Traumatic spondylopathy

M13_SPONDYLOTRAUM

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M48.3 Hospital discharge: ICD-8 — 7132 Cause of death: ICD-10 — M48.3 Cause of death: ICD-8 — 7132 2 out of 7 registries used, show all original rules.	104
4. Check minimum number of events None	104
5. Include endpoints None	104
6. Filter based on genotype QC (FinnGen only)	88

Control definitions (FinnGen only)

Control exclude: M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M48
Name in latin: Spondylopathia traumatica

NAME	M13_SPONDYLOTRAUM
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M483
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	7132
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M483
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	7132
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Traumatic spondylopathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	861	449	403
Only index persons	672	376	296
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	59.90	63.11	56.48
Only index persons	59.56	62.52	55.79

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	88	54	34
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	56.55	58.70	53.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
92: Matched controls
920

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M48.3

ICD-10 Finland

Traumatic spondylopathy

+∞

94.9

M48.0

ICD-10 Finland

Spinal stenosis

160.7

32.0

N03AX16

ATC

[U] pregabalin

11.6

29.4

N03AX12

ATC

[U] gabapentin; oral

12.3

27.1

M54.5

ICD-10 Finland

Low back pain

8.3

23.9

124

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

30.2

21.1

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

8.3

19.7

N02AX02

ATC

tramadol; systemic, rectal

6.3

17.2

204

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

26.7

15.5

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

+∞

12.8

71320

ICD-8 Finland

Osteo-arthritis and allied conditions, Traumatic spondylopathy

+∞

12.8

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

44.2

12.6

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

35.3

12.1

N06AX21

ATC

duloxetine; oral

10.0

10.9

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

+∞

10.6

M54.4

ICD-10 Finland

Lumbago with sciatica

6.3

10.4

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

45.4

10.2

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

14.6

9.8

L03

ICPC

Low back symptom/complaint

4.3

9.7

116

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

24.9

9.7

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

41.1

9.2

M80.9

ICD-10 Finland

Unspecified osteoporosis with pathological fracture

55.5

8.9

M43.1

ICD-10 Finland

Spondylolisthesis

55.5

8.9

N02BF01

ATC

gabapentin; oral

8.0

8.4

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

20.5

7.8

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.4

7.7

232

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

86.8

7.5

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

+∞

7.4

N05CD07

ATC

temazepam; oral

4.0

7.2

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.1

6.8

245

M54.9

ICD-10 Finland

Dorsalgia, unspecified

6.5

6.7

L28

ICPC

Limited function/disability (L)

3.5

6.6

101

M03BX02

ATC

tizanidine; oral

3.2

6.5

342

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

74.8

6.5

A02BC03

ATC

lansoprazole; oral

3.2

6.5

161

N05BA01

ATC

diazepam; systemic, rectal

4.3

6.4

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

+∞

6.3

N02AA05

ATC

oxycodone; systemic

3.3

6.3

117

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

206

2.55

4.46

5.5

3.9

—

(3001604) Monocytes [#/volume] in Blood

353

2.50

4.35

6.8

5.6

0.58

0.56

e9/l

0.18

298

(3006315) Basophils [#/volume] in Blood

353

2.50

4.35

6.7

5.7

0.04

e9/l

0.19

296

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

399

2.33

3.67

6.5

6.1

1.22

mmol/l

0.47

339

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

138

2.48

3.61

3.8

1345.81

229.11

ng/l

0.39

115

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

309

2.25

3.58

2.6

2.5

—

estimate

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

316

2.18

3.31

2.4

2.3

74.96

79.58

nmol/l

0.59

285

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

156

2.25

3.02

2.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.88

2.86

1.9

1.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

6.33

2.74

1.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

315

2.01

2.71

2.3

1.9

86.04

99.13

pmol/l

1.00

152

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

460

2.07

2.67

3.6

2.9

62.54

49.37

u/l

0.54

431

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

125

2.24

2.67

3.1

2.5

0.77

1.45

e6/l

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.92

2.56

5.1

7.2

91.98

94.15

0.32

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

220

1.95

2.36

2.3

2.2

115.86

307.23

u/l

1.52

207

(3031040) Bacteria [#/volume] in Urine by Automated count

472

1.96

2.34

7.2

4.2

—

5122.36

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

117

2.16

2.31

3.5

2.5

4.06

3.46

e6/l

—

(3019977) pH of Arterial blood

2.30

3.8

5.4

7.41

7.43

0.40

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.67

2.21

4.6

6.7

1.44

1.23

0.55

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.67

2.21

4.2

6.7

0.68

0.59

0.40

(3044640) Blood type and Crossmatch panel - Blood

217

1.90

2.16

2.0

2.2

—

(3030467) Casts [#/volume] in Urine by Automated count

210

1.89

2.11

4.3

2.7

0.11

0.36

e6/l

1.55

155

(3002582) Erythrocytes [#/volume] in Urine

254

1.85

2.09

4.2

3.0

32.90

320.59

e6/l

0.59

195

(3018095) Leukocytes [#/volume] in Urine

290

1.82

2.08

4.9

3.5

58.98

94.65

e6/l

0.38

202

(3018418) pH of Serum or Plasma

255

1.84

2.05

4.1

3.7

7.41

7.40

0.47

177

(3021960) Folate [Moles/volume] in Serum or Plasma

212

1.87

2.04

1.5

1.7

19.80

21.87

nmol/l

0.27

175

(3013650) Neutrophils [#/volume] in Blood by Automated count

404

1.82

2.04

11.6

11.0

4.44

3.90

e9/l

0.84

350

(3042936) Bacteria identified in Isolate by Culture

101

2.11

1.99

2.5

2.0

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

4.74

1.96

1.0

3.5

429.60

437.05

ug/l

—

(3026008) Bacteria identified in Urine by Culture

233

1.81

1.92

5.8

3.3

—

(3000764) Benzodiazepines [Presence] in Urine

3.70

1.87

1.0

1.5

—

(3020891) Body temperature

2.74

1.86

3.7

3.2

37.02

37.06

°c

—

(3016879) Cocaine [Presence] in Urine

3.49

1.77

1.0

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

114

1.96

1.74

3.6

4.8

104.05

104.75

mmol/l

0.26

114

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

302

1.72

1.74

4.5

4.2

47.17

47.19

ng/l

0.00

231

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

130

1.91

1.73

2.5

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.10

1.72

1.3

1.4

—

(3012544) pH of Venous blood

2.13

1.71

2.1

2.9

7.39

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.61

1.70

1.6

1.7

—

(3028300) Cannabinoids [Presence] in Urine

3.30

1.69

1.0

1.4

—

(3027008) Opiates [Presence] in Urine

3.30

1.69

1.0

1.4

—

(3027944) Amphetamines [Presence] in Urine

3.30

1.69

1.0

1.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

251

1.71

1.65

3.3

3.4

1180.88

1633.91

ng/l

0.70

219

(3019060) Gas panel - Arterial blood

2.36

1.64

2.0

3.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.71

1.63

1.0

1.4

—

(3043409) Potassium [Moles/volume] in Arterial blood

2.83

1.61

2.0

2.7

3.91

4.02

mmol/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.08

1.53

1.7

—

(40758558) Short blood count panel - Blood

231

1.67

1.46

8.3

7.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.24

1.45

2.6

1.1

—

(3032080) INR in Blood by Coagulation assay

371

1.61

1.44

17.7

14.1

1.37

1.30

inr

0.31

307

(3018405) Lactate [Moles/volume] in Arterial blood

2.53

1.42

2.0

2.6

1.06

1.49

mmol/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

131

1.78

1.39

1.6

1.5

1085.79

1170.30

nmol/l

0.13

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.72

1.39

1.7

1.5

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.72

1.39

1.7

1.4

55.17

41.87

nmol/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.34

1.28

1.3

1.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.49

1.26

2.0

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.27

1.25

2.0

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

394

1.52

1.16

7.0

4.0

0.00

estimate

—

(3015736) pH of Urine

309

1.52

1.13

6.7

3.6

6.60

6.20

1.36

165

(3018677) aPTT in Platelet poor plasma by Coagulation assay

114

1.72

1.13

1.4

1.7

27.78

29.83

1.41

109

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

655

1.66

1.11

6.1

5.5

1.63

1.92

mu/l

1.81

588

(4094501) Cardiovascular stress test using bicycle ergometer

2.46

1.10

1.2

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.75

1.09

2.3

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

389

1.49

1.06

6.2

4.0

0.00

estimate

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

540

1.53

1.06

4.9

4.6

15.21

pmol/l

0.00

478

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.79

1.05

19.9

7.7

—

(3035350) Ketones [Presence] in Urine by Test strip

390

1.48

1.05

7.0

4.0

0.00

estimate

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.97

1.04

3.8

2.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

704

1.71

1.02

26.2

15.0

26.63

25.27

mg/l

0.12

589

(40761511) CBC panel - Blood by Automated count

728

1.76

1.00

17.2

13.6

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.89

1.00

2.3

2.8

141.56

129.90

g/l

—

(40761535) Cells panel - Urine sediment

1.81

0.95

6.3

3.0

—

(3021589) Normoblasts [#/volume] in Blood

337

1.45

0.95

9.4

11.9

0.00

0.01

e9/l

0.45

279

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.30

0.95

2.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.30

0.95

2.3

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.30

0.95

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.85

0.95

1.6

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.69

0.94

2.9

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

386

1.44

0.94

3.1

2.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

148

1.54

0.88

7.1

5.5

—

(3022313) Gas panel - Capillary blood

2.00

0.86

2.2

4.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.81

0.85

3.4

3.8

58.37

41.85

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

737

1.66

0.83

27.7

17.7

138.95

139.80

mmol/l

2.24

722

(3029937) Albumin [Presence] in Urine by Test strip

204

1.46

0.82

5.5

4.1

0.00

estimate

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.80

0.0

3.5

—

31.29

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

740

1.62

0.78

27.4

17.7

4.10

3.98

mmol/l

2.67

725

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.82

0.78

1.2

1.1

—

(42870588) Differential panel, method unspecified - Blood

234

1.42

0.77

6.3

5.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.67

0.76

2.0

1.4

—

(3014051) Protein [Presence] in Urine by Test strip

207

1.43

0.76

5.6

3.4

—

0.00

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.91

0.75

1.6

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

301

1.38

0.74

6.4

4.2

0.00

estimate

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.06

0.74

1.4

2.7

23.74

25.94

mmol/l

—

(3012516) Albumin [Mass/volume] in Urine

244

0.67

0.73

2.7

3.1

19.57

50.39

mg/l

—

148

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.97

0.72

1.0

1.2

—

(3008037) Lactate [Moles/volume] in Venous blood

1.83

0.67

3.8

3.0

2.70

1.63

mmol/l

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

269

1.35

0.64

1.9

3.6

2.36

mmol/l

0.03

251

(1761482) Bacteria [#/volume] in Urine by Culture

1.70

0.62

8.8

6.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.70

0.62

1.4

1.0

—

(40768793) Breast Pathology biopsy report

0.00

0.60

0.0

1.3

—

(4024509) Urine culture

1.76

0.59

3.8

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

686

1.40

0.58

5.1

5.3

6.00

5.91

mmol/l

0.26

621

(1761868) Lipid panel - Serum or Plasma

276

0.73

0.57

3.7

3.6

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.55

0.56

1.8

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

687

1.39

0.56

5.3

5.1

1.53

1.51

mmol/l

0.09

616

(3009508) Creatinine [Moles/volume] in Urine

254

0.73

0.56

2.3

3.1

6.85

7.40

mmol/l

0.19

205

(3000991) Gas panel - Venous blood

1.47

0.54

4.8

5.9

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

110

1.43

0.53

1.3

1.07

9.54

u/ml

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

155

1.37

0.52

2.1

1.6

0.77

1.21

mg/l

1.33

128

(3022145) Colonoscopy Study observation

1.55

0.52

1.5

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.56

0.49

2.3

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.53

0.49

2.3

2.6

2.31

0.98

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

693

1.35

0.47

5.6

5.2

4.92

4.65

mmol/l

1.39

627

(36660697) Celiac disease serology panel - Serum

1.43

0.46

1.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.40

0.0

2.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

252

0.78

0.38

3.1

3.8

3.04

9.29

mg/mmol

—

148

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.42

0.36

1.8

4.2

1.13

2.42

mmol/l

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.42

0.36

1.2

1.1

37.83

331.81

u/ml

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

672

1.25

0.33

5.9

6.4

