Pneumoconiosis due to dust containing silica

J10_SILICAPNEUMOC

silicosis: Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20years) to low amounts of silica dust. Simple chronic silicosismay causepeople to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 yearsof exposure of higher levels of silica.Swelling of the lungsand other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica.The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J62 Hospital discharge: ICD-9 — 502 Hospital discharge: ICD-8 — 5150 Cause of death: ICD-10 — J62 Cause of death: ICD-9 — 502 Cause of death: ICD-8 — 5150 2 out of 7 registries used, show all original rules.	139
4. Check minimum number of events None	139
5. Include endpoints None	139
6. Filter based on genotype QC (FinnGen only)	128

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Silicosis

NAME	J10_SILICAPNEUMOC
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J62
HD_ICD_9	502
HD_ICD_8	5150
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J62
COD_ICD_9	502
COD_ICD_8	5150
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pneumoconiosis due to dust containing silica based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1139	103	997
Only index persons	595	70	525
Unadjusted period prevalence (%)
Whole population	0.03	0.00	0.03
Only index persons	0.02	0.00	0.02
Median age at first event (years)
Whole population	64.26	62.16	64.36
Only index persons	62.00	51.82	63.36

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	128	11	117
Unadjusted period prevalence (%)	0.05	0.00	0.05
Median age at first event (years)	64.30	41.77	66.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
132: Matched controls
1320

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J62.8

ICD-10 Finland

Pneumoconiosis due to other dust containing silica

+∞

95.9

J62.0

ICD-10 Finland

Pneumoconiosis due to talc dust

+∞

57.6

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

10.7

42.3

123

UGC12

NOMESCO Finland

Flexible bronchoscopy

8.0

26.6

J92.0

ICD-10 Finland

Pleural plaque with presence of asbestos

11.1

22.9

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

8.1

21.2

J62

ICD-10 Finland

Pneumoconiosis due to dust containing silica

+∞

13.8

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

6.4

13.1

J61

ICD-10 Finland

Pneumoconiosis due to asbestos and other mineral fibres

+∞

12.7

51500

ICD-8 Finland

Pneumoconiosis due to silica and silicates, Silicosis

+∞

12.7

GD1AD

NOMESCO Finland

Thorax CT examination

6.0

11.7

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

3.8

11.4

168

5020A

ICD-9 Finland

Pneumoconiosis due to other silica or silicates[SILICOSIS]

+∞

10.6

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.5

10.4

521

Z57.2

ICD-10 Finland

Occupational exposure to dust

28.6

10.0

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

11.2

8.8

J45.1

ICD-10 Finland

Nonallergic asthma

4.9

8.5

R03BB04

ATC

tiotropium bromide; inhalant

3.3

8.0

133

H02AB06

ATC

prednisolone; systemic

2.8

7.4

491

R04.2

ICD-10 Finland

Haemoptysis

6.1

6.9

J44.0

ICD-10 Finland

Chronic obstructive pulmonary disease with acute lower respiratory infection

4.0

6.8

TGC00

NOMESCO Finland

Bronchial lavation

7.2

6.6

J45.9

ICD-10 Finland

Asthma, unspecified

3.0

6.5

136

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

2.7

6.2

186

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

6.27

14.12

4.3

2.8

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

6.95

4.88

1.1

1.2

—

(3044927) Protein electrophoresis panel - Urine

8.43

4.12

1.0

1.1

—

(3042631) Mycobacterium sp identified in Specimen

5.92

4.06

2.5

2.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

5.92

4.06

1.4

1.5

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.65

3.61

1.5

1.4

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

6.00

3.39

1.6

1.1

—

(3023419) Bacteria identified in Sputum by Culture

6.00

3.39

7.0

2.3

—

(3019060) Gas panel - Arterial blood

2.47

3.05

4.5

2.9

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

4.94

2.97

1.8

1.4

—

(1616796) Gas panel - Central venous blood

3.64

2.75

2.1

4.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

6.22

2.73

1.2

1.8

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

6.22

2.73

1.2

1.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

6.22

2.73

1.2

1.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.52

2.66

1.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.19

2.61

1.6

1.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

5.65

2.57

1.2

1.6

—

(3037522) Nuclear Ab [Titer] in Serum

120

2.11

2.44

1.2

1.4

2297.14

490.00

titre

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

5.18

2.43

1.2

1.6

—

(3023199) Leukocytes [#/volume] in Pleural fluid

4.29

2.39

1.3

1.5

3357.71

2400.45

e6/l

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.37

2.35

1.6

1.4

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.63

2.31

1.6

1.3

—

(3023368) Bacteria identified in Blood by Culture

371

1.72

2.29

5.3

4.6

—

(42870588) Differential panel, method unspecified - Blood

381

1.71

2.27

9.4

5.7

—

(3012441) Differential panel - Pleural fluid

3.83

2.18

1.3

1.8

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

4.43

2.17

1.0

1.6

11.83

14.64

u/l

—

(3035715) Granulocytes [#/volume] in Blood

4.43

2.17

1.8

2.9

5.11

4.38

e9/l

—

(3000492) Spirometry study

2.20

2.12

1.7

1.6

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

5.15

2.09

2.2

1.6

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.21

2.05

1.6

1.3

—

(3001604) Monocytes [#/volume] in Blood

532

1.62

1.99

6.4

6.1

0.69

0.62

e9/l

0.87

446

(3006315) Basophils [#/volume] in Blood

533

1.62

1.97

6.4

6.1

0.04

e9/l

0.72

448

(3022313) Gas panel - Capillary blood

2.22

1.95

3.7

2.6

—

(40768806) Pleura Pathology biopsy report

3.30

1.91

1.1

2.2

—

(3013115) Eosinophils [#/volume] in Blood

546

1.60

1.90

9.5

6.3

0.19

0.20

e9/l

0.19

468

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

213

1.73

1.87

2.2

1.9

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

119

1.91

1.79

1.1

1.4

1.15

13.07

u/ml

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

3.44

1.76

1.0

1.2

15.00

10.28

u/l

—

(3019198) Lymphocytes [#/volume] in Blood

543

1.57

1.76

6.5

6.2

1.73

1.80

e9/l

0.21

471

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.95

1.73

1.0

1.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

3.95

1.73

1.0

1.1

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

508

1.55

1.69

6.3

6.2

1.19

1.20

mmol/l

0.58

455

(3042936) Bacteria identified in Isolate by Culture

181

1.69

1.57

1.8

2.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

1.55

0.0

6.8

—

(3035933) Granulocytes/Leukocytes in Blood

2.94

1.52

1.8

2.6

59.33

57.29

—

(3019309) Folate [Moles/volume] in Red Blood Cells

242

1.61

1.52

2.0

1.8

1031.47

1208.68

nmol/l

0.59

185

(3019977) pH of Arterial blood

152

1.71

1.44

5.0

6.8

7.43

7.42

0.68

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

493

1.49

1.42

4.7

4.8

77.16

52.20

ng/l

0.29

406

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

1.36

0.0

1.9

—

(4035726) Immunohistochemistry procedure

1.86

1.36

1.6

1.5

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

2.57

1.32

1.5

1.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.57

1.32

1.5

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

100

1.80

1.31

1.9

2.3

—

(3018418) pH of Serum or Plasma

325

1.48

1.24

4.0

4.3

7.39

0.05

237

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

159

1.62

1.23

1.9

1.8

—

(3018010) Neutrophils/Leukocytes in Blood

494

1.44

1.23

6.1

6.2

59.75

59.02

0.19

464

(3006504) Eosinophils/Leukocytes in Blood

496

1.43

1.19

6.5

6.2

2.52

2.86

0.68

459

(3019069) Monocytes/Leukocytes in Blood

496

1.43

1.19

6.7

6.3

9.78

9.18

0.79

462

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

152

1.62

1.19

2.2

1.9

—

(3022096) Basophils/Leukocytes in Blood

497

1.42

1.18

6.6

6.2

0.70

0.62

0.58

461

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

1.18

0.0

1.8

—

(3002030) Lymphocytes/Leukocytes in Blood

500

1.41

1.13

6.4

6.3

25.10

25.46

0.10

471

(3013650) Neutrophils [#/volume] in Blood by Automated count

588

1.41

1.12

11.8

9.1

4.52

4.26

e9/l

0.46

495

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.25

1.10

2.4

1.5

1.19

1.12

g/l

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.32

1.04

1.8

1.2

—

(4094501) Cardiovascular stress test using bicycle ergometer

2.32

1.04

1.0

1.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.32

1.04

1.8

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

309

0.65

1.01

3.0

4.0

0.00

estimate

—

113

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.98

0.0

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

868

0.73

0.97

5.1

5.4

1.22

1.33

mmol/l

2.16

782

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

896

0.73

0.96

5.7

6.2

2.25

2.41

mmol/l

1.17

812

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

2.28

0.95

1.2

1.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

446

1.36

0.91

4.3

3.6

1801.86

1857.46

ng/l

0.04

389

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.69

0.88

2.1

1.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.87

0.87

2.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

208

1.44

0.87

4.8

5.8

—

(1761868) Lipid panel - Serum or Plasma

309

0.69

0.83

2.7

3.8

—

(3037756) Immunofixation for Serum or Plasma

1.86

0.80

1.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

720

0.76

0.80

5.6

6.0

1.88

2.67

ug/l

0.86

625

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

1.66

0.78

3.0

3.2

64.00

53.55

ml/min/173m2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.70

0.78

1.7

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

572

1.31

0.78

6.9

6.8

1.20

mmol/l

0.24

488

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.75

0.77

2.2

2.0

2.52

0.97

ug/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

845

0.76

0.77

4.3

4.6

1.22

1.26

mmol/l

0.26

754

(3022145) Colonoscopy Study observation

109

1.53

0.75

1.3

1.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

872

0.77

0.74

5.0

5.4

3.91

4.19

mmol/l

2.29

795

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.84

0.74

1.4

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.84

0.74

1.6

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

409

0.74

0.73

3.9

4.3

0.17

0.03

estimate

—

125

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.75

0.71

1.7

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

375

0.74

0.70

3.9

4.1

13.27

13.34

mg/mmol

0.00

246

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

112

1.49

0.67

7.2

9.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.62

0.66

2.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

872

0.79

0.61

6.0

7.5

38.91

40.65

mmol/mol

1.29

805

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.60

0.0

1.2

—

253.00

—

(3049717) Cytology report of Urine Cyto stain

1.61

0.60

2.0

2.7

—

(3000494) Fungus identified in Specimen by Culture

115

1.45

0.60

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.75

0.58

1.8

1.4

—

(4034850) Laboratory test

1.75

0.58

15.7

15.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.46

0.53

1.6

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

884

0.81

0.52

4.9

5.6

5.82

6.18

mmol/l

3.41

788

(3012516) Albumin [Mass/volume] in Urine

359

0.79

0.50

3.5

3.4

93.23

87.43

mg/l

0.05

244

(3032080) INR in Blood by Coagulation assay

605

1.22

0.49

16.8

18.7

1.40

1.35

inr

0.27

513

(3019150) Specific gravity of Urine by Refractometry

220

1.29

0.49

4.3

4.5

1.02

kg/l

0.12

148

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.42

0.48

3.0

1.9

0.18

0.20

g/l

0.36

(40768443) Skin Pathology biopsy report

1.48

0.47

1.1

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

242

1.25

0.44

4.3

2.3

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

205

1.27

0.43

2.9

1.9

30.36

29.34

0.44

199

(3034770) Mitochondria Ab [Titer] in Serum

1.64

0.43

1.4

1.3

—

(40768797) Stomach Pathology biopsy report

132

1.33

0.43

1.1

1.3

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.41

0.0

3.6

—

17.29

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.35

0.41

2.4

2.7

3.35

2.91

g/l

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

216

1.25

0.41

2.4

1.7

2.53

1.53

mg/l

0.29

175

(3001122) Ferritin [Mass/volume] in Serum or Plasma

454

0.83

0.40

3.3

3.1

266.89

171.91

ug/l

1.26

417

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

106.22

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

4.08

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

1.19

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.41

0.40

1.1

1.5

—

(3013512) EKG study

408

1.20

0.39

3.9

4.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

824

0.84

0.39

4.8

4.6

2.18

2.11

mu/l

0.24

718

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

411

0.83

0.38

4.3

3.4

0.66

0.81

ug/l

0.72

272

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.37

0.37

3.0

3.8

277.83

252.72

ng/l

0.07

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.29

0.37

3.1

4.0

24.92

23.56

mmol/l

—

(3044889) 12 lead EKG panel

683

0.85

0.37

5.2

4.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

521

0.85

0.36

3.5

4.1

0.10

0.00

estimate

—

139

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

136

1.29

0.36

4.8

3.7

—

(3026008) Bacteria identified in Urine by Culture

304

0.82

0.35

2.9

3.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

549

0.86

0.33

4.9

5.0

23.22

22.40

0.13

289

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.38

0.33

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

333

0.83

0.33

1.9

2.0

1.14

1.25

mmol/l

0.74

260

(3014051) Protein [Presence] in Urine by Test strip

248

0.82

0.31

1.9

3.7

—

0.25

—

(3009261) Glucose [Presence] in Urine by Test strip

535

0.87

0.30

3.7

4.2

0.00

0.03

estimate

—

129

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.27

0.28

2.4

2.6

3.67

3.57

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.27

0.28

2.4

2.6

4.45

4.26

g/l

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.27

0.28

2.4

2.6

7.88

7.29

g/l

—

(3017181) Myelocytes/Leukocytes in Blood

113

1.27

0.28

3.6

4.7

0.86

0.85

—

(40761511) CBC panel - Blood by Automated count

930

0.87

0.27

24.2

18.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

114

1.26

0.26

2.0

1.9

—

(3029937) Albumin [Presence] in Urine by Test strip

315

0.86

0.25

4.5

3.9

0.00

0.02

estimate

—

124

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

594

1.12

0.21

3.6

3.4

86.86

56.60

u/l

0.77

554

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.5

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

2.0

—

9.39

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.21

0.0

4.1

—

13.00

—

(3004775) Volume in Urine collected for unspecified duration

0.00

0.21

0.0

1.8

—

491.29

—

(3021440) Promyelocytes/Leukocytes in Blood

108

1.23

0.21

3.8

4.7

0.00

0.09

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

1.26

0.20

2.7

3.0

0.00

g/l

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.21

0.20

2.3

4.2

4.30

4.36

pmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

203

0.87

0.16

3.4

3.3

2.30

0.87

e6/l

—

119

(3025159) Blasts/Leukocytes in Blood

111

1.19

0.16

3.8

5.0

0.00

0.29

—

(3007164) IgA [Mass/volume] in Serum or Plasma

178

1.15

0.16

1.6

3.72

3.01

g/l

0.52

103

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

407

0.91

0.16

3.0

2.5

84.88

73.53

nmol/l

0.97

358

(3021447) Carbon dioxide [Partial pressure] in Venous blood

136

0.87

0.11

3.0

4.1

6.53

5.67

kpa

0.97

129

(3007853) Bacteria identified in Skin by Aerobe culture

125

1.13

0.10

1.9

1.8

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

1.14

0.10

3.0

3.1

0.00

g/l

—

(40768804) Tissue Pathology biopsy report

359

0.93

0.10

2.1

2.4

—

(3003694) ABO and Rh group [Type] in Blood

247

0.92

0.09

1.4

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

650

0.94

0.09

3.9

3.6

14.98

14.81

pmol/l

0.19

563

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.10

0.09

2.7

10.98

11.21

g/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.77

0.08

2.4

3.1

1.18

1.10

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

492

1.06

0.08

2.4

2.3

99.91

91.40

pmol/l

0.39

285

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.86

0.07

1.0

1.6

—

(3002179) Metamyelocytes/Leukocytes in Blood

109

1.11

0.06

3.9

4.4

0.00

0.64

—

(3026493) Urate [Moles/volume] in Serum or Plasma

297

1.06

0.05

3.1

2.9

380.52

382.41

umol/l

0.04

247

(3044640) Blood type and Crossmatch panel - Blood

337

1.05

0.05

4.0

2.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

100

1.11

0.05

1.8

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.11

0.04

1.7

1.6

—

(40758558) Short blood count panel - Blood

291

0.95

0.04

5.3

6.0

—

(3035350) Ketones [Presence] in Urine by Test strip

530

0.97

0.03

3.6

4.2

0.00

estimate

-0.00

142

(3015736) pH of Urine

409

0.97

0.02

3.1

3.9

6.39

6.14

0.73

235

(3000991) Gas panel - Venous blood

113

1.07

0.02

3.4

8.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

462

1.03

0.02

3.9

2.7

—

estimate

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

307

0.97

0.01

3.2

3.4

35.93

34.09

u/l

0.15

289

(40761536) Microorganisms panel - Urine sediment

1.07

0.01

3.5

3.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

204

1.03

0.00

2.9

3.1

2.08

1.06

e6/l

0.27

119

(3024354) Oxygen [Partial pressure] in Venous blood

114

0.96

0.00

2.6

3.5

4.07

4.33

kpa

0.18

108

(3002256) Pathology report gross observation

136

1.03

0.00

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

459

1.00

0.00

2.5

2.6

—

(3026782) Osmolality of Urine

265

0.98

0.00

2.6

3.4

550.60

580.00

mosm/kgh2o

0.23

234

(3018095) Leukocytes [#/volume] in Urine

435

1.02

0.00

3.7

4.0

63.41

120.16

e6/l

0.52

340

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.5

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

3.3

—

89.00

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.3

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

96.17

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.3

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

0.0

1.0

—

16.87

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

19.22

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

124.60

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

245.20

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.95

-0.00

3.2

3.1

0.57

0.67

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

260

1.00

-0.00

2.0

1.9

450.95

26027804.57

pmol/l

0.50

219

(40768793) Breast Pathology biopsy report

0.00

-0.00

0.0

1.6

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

4.3

—

0.57

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.2

—

108.20

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

12.24

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.1

—

8.96

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

1.76

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(36660697) Celiac disease serology panel - Serum

1.00

-0.00

1.1

1.3

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.8

—

(3021589) Normoblasts [#/volume] in Blood

470

1.00

-0.00

16.0

13.8

0.00

0.01

e9/l

0.55

391

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

-0.00

0.0

1.2

—

1.12

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.3

—

(3022621) pH of Urine by Test strip

0.88

-0.00

2.3

2.2

5.83

6.11

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

2.0

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

0.59

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

210.13

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.8

—

11.04

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.6

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.8

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

164.89

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_SILICAPNEUMOC and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
J10_SILICAPNEUMOC	1.875 [1.51, 2.33]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.019

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 466 males with J10_SILICAPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_SILICAPNEUMOC.

N-year risk	Females	Males
1	No data	0.447%
5	No data	2.501%
10	No data	5.67%
15	No data	10.948%
20	No data	18.021%

Relationships between endpoints

↥

Index endpoint: J10_SILICAPNEUMOC – Pneumoconiosis due to dust containing silica

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pneumoconiosis due to dust containing silica

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints