No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
109 |
4. Check minimum number of eventsNone |
109 |
5. Include endpointsNone |
109 |
6. Filter based on genotype QC (FinnGen only) |
97 |
Control definitions (FinnGen only)
- Control exclude
- N14_GLOMERULAR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N00-N08
- Name in latin
- Nephropathia hereditaria non alibi classificata
Similar endpoints
↥List of similar endpoints to
Hereditary nephropathy, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- All chronic kidney diseases
- All kidney diseases
- Genitourinary diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 696 | 397 | 292 |
| Only index persons | 604 | 359 | 245 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.77 | 56.15 | 57.22 |
| Only index persons | 54.59 | 53.86 | 55.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 97 | 50 | 47 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 58.05 | 55.27 | 61.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 100
- Matched controls
- 1000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N07.4
ICD-10 Finland
Hereditary nephropathy, not elsewhere classified, diffuse endocapillary proliferative glomerulonephritis
+∞
45.3
40
*
N07.3
ICD-10 Finland
Hereditary nephropathy, not elsewhere classified, diffuse mesangial proliferative glomerulonephritis
+∞
35.6
32
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
51.9
23.1
27
7
M07.3
ICD-10 Finland
Other psoriatic arthropathies
92.7
20.6
22
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
40.9
20.4
25
8
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.8
13.9
32
75
R07.4
ICD-10 Finland
Chest pain, unspecified
4.8
13.8
54
197
L01BA01
ATC
methotrexate; systemic
14.4
12.0
20
17
N07.9
ICD-10 Finland
Hereditary nephropathy, not elsewhere classified, unspecified
+∞
10.6
10
*
E000001, ,
ATC
4.1
9.6
35
116
L04AA01
ATC
[U] ciclosporin
+∞
9.5
9
*
D05AX02
ATC
calcipotriol; topical
13.3
9.5
16
14
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.2
9.2
31
97
A06AD11
ATC
lactulose; oral
4.1
9.1
32
103
L40.0
ICD-10 Finland
Psoriasis vulgaris
9.7
9.1
18
22
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.3
8.7
27
79
M07.0*L40.5
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
98.0
8.6
9
*
L04AX03
ATC
methotrexate; systemic
4.7
8.5
23
60
R52.9
ICD-10 Finland
Pain, unspecified
4.8
8.4
22
56
E0000UV, ,
ATC
3.4
8.3
57
281
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
8.0
52
247
J01FF01
ATC
clindamycin; systemic
3.3
7.8
43
184
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
27.5
7.7
10
*
A11CC03
ATC
alfacalcidol; systemic
17.4
7.4
11
7
6960A
ICD-9 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
7.4
7
*
N07.0
ICD-10 Finland
Hereditary nephropathy, not elsewhere classified, minor glomerular abnormality
+∞
7.4
7
*
M04AA01
ATC
allopurinol; systemic
3.7
7.2
27
90
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
7.1
7.2
17
28
D05AX52
ATC
calcipotriol, combinations; topical
7.1
7.2
17
28
H02AB07
ATC
prednisone; oral
3.8
6.9
25
81
C03CA01
ATC
furosemide; systemic
2.9
6.5
49
247
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
6.6
6.5
16
28
A02BC01
ATC
omeprazole; systemic
3.0
6.4
42
195
M07.0
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
6.3
6
*
XF400
NOMESCO Finland
ECG with 12 standard connections
3.3
6.2
29
111
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.9
6.1
20
60
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
6.1
32
131
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.9
6.1
39
179
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
16.3
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
74
478
3.11
6.00
24.5
6.9
1.21
1.21
mmol/l
0.18
68
406
62
375
2.72
5.51
6.8
4.2
29.77
38.97
ng/l
0.38
43
283
18
54
3.85
5.47
4.3
3.4
2.02
1.69
mmol/l
—
9
39
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
11
19
6.36
4.59
6.7
2.6
0.35
0.36
iu/ml
—
6
8
31
145
2.65
4.47
31.1
6.6
104.84
104.18
mmol/l
0.22
31
145
55
340
2.37
4.32
8.6
3.6
—
—
—
0
0
69
472
2.49
4.30
7.8
4.4
0.00
0.00
estimate
-0.00
17
104
19
70
3.12
4.20
2.8
1.5
—
—
—
0
0
14
36
4.35
4.20
1.4
1.3
—
—
—
0
0
68
469
2.41
4.05
7.7
4.3
0.00
0.00
estimate
-0.00
16
99
33
169
2.42
3.89
7.6
3.2
0.51
0.79
e6/l
0.62
28
93
68
475
2.35
3.85
7.8
4.4
0.00
0.00
estimate
-0.00
16
96
32
163
2.42
3.81
2.4
2.0
—
—
—
0
0
18
69
2.96
3.71
7.1
3.9
51.50
57.64
ml/min/173m2
—
8
36
26
122
2.53
3.67
2.0
1.8
—
—
—
0
0
27
130
2.48
3.61
4.7
2.4
19.61
24.36
%
1.28
27
121
9
17
5.70
3.60
3.9
1.5
14.50
4.82
pmol/l
—
9
17
28
141
2.37
3.38
4.9
2.4
11.18
14.09
umol/l
1.21
28
130
48
308
2.07
3.16
4.0
3.4
2919.07
1168.99
ng/l
0.96
43
263
44
274
2.08
3.13
8.9
3.3
0.39
0.48
e6/l
0.15
39
199
42
264
2.02
2.87
6.7
4.4
0.00
0.00
estimate
-0.00
15
95
5
6
8.68
2.78
3.6
4.0
—
—
—
0
0
15
62
2.67
2.69
28.6
5.0
24.59
24.02
mmol/l
0.46
15
62
45
296
1.95
2.66
6.6
3.5
42.78
5.48
mg/mmol
1.42
36
178
35
211
2.01
2.65
6.8
4.6
1.02
1.02
kg/l
0.37
27
137
51
351
1.92
2.62
7.3
4.5
0.00
0.00
estimate
-0.00
12
84
13
51
2.78
2.56
1.4
1.4
—
—
—
0
0
28
158
2.07
2.52
8.7
3.3
2.67
2.51
e6/l
0.03
23
83
18
85
2.36
2.47
4.1
2.6
0.20
0.22
g/l
0.42
18
76
9
27
3.56
2.46
1.0
1.5
—
—
—
0
0
47
320
1.88
2.46
4.6
3.3
2.34
2.37
mmol/l
1.03
42
289
70
543
1.96
2.44
19.7
5.2
7.08
6.66
mmol/l
0.86
70
514
7
17
4.34
2.40
1.3
1.5
—
—
—
0
0
22
115
2.17
2.39
2.2
2.0
—
—
—
0
0
30
179
1.97
2.30
1.3
1.3
1.83
2.83
u/ml
0.54
13
68
14
62
2.46
2.19
70.4
9.5
24.11
24.94
mmol/l
0.43
14
62
33
207
1.89
2.18
4.5
1.6
0.96
1.21
mg/l
0.49
26
167
56
415
1.79
2.14
4.2
2.5
73.59
78.89
nmol/l
0.61
49
372
5
10
5.20
2.09
1.4
1.3
—
—
—
0
0
5
11
4.72
1.96
1.4
1.3
—
—
—
0
0
5
11
4.72
1.96
1.0
1.0
—
—
—
0
0
30
193
1.79
1.79
1.4
1.3
14.62
33.68
iu/ml
—
6
59
81
689
1.92
1.79
17.9
9.1
89.89
82.40
u/l
0.34
76
648
8
30
2.81
1.76
1.5
1.5
—
—
—
0
0
7
24
3.06
1.75
2.7
1.3
—
—
—
0
0
28
178
1.80
1.74
6.4
3.7
449.43
311.55
ng/l
0.21
21
148
6
19
3.29
1.69
1.7
1.5
—
—
—
0
0
6
21
2.97
1.53
1.7
1.5
—
—
—
0
0
6
21
2.97
1.53
1.7
1.5
—
—
—
0
0
9
37
2.57
1.52
1.1
1.4
0.25
0.21
g/l
—
9
37
13
66
2.11
1.51
47.5
10.1
93.91
94.20
%
0.13
13
66
12
59
2.17
1.50
24.7
2.8
1.84
1.20
%
0.36
12
59
12
59
2.17
1.50
1.3
1.7
—
—
—
0
0
7
28
2.61
1.48
1.4
1.6
—
—
—
0
0
26
170
1.72
1.45
1.8
1.7
759.99
1246.20
nmol/l
2.45
18
134
12
60
2.14
1.45
24.7
2.8
0.78
0.65
%
0.33
12
60
11
53
2.21
1.44
7.8
3.0
4.44
4.39
pmol/l
0.04
11
43
62
511
1.56
1.32
2.8
3.0
—
—
—
0
0
51
404
1.54
1.29
4.5
2.9
—
—
estimate
—
0
0
6
25
2.49
1.26
3.3
1.3
8217.50
3648.00
e6/l
—
6
12
27
186
1.62
1.24
1.9
1.8
408.55
456.26
pmol/l
0.58
22
155
8
38
2.20
1.21
6.3
2.3
—
—
—
0
0
7
30
2.43
1.15
1.0
1.4
—
—
—
0
0
20
130
1.67
1.14
1.5
1.5
—
—
—
0
0
50
404
1.48
1.10
2.8
2.2
89.01
94.26
pmol/l
0.37
27
189
7
34
2.14
1.05
3.0
1.8
—
—
—
0
0
5
22
2.34
1.04
1.6
1.6
—
—
—
0
0
7
35
2.07
1.02
3.6
2.0
—
—
—
0
0
90
830
1.84
1.02
44.7
18.0
19.50
23.08
mg/l
0.81
85
703
36
277
1.47
0.99
2.4
1.7
18.63
23.81
nmol/l
0.88
31
229
66
570
1.46
0.99
6.2
3.3
77.63
49.43
u/l
0.86
59
538
29
215
1.49
0.96
4.9
2.5
—
—
—
0
0
39
310
1.42
0.90
5.3
2.9
35.74
31.75
u/l
0.27
34
292
8
43
1.93
0.90
1.0
1.0
—
—
—
0
0
33
259
1.41
0.80
6.4
3.8
0.00
0.00
estimate
-0.00
13
84
84
773
1.54
0.80
6.7
5.6
1.97
1.96
mu/l
0.03
76
695
5
26
1.97
0.71
1.8
1.3
—
—
—
0
0
5
26
1.97
0.71
1.8
1.6
—
—
—
0
0
7
41
1.76
0.71
1.1
1.2
—
—
—
0
0
85
790
1.51
0.70
8.3
6.6
42.09
39.68
mmol/mol
1.14
79
740
5
30
1.70
0.62
7.8
4.3
2.60
2.59
index
—
5
17
90
852
1.56
0.61
52.1
20.7
4.02
3.98
mmol/l
0.79
90
828
90
853
1.55
0.59
51.9
20.6
139.66
139.75
mmol/l
0.08
90
836
41
353
1.27
0.51
2.1
2.0
1.39
1.30
mmol/l
0.25
33
291
14
103
1.42
0.48
2.1
1.4
—
—
—
0
0
5
33
1.54
0.42
1.2
1.1
—
—
—
0
0
5
33
1.54
0.42
1.2
1.1
—
—
—
0
0
11
80
1.42
0.40
1.5
1.2
—
—
—
0
0
25
211
1.25
0.36
1.5
1.3
0.51
2.23
u/ml
—
8
61
83
802
1.21
0.23
6.8
5.4
6.03
5.95
mmol/l
0.22
73
729
0
14
0.00
0.20
0.0
1.1
—
1.72
—
0
5
20
224
0.87
0.17
4.5
4.8
20.99
23.23
%
—
10
110
5
66
0.74
0.17
2.2
1.7
—
—
—
0
0
11
92
1.22
0.17
12.5
9.1
—
—
—
0
0
10
86
1.18
0.11
5.2
4.0
—
—
—
0
0
79
772
1.11
0.11
5.8
4.4
1.40
1.27
mmol/l
0.65
72
699
84
824
1.12
0.10
7.1
6.0
2.47
2.63
mmol/l
0.82
78
757
15
165
0.89
0.09
3.3
3.1
0.51
0.69
ug/l
—
10
115
6
72
0.82
0.08
2.0
1.8
—
—
—
0
0
82
813
1.05
0.01
6.6
5.2
1.42
1.48
mmol/l
0.50
77
742
90
894
1.07
0.01
68.8
27.2
38.77
40.30
%
1.59
90
883
90
894
1.07
0.01
59.9
26.8
129.20
134.66
g/l
2.43
90
882
90
894
1.07
0.01
59.3
26.6
92.09
91.35
fl
0.72
90
883
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
9.64
—
0
8
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
43.32
—
0
5
0
5
0.00
-0.00
0.0
2.8
—
13.94
—
0
5
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
38.38
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_NEPHROPATHYHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHROPATHYHER | 1.877 [1.41, 2.5] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.831 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 364 females with N14_NEPHROPATHYHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHROPATHYHER | 2.079 [1.56, 2.77] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 265 males with N14_NEPHROPATHYHER died.
Mortality risk
Mortality risk for people of age
years, who have N14_NEPHROPATHYHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.338% |
| 5 | 1.2% | 2.306% |
| 10 | 3.01% | 5.455% |
| 15 | 5.937% | 10.541% |
| 20 | 10.864% | 17.371% |
Relationships between endpoints
↥Index endpoint: N14_NEPHROPATHYHER – Hereditary nephropathy, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data