38.89

39.52

mmol/mol

0.29

619

(3000492) Spirometry study

1.29

0.31

1.9

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

159

1.25

0.30

1.2

1.3

5.72

1.59

u/ml

—

(3000494) Fungus identified in Specimen by Culture

1.22

0.26

1.4

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

658

1.19

0.25

4.5

4.4

1.38

1.26

mmol/l

0.60

585

(3041096) Erythrocytes [Presence] in Urine by Automated

221

1.18

0.23

5.7

3.9

0.00

estimate

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.26

0.23

3.4

3.6

25.44

25.07

mmol/l

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

3.83

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

1.5

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

1.2

—

114.50

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(4195642) Thrombophilia screening test

0.00

0.21

0.0

1.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

0.21

0.0

1.3

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.9

—

0.67

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.30

0.21

2.5

2.6

0.62

0.59

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.30

0.21

6.7

2.3

10.94

9.68

g/l

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.27

0.21

6.2

6.3

25.75

24.60

mmol/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

715

1.18

0.19

6.3

5.9

2.91

2.68

mmol/l

1.49

646

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.74

0.17

2.4

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

296

1.12

0.16

2.1

1.9

1.61

1.35

mmol/l

0.61

229

(40768797) Stomach Pathology biopsy report

0.81

0.15

1.1

1.2

—

(40761536) Microorganisms panel - Urine sediment

1.06

0.09

2.3

4.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.08

0.08

1.4

—

(40768804) Tissue Pathology biopsy report

294

0.93

0.07

1.6

2.3

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

677

1.08

0.06

22.8

15.5

78.87

76.08

ml/min/173m2

0.52

625

(3003694) ABO and Rh group [Type] in Blood

180

0.93

0.04

1.3

—

(3002256) Pathology report gross observation

111

1.09

0.04

1.6

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

116

1.04

0.00

2.1

3.0

0.54

0.71

ug/l

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.0

—

1.00

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

3.7

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

257.43

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.2

—

4.71

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.5

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

94.86

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.4

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.1

—

104.67

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.2

—

9.78

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.5

—

136.21

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.00

-0.00

3.5

3.3

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.2

—

7.40

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.0

—

137.20

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

7.0

—

0.56

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

10.14

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.3

—

97.67

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.7

—

21.93

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

1.1

—

14.23

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.92

-0.00

1.5

—

(4268621) Lupus anticoagulant assay

0.00

-0.00

0.0

2.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

3.7

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.2

—

21.83

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

3.4

—

(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

289.67

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.5

—

6.33

—

(3003329) Lymphocytes/Leukocytes in Synovial fluid

0.00

-0.00

0.0

1.4

—

42.40

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

11.8

—

578.80

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

7.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

-0.00

0.0

2.1

—

31.57

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.4

—

5.56

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.1

—

7.59

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

9.8

—

912.80

—

(3007164) IgA [Mass/volume] in Serum or Plasma

140

1.00

-0.00

1.4

2.02

2.55

g/l

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_SPONDYLOTRAUM and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_SPONDYLOTRAUM	1.502 [1.12, 2.01]	0.006
Birth year	0.994 [0.99, 1.0]	0.184

During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 278 females with M13_SPONDYLOTRAUM died.

Males

Parameter	HR [95% CI]	p-value
M13_SPONDYLOTRAUM	1.588 [1.09, 2.31]	0.015
Birth year	0.988 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 217 males with M13_SPONDYLOTRAUM died.

Mortality risk

Mortality risk for people of age

years, who have M13_SPONDYLOTRAUM.

N-year risk	Females	Males
1	0.098%	0.327%
5	0.726%	2.047%
10	2.085%	4.789%
15	4.192%	8.912%
20	7.266%	14.514%

Relationships between endpoints

↥

Index endpoint: M13_SPONDYLOTRAUM – Traumatic spondylopathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Traumatic spondylopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints