16.4
5.6
5.24
4.93
kpa
—
5
19
5
19
2.71
1.23
1.8
1.0
—
—
—
0
0
5
19
2.71
1.23
16.4
5.6
8.16
7.99
kpa
—
5
19
6
26
2.39
1.20
1.7
1.1
1.18
1.15
g/l
—
6
26
29
205
1.58
1.19
8.3
2.8
0.29
0.59
e6/l
0.98
22
151
8
39
2.14
1.18
4.8
2.2
0.36
0.99
ug/l
—
8
34
53
431
1.48
1.13
7.6
3.2
0.00
0.00
estimate
-0.00
11
102
7
33
2.20
1.08
2.9
2.6
—
—
—
0
0
53
435
1.45
1.05
7.7
3.2
0.00
0.00
estimate
-0.00
11
91
5
22
2.34
1.04
16.6
5.1
7.43
7.42
ph
—
5
22
37
284
1.48
1.03
8.6
3.4
41.68
103.60
e6/l
0.64
28
194
42
336
1.43
0.93
7.5
3.1
6.35
6.15
ph
0.71
26
201
31
236
1.45
0.89
8.7
3.2
0.00
0.01
estimate
—
8
87
51
426
1.39
0.87
7.8
3.2
0.00
0.00
estimate
-0.00
11
101
17
114
1.59
0.86
2.0
1.2
166.57
33.87
iu/ml
—
6
28
39
313
1.40
0.84
2.2
2.0
—
—
—
0
0
44
361
1.38
0.83
25.7
10.9
0.00
0.00
e9/l
0.50
33
295
10
58
1.80
0.83
5.9
3.0
—
—
—
0
0
5
100
0.47
0.82
1.0
1.3
—
—
—
0
0
0
24
0.00
0.80
0.0
1.2
—
—
—
0
0
9
57
1.63
0.73
1.3
2.6
2.89
7.11
ug/l
—
9
51
10
62
1.68
0.68
3.6
1.5
—
0.00
estimate
—
0
20
24
184
1.40
0.66
10.0
4.4
—
—
—
0
0
0
22
0.00
0.60
0.0
4.4
—
—
—
0
0
75
688
1.34
0.60
50.4
17.6
330.43
332.81
g/l
1.23
75
683
6
35
1.76
0.59
1.0
1.3
—
—
—
0
0
11
75
1.52
0.53
1.3
1.5
—
—
—
0
0
6
40
1.53
0.52
4.8
2.1
0.33
0.59
%
—
6
40
93
890
1.51
0.46
53.5
18.3
84.42
80.06
umol/l
0.35
93
878
0
15
0.00
0.41
0.0
2.0
—
—
—
0
0
10
71
1.45
0.41
6.2
4.3
0.00
0.44
%
—
5
18
5
34
1.49
0.41
3.8
1.5
—
0.00
estimate
—
0
14
0
18
0.00
0.40
0.0
2.1
—
—
—
0
0
6
41
1.49
0.37
4.8
2.2
0.67
1.17
%
—
6
41
6
44
1.39
0.35
3.8
4.8
—
—
—
0
0
91
881
1.31
0.29
40.4
13.1
—
—
—
0
0
37
333
1.17
0.28
8.6
3.1
0.00
0.00
estimate
—
10
81
10
77
1.33
0.27
4.8
2.6
13.42
13.25
nmol/l
—
10
68
9
73
1.26
0.26
1.2
1.6
—
—
—
0
0
9
74
1.24
0.26
1.2
1.6
—
—
—
0
0
5
39
1.30
0.23
3.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
1.18
—
0
10
0
10
0.00
0.21
0.0
2.6
—
4.18
—
0
10
0
10
0.00
0.21
0.0
2.6
—
106.80
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
8
69
1.17
0.17
12.9
3.3
1.22
1.22
mmol/l
—
8
59
8
71
1.14
0.16
2.3
1.6
—
—
—
0
0
9
107
0.83
0.13
2.0
1.2
—
—
—
0
0
5
43
1.17
0.10
1.6
1.6
—
—
—
0
0
18
196
0.90
0.10
3.0
3.2
0.43
0.80
ug/l
3.81
11
133
7
67
1.05
0.08
15.1
2.9
—
—
—
0
0
7
82
0.84
0.07
1.3
1.3
—
—
—
0
0
94
927
1.18
0.07
63.1
20.9
129.23
136.15
g/l
3.72
94
913
94
927
1.18
0.07
62.5
20.7
91.32
91.29
fl
0.02
94
913
94
927
1.18
0.07
62.5
20.6
30.23
30.43
pg
0.54
94
913
94
927
1.18
0.07
63.7
21.0
39.24
40.58
%
2.10
94
913
26
248
1.06
0.05
6.8
2.7
0.00
0.00
estimate
—
10
73
25
248
1.01
0.00
1.4
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
7.05
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
30.0
—
912.14
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
34.68
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.00
—
0
6
6
61
0.98
-0.00
1.3
1.8
3.58
3.35
mmol/l
—
6
44
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
37.1
—
1679.43
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
144.32
—
0
6
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint PHANTOMLIMB and mortality.

Females

Parameter HR [95% CI] p-value
PHANTOMLIMB 2.807 [1.79, 4.39] < 0.001
Birth year 0.993 [0.98, 1.0] 0.11

During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 255 females with PHANTOMLIMB died.

Males

Parameter HR [95% CI] p-value
PHANTOMLIMB 2.059 [1.54, 2.76] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 males with PHANTOMLIMB died.

Mortality risk

Mortality risk for people of age

years, who have PHANTOMLIMB.

N-year risk Females Males
1 0.292% 0.332%
5 1.62% 1.938%
10 4.051% 5.199%
15 7.699% 10.008%
20 12.73% 16.672%

Relationships between endpoints

Index endpoint: PHANTOMLIMB – Phantom limb syndrome with pain

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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