hypersensitivity vasculitis: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
193 |
4. Check minimum number of eventsNone |
193 |
5. Include endpointsNone |
193 |
6. Filter based on genotype QC (FinnGen only) |
181 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M31
- Name in latin
- Angi(i)tis hypersensitivitatis
Similar endpoints
↥List of similar endpoints to
Hypersensitivity angiitis
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1066 | 579 | 476 |
| Only index persons | 811 | 452 | 359 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 60.49 | 61.23 | 59.53 |
| Only index persons | 57.92 | 58.46 | 57.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 181 | 95 | 86 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 58.36 | 57.42 | 59.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 184
- Matched controls
- 1840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
130.1
109
*
L04AX01
ATC
azathioprine; systemic
44.2
103.2
66
23
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
54.6
95.8
57
15
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
20.3
95.7
98
98
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
57.1
95.3
56
14
L04AA06
ATC
mycophenolic acid; systemic
72.1
93.4
52
10
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
74.1
66
*
TK800
NOMESCO Finland
Hemodialysis
35.8
66.7
44
16
A11CC03
ATC
alfacalcidol; systemic
30.1
62.7
44
19
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
51.5
47
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.5
49.7
54
55
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
13.1
49.4
55
58
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
44.6
41
*
H02AB04
ATC
methylprednisolone; systemic
7.6
39.5
78
163
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
38.9
36
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
11.5
37.6
44
49
Z94.0
ICD-10 Finland
Kidney transplant status
158.5
37.3
38
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
91.9
34.3
37
5
Z49.1
ICD-10 Finland
Extracorporeal dialysis
59.4
33.0
38
8
N17.9
ICD-10 Finland
Acute renal failure, unspecified
12.2
32.9
36
36
TPX10
NOMESCO Finland
Implantation of vascular injection port
13.6
32.7
33
29
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
11.3
32.0
37
40
A12AA04
ATC
calcium carbonate; oral
57.4
32.0
37
8
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.8
31.2
45
65
WW400
NOMESCO Finland
Plasmaferesis
+∞
31.1
29
*
127
Kela drug reimbursment
Transplant complication
55.5
31.0
36
8
4462A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Hypersensitivity angiitis
+∞
30.0
28
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.0
27.1
62
144
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
8.8
26.5
37
51
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
157.2
26.4
27
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.0
25.8
113
446
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
46.2
25.8
31
8
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
274.2
24.3
24
*
M05BA04
ATC
alendronic acid; oral
6.5
23.9
46
90
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
9.8
23.8
30
36
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
261.2
23.2
23
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
60.1
22.8
26
5
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.3
22.5
37
61
WX892
NOMESCO Finland
Monitored bed care
7.1
22.4
38
65
B03XA02
ATC
darbepoetin alfa; parenteral
22.5
22.2
32
17
Z2446
NOMESCO Finland
Social worker
7.8
22.1
34
52
ZX120
NOMESCO Finland
Intravenous
5.7
21.6
49
111
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.6
20.3
66
201
GD1AD
NOMESCO Finland
Thorax CT examination
7.1
19.8
33
55
N18.0
ICD-10 Finland
End-stage renal disease
62.0
19.4
22
*
L01AA01
ATC
cyclophosphamide; systemic
78.4
19.1
21
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
43.4
19.1
23
6
H02AB07
ATC
prednisone; oral
5.1
18.8
48
120
TPH04
NOMESCO Finland
Cathetrisation of vein
4.1
18.7
73
253
L04AD02
ATC
tacrolimus; systemic
58.9
18.4
21
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
58.9
18.4
21
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
19.5
18.0
27
16
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
18.0
17
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
17.9
51
139
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.1
17.9
129
672
N18.8
ICD-10 Finland
Other chronic renal failure
17.2
17.8
28
19
H02AB06
ATC
prednisolone; systemic
3.8
17.2
122
623
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.4
17.1
39
88
ZXD05
NOMESCO Finland
Urgent procedure
3.7
17.0
88
366
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
16.9
16
*
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
16.9
16
*
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
16.9
16
*
A07AA02
ATC
nystatin; oral
5.5
15.4
33
70
L04AD01
ATC
ciclosporin; systemic
27.8
15.0
20
8
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
14.8
14
*
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
14.8
14
*
R50.9
ICD-10 Finland
Fever, unspecified
3.9
14.7
54
176
WW200
NOMESCO Finland
Immunization
15.1
14.7
24
18
C03CA01
ATC
furosemide; systemic
3.3
14.5
96
455
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
14.2
83
364
V03AE01
ATC
polystyrene sulfonate; oral
26.3
14.1
19
8
N19
ICD-10 Finland
Unspecified kidney failure
6.8
13.8
23
38
L04AX03
ATC
methotrexate; systemic
4.9
13.6
34
82
J01MA14
ATC
moxifloxacin; systemic
4.7
13.5
35
87
TPH07
NOMESCO Finland
Cathetrisation of artery
4.4
13.5
39
106
B03XA01
ATC
erythropoietin; parenteral
31.0
13.2
17
6
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
6.0
12.7
24
45
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
12.6
12
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
139.1
12.6
13
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.9
12.4
43
133
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.8
12.4
24
46
ZX108
NOMESCO Finland
Inhalation
29.0
12.3
16
6
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.5
12.0
33
86
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
32.4
11.8
15
5
137
Kela drug reimbursment
Uraemia requiring dialysis
32.4
11.8
15
5
Z3226
NOMESCO Finland
Physiotherapist
3.3
11.7
55
208
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.7
11.6
21
20
L01BA01
ATC
methotrexate; systemic
11.7
11.6
21
20
R4110
NOMESCO Finland
Physiotherapy
3.0
11.6
76
349
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.4
11.3
24
50
J01MA02
ATC
ciprofloxacin; systemic
2.9
11.3
95
498
C08CA02
ATC
felodipine; oral
4.0
11.1
35
101
V03AE02
ATC
sevelamer; oral
63.8
10.8
12
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.1
10.7
58
238
A41.9
ICD-10 Finland
Sepsis, unspecified
5.9
10.7
20
37
Z3231
NOMESCO Finland
Registered nurse
2.9
10.6
73
341
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
116.4
10.5
11
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
10.5
10
*
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
+∞
10.5
10
*
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
10.5
10
*
TK810
NOMESCO Finland
Hemofiltration
34.7
10.5
13
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
8.5
10.3
22
29
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.0
10.1
23
51
Z49.0
ICD-10 Finland
Preparatory care for dialysis
31.9
9.5
12
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
9.5
9
*
TKC20
NOMESCO Finland
Catheterisation of bladder
4.1
9.4
28
77
P01BA02
ATC
hydroxychloroquine; oral
4.4
9.4
25
63
L04AA01
ATC
[U] ciclosporin
19.8
9.1
13
7
B01AB04
ATC
dalteparin; parenteral
5.3
9.1
19
39
WX002
NOMESCO Finland
Sedation and analgesia
2.9
9.0
52
219
205
Kela drug reimbursment
Chronic hypertension
2.6
8.9
72
360
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
8.9
64
302
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
8.8
31
96
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
52.5
8.8
10
*
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
52.5
8.8
10
*
N17.8
ICD-10 Finland
Other acute renal failure
17.4
8.7
13
8
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
8.5
44
173
TGC00
NOMESCO Finland
Bronchial lavation
7.7
8.5
19
27
A12AA12
ATC
[U] calcium acetate
94.2
8.5
9
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
8.4
8
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
8.4
8
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
8.4
8
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
8.3
31
100
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.7
8.2
28
85
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
35.0
8.2
10
*
321
Kela drug reimbursment
Paricalcitol and cinacalcet
23.2
8.1
11
5
J01MA12
ATC
levofloxacin; systemic
2.8
8.1
50
217
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
8.4
8.1
17
22
A02BC02
ATC
pantoprazole; systemic
2.7
8.0
140
990
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.9
8.0
19
30
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.2
7.9
34
120
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
7.9
42
168
3025
Kela drug reimbursment
Calcium carbonate
47.0
7.8
9
*
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
47.0
7.8
9
*
B05DA
ATC
Isotonic solutions
26.3
7.7
10
*
ZXA00
NOMESCO Finland
Right side
2.5
7.6
66
337
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
7.5
45
191
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
83.3
7.5
8
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
7.5
52
239
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.7
7.4
25
75
N085, M318,
ICD-10 Finland
+∞
7.3
7
*
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
7.3
7
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
31.4
7.2
9
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
31.4
7.2
9
*
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
7.5
7.2
16
23
WX203
NOMESCO Finland
Infraclavicular plexus blockade
8.1
7.1
15
20
N02AX02
ATC
tramadol; systemic, rectal
2.3
6.9
91
553
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
6.9
39
160
Z2221
NOMESCO Finland
Medical doctor
2.4
6.8
61
314
H05BX01
ATC
cinacalcet; oral
17.5
6.8
10
6
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.7
6.8
23
69
Z49.2
ICD-10 Finland
Other dialysis
23.5
6.7
9
*
B01AB10
ATC
tinzaparin; parenteral
3.1
6.6
30
109
R31
ICD-10 Finland
Unspecified haematuria
3.0
6.6
32
121
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
7.9
6.5
14
19
A02BC01
ATC
omeprazole; systemic
2.3
6.5
64
343
DHA10
NOMESCO Finland
Biopsy of cavity of nose
15.0
6.5
10
7
N25.0
ICD-10 Finland
Renal osteodystrophy
72.3
6.5
7
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.8
6.4
20
57
4476A
ICD-9 Finland
Other disorders of arteries and arterioles, Arteritis, unspecified
+∞
6.3
6
*
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
+∞
6.3
6
*
PAW37
NOMESCO Finland
Biopsy of temporal artery
+∞
6.3
6
*
N085M, ,
ICD-10 Finland
+∞
6.3
6
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
6.3
6
*
D69.0
ICD-10 Finland
Allergic purpura
27.7
6.3
8
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
8.1
6.2
13
17
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.5
6.2
22
68
Z3229
NOMESCO Finland
Other healthcare associate professional
3.3
6.2
24
79
J01FF01
ATC
clindamycin; systemic
2.3
6.1
64
350
XQ845
NOMESCO Finland
Dermatoscopy
10.5
6.1
11
11
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
6.0
28
103
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
16
42.54
79.25
12.2
1.1
100.76
—
u/ml
—
15
0
54
44
16.96
57.33
6.0
1.1
16.19
—
iu/ml
—
11
0
41
23
22.65
52.28
2.7
1.1
91.43
—
titre
—
7
0
41
24
21.69
51.25
2.7
1.1
400.00
—
titre
—
10
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
37
52
8.65
26.05
3.5
2.0
0.24
0.36
iu/ml
0.99
20
31
27
29
10.74
23.22
1.5
1.2
—
—
—
0
0
83
278
4.62
22.97
5.6
3.7
0.83
0.82
mmol/l
0.12
77
266
79
278
4.23
20.02
2.8
1.8
—
—
—
0
0
67
209
4.47
19.97
2.4
1.7
—
—
—
0
0
65
203
4.40
19.27
2.5
1.8
—
—
—
0
0
32
58
6.47
17.66
4.7
1.2
10.55
5.97
iu/ml
0.35
11
13
48
134
4.49
16.23
1.7
2.8
60.41
66.78
g/l
6.31
43
122
29
52
6.43
16.12
1.6
1.5
—
—
—
0
0
46
125
4.57
16.08
2.0
1.5
—
—
—
0
0
30
57
6.09
15.73
2.7
1.2
—
—
—
0
0
52
166
3.97
14.56
4.6
3.6
—
—
—
0
0
27
51
6.03
14.20
1.5
1.5
—
—
—
0
0
26
28
10.62
13.51
1.7
1.2
344.06
257.88
u/ml
0.29
17
16
39
107
4.36
13.33
10.4
8.1
24.50
24.78
mmol/l
0.19
39
107
65
256
3.38
13.11
11.7
7.3
103.43
104.49
mmol/l
0.94
65
256
24
24
11.32
12.94
2.8
1.3
126.43
167.93
au/ml
—
7
9
24
46
5.85
12.38
1.4
1.5
—
—
—
0
0
103
545
3.02
12.30
11.9
4.0
37.79
9.95
mg/mmol
1.07
84
335
104
557
2.99
12.08
10.3
3.2
6.16
7.68
mmol/l
4.96
99
471
22
41
5.96
11.66
1.4
1.5
—
—
—
0
0
93
478
2.91
11.51
14.7
3.4
0.10
0.39
e6/l
3.52
88
356
67
293
3.02
11.07
11.5
3.1
0.47
0.99
e6/l
1.93
47
165
138
904
3.11
10.44
22.5
9.4
4.52
4.15
e9/l
1.22
131
780
63
274
2.98
10.43
12.0
3.2
1.66
2.28
e6/l
0.34
44
148
130
828
2.94
10.29
39.3
8.2
1.21
1.21
mmol/l
0.06
118
715
14
7
21.50
9.96
3.6
2.0
0.58
0.61
mmol/l
—
14
7
19
36
5.77
9.87
1.4
1.2
2.00
2.67
u/ml
—
5
7
20
40
5.49
9.82
1.7
1.4
—
—
—
0
0
128
837
2.74
9.13
11.5
3.8
0.00
0.00
estimate
-0.00
31
175
37
128
3.37
8.91
4.4
3.2
39.23
60.41
ml/min/173m2
1.89
13
54
129
854
2.71
8.85
11.5
3.9
0.00
0.00
estimate
-0.00
31
167
128
848
2.67
8.70
11.4
3.9
0.00
0.00
estimate
-0.00
31
183
29
87
3.77
8.63
2.7
1.6
—
—
—
0
0
73
375
2.57
8.49
4.6
2.6
—
—
—
0
0
12
7
18.20
8.19
1.1
1.0
—
—
—
0
0
18
26
7.55
8.00
1.6
1.4
—
—
—
0
0
15
16
10.09
7.95
1.7
1.4
—
—
—
0
0
23
62
4.10
7.91
1.8
2.8
—
—
—
0
0
19
31
6.71
7.78
1.6
1.6
—
—
—
0
0
16
20
8.65
7.78
1.2
1.1
—
—
—
0
0
20
51
4.28
7.38
1.6
2.8
1.33
2.81
ratio
0.56
15
22
21
56
4.10
7.31
1.8
1.6
0.00
0.00
g/l
-0.00
21
51
13
14
9.89
6.91
3.9
4.4
1334.08
972.93
mg
0.29
13
14
20
54
4.03
6.85
1.4
1.2
—
—
—
0
0
17
29
6.35
6.80
6.7
3.4
13.32
9.70
pmol/l
0.47
17
29
56
278
2.46
6.78
1.8
1.7
1128.81
1195.70
nmol/l
0.21
49
216
106
692
2.25
6.73
8.1
3.1
185.23
127.47
ug/l
2.44
100
638
16
26
6.63
6.63
1.7
1.5
—
—
—
0
0
76
436
2.27
6.58
2.7
2.1
2.58
2.99
mg/l
1.12
65
378
17
31
5.93
6.48
1.8
1.4
—
—
—
0
0
17
31
5.93
6.48
1.8
1.4
—
—
—
0
0
18
47
4.14
6.43
6.1
3.0
3.17
2.77
index
0.09
12
26
14
21
7.12
6.17
3.6
4.0
—
—
—
0
0
107
719
2.17
6.11
4.7
3.1
—
—
estimate
—
0
0
8
6
13.85
5.12
1.5
1.2
1.94
1.32
ratio
—
8
6
18
56
3.45
5.04
1.4
1.6
0.00
0.00
g/l
-0.00
18
49
15
33
4.85
4.99
1.3
1.5
—
—
—
0
0
16
47
3.63
4.87
1.6
1.4
—
—
—
0
0
42
212
2.27
4.76
11.6
10.2
-0.42
1.01
mmol/l
1.12
33
179
56
318
2.09
4.73
4.6
4.1
576.15
208.66
ng/l
0.67
48
261
126
956
2.01
4.59
12.3
5.6
6.63
6.70
mmol/l
0.18
121
902
23
89
2.81
4.51
15.4
3.9
24.34
25.15
mmol/l
0.49
23
89
17
55
3.30
4.49
5.9
2.3
24.34
24.06
mmol/l
0.11
17
55
16
50
3.41
4.45
1.7
1.6
—
—
—
0
0
15
38
4.20
4.41
1.3
1.6
—
—
—
0
0
10
16
6.54
4.35
1.2
1.7
—
—
—
0
0
60
360
1.99
4.32
3.2
1.8
2.07
1.53
mg/l
0.46
55
291
9
13
7.21
4.21
1.4
1.4
—
—
—
0
0
10
17
6.15
4.19
1.2
1.7
—
—
—
0
0
9
14
6.69
4.03
5.6
2.1
0.67
0.86
index
—
9
14
142
1149
2.03
3.99
11.9
4.0
19.52
12.54
mm/h
4.03
137
1055
8
12
6.91
3.71
2.9
2.8
—
—
—
0
0
9
16
5.85
3.70
1.6
1.7
—
—
—
0
0
9
16
5.85
3.70
1.6
1.7
—
—
—
0
0
9
16
5.85
3.70
1.6
1.7
—
—
—
0
0
15
51
3.11
3.67
1.8
1.4
—
—
—
0
0
8
13
6.38
3.54
1.6
1.5
—
—
—
0
0
14
48
3.07
3.38
1.2
1.4
—
—
—
0
0
6
7
8.81
3.28
2.3
2.0
107.50
76.57
ug/l
—
6
7
6
7
8.81
3.28
2.0
3.1
—
—
—
0
0
69
470
1.75
3.19
10.0
3.9
0.00
0.01
estimate
0.50
29
163
12
36
3.49
3.08
1.7
1.4
—
—
—
0
0
93
697
1.68
2.98
2.4
2.2
94.29
96.53
pmol/l
0.16
54
375
70
487
1.71
2.96
2.0
1.8
18.66
20.67
nmol/l
0.48
65
406
6
9
6.84
2.89
1.7
1.3
—
—
—
0
0
79
571
1.67
2.88
6.6
3.5
2.31
2.36
mmol/l
2.60
74
506
26
135
2.08
2.72
11.9
4.3
1.24
1.22
mmol/l
0.99
26
114
6
10
6.16
2.72
1.7
1.4
—
—
—
0
0
6
12
5.13
2.42
1.3
1.1
—
—
—
0
0
8
22
3.75
2.39
1.3
1.3
—
—
—
0
0
5
8
6.39
2.38
1.8
1.5
—
—
—
0
0
5
8
6.39
2.38
1.8
1.5
—
—
—
0
0
5
8
6.39
2.38
1.8
1.5
—
—
—
0
0
5
8
6.39
2.38
1.8
1.5
—
—
—
0
0
13
54
2.51
2.25
3.6
1.7
—
—
—
0
0
12
48
2.60
2.23
1.3
1.2
—
—
—
0
0
13
55
2.47
2.17
4.0
1.8
—
—
—
0
0
6
14
4.39
2.17
2.2
4.5
0.67
0.86
%
—
6
14
12
49
2.55
2.15
1.3
1.2
—
—
—
0
0
13
56
2.42
2.10
6.5
3.7
1.16
1.70
mmol/l
2.62
13
56
5
10
5.10
2.08
1.4
1.1
—
—
—
0
0
70
528
1.53
1.99
3.6
3.2
4269.43
1368.26
ng/l
0.70
60
446
5
11
4.64
1.95
1.4
1.2
—
—
—
0
0
5
11
4.64
1.95
1.4
1.1
—
—
—
0
0
5
11
4.64
1.95
7.8
1.7
1.52
-0.95
mmol/l
—
5
11
5
11
4.64
1.95
1.4
1.1
—
—
—
0
0
5
12
4.25
1.83
1.4
1.1
—
—
—
0
0
7
23
3.12
1.82
2.0
1.1
—
—
—
0
0
19
103
1.94
1.79
2.1
1.4
—
—
—
0
0
82
650
1.47
1.79
12.3
3.8
0.00
0.06
estimate
1.05
28
141
6
18
3.41
1.76
1.2
1.2
—
—
—
0
0
19
105
1.90
1.70
12.9
4.3
53.26
51.11
%
0.14
19
105
6
19
3.23
1.67
1.7
1.3
—
—
—
0
0
62
480
1.44
1.48
11.5
3.3
0.00
0.01
estimate
0.50
27
141
6
25
2.45
1.25
1.0
1.1
—
—
—
0
0
15
87
1.79
1.19
1.2
1.2
—
—
—
0
0
24
168
1.49
0.96
2.1
2.5
0.22
0.22
g/l
0.11
24
154
135
1446
0.75
0.91
5.5
5.2
5.90
5.98
mmol/l
0.18
127
1322
48
385
1.33
0.90
10.3
3.9
1.02
1.02
kg/l
0.04
38
262
6
33
1.84
0.80
1.5
1.3
—
—
—
0
0
0
25
0.00
0.79
0.0
1.8
—
—
—
0
0
7
42
1.69
0.69
1.0
1.3
—
—
—
0
0
74
655
1.22
0.61
5.6
4.0
120.51
39.11
ng/l
0.78
62
483
0
23
0.00
0.58
0.0
1.5
—
1.17
—
0
13
0
23
0.00
0.58
0.0
1.5
—
0.90
—
0
13
0
23
0.00
0.58
0.0
1.5
—
0.98
—
0
13
6
37
1.64
0.56
4.0
4.2
31.67
34.09
mg/l
—
6
29
6
40
1.52
0.52
1.3
1.3
—
—
—
0
0
156
1500
1.26
0.49
57.6
16.9
24.48
25.38
mg/l
0.17
151
1258
107
996
1.18
0.48
4.5
3.2
70.74
52.37
u/l
0.66
102
938
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
36
415
0.84
0.39
4.3
4.6
25.41
22.49
%
0.35
17
213
5
35
1.44
0.39
1.8
1.4
—
—
—
0
0
26
304
0.83
0.33
3.0
3.2
1.03
0.78
ug/l
0.26
20
209
23
193
1.22
0.32
1.6
1.5
—
—
—
0
0
31
270
1.18
0.30
1.4
1.3
31.47
35.08
iu/ml
0.13
12
86
32
282
1.16
0.28
1.5
1.6
—
—
—
0
0
18
150
1.22
0.27
2.0
1.4
—
—
—
0
0
145
1488
0.88
0.25
7.4
6.0
2.62
2.64
mmol/l
0.09
139
1375
14
168
0.82
0.24
1.5
2.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
94
903
1.08
0.18
3.6
2.9
—
—
—
0
0
41
382
1.09
0.16
1.4
1.2
0.90
0.92
u/ml
—
9
94
7
85
0.82
0.15
1.3
1.0
—
—
—
0
0
136
1387
0.93
0.14
6.1
5.4
2.02
1.92
mu/l
0.37
130
1251
136
1386
0.93
0.13
6.0
4.4
1.36
1.28
mmol/l
0.73
129
1260
143
1453
0.93
0.12
7.0
5.1
1.50
1.45
mmol/l
0.75
137
1334
5
45
1.11
0.10
1.0
1.2
1.70
1.51
g/l
—
5
45
5
47
1.07
0.09
1.0
1.2
0.72
0.87
g/l
—
5
47
14
155
0.90
0.09
1.4
2.3
—
—
—
0
0
144
1459
0.94
0.09
7.0
5.2
4.57
4.54
mmol/l
0.12
137
1347
18
192
0.93
0.06
18.6
8.2
—
—
—
0
0
115
1151
1.00
0.00
5.4
4.3
14.89
14.87
pmol/l
0.02
106
1035
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
7.19
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_HYPERANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HYPERANG | 3.134 [2.31, 4.24] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.178 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 383 females with M13_HYPERANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HYPERANG | 2.479 [1.81, 3.4] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 304 males with M13_HYPERANG died.
Mortality risk
Mortality risk for people of age
years, who have M13_HYPERANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.298% | 0.555% |
| 5 | 1.629% | 3.059% |
| 10 | 4.34% | 7.777% |
| 15 | 7.969% | 14.342% |
| 20 | 13.634% | 23.512% |
Relationships between endpoints
↥Index endpoint: M13_HYPERANG – Hypersensitivity angiitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data