Chronic postrheumatic arthropathy [Jaccoud]

M13_POSTRHEU

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M12.0 Hospital discharge: ICD-8 — 7125 Cause of death: ICD-10 — M12.0 Cause of death: ICD-8 — 7125 2 out of 7 registries used, show all original rules.	54
4. Check minimum number of events None	54
5. Include endpoints None	54
6. Filter based on genotype QC (FinnGen only)	49

Control definitions (FinnGen only)

Control exclude: M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M12
Name in latin: Arthropathia postrheumatica chronica (Jaccoud)

NAME	M13_POSTRHEU
CONTROL_EXCLUDE	M13_ARTHROPATHIES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M120
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	7125
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M120
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	7125
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chronic postrheumatic arthropathy [Jaccoud] based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	427	288	134
Only index persons	340	231	109
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	57.18	57.81	55.83
Only index persons	56.18	56.77	54.92

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	49	30	19
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	56.09	53.09	60.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
51: Matched controls
510

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M12.0

ICD-10 Finland

Chronic postrheumatic arthropathy [Jaccoud]

+∞

55.9

M17.1

ICD-10 Finland

Other primary gonarthrosis

101.4

22.2

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

41.4

18.0

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

+∞

16.5

M25.5

ICD-10 Finland

Pain in joint

10.2

15.4

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

85.1

12.2

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

31.3

10.9

M01AH05

ATC

etoricoxib; oral

8.7

10.6

164

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

+∞

9.7

M19.0

ICD-10 Finland

Primary arthrosis of other joints

30.6

9.4

M09AX01

ATC

hyaluronic acid; parenteral

34.2

8.9

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

15.3

8.1

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

93.1

7.6

71250

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Chronic rheumatoid nodular fibrositis

+∞

7.5

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

35.6

7.4

L04AX03

ATC

methotrexate; systemic

35.6

7.4

L15

ICPC

Knee symptom/complaint

5.3

7.2

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

4.7

7.0

105

N02AJ06

ATC

codeine and paracetamol; systemic

4.5

6.7

108

B01AB05

ATC

enoxaparin; parenteral

4.7

6.6

ZXE10

NOMESCO Finland

More than one and less than three hours

4.4

6.4

104

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

+∞

6.4

NGB40

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis

+∞

6.4

M22.0

ICD-10 Finland

Recurrent dislocation of patella

+∞

6.4

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

13.4

6.1

M01AC06

ATC

meloxicam; systemic, rectal

4.2

6.0

101

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

4.50

5.46

1.4

1.2

35.88

18.12

iu/ml

—

(3045414) Leukocytes [Presence] in Urine

4.38

3.33

2.5

2.1

—

0.00

estimate

—

(42870588) Differential panel, method unspecified - Blood

121

2.86

3.27

7.3

4.4

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

3.54

2.36

5.1

2.7

—

57.85

—

(3002030) Lymphocytes/Leukocytes in Blood

184

2.34

2.24

8.4

5.1

28.42

27.11

0.30

175

(4024509) Urine culture

4.09

2.24

3.4

2.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

4.10

2.00

1.3

2.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

2.39

1.97

5.2

3.2

360.91

350.28

umol/l

0.12

(3020682) Albumin/Creatinine [Ratio] in Urine

139

2.19

1.93

4.0

3.9

1.08

10.72

mg/mmol

1.96

(3012516) Albumin [Mass/volume] in Urine

134

2.13

1.78

3.0

3.1

9.76

58.71

mg/l

1.50

(3042936) Bacteria identified in Isolate by Culture

2.53

1.71

1.8

1.5

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.57

1.56

2.2

2.0

10.40

10.03

g/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.10

1.55

1.5

1.0

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.34

1.47

2.2

1.9

7.98

7.56

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.34

1.47

2.2

1.9

4.42

4.16

g/l

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.34

1.47

2.2

1.9

3.96

3.57

g/l

—

(3000850) Epithelial cells [#/volume] in Urine

102

2.00

1.38

3.8

2.7

4.55

2.77

e6/l

0.48

(3013512) EKG study

145

1.91

1.37

4.3

3.8

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.18

1.36

1.4

2.2

2.38

2.35

g/l

0.10

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.44

1.31

2.0

2.8

0.00

0.16

e6/l

—

(3009261) Glucose [Presence] in Urine by Test strip

223

1.84

1.26

5.2

4.2

0.00

estimate

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.97

1.20

7.8

6.9

—

(3015736) pH of Urine

178

1.79

1.19

3.0

3.9

6.00

6.29

0.66

108

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

169

1.79

1.18

3.5

3.8

20.06

57.33

ng/l

0.91

128

(3035350) Ketones [Presence] in Urine by Test strip

226

1.80

1.18

5.3

4.1

0.00

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

170

1.78

1.15

4.3

4.0

0.00

0.02

estimate

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.15

1.15

1.5

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

220

1.74

1.08

5.4

4.2

0.00

estimate

—

(40761535) Cells panel - Urine sediment

2.16

1.04

3.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

1.01

0.0

9.9

—

94.01

—

(3023520) Reticulocytes [#/volume] in Blood

2.07

0.94

1.6

3.6

78.26

67.55

e9/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.97

0.91

2.4

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.87

0.87

4.4

6.7

—

(3020891) Body temperature

0.00

0.81

0.0

3.8

—

36.97

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.30

0.78

1.6

1.7

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.30

0.78

1.0

4.1

4.92

4.97

kpa

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.97

0.77

1.4

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.02

0.73

1.8

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.02

0.73

4.2

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

409

1.85

0.71

19.6

15.4

18.80

25.41

mg/l

0.71

326

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.68

0.68

2.9

3.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

180

1.51

0.66

2.6

—

estimate

—

(3029937) Albumin [Presence] in Urine by Test strip

126

1.52

0.62

4.9

4.1

0.00

estimate

—

(40758558) Short blood count panel - Blood

126

1.52

0.62

9.3

6.3

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

0.60

0.0

11.2

—

24.60

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.64

0.59

1.4

1.9

—

(3026008) Bacteria identified in Urine by Culture

138

1.47

0.56

5.2

3.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.57

0.53

1.5

2.0

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

385

1.51

0.51

17.0

16.0

77.98

79.26

ml/min/173m2

0.16

359

(3022145) Colonoscopy Study observation

1.46

0.47

1.6

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.42

0.43

1.5

1.9

—

(3036489) Thrombin time

0.00

0.42

0.0

1.1

—

21.07

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.42

0.0

1.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

232

1.35

0.42

3.3

3.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.42

0.41

2.3

1.5

—

(1002224) Polysomnography panel

0.00

0.40

0.0

1.1

—

(40761511) CBC panel - Blood by Automated count

424

1.52

0.37

19.8

14.7

—

(40761536) Microorganisms panel - Urine sediment

1.41

0.36

5.3

3.3

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

414

1.46

0.35

21.3

19.0

3.96

mmol/l

0.02

402

(40768797) Stomach Pathology biopsy report

1.40

0.33

1.0

1.1

—

(1761868) Lipid panel - Serum or Plasma

141

1.31

0.31

3.4

3.8

—

(3002582) Erythrocytes [#/volume] in Urine

151

1.30

0.31

4.3

3.2

9.86

49.34

e6/l

0.97

112

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.37

0.30

2.0

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.28

0.27

1.7

1.6

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

416

1.42

0.25

20.8

18.7

139.98

139.83

mmol/l

0.16

404

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.8

—

(3011288) Drugs identified in Urine by Screen method Nominal

0.00

0.21

0.0

1.5

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

37.80

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.21

0.0

1.3

—

46.18

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

5.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.21

0.0

1.1

—

86.50

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

1.8

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.21

0.0

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

196

1.22

0.21

2.9

2.0

95.83

95.63

pmol/l

0.01

100

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

1.5

—

3.22

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

206

1.21

0.21

6.7

7.0

1.21

1.22

mmol/l

0.30

191

(3027944) Amphetamines [Presence] in Urine

0.00

0.21

0.0

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.20

0.0

1.3

—

1.04

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.20

0.0

1.4

—

(3027008) Opiates [Presence] in Urine

0.00

0.20

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.20

0.0

1.3

—

1.03

—

(3016879) Cocaine [Presence] in Urine

0.00

0.20

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.20

0.0

1.3

—

1.33

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.20

0.0

1.3

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.2

—

810.46

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.20

0.0

1.4

—

(3003694) ABO and Rh group [Type] in Blood

120

0.79

0.19

1.3

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.74

0.18

2.0

7.2

104.00

104.25

mmol/l

—

(3030467) Casts [#/volume] in Urine by Automated count

131

1.21

0.17

4.3

3.0

0.02

0.37

e6/l

1.76

(40768804) Tissue Pathology biopsy report

180

1.18

0.16

2.1

2.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.82

0.15

1.5

2.0

—

(3026782) Osmolality of Urine

1.22

0.14

3.0

3.4

535.73

532.59

mosm/kgh2o

0.02

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

163

1.16

0.13

2.9

3.3

—

(3044640) Blood type and Crossmatch panel - Blood

124

1.18

0.13

1.6

2.2

—

(3002256) Pathology report gross observation

1.15

0.09

1.3

1.2

—

(3023368) Bacteria identified in Blood by Culture

118

1.14

0.08

5.2

4.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

431

1.15

0.08

25.8

20.5

77.70

78.67

umol/l

0.09

426

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

330

0.92

0.05

26.2

20.0

331.47

331.62

g/l

0.04

330

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.12

0.04

2.3

3.6

2.45

2.46

mmol/l

—

(36304419) Bacteria [Presence] in Urine

124

1.06

0.01

3.9

3.0

—

estimate

—

(3041096) Erythrocytes [Presence] in Urine by Automated

129

1.01

0.00

4.8

3.3

0.00

estimate

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

349

1.01

0.00

23.3

20.3

13.89

13.65

0.77

342

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.01

0.00

2.6

1.8

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.2

—

7.72

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.6

—

(3035941) MCH [Entitic mass]

445

1.10

-0.00

30.1

22.9

30.49

30.26

0.38

440

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.2

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

52.86

—

(3010813) Leukocytes [#/volume] in Blood

445

1.10

-0.00

30.3

23.0

7.35

6.76

e9/l

0.76

435

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

-0.00

0.0

1.0

—

1.41

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.4

—

0.80

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

17.51

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

358.00

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

-0.00

0.0

2.2

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(3007461) Platelets [#/volume] in Blood

444

1.11

-0.00

30.3

23.0

253.51

248.15

e9/l

0.21

434

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

1.0

—

13.00

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3024731) MCV [Entitic mean volume] in Red Blood Cells

445

1.10

-0.00

30.1

22.9

92.18

91.07

0.84

440

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3011985) Renin [Units/volume] in Plasma

0.00

-0.00

0.0

1.0

—

25.70

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.2

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

-0.00

0.0

1.8

—

25.00

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.2

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.0

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

0.74

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

328.20

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.1

—

245.67

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

2.8

—

28.12

—

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

445

1.10

-0.00

30.2

23.2

39.35

39.64

0.10

440

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

2.8

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.3

—

3.10

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

0.94

-0.00

4.3

2.7

0.49

1.47

e6/l

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

7.5

—

23.99

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.3

—

33.68

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

2.1

—

12.64

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

-0.00

0.0

5.0

—

1.09

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3026361) Erythrocytes [#/volume] in Blood

445

1.10

-0.00

30.2

23.0

4.37

4.41

e12/l

0.21

435

(3000963) Hemoglobin [Mass/volume] in Blood

445

1.10

-0.00

30.4

23.1

133.18

132.70

g/l

0.08

439

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.2

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.0

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_POSTRHEU and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_POSTRHEU	1.159 [0.87, 1.54]	0.311
Birth year	0.989 [0.98, 1.0]	0.013

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 185 females with M13_POSTRHEU died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_POSTRHEU.

N-year risk	Females	Males
1	0.088%	No data
5	0.514%	No data
10	1.368%	No data
15	2.583%	No data
20	4.369%	No data

Relationships between endpoints

↥

Index endpoint: M13_POSTRHEU – Chronic postrheumatic arthropathy [Jaccoud]

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chronic postrheumatic arthropathy [Jaccoud]

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints