Sunburn

L12_SUNBURN

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L55
  • Hospital discharge: ICD-9 6927A
  • Cause of death: ICD-10 L55
  • Cause of death: ICD-9 6927A

2 out of 7 registries used, show all original rules.

86

4. Check minimum number of events

None

86

5. Include endpoints

None

86

6. Filter based on genotype QC (FinnGen only)

74

Control definitions (FinnGen only)

Control exclude
L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L55-L59
Name in latin
Erythema solare

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 631 298 326
Only index persons 553 272 281
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 37.42 44.67 30.51
Only index persons 36.73 43.53 30.16

-FinnGen-

Key figures

All Female Male
Number of individuals 74 38 36
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 45.39 46.94 43.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
76
Matched controls
760
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L55.9
ICD-10 Finland
Sunburn, unspecified
+∞
36.4
32
*
L55.0
ICD-10 Finland
Sunburn of first degree
+∞
21.9
20
*
L55.8
ICD-10 Finland
Other sunburn
+∞
11.8
11
*
L55.1
ICD-10 Finland
Sunburn of second degree
+∞
8.5
8
*
6927A
ICD-9 Finland
Contact dermatitis and other eczema, Due to solar radiation[ERYTHEMA SOLARE]
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
92
3.35
5.18
3.6
2.3
11.38
13.76
umol/l
1.10
24
85
15
49
3.57
4.07
6.2
8.7
—
—
—
0
0
35
188
2.60
3.96
3.4
2.0
342.40
169.53
u/l
0.34
35
181
16
58
3.23
3.69
5.8
2.8
7.37
7.40
ph
—
9
39
21
91
2.81
3.57
3.9
2.2
2.31
2.37
g/l
0.16
21
83
31
167
2.45
3.39
5.9
4.0
—
—
—
0
0
20
89
2.69
3.21
1.3
1.4
—
—
—
0
0
45
292
2.33
3.17
16.1
10.6
0.00
0.00
e9/l
0.50
38
243
31
174
2.32
3.04
3.6
2.7
362.28
333.15
umol/l
0.64
25
152
6
9
7.12
2.92
1.3
1.0
—
—
—
0
0
54
387
2.37
2.91
5.8
4.6
6.39
6.62
mmol/l
0.63
54
363
47
324
2.18
2.70
9.5
6.5
0.04
0.04
e9/l
0.27
42
286
47
324
2.18
2.70
9.6
6.5
0.64
0.56
e9/l
1.33
42
286
16
70
2.63
2.63
7.4
3.5
1.05
1.00
mmol/l
0.71
16
62
13
51
2.87
2.60
6.8
8.2
2.07
1.05
mmol/l
1.75
13
51
6
11
5.81
2.59
7.3
1.3
—
—
—
0
0
52
380
2.17
2.49
12.4
10.9
4.75
4.14
e9/l
1.02
47
340
47
333
2.08
2.41
9.4
6.4
1.93
1.82
e9/l
0.41
42
302
5
8
6.59
2.41
1.4
1.1
—
—
—
0
0
47
337
2.03
2.29
9.8
6.5
0.21
0.20
e9/l
0.27
42
304
33
210
2.01
2.24
9.5
5.4
—
—
—
0
0
6
14
4.55
2.19
1.2
1.1
—
—
—
0
0
9
31
3.15
2.15
2.2
2.4
25.00
24.95
mmol/l
—
9
31
5
10
5.26
2.10
1.2
1.1
—
—
—
0
0
8
27
3.19
2.00
11.0
11.6
25.06
24.69
mmol/l
—
8
27
25
150
1.99
1.96
1.8
1.6
1.09
0.84
mg/l
0.20
17
120
5
12
4.38
1.85
1.0
1.0
—
—
—
0
0
8
29
2.96
1.85
4.9
3.5
0.60
0.63
%
—
8
29
15
75
2.25
1.85
1.1
1.3
—
—
—
0
0
15
76
2.21
1.79
2.0
1.4
—
—
—
0
0
16
84
2.15
1.76
1.9
1.6
—
—
—
0
0
8
31
2.76
1.71
4.9
3.5
1.15
1.55
%
—
8
31
36
255
1.78
1.65
8.4
6.0
1.20
1.21
mmol/l
0.11
31
243
16
88
2.04
1.56
7.9
7.5
105.31
103.40
mmol/l
1.01
16
88
7
27
2.75
1.55
6.4
1.2
—
—
—
0
0
6
21
3.01
1.54
1.0
1.1
—
—
—
0
0
26
172
1.78
1.47
4.7
3.0
0.15
0.41
e6/l
1.06
21
131
5
17
3.07
1.38
1.6
1.1
—
—
—
0
0
10
48
2.25
1.34
1.3
1.8
—
—
—
0
0
30
212
1.69
1.33
2.5
2.2
—
—
—
0
0
57
482
1.73
1.23
3.8
4.6
14.88
14.81
pmol/l
0.08
52
453
35
263
1.61
1.20
4.7
4.3
35.00
36.12
g/l
0.48
35
250
19
122
1.74
1.17
1.8
1.4
0.98
11.93
u/ml
—
9
55
5
20
2.60
1.17
1.4
1.3
—
—
—
0
0
5
20
2.60
1.17
11.6
1.4
—
—
—
0
0
32
237
1.60
1.16
4.1
3.6
18.10
49.67
ng/l
1.07
22
150
49
402
1.62
1.15
5.3
4.4
—
625.50
—
0
6
33
249
1.57
1.09
2.5
1.9
91.20
95.73
pmol/l
0.16
16
120
23
159
1.64
1.08
4.7
6.2
—
—
—
0
0
5
22
2.36
1.05
1.8
2.3
—
—
—
0
0
7
35
2.10
1.03
7.4
3.3
0.83
0.93
%
—
7
30
37
291
1.53
1.00
26.4
12.1
1.27
1.18
inr
0.43
32
239
7
36
2.04
1.00
6.4
1.3
—
—
—
0
0
7
36
2.04
1.00
1.6
1.4
—
—
—
0
0
7
37
1.98
0.97
6.4
1.3
—
—
—
0
0
41
333
1.50
0.94
4.9
3.8
0.00
0.00
estimate
—
10
64
21
147
1.59
0.93
2.4
1.9
—
—
—
0
0
70
645
2.08
0.92
30.9
14.5
26.33
21.99
mg/l
0.42
62
526
41
335
1.49
0.90
4.7
3.9
0.00
0.00
estimate
-0.00
11
64
19
131
1.60
0.90
1.8
1.3
37.54
23.82
iu/ml
—
8
41
6
30
2.08
0.89
1.0
1.1
—
—
—
0
0
8
46
1.82
0.85
8.9
8.5
21.96
24.87
mmol/l
—
8
46
16
107
1.63
0.85
1.6
1.7
—
—
—
0
0
41
339
1.45
0.82
5.0
3.9
0.00
0.07
estimate
0.49
11
61
0
26
0.00
0.80
0.0
2.5
—
3.49
—
0
14
18
127
1.55
0.77
6.1
3.2
205.33
440.91
ng/l
—
9
94
7
39
1.87
0.75
7.9
3.2
1.36
1.56
%
—
7
34
7
39
1.87
0.75
6.4
1.3
—
—
—
0
0
7
39
1.87
0.75
6.6
1.3
—
—
—
0
0
5
25
2.07
0.74
3.6
1.3
—
—
—
0
0
24
182
1.47
0.74
5.1
3.8
0.00
0.00
estimate
-0.00
11
62
29
230
1.42
0.70
5.8
3.8
103.95
49.02
e6/l
0.25
23
165
7
44
1.65
0.67
1.6
2.0
1.79
6.37
ug/l
—
7
38
8
51
1.63
0.63
1.8
2.3
0.36
0.12
e6/l
—
8
51
61
652
0.67
0.59
6.9
5.3
2.78
2.77
mmol/l
0.03
56
614
6
39
1.58
0.54
7.3
1.2
—
—
—
0
0
20
155
1.39
0.54
2.2
1.3
2.20
2.65
g/l
0.42
15
94
23
183
1.37
0.53
3.9
2.9
—
—
—
0
0
12
84
1.51
0.53
9.5
7.1
7.43
7.42
ph
—
6
49
32
269
1.33
0.52
4.4
3.6
6.02
6.20
ph
0.59
20
159
18
139
1.39
0.49
3.9
4.0
—
—
—
0
0
24
195
1.34
0.49
6.1
3.6
5.30
10.79
mg/mmol
0.66
16
127
5
84
0.57
0.49
5.8
2.7
9.74
9.35
umol/l
—
5
76
23
186
1.34
0.48
6.3
3.2
—
—
—
0
0
24
196
1.33
0.47
4.5
3.2
0.33
0.02
estimate
—
9
54
31
264
1.29
0.45
2.0
1.9
1.47
1.34
mmol/l
0.32
24
219
25
207
1.31
0.44
8.0
6.4
—
—
—
0
0
5
32
1.60
0.43
2.4
1.7
—
6.89
—
0
8
63
591
1.39
0.43
5.8
5.3
1.88
1.96
mu/l
0.25
58
552
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
23
192
1.28
0.38
4.8
3.1
24.62
67.45
mg/l
1.31
14
131
35
310
1.24
0.35
2.6
2.6
—
—
estimate
—
0
0
6
44
1.39
0.35
2.2
1.6
—
—
—
0
0
17
206
0.77
0.35
1.4
1.5
—
—
—
0
0
11
83
1.38
0.34
2.0
1.6
—
—
—
0
0
29
253
1.24
0.33
5.1
3.7
0.20
0.00
estimate
—
10
58
0
11
0.00
0.21
0.0
4.2
—
18.73
—
0
11
0
10
0.00
0.21
0.0
4.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
6.13
—
0
14
16
139
1.19
0.18
5.7
4.2
1.02
1.02
kg/l
—
10
89
9
77
1.19
0.16
1.2
1.2
—
—
—
0
0
28
260
1.12
0.13
2.4
1.9
—
—
—
0
0
27
287
0.91
0.10
3.7
3.0
—
—
—
0
0
6
56
1.08
0.09
1.3
1.4
—
—
—
0
0
7
64
1.10
0.08
1.4
1.6
—
—
—
0
0
8
91
0.87
0.07
2.9
2.0
—
—
—
0
0
10
93
1.09
0.02
1.2
1.4
—
—
—
0
0
62
614
1.05
0.00
6.1
4.5
5.95
5.94
mmol/l
0.02
56
568
10
97
1.04
0.00
1.2
1.3
—
—
—
0
0
19
186
1.03
0.00
5.7
3.7
7.42
7.40
ph
0.62
13
140
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
6.74
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
200.87
—
0
9
6
65
0.92
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.12
—
0
5
0
5
0.00
-0.00
0.0
2.4
—
1.19
—
0
5
8
83
0.96
-0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.0
—
2.27
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
23.22
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_SUNBURN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SUNBURN.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_SUNBURN – Sunburn

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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