Calcification and ossification of muscle

M13_CALCIOSSIMUSCLE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M61 Hospital discharge: ICD-9 — 7281B\|7281X Hospital discharge: excluded ICD-10 — M61.0, M61.1 Cause of death: ICD-10 — M61 Cause of death: ICD-9 — 7281B\|7281X Cause of death: excluded ICD-10 — M61.0, M61.1 2 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	94

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M60-M63
Name in latin: Calcificatio et ossificatio musculi

NAME	M13_CALCIOSSIMUSCLE
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M61
HD_ICD_9	7281B\|7281X
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL	M61[0-1]
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M61
COD_ICD_9	7281B\|7281X
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL	M61[0-1]
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Calcification and ossification of muscle based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	594	264	323
Only index persons	508	233	275
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	53.41	53.62	53.09
Only index persons	52.03	52.67	51.49

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	94	44	50
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	53.60	48.76	57.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
96: Matched controls
960

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M61.9

ICD-10 Finland

Calcification and ossification of muscle, unspecified

+∞

41.7

M61.4

ICD-10 Finland

Other calcification of muscle

+∞

22.8

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

7.0

14.7

N03AX16

ATC

[U] pregabalin

5.2

13.4

107

M61.5

ICD-10 Finland

Other ossification of muscle

+∞

11.7

M61.3

ICD-10 Finland

Calcification and ossification of muscles associated with burns

+∞

10.6

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

61.4

9.9

M61.2

ICD-10 Finland

Paralytic calcification and ossification of muscle

+∞

9.5

N02AX02

ATC

tramadol; systemic, rectal

3.7

9.4

253

M75.1

ICD-10 Finland

Rotator cuff syndrome

4.2

8.8

N06AX21

ATC

duloxetine; oral

5.8

8.8

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

3.5

8.5

205

M16.1

ICD-10 Finland

Other primary coxarthrosis

4.6

7.7

L13

ICPC

Hip symptom/complaint

3.6

6.8

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

13.6

6.8

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

3.2

6.6

145

M79.6

ICD-10 Finland

Pain in limb

3.0

6.6

209

N02BF01

ATC

gabapentin; oral

4.7

6.4

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.3

6.3

116

7281X

ICD-9 Finland

Disorders of muscle, ligament and fascia, Muscular calcification and ossification[CALCIFICATIO ET OSSIFICATIO MUSCULI ALIA]

+∞

6.3

J01MA02

ATC

ciprofloxacin; systemic

2.9

6.2

237

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020779) Urea [Moles/volume] in Serum or Plasma

4.03

6.77

9.6

6.4

9.25

10.43

mmol/l

0.16

(3019977) pH of Arterial blood

3.68

6.75

9.2

7.1

7.43

7.42

0.28

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

353

2.62

5.01

4.1

2.7

—

estimate

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.89

5.00

12.4

8.8

95.24

92.79

1.27

(3003458) Phosphate [Moles/volume] in Serum or Plasma

100

3.03

4.87

9.0

5.0

1.08

1.07

mmol/l

0.05

(3019060) Gas panel - Arterial blood

3.77

4.54

4.9

3.6

—

(3026008) Bacteria identified in Urine by Culture

217

2.45

4.24

4.8

2.9

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

3.23

4.23

2.6

2.2

2.29

12.75

ug/l

1.59

(3005322) IgE [Units/volume] in Serum or Plasma

4.53

4.09

1.6

1.3

260.05

113.77

u/ml

0.31

(3007853) Bacteria identified in Skin by Aerobe culture

2.87

4.08

3.4

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

167

2.49

4.04

2.2

1.7

1.29

1.79

mg/l

0.45

133

(3052851) Hemolysis interference index of Serum or Plasma

5.26

4.01

2.6

3.3

0.17

3.57

index

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

132

2.58

3.96

1.8

1.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.29

3.96

1.6

1.5

—

(3042936) Bacteria identified in Isolate by Culture

120

2.60

3.83

2.5

1.9

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

3.06

3.72

1.5

2.0

0.22

g/l

0.16

(3004588) Protein electrophoresis panel - Serum or Plasma

3.00

3.43

1.6

2.7

—

(3032080) INR in Blood by Coagulation assay

370

2.14

3.27

15.8

13.1

1.22

1.24

inr

0.16

301

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

4.34

3.19

3.4

2.4

233.30

251.04

ug/l

—

(4195642) Thrombophilia screening test

7.90

3.10

1.2

1.5

—

(42870588) Differential panel, method unspecified - Blood

259

2.11

3.10

6.8

5.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

6.19

3.08

1.0

1.8

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

186

2.18

3.05

2.3

1.9

2.34

2.94

mg/l

1.24

161

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

202

2.15

3.05

4.3

2.3

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

3.75

3.01

1.4

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

7.02

2.91

1.2

2.7

—

(3018418) pH of Serum or Plasma

232

2.06

2.83

6.5

4.1

7.39

7.40

0.35

164

(3014576) Chloride [Moles/volume] in Serum or Plasma

115

2.32

2.80

12.7

5.6

104.52

105.17

mmol/l

0.30

115

(3037522) Nuclear Ab [Titer] in Serum

2.48

2.80

1.7

1.3

337.14

498.18

titre

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.73

2.78

2.3

1.9

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

5.30

2.78

1.4

1.3

—

(40761535) Cells panel - Urine sediment

3.05

2.76

4.8

3.1

—

(3023368) Bacteria identified in Blood by Culture

234

2.03

2.75

6.6

4.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

304

1.99

2.73

4.1

4.0

21.67

50.82

ng/l

1.33

217

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.26

2.63

2.3

2.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

107

2.23

2.44

1.5

1.2

1.27

8.30

u/ml

—

(3002582) Erythrocytes [#/volume] in Urine

260

1.92

2.43

4.6

2.7

89.14

300.48

e6/l

0.38

199

(40768806) Pleura Pathology biopsy report

6.52

2.40

1.6

2.4

—

(3020891) Body temperature

3.16

2.36

7.6

4.1

36.88

37.01

°c

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

102

2.21

2.31

1.6

1.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

132

2.09

2.31

3.8

2.4

1.89

1.18

e6/l

0.34

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

329

1.84

2.23

2.4

2.0

87.24

92.88

pmol/l

0.45

175

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

275

1.86

2.23

5.0

2.7

—

(3021589) Normoblasts [#/volume] in Blood

330

1.83

2.20

10.4

13.0

0.00

0.01

e9/l

0.60

267

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.15

2.08

4.7

4.8

227.84

262.41

u/l

0.53

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.26

2.06

2.1

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

263

1.81

2.05

4.7

2.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

138

1.99

2.04

1.5

2.13

2.90

g/l

1.04

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.51

2.00

1.6

1.1

—

(3013512) EKG study

276

1.77

1.93

3.4

3.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.35

1.92

1.6

1.0

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

3.35

1.92

1.6

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

4.33

1.84

1.0

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

120

1.96

1.81

3.8

2.6

2.14

2.36

e6/l

0.06

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.48

1.77

2.0

1.4

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

3.99

1.73

1.4

1.1

345.00

429.38

mg/l

—

(3000991) Gas panel - Venous blood

2.17

1.69

15.9

6.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.03

1.69

1.5

1.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.94

1.68

1.3

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

223

1.73

1.67

4.5

2.6

0.42

0.50

e6/l

0.10

166

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.06

1.67

3.7

6.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

124

1.89

1.64

1.5

1.2

36.08

59.57

iu/ml

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

2.55

1.57

2.5

2.3

1.11

1.69

g/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

151

1.79

1.54

1.2

17.26

1.65

u/ml

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

768

2.15

1.49

30.6

14.7

30.59

26.42

mg/l

0.41

624

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

466

1.62

1.46

2.6

3.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.84

1.46

2.7

1.7

—

(3018095) Leukocytes [#/volume] in Urine

304

1.61

1.43

5.4

3.1

66.79

93.81

e6/l

0.29

217

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.52

1.42

1.4

2.5

24.16

25.63

mmol/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.40

1.30

1.0

1.1

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

2.87

1.30

1.2

7.80

6.54

u/l

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

808

2.07

1.28

35.7

17.3

4.02

3.98

mmol/l

0.71

788

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.20

1.21

4.3

2.6

0.56

0.67

—

(3019309) Folate [Moles/volume] in Red Blood Cells

136

1.70

1.21

1.8

1.6

856.37

1203.68

nmol/l

1.37

102

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.39

1.20

1.3

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.09

1.15

4.3

2.7

1.45

1.29

—

(40760892) CBC W Ordered Manual Differential panel - Blood

191

1.58

1.11

3.4

4.4

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.45

1.10

2.2

3.2

—

(3022145) Colonoscopy Study observation

1.85

1.09

1.2

1.4

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.77

1.08

1.5

4.7

2.24

89.97

ug/l

—

(36660697) Celiac disease serology panel - Serum

2.05

1.07

1.0

1.3

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.95

1.01

1.5

0.97

1.69

g/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

135

1.61

0.99

1.9

1.8

—

(3015736) pH of Urine

334

1.46

0.99

4.0

2.9

6.20

6.12

0.13

190

(3012544) pH of Venous blood

1.75

0.93

8.3

2.7

7.33

7.39

—

(40758558) Short blood count panel - Blood

226

1.48

0.92

5.4

6.6

—

(3035350) Ketones [Presence] in Urine by Test strip

406

1.42

0.91

4.2

3.5

0.00

estimate

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.81

0.90

1.5

1.3

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.81

0.83

4.9

3.3

5.11

5.19

kpa

—

(3021601) Nitrite [Presence] in Urine by Test strip

402

1.39

0.81

4.1

3.5

0.00

estimate

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.80

0.0

1.5

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.80

0.0

1.3

—

200.73

—

(3009261) Glucose [Presence] in Urine by Test strip

414

1.37

0.78

4.3

3.5

0.00

estimate

—

(3016879) Cocaine [Presence] in Urine

2.24

0.77

1.4

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.73

0.77

1.2

1.5

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.14

0.75

1.2

1.6

—

(3019150) Specific gravity of Urine by Refractometry

171

1.45

0.75

5.4

3.3

1.02

kg/l

0.28

110

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.86

0.74

1.3

1.7

—

(3028300) Cannabinoids [Presence] in Urine

2.05

0.74

1.4

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.05

0.74

1.2

2.0

—

(3027008) Opiates [Presence] in Urine

2.05

0.74

1.4

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

843

1.76

0.73

37.0

19.4

85.13

79.18

umol/l

0.37

826

(3019550) Sodium [Moles/volume] in Serum or Plasma

805

1.66

0.73

36.4

17.3

139.38

139.78

mmol/l

0.71

787

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.61

0.73

2.3

2.4

14.75

13.61

nmol/l

0.12

(3000764) Benzodiazepines [Presence] in Urine

1.97

0.71

1.4

1.3

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

642

1.41

0.71

30.7

19.6

14.01

13.72

1.13

637

(3041096) Erythrocytes [Presence] in Urine by Automated

242

0.68

0.69

3.2

3.1

0.00

estimate

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.64

0.66

6.9

2.5

23.90

23.67

mmol/l

—

(3000492) Spirometry study

1.59

0.66

2.2

1.5

—

(40761511) CBC panel - Blood by Automated count

810

1.59

0.64

23.5

14.3

—

(3008898) HLA-B27 [Presence]

1.70

0.62

1.2

1.1

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.59

0.0

1.1

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.76

0.59

1.0

1.1

—

(3022313) Gas panel - Capillary blood

1.62

0.55

7.2

3.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.57

0.54

1.5

1.3

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.57

0.54

4.0

4.2

1.57

1.54

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

119

1.41

0.52

1.3

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

108

0.62

0.52

1.3

1.5

—

(40768804) Tissue Pathology biopsy report

315

1.28

0.51

2.4

2.1

—

(40768797) Stomach Pathology biopsy report

1.46

0.51

1.4

1.3

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

842

1.54

0.49

15.9

11.0

25.81

26.21

u/l

0.11

819

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

112

1.40

0.48

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.48

0.48

2.1

3.9

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

280

1.27

0.46

4.1

3.0

36.68

29.97

u/l

0.34

269

(3002256) Pathology report gross observation

104

1.41

0.46

1.5

1.3

—

(3012516) Albumin [Mass/volume] in Urine

262

1.27

0.45

3.7

3.2

229.02

47.28

mg/l

0.48

181

(1761868) Lipid panel - Serum or Plasma

330

0.79

0.44

2.5

3.1

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.7

—

15.77

—

(3012501) Base excess in Blood by calculation

0.00

0.41

0.0

3.3

—

2.59

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.41

0.0

3.3

—

8.59

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.41

0.0

3.3

—

4.76

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.50

0.41

4.6

4.9

1.06

0.87

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.40

0.40

1.5

1.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.41

0.39

1.0

1.6

—

(3000494) Fungus identified in Specimen by Culture

1.36

0.38

1.5

—

(3025941) Bacteria identified in Stool by Culture

1.46

0.36

1.7

1.2

—

(3003694) ABO and Rh group [Type] in Blood

221

1.24

0.36

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

322

0.82

0.35

4.8

3.4

0.00

0.05

estimate

—

(3029937) Albumin [Presence] in Urine by Test strip

231

0.83

0.25

5.3

3.6

0.00

0.02

estimate

—

(21494755) Public health laboratory ask at order entry panel

0.70

0.25

1.3

1.4

—

(3000963) Hemoglobin [Mass/volume] in Blood

869

1.33

0.23

42.5

22.7

132.16

135.89

g/l

1.39

860

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

868

1.35

0.23

43.9

22.8

39.73

40.71

1.11

857

(3026361) Erythrocytes [#/volume] in Blood

868

1.35

0.23

43.0

22.6

4.37

4.51

e12/l

1.68

848

(3010813) Leukocytes [#/volume] in Blood

868

1.35

0.23

42.9

22.7

6.96

6.68

e9/l

0.65

848

(3024731) MCV [Entitic mean volume] in Red Blood Cells

868

1.35

0.23

42.1

22.6

91.92

91.23

0.85

858

(3035941) MCH [Entitic mass]

868

1.35

0.23

42.1

22.5

30.55

30.41

0.37

858

(4035726) Immunohistochemistry procedure

0.76

0.23

1.7

1.5

—

(3007461) Platelets [#/volume] in Blood

867

1.36

0.23

42.9

22.6

248.10

245.65

e9/l

0.14

850

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.8

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.4

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.21

0.0

2.5

—

1.32

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.27

0.20

5.7

5.3

25.83

24.48

mmol/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

272

1.15

0.20

4.4

3.9

55.82

7.94

mg/mmol

0.49

178

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.76

0.17

1.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.21

0.17

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.07

0.08

2.1

1.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

252

1.04

0.02

3.3

4.7

20.38

20.46

0.01

124

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

187

1.02

0.00

2.9

3.2

0.68

0.80

ug/l

0.33

122

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

15.2

—

8.42

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

1.0

—

13.40

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

30.7

—

1558.00

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

75.20

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

337.40

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.4

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.6

—

14.75

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

2.7

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.0

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.97

-0.00

2.1

1.8

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

2.9

—

89.80

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.6

—

3.51

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

19.8

—

845.89

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_CALCIOSSIMUSCLE and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
M13_CALCIOSSIMUSCLE	1.461 [1.02, 2.09]	0.037
Birth year	0.993 [0.98, 1.0]	0.108

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 217 males with M13_CALCIOSSIMUSCLE died.

Mortality risk

Mortality risk for people of age

years, who have M13_CALCIOSSIMUSCLE.

N-year risk	Females	Males
1	No data	0.288%
5	No data	2.012%
10	No data	5.072%
15	No data	9.751%
20	No data	16.361%

Relationships between endpoints

↥

Index endpoint: M13_CALCIOSSIMUSCLE – Calcification and ossification of muscle

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Calcification and ossification of muscle

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints