Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

L12_SKININOTH

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints L12_AMYLOIDOSISSKIN L12_SKININOTHNAS	46
6. Filter based on genotype QC (FinnGen only)	42

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	L12_SKININOTH
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	L12_AMYLOIDOSISSKIN\|L12_SKININOTHNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other disorders of skin and subcutaneous tissue in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	252	125	126
Only index persons	231	118	113
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	57.92	58.77	57.06
Only index persons	57.10	57.14	57.06

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	42	19	23
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	56.20	50.35	61.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037756) Immunofixation for Serum or Plasma

17.74

7.35

1.7

1.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

20.96

7.13

6.9

4.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.23

5.00

2.7

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.42

4.49

3.6

1.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

5.50

4.48

4.5

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.81

3.70

2.7

1.7

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.99

3.59

2.8

1.1

2.07

3.13

g/l

—

(3018010) Neutrophils/Leukocytes in Blood

188

3.57

3.58

10.6

6.2

55.75

57.47

0.33

181

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.64

3.47

2.8

1.7

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.66

3.45

2.8

1.1

6.27

8.20

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.66

3.45

2.8

1.1

4.87

4.37

g/l

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.66

3.45

2.8

1.1

2.63

3.86

g/l

—

(40768443) Skin Pathology biopsy report

6.70

3.15

1.1

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

5.33

2.72

2.1

1.5

—

(3042936) Bacteria identified in Isolate by Culture

2.98

2.68

3.6

1.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

4.68

2.47

2.4

1.5

—

(40758558) Short blood count panel - Blood

111

2.47

2.16

5.9

7.2

—

(42870588) Differential panel, method unspecified - Blood

131

2.36

2.01

13.0

5.8

—

(3019060) Gas panel - Arterial blood

3.26

1.97

3.5

3.9

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

3.91

1.91

3.8

1.1

2.40

0.06

g/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.19

1.76

2.0

2.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.29

1.70

3.6

2.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.58

1.60

17.0

9.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

178

2.13

1.59

4.8

2.8

—

estimate

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

3.14

1.56

10.8

2.4

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.14

1.56

4.2

3.3

23.90

24.75

mmol/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

129

2.01

1.38

2.9

2.2

133.40

338.23

u/l

0.81

123

(3023420) DNA double strand Ab [Units/volume] in Serum

2.73

1.35

1.3

2.2

—

6.67

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.73

1.35

11.5

2.5

—

(3003694) ABO and Rh group [Type] in Blood

104

2.03

1.35

1.4

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.02

1.29

8.5

4.9

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.61

1.29

4.5

2.5

120.33

130.88

g/l

—

(36660697) Celiac disease serology panel - Serum

2.58

1.18

1.3

1.1

—

(3023368) Bacteria identified in Blood by Culture

118

1.89

1.15

5.4

3.9

—

(3020779) Urea [Moles/volume] in Serum or Plasma

2.25

1.08

10.0

7.3

10.14

8.55

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

158

1.78

1.03

4.5

3.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.10

0.95

4.6

2.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.05

0.94

3.3

2.1

—

(3019150) Specific gravity of Urine by Refractometry

1.81

0.92

7.7

3.7

1.02

kg/l

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.15

0.91

10.0

8.9

1.27

1.17

mmol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

173

1.69

0.88

2.9

2.2

83.76

92.59

pmol/l

0.40

(3023520) Reticulocytes [#/volume] in Blood

2.08

0.88

4.0

3.2

55.83

69.44

e9/l

—

(3044640) Blood type and Crossmatch panel - Blood

118

1.72

0.87

3.8

2.6

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.90

0.84

2.2

2.0

28.30

28.10

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.94

0.82

1.8

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.94

0.82

7.3

1.9

—

(40761535) Cells panel - Urine sediment

1.94

0.82

5.7

3.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.80

0.82

5.6

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

215

1.66

0.81

5.9

3.6

0.00

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

216

1.65

0.79

6.0

3.6

0.00

estimate

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.94

0.77

6.7

2.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.79

0.72

2.1

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.96

0.71

5.2

3.3

53.90

46.04

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

134

1.58

0.68

3.9

4.1

29.67

34.22

u/l

0.30

129

(3012544) pH of Venous blood

1.77

0.67

4.1

2.6

7.38

7.39

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.69

0.65

4.0

2.6

5.60

5.70

kpa

—

(1761868) Lipid panel - Serum or Plasma

166

0.62

0.64

3.1

3.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.88

0.61

4.3

4.4

—

(3021589) Normoblasts [#/volume] in Blood

165

1.52

0.61

12.5

12.7

0.00

e9/l

-0.00

132

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

128

1.53

0.60

5.8

4.0

2172.94

1359.31

ng/l

0.40

112

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.60

0.0

1.4

—

0.17

—

(3021601) Nitrite [Presence] in Urine by Test strip

215

1.51

0.59

6.2

3.7

0.00

estimate

—

(3000850) Epithelial cells [#/volume] in Urine

101

1.57

0.59

3.3

2.5

8.02

3.94

e6/l

0.46

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.67

0.57

1.8

1.7

—

(3000991) Gas panel - Venous blood

1.67

0.57

10.0

7.8

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.58

0.54

4.3

2.4

5.60

4.61

kpa

—

(40768804) Tissue Pathology biopsy report

150

1.47

0.53

3.2

2.1

—

(3002256) Pathology report gross observation

1.58

0.51

1.1

—

(3027008) Opiates [Presence] in Urine

0.00

0.42

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.00

0.42

0.0

1.3

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.42

0.0

2.4

—

4.16

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.42

0.0

1.3

—

(3000494) Fungus identified in Specimen by Culture

1.44

0.34

1.9

1.4

—

(3015736) pH of Urine

171

1.31

0.31

6.0

3.4

6.08

6.11

0.03

102

(3013512) EKG study

124

1.32

0.29

5.3

3.6

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.36

0.24

3.4

2.6

0.02

0.06

e6/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

137

1.26

0.23

3.0

3.8

2.90

8.17

mg/mmol

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

4.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

2.0

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.9

—

2.05

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.6

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.0

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

5.7

—

1961.18

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(4034850) Laboratory test

0.00

0.21

0.0

4.8

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.3

—

(3026008) Bacteria identified in Urine by Culture

129

1.25

0.20

3.2

2.8

—

(40768800) Prostate Pathology biopsy report

0.00

0.20

0.0

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.22

0.19

2.9

1.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

138

0.82

0.16

3.8

4.8

35.06

21.58

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.13

0.10

1.6

1.8

25.40

29.16

u/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.10

0.10

2.2

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.13

0.09

12.9

6.0

102.57

104.29

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

167

1.13

0.08

7.2

3.6

0.00

estimate

—

(3009508) Creatinine [Moles/volume] in Urine

139

1.12

0.06

2.8

3.2

8.38

8.94

mmol/l

0.19

123

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

230

1.10

0.05

4.0

2.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

151

0.99

0.00

1.7

1.03

1.43

mmol/l

3.15

125

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

4.6

—

5.00

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.2

—

18.18

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

96.83

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.3

—

5.98

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.6

—

9.92

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.02

-0.00

2.3

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

4.0

—

3.95

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.8

—

5.65

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

-0.00

0.0

1.5

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

39.98

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.2

—

9.93

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

3.6

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.4

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.0

—

20.20

—

(4195642) Thrombophilia screening test

0.00

-0.00

0.0

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

4.0

—

1.19

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

4.0

—

106.83

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.6

—

4.60

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.3

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

-0.00

0.0

1.0

—

1.50

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_SKININOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SKININOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_SKININOTH – Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

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Other disorders of skin and subcutaneous tissue in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints