Lichenoid drug reaction

LICHENOID_DRUG_REACTION

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L43.2# 1 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	94

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	LICHENOID_DRUG_REACTION
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L432
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lichenoid drug reaction based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	477	331	146
Only index persons	447	310	137
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	-	60.35	59.94
Only index persons	59.71	59.82	59.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	94	66	28
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	58.16	57.86	58.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
97: Matched controls
970

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L43.2

ICD-10 Finland

Lichenoid drug reaction

+∞

139.8

L43.8

ICD-10 Finland

Other lichen planus

40.6

23.5

L43.9

ICD-10 Finland

Lichen planus, unspecified

23.9

15.0

A07AA02

ATC

nystatin; oral

6.0

10.1

EKA10

NOMESCO Finland

iopsy of buccal mucosa

12.0

10.0

L43.0

ICD-10 Finland

Hypertrophic lichen planus

61.3

9.9

EJA10

NOMESCO Finland

Biopsy of tongue or floor of mouth

21.1

9.2

D07AD01

ATC

clobetasol; topical

4.0

9.1

115

K03.66

ICD-10 Finland

Tooth plaque

5.7

9.0

ECA20

NOMESCO Finland

Biopsy of gingiva

36.7

8.2

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

4.5

7.9

K13.74

ICD-10 Finland

Lichen rubs planus in the mouth

12.3

7.6

K13.78

ICD-10 Finland

Other change in the oral mucosa

12.3

7.6

D07AC01

ATC

betamethasone; topical

3.2

7.3

274

XQ802

NOMESCO Finland

Epicutan test

8.9

6.9

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

125

3.65

7.91

6.4

5.5

29.00

34.11

1.26

(3019225) pH of Specimen

3.74

7.28

7.8

3.2

7.43

7.33

1.34

(3026389) Candida sp identified in Specimen by Organism specific culture

13.58

6.77

2.1

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

112

3.43

6.70

7.5

8.3

—

(4146454) Self-monitoring of blood glucose

9.55

4.37

3.3

3.1

—

(3045414) Leukocytes [Presence] in Urine

2.87

4.07

2.2

0.00

estimate

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

698

0.43

3.95

24.2

23.3

13.81

13.88

0.16

690

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

234

2.30

3.79

2.0

2.3

—

(3044640) Blood type and Crossmatch panel - Blood

313

2.23

3.68

2.0

2.3

—

(1761868) Lipid panel - Serum or Plasma

306

0.34

3.51

3.2

3.7

—

(3029937) Albumin [Presence] in Urine by Test strip

287

2.15

3.33

6.5

4.5

0.00

estimate

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

7.90

3.10

1.0

1.1

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.46

2.43

1.4

1.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

351

1.88

2.38

4.0

3.7

1642.65

1290.40

ng/l

0.26

301

(3012516) Albumin [Mass/volume] in Urine

353

1.86

2.33

3.5

3.2

91.17

58.71

mg/l

0.16

217

(3037522) Nuclear Ab [Titer] in Serum

134

2.05

2.21

1.5

1.4

1073.33

619.46

titre

—

(42870588) Differential panel, method unspecified - Blood

304

1.82

2.15

8.1

5.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

436

1.82

2.14

3.3

2.6

78.42

79.18

nmol/l

0.07

383

(3044927) Protein electrophoresis panel - Urine

5.20

2.09

1.4

1.1

—

(3009508) Creatinine [Moles/volume] in Urine

352

1.79

2.09

3.5

3.1

7.12

7.05

mmol/l

0.03

284

(3020682) Albumin/Creatinine [Ratio] in Urine

363

1.78

2.05

4.1

3.8

17.01

10.43

mg/mmol

0.17

212

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

431

1.78

2.02

2.4

2.8

—

estimate

—

(3015736) pH of Urine

412

1.77

2.01

5.4

3.9

6.74

6.23

2.65

232

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

472

1.79

1.99

11.9

6.3

1.20

1.22

mmol/l

0.74

434

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

4.73

1.96

1.2

1.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

526

1.80

1.91

12.5

6.8

1.20

1.22

mmol/l

0.45

451

(3009261) Glucose [Presence] in Urine by Test strip

516

1.79

1.90

5.9

4.5

0.00

estimate

—

100

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

689

2.06

1.90

7.4

5.0

14.93

13.76

mm/h

0.30

625

(3035350) Ketones [Presence] in Urine by Test strip

512

1.73

1.76

5.9

4.5

0.00

14.76

estimate

—

110

(40761535) Cells panel - Urine sediment

2.15

1.75

3.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

503

1.72

1.73

5.9

4.4

0.00

estimate

—

107

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

676

0.59

1.67

28.6

24.8

332.54

330.55

g/l

0.80

676

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

725

2.00

1.61

11.0

8.8

80.90

80.70

u/l

0.02

675

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

402

1.63

1.56

3.7

4.5

17.45

38.37

ng/l

1.79

317

(3000991) Gas panel - Venous blood

1.98

1.52

15.3

8.2

—

(3022313) Gas panel - Capillary blood

2.44

1.47

5.2

2.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.84

1.46

2.2

1.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

231

1.65

1.44

2.4

3.4

351.74

348.32

umol/l

0.05

190

(3005719) IgG [Mass/volume] in Serum or Plasma

2.01

1.43

3.2

2.9

10.66

9.86

g/l

0.31

(3000494) Fungus identified in Specimen by Culture

122

1.81

1.41

1.4

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

3.04

1.37

1.0

1.2

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.93

1.36

3.1

2.5

0.19

0.21

g/l

0.56

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

1.34

0.0

2.2

—

0.00

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

432

1.56

1.33

2.0

2.2

103.06

99.60

pmol/l

0.18

206

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

553

1.61

1.33

3.7

3.3

57.26

50.70

u/l

0.21

514

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.47

1.33

2.1

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.40

1.30

1.6

2.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.35

1.13

1.7

1.9

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.45

1.10

1.0

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

837

2.04

1.09

6.7

5.7

1.53

1.52

mmol/l

0.03

758

(3024561) Albumin [Mass/volume] in Serum or Plasma

447

1.47

1.05

5.5

4.3

35.26

35.21

g/l

0.02

417

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

829

1.89

1.03

19.7

19.0

71.55

74.71

ml/min/173m2

0.82

774

(1002224) Polysomnography panel

0.00

0.99

0.0

1.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

153

1.57

0.97

11.4

6.5

101.14

103.88

mmol/l

0.94

153

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

690

1.56

0.96

6.0

4.7

15.13

15.03

pmol/l

0.13

630

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

841

1.97

0.96

6.6

5.8

4.58

4.59

mmol/l

0.02

768

(3019150) Specific gravity of Urine by Refractometry

215

1.50

0.96

8.4

4.6

1.02

kg/l

0.18

146

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

128

1.60

0.95

3.2

4.4

6.09

13.48

ug/l

0.74

104

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

252

1.47

0.95

2.7

2.3

2.59

3.20

mg/l

1.23

216

(3002032) Base excess in Venous blood by calculation

103

1.66

0.95

2.8

3.5

1.99

2.56

mmol/l

0.43

(40768797) Stomach Pathology biopsy report

137

1.58

0.94

1.5

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.75

0.93

1.2

2.6

—

(3048689) Calprotectin [Mass/mass] in Stool

104

1.64

0.91

2.9

1.8

127.55

125.45

ug/g

0.01

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

202

1.47

0.85

1.3

1.16

1.89

u/ml

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.93

0.83

1.5

1.8

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.81

0.83

2.3

3.0

0.56

0.66

—

(40768443) Skin Pathology biopsy report

1.76

0.83

1.5

1.3

—

(3018418) pH of Serum or Plasma

346

0.70

0.82

4.0

4.4

7.40

7.39

0.23

254

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

392

1.39

0.81

6.0

4.3

0.00

estimate

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.77

0.79

2.3

3.1

1.09

1.04

—

(3019060) Gas panel - Arterial blood

1.77

0.79

5.2

3.9

—

(40768804) Tissue Pathology biopsy report

384

1.38

0.78

2.5

2.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.78

0.0

5.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

100

1.59

0.78

1.7

1.6

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.14

0.75

1.2

1.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.91

0.75

1.1

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

171

1.45

0.75

2.0

1.9

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.61

0.72

2.8

3.6

24.26

25.07

mmol/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

805

1.60

0.71

5.6

4.8

1.26

1.28

mmol/l

0.11

726

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

834

1.59

0.66

8.4

7.3

40.24

40.28

mmol/mol

0.02

775

(3019309) Folate [Moles/volume] in Red Blood Cells

184

1.40

0.66

2.0

1.7

1217.65

1246.16

nmol/l

0.04

136

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.76

0.64

1.2

1.7

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

1.76

0.64

1.4

—

0.01

—

(3019977) pH of Arterial blood

123

1.46

0.63

15.5

6.8

7.41

7.42

0.16

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

856

1.71

0.62

7.4

6.8

2.61

mmol/l

0.00

778

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.70

0.62

1.2

1.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.60

0.0

3.1

—

48.77

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.60

0.0

1.2

—

2.47

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

848

1.60

0.59

21.7

18.4

20.00

23.96

mg/l

0.55

707

(4035726) Immunohistochemistry procedure

1.48

0.58

1.4

1.5

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.59

0.55

3.5

3.0

28.83

28.51

u/l

—

(36660697) Celiac disease serology panel - Serum

1.42

0.52

1.2

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

324

1.28

0.52

2.8

2.5

56.87

69.67

u/l

0.44

295

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

542

1.28

0.52

7.0

6.9

11.03

11.12

umol/l

0.03

510

(3000492) Spirometry study

1.50

0.50

2.0

1.7

—

(3023420) DNA double strand Ab [Units/volume] in Serum

1.60

0.50

3.9

1.6

—

6.92

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.60

0.50

1.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.56

0.49

1.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

844

1.46

0.47

7.2

5.9

6.12

6.07

mmol/l

0.10

771

(3015377) Calcium [Moles/volume] in Serum or Plasma

357

1.26

0.47

4.2

3.3

2.39

2.36

mmol/l

0.58

322

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.46

0.45

1.7

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

215

1.29

0.44

1.5

1.9

790476593.62

460.13

pmol/l

0.79

176

(3042936) Bacteria identified in Isolate by Culture

142

1.33

0.42

1.5

1.9

—

(40761511) CBC panel - Blood by Automated count

869

1.49

0.42

18.9

15.9

—

(3000012) Reticulocyte production index

0.00

0.41

0.0

2.5

—

0.81

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.41

0.0

1.0

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

327

0.80

0.40

3.7

3.1

38.18

30.91

u/l

0.28

306

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.40

0.0

1.9

—

40.00

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

171

1.29

0.40

1.3

1.4

60.74

39.06

iu/ml

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.39

0.0

1.9

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.43

0.38

22.2

7.8

23.26

24.98

mmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

433

1.21

0.38

3.3

2.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.49

0.37

3.8

2.5

—

(3021960) Folate [Moles/volume] in Serum or Plasma

298

1.22

0.35

1.6

1.8

19.25

21.36

nmol/l

0.31

241

(40760892) CBC W Ordered Manual Differential panel - Blood

218

0.79

0.35

6.8

6.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.32

0.33

1.7

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

129

1.29

0.33

2.1

1.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.40

0.32

1.3

—

(3020891) Body temperature

1.40

0.32

3.3

4.5

36.56

36.96

°c

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

205

1.23

0.31

1.9

0.78

1.36

mg/l

1.21

175

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

109

0.71

0.31

5.0

3.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

178

1.23

0.29

1.6

2.19

2.45

g/l

0.35

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

810

1.28

0.28

7.7

5.8

2.08

1.98

mu/l

0.27

736

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

161

1.22

0.26

1.3

1.4

1.29

15.63

u/ml

—

(3018095) Leukocytes [#/volume] in Urine

376

0.85

0.26

5.6

4.5

57.36

46.10

e6/l

0.11

259

(3012544) pH of Venous blood

105

1.27

0.26

3.3

3.4

7.40

7.39

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

157

0.80

0.24

3.8

3.5

1.67

3.67

e6/l

—

(3026008) Bacteria identified in Urine by Culture

337

1.16

0.24

3.0

3.2

—

(3049717) Cytology report of Urine Cyto stain

1.33

0.23

2.8

3.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

136

1.21

0.22

2.4

1.4

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

8.05

—

(3004775) Volume in Urine collected for unspecified duration

0.00

0.21

0.0

2.8

—

709.40

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.21

0.0

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

0.16

—

(3014037) CD3+CD4+ (T4 helper) cells/cells in Blood

0.00

0.20

0.0

2.5

—

46.88

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.20

0.0

2.4

—

107.50

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.20

0.0

2.4

—

4.02

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.20

0.0

2.4

—

1.18

—

(3002256) Pathology report gross observation

119

1.21

0.19

1.4

1.3

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

406

0.89

0.16

4.2

3.0

124.60

107.80

ug/l

0.25

373

(40761536) Microorganisms panel - Urine sediment

0.75

0.16

4.2

4.1

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.17

0.16

23.6

8.1

1.22

1.28

—

(3007853) Bacteria identified in Skin by Aerobe culture

103

1.19

0.14

1.7

1.5

—

(3014051) Protein [Presence] in Urine by Test strip

261

0.89

0.13

3.5

—

0.33

—

(3023368) Bacteria identified in Blood by Culture

270

1.11

0.12

2.9

4.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.18

0.12

2.0

1.5

—

(4024509) Urine culture

1.12

0.09

1.3

1.9

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.10

0.09

3.5

7.05

3848.39

u/ml

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.04

0.07

1.4

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.85

0.07

2.1

1.5

—

(3032080) INR in Blood by Coagulation assay

496

1.06

0.06

14.7

13.4

1.32

1.24

inr

0.37

410

(3003694) ABO and Rh group [Type] in Blood

230

0.94

0.04

1.2

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

380

1.04

0.03

1.9

2.0

1.35

1.30

mmol/l

0.14

306

(3002173) Hemoglobin [Mass/volume] in Arterial blood

112

1.08

0.03

20.3

7.0

120.75

115.36

g/l

0.43

112

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

118

0.92

0.03

1.6

1.4

—

(40758558) Short blood count panel - Blood

289

0.96

0.03

7.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

178

0.95

0.02

4.1

3.3

0.96

0.94

e6/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

166

0.96

0.00

4.0

5.5

26.96

22.05

—

(3041096) Erythrocytes [Presence] in Urine by Automated

284

1.03

0.00

3.5

3.9

0.00

estimate

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

127

1.03

0.00

1.9

—

(3022145) Colonoscopy Study observation

121

0.99

0.00

1.4

1.2

—

(3017732) Neutrophils [#/volume] in Blood

121

0.99

0.00

2.3

3.4

2.60

6.43

e9/l

—

102

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.91

-0.00

29.0

8.1

0.47

0.68

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.1

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.2

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

-0.00

0.0

6.0

—

53.17

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

4.38

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

131.60

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.2

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3027008) Opiates [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.3

—

54.29

—

(3047189) Immunofixation for 24 hour Urine

0.00

-0.00

0.0

2.6

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3028300) Cannabinoids [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.00

-0.00

2.0

1.4

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

99.80

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3000919) Neutrophils/Leukocytes in Pleural fluid

0.00

-0.00

0.0

1.2

—

18.33

—

(3001893) Eosinophils/Leukocytes in Pleural fluid

0.00

-0.00

0.0

1.2

—

1.14

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.1

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.2

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(37021550) Renin [Units/volume] in Plasma --upright

0.00

-0.00

0.0

2.0

—

202.94

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.3

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.2

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

3.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.3

—

37.77

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.0

—

(3027944) Amphetamines [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(3016879) Cocaine [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3039429) Cortisol [Moles/volume] in Saliva (oral fluid)

0.00

-0.00

0.0

2.0

—

33.00

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

13.00

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.5

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.7

—

7.37

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3005532) Lymphocytes/Leukocytes in Pleural fluid

0.00

-0.00

0.0

1.2

—

68.00

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint LICHENOID_DRUG_REACTION and mortality.

Females

Parameter	HR [95% CI]	p-value
LICHENOID_DRUG_REACTION	1.212 [0.91, 1.62]	0.194
Birth year	0.994 [0.99, 1.0]	0.168

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 311 females with LICHENOID_DRUG_REACTION died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have LICHENOID_DRUG_REACTION.

N-year risk	Females	Males
1	0.102%	No data
5	0.546%	No data
10	1.518%	No data
15	3.23%	No data
20	5.826%	No data

Relationships between endpoints

↥

Index endpoint: LICHENOID_DRUG_REACTION – Lichenoid drug reaction

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lichenoid drug reaction

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints