Fibrothorax

J10_FIBROTHORAX

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J94.1 Cause of death: ICD-10 — J94.1 2 out of 7 registries used, show all original rules.	81
4. Check minimum number of events None	81
5. Include endpoints None	81
6. Filter based on genotype QC (FinnGen only)	71

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

NAME	J10_FIBROTHORAX
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J941
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J941
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Fibrothorax based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	71	17	54
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	69.72	68.12	70.23

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
72: Matched controls
720

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J94.1

ICD-10 Finland

Fibrothorax

+∞

103.5

J84.1

ICD-10 Finland

Other interstitial pulmonary diseases with fibrosis

43.1

29.8

UGC12

NOMESCO Finland

Flexible bronchoscopy

7.7

13.7

H02AB06

ATC

prednisolone; systemic

8.2

12.7

272

R03BB04

ATC

tiotropium bromide; inhalant

5.7

11.3

J96.1

ICD-10 Finland

Chronic respiratory failure

12.9

10.3

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

8.8

9.6

J84.9

ICD-10 Finland

Interstitial pulmonary disease, unspecified

15.4

9.4

R03AK06

ATC

salmeterol and fluticasone; inhalant

4.7

8.9

J45.9

ICD-10 Finland

Asthma, unspecified

4.1

7.1

J84.8

ICD-10 Finland

Other specified interstitial pulmonary diseases

25.3

6.9

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

6.8

R03BA01

ATC

beclometasone; inhalant

4.4

6.6

R03AC02

ATC

salbutamol; inhalant

3.8

6.4

282

M05BA04

ATC

alendronic acid; oral

6.0

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019060) Gas panel - Arterial blood

2.95

2.70

2.1

3.5

—

(3003396) Base excess in Arterial blood by calculation

2.46

2.49

18.6

5.8

1.52

0.43

mmol/l

0.24

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.96

2.44

2.1

3.0

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.86

2.41

4.1

3.4

121.18

221.99

ng/l

0.65

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.06

2.40

27.5

5.8

27.98

23.77

mmol/l

1.63

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

5.28

2.10

1.4

1.2

—

(42870588) Differential panel, method unspecified - Blood

175

1.98

12.0

4.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.54

1.67

3.2

2.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

3.50

1.55

5.8

4.4

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.42

1.54

1.4

1.9

2.36

1.45

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

476

0.57

1.48

4.9

5.6

6.27

6.25

mmol/l

0.02

423

(3000494) Fungus identified in Specimen by Culture

2.22

1.41

4.4

1.6

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

457

0.61

1.23

7.9

7.4

43.53

41.52

mmol/mol

0.59

420

(3018418) pH of Serum or Plasma

169

1.63

1.06

3.5

4.7

7.41

7.39

1.61

120

(3022145) Colonoscopy Study observation

1.95

1.03

1.2

1.4

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.11

1.03

2.4

2.9

9.80

9.76

g/l

—

(3022313) Gas panel - Capillary blood

2.04

1.00

6.1

3.0

—

(3000492) Spirometry study

1.87

0.99

4.3

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

120

1.67

0.97

3.4

2.0

—

(3023368) Bacteria identified in Blood by Culture

200

1.56

0.96

7.0

4.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.85

0.92

2.5

2.2

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.16

0.91

1.8

1.4

1.13

1.12

g/l

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.16

0.91

1.3

1.2

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.83

0.86

2.4

2.9

27.00

23.68

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.84

0.84

5.0

4.2

—

(40761511) CBC panel - Blood by Automated count

484

0.68

0.79

24.0

19.4

—

(3009343) pH of Capillary blood

1.76

0.78

7.1

3.0

7.42

7.43

—

(3000991) Gas panel - Venous blood

1.76

0.78

34.9

7.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.63

0.76

4.6

3.1

1.13

0.54

e6/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.65

0.75

3.5

1.9

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.99

0.72

1.0

1.2

—

(3049717) Cytology report of Urine Cyto stain

1.84

0.67

1.8

3.1

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.71

0.65

3.1

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.53

0.62

4.6

3.1

0.58

0.90

e6/l

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

316

0.72

0.60

5.5

5.8

2.26

2.49

ug/l

0.16

278

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.73

0.58

2.2

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.52

0.58

3.5

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

263

0.72

0.58

2.4

86.52

92.02

pmol/l

0.29

147

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

249

0.73

0.52

5.3

2.8

—

estimate

—

(3003694) ABO and Rh group [Type] in Blood

118

0.64

0.51

1.1

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.58

0.50

43.1

8.3

93.60

93.95

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.41

0.0

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.41

0.0

1.3

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.2

—

(1002224) Polysomnography panel

0.00

0.41

0.0

1.1

—

(40761536) Microorganisms panel - Urine sediment

1.50

0.41

2.6

4.7

—

(40768804) Tissue Pathology biopsy report

189

0.74

0.41

2.0

2.3

—

(3026008) Bacteria identified in Urine by Culture

198

0.75

0.39

3.1

3.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

281

0.78

0.38

4.2

4.7

0.00

estimate

—

(40760892) CBC W Ordered Manual Differential panel - Blood

109

1.35

0.37

7.2

6.5

—

(3048689) Calprotectin [Mass/mass] in Stool

1.47

0.36

3.2

2.7

107.67

233.90

ug/g

—

(3030467) Casts [#/volume] in Urine by Automated count

176

1.27

0.34

4.7

3.1

0.32

0.41

e6/l

0.11

142

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.38

0.32

1.6

1.7

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

103

1.32

0.31

7.9

2.5

0.78

0.82

mmol/l

0.89

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

233

0.80

0.29

3.0

4.8

0.00

0.06

estimate

—

(3002032) Base excess in Venous blood by calculation

1.35

0.28

2.2

3.2

4.37

1.16

mmol/l

—

(3002582) Erythrocytes [#/volume] in Urine

219

1.22

0.27

4.4

3.3

10.47

372.45

e6/l

0.72

181

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

137

0.77

0.27

6.1

2.6

—

(1761868) Lipid panel - Serum or Plasma

126

0.76

0.27

3.3

4.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

230

1.20

0.25

4.6

3.3

—

(3035350) Ketones [Presence] in Urine by Test strip

281

0.83

0.25

4.0

4.7

0.00

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

250

0.83

0.25

4.4

4.7

22.45

22.62

0.02

135

(3042936) Bacteria identified in Isolate by Culture

0.74

0.24

4.3

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.34

0.24

1.2

—

(3015736) pH of Urine

227

0.84

0.22

3.9

4.4

6.19

0.00

135

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.21

0.0

2.0

—

8.90

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.6

—

2.24

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

34.14

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.3

—

320.76

—

(3000475) Leukocytes [#/volume] in Synovial fluid

0.00

0.21

0.0

1.2

—

39319.29

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.20

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.20

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.20

0.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.20

0.0

1.2

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.70

0.17

3.0

0.24

0.18

e6/l

—

(3018095) Leukocytes [#/volume] in Urine

231

1.13

0.13

6.0

4.0

3.06

99.65

e6/l

1.63

185

(3044640) Blood type and Crossmatch panel - Blood

187

0.88

0.11

4.7

2.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

155

1.13

0.10

2.6

4.0

0.00

estimate

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.14

0.09

1.3

1.9

—

(3002256) Pathology report gross observation

1.10

0.08

1.0

1.4

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.83

0.08

5.0

2.5

3.68

6.44

ug/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

119

1.11

0.06

7.9

3.4

222.54

382.84

ng/l

0.28

100

(3012516) Albumin [Mass/volume] in Urine

191

0.92

0.05

4.2

3.0

57.73

92.94

mg/l

0.40

132

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

231

0.93

0.05

4.1

2.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

131

1.09

0.04

3.9

4.8

—

0.33

—

(3026493) Urate [Moles/volume] in Serum or Plasma

141

1.08

0.04

4.5

3.4

385.40

365.59

umol/l

—

116

(40758558) Short blood count panel - Blood

162

1.06

0.02

5.8

5.7

—

(3031040) Bacteria [#/volume] in Urine by Automated count

373

1.04

0.01

4.8

5.1

—

5480.00

—

(3020682) Albumin/Creatinine [Ratio] in Urine

199

1.01

0.00

5.1

3.7

11.14

16.87

mg/mmol

0.29

133

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

15.95

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.1

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.3

—

1.17

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.3

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

6.6

—

1471.00

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.8

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

5.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3004451) EKG impression Narrative

0.00

0.0

1.5

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.4

—

1.49

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

4.4

—

14.60

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

3.6

—

1.00

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

664.57

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.3

—

21.00

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

2.0

—

24.43

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.6

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.0

—

(3003129) Base excess in Capillary blood by calculation

0.00

-0.00

0.0

1.4

—

1.34

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.0

—

10.52

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.4

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

3.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

-0.00

0.0

2.4

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(40768793) Breast Pathology biopsy report

0.00

-0.00

0.0

1.6

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.1

—

9.53

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

0.79

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3021788) Differential panel - Synovial fluid

0.00

-0.00

0.0

1.1

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3005532) Lymphocytes/Leukocytes in Pleural fluid

0.00

-0.00

0.0

2.0

—

62.40

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.6

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

1.85

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.6

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: J10_FIBROTHORAX – Fibrothorax

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Fibrothorax

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Fibrothorax (J10_FIBROTHORAX)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints