portal hypertension: Increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
133 |
4. Check minimum number of eventsNone |
133 |
5. Include endpointsNone |
133 |
6. Filter based on genotype QC (FinnGen only) |
118 |
Control definitions (FinnGen only)
- Control exclude
- CIRRHOSIS_BROAD
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K76
- Name in latin
- Hypertensio venae portae
Similar endpoints
↥List of similar endpoints to
Hypertension, portal
based on the number of shared cases.
Similar with more cases:
- Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
- Other diseases of liver
- Diseases of liver
- Gastrointestinal diseases
- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 745 | 296 | 439 |
| Only index persons | 603 | 241 | 362 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.88 | 59.75 | 58.18 |
| Only index persons | 58.65 | 58.48 | 58.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 118 | 52 | 66 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 59.34 | 57.75 | 60.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 122
- Matched controls
- 1220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K76.6
ICD-10 Finland
Portal hypertension
+∞
173.0
121
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
22.8
71.7
80
94
C03DA01
ATC
spironolactone; oral
21.3
68.4
75
85
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
68.3
59
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
34.9
65.0
108
221
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
+∞
59.3
52
*
R18
ICD-10 Finland
Ascites
208.6
51.4
50
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
+∞
44.5
40
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
14.1
44.4
52
61
A06AD11
ATC
lactulose; oral
13.0
41.3
51
64
C07AG02
ATC
carvedilol; oral
17.3
39.4
37
30
C03CA01
ATC
furosemide; systemic
11.1
39.0
86
216
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
174.9
37.1
37
*
D64.9
ICD-10 Finland
Anaemia, unspecified
8.7
26.8
43
72
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
26.0
24
*
A10AB05
ATC
insulin aspart; parenteral
9.2
24.9
36
53
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
280.5
23.5
23
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.3
22.8
29
36
C07AA05
ATC
propranolol; systemic
6.2
22.5
61
170
K92.1
ICD-10 Finland
Melaena
10.6
21.9
27
32
K70.4
ICD-10 Finland
Alcoholic hepatic failure
+∞
21.5
20
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
132.9
21.3
22
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
34.2
21.1
27
10
Z94.4
ICD-10 Finland
Liver transplant status
+∞
19.3
18
*
A10AE04
ATC
insulin glargine; parenteral
6.9
19.1
36
70
UJF32
NOMESCO Finland
Coloscopy
5.3
18.8
62
200
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.5
18.2
97
457
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
25.8
18.2
25
12
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
7.8
18.1
29
47
JN3AD
NOMESCO Finland
Abdominal CT examination
5.9
17.6
41
97
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.4
17.4
35
72
ZX120
NOMESCO Finland
Intravenous
6.7
17.4
33
64
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.0
16.1
49
145
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
16.0
15
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
182.4
15.9
16
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.6
15.6
57
194
L04AA06
ATC
mycophenolic acid; systemic
52.3
15.5
18
*
127
Kela drug reimbursment
Transplant complication
52.3
15.5
18
*
K92.0
ICD-10 Finland
Haematemesis
37.1
15.3
19
6
103
Kela drug reimbursment
Diabetes, insulin-treated
4.5
15.3
59
209
I81
ICD-10 Finland
Portal vein thrombosis
65.2
15.2
17
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
14.9
14
*
A07AA11
ATC
rifaximin; oral
+∞
14.9
14
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.7
14.8
33
74
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.4
14.5
56
197
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.0
14.1
24
41
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.6
14.1
32
73
L04AD02
ATC
tacrolimus; systemic
84.5
13.9
15
*
A10BH01
ATC
sitagliptin; oral
5.9
13.9
29
61
K70.1
ICD-10 Finland
Alcoholic hepatitis
+∞
13.8
13
*
T90
ICPC
Diabetes non-insulin dependent
4.2
13.5
53
187
J01MA02
ATC
ciprofloxacin; systemic
4.2
13.5
76
346
Z51.5
ICD-10 Finland
Palliative care
6.7
13.5
24
43
TPH04
NOMESCO Finland
Cathetrisation of vein
4.2
13.2
50
172
K83.0
ICD-10 Finland
Cholangitis
56.5
13.2
15
*
WW500
NOMESCO Finland
Blood transfusion
11.7
13.0
24
25
Z2446
NOMESCO Finland
Social worker
6.8
12.8
22
38
K72.9
ICD-10 Finland
Hepatic failure, unspecified
+∞
12.7
12
*
D97
ICPC
Liver disease NOS
+∞
12.7
12
*
K76.9
ICD-10 Finland
Liver disease, unspecified
42.3
12.5
15
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
52.2
12.2
14
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
21.7
12.0
17
9
N02AX02
ATC
tramadol; systemic, rectal
3.9
11.8
80
402
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
+∞
11.6
11
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.1
11.5
41
133
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
11.3
31
82
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
48.1
11.2
13
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.8
10.9
29
75
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
4.5
10.8
32
90
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
13.8
10.8
18
15
SPAT1262
SPAT
Handing over of treatment supplies
4.2
10.7
35
106
K76.7
ICD-10 Finland
Hepatorenal syndrome
+∞
10.6
10
*
R4110
NOMESCO Finland
Physiotherapy
3.5
10.5
56
237
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
10.1
59
263
UJF30
NOMESCO Finland
Ileoscopy through colon
4.7
10.0
27
70
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.8
9.9
40
140
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
13.0
9.9
17
15
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
59.9
9.8
11
*
L04AD01
ATC
ciclosporin; systemic
24.0
9.6
13
6
A10BA02
ATC
metformin; oral
3.3
9.3
53
230
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.2
9.3
62
296
J01MA12
ATC
levofloxacin; systemic
3.6
9.3
39
140
JN4AD
NOMESCO Finland
Body CT examination
4.1
9.2
30
90
TKC20
NOMESCO Finland
Catheterisation of bladder
5.4
8.9
19
40
A02BC02
ATC
pantoprazole; systemic
4.3
8.8
103
679
A05AA02
ATC
ursodeoxycholic acid; oral
22.0
8.7
12
6
WX002
NOMESCO Finland
Sedation and analgesia
3.5
8.6
37
134
L04AX01
ATC
azathioprine; systemic
10.6
8.6
16
17
N17.9
ICD-10 Finland
Acute renal failure, unspecified
10.6
8.6
16
17
3AC01, ,
NOMESCO Finland
96.4
8.5
9
*
ZXD05
NOMESCO Finland
Urgent procedure
3.1
8.5
54
248
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
8.4
8
*
I86.4
ICD-10 Finland
Gastric varices
+∞
8.4
8
*
JJ5AT, ,
NOMESCO Finland
+∞
8.4
8
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
16.0
8.4
13
9
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
16.0
8.4
13
9
EBA15
NOMESCO Finland
Extraction of multiple teeth
13.0
8.3
14
12
JN4BD
NOMESCO Finland
Extensive body CT
4.0
8.2
27
81
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
23.9
8.2
11
5
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
8.1
27
82
UJD02
NOMESCO Finland
Gastroscopy
7.6
7.9
18
27
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.3
7.9
37
141
R50.9
ICD-10 Finland
Fever, unspecified
3.5
7.8
32
112
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
13.1
7.8
13
11
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
11.1
7.8
14
14
A10BB12
ATC
glimepiride; oral
4.9
7.5
18
42
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
17.1
7.4
11
7
K70.2
ICD-10 Finland
Alcoholic fibrosis and sclerosis of liver
+∞
7.4
7
*
A08
ICPC
Swelling
6.6
7.3
18
31
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
13.3
6.7
11
9
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.4
6.7
18
46
N02AA05
ATC
oxycodone; systemic
3.1
6.7
35
141
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
6.6
40
175
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.3
6.6
15
23
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
6.7
6.6
16
27
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
73.5
6.5
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
6.5
44
205
A02BC05
ATC
esomeprazole; systemic
2.6
6.4
62
344
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
4.2
6.4
18
48
WX892
NOMESCO Finland
Monitored bed care
4.2
6.4
18
48
Z2221
NOMESCO Finland
Medical doctor
2.8
6.3
44
207
Z3231
NOMESCO Finland
Registered nurse
2.7
6.3
47
229
A41.9
ICD-10 Finland
Sepsis, unspecified
8.4
6.3
13
17
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.6
6.3
16
39
D73.1
ICD-10 Finland
Hypersplenism
+∞
6.3
6
*
WX402
NOMESCO Finland
General anaesthesia
2.8
6.2
41
187
A10AC01
ATC
insulin (human); parenteral
4.1
6.2
18
49
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.0
6.2
19
54
L28
ICPC
Limited function/disability (L)
3.0
6.0
33
136
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
89
107
28.05
79.81
8.5
2.4
0.17
0.22
g/l
5.29
81
101
85
173
13.90
48.25
4.5
2.4
2.19
2.27
g/l
0.42
80
162
32
26
16.33
33.76
1.3
1.3
—
—
—
0
0
45
62
10.92
33.45
2.2
1.5
0.40
0.40
mg/l
0.00
17
26
35
7
69.20
31.38
1.2
1.4
—
—
—
0
0
85
270
8.08
28.60
4.6
2.2
3.48
2.90
mg/l
0.96
77
243
28
32
11.06
23.39
5.5
1.6
75.57
91.53
%
1.93
28
32
46
96
7.09
23.08
5.6
2.5
30.77
31.97
u/l
0.07
39
78
36
75
6.39
17.71
18.7
10.6
23.38
25.29
mmol/l
2.38
36
75
53
164
4.95
16.54
18.0
8.1
105.38
104.04
mmol/l
1.08
53
164
28
26
13.62
16.04
5.6
1.8
204.61
215.46
%
0.15
28
26
25
22
13.97
14.62
1.4
1.3
—
—
—
0
0
67
275
4.19
13.92
7.0
2.7
—
—
—
0
0
54
191
4.28
13.78
2.2
2.0
—
—
—
0
0
29
63
5.73
13.42
2.1
1.8
—
—
—
0
0
24
24
12.15
13.23
2.1
1.6
—
—
—
0
0
23
21
13.21
13.21
1.4
1.4
—
—
—
0
0
44
138
4.42
13.11
18.6
9.1
4.90
5.19
kpa
1.38
44
130
30
69
5.44
13.02
19.2
9.1
13.61
15.96
%
3.95
30
64
31
74
5.28
12.90
1.7
1.6
—
—
—
0
0
40
118
4.56
12.88
7.3
4.2
0.58
1.50
mmol/l
1.08
32
98
43
138
4.27
12.35
18.9
9.1
13.46
11.81
kpa
1.04
43
131
21
19
13.09
12.10
1.4
1.4
442.69
245.60
u/ml
—
13
5
21
38
6.47
11.62
1.1
1.3
—
—
—
0
0
16
8
22.73
11.48
1.0
1.0
—
—
—
0
0
104
635
5.32
11.38
24.5
10.7
3.26
4.02
e9/l
3.36
99
551
88
478
4.02
11.38
2.8
2.1
93.16
96.49
pmol/l
0.23
52
236
92
517
4.17
11.26
7.5
2.9
—
—
estimate
—
0
0
38
120
4.15
11.03
20.9
10.0
107.84
122.29
g/l
3.33
38
115
26
61
5.15
10.93
3.9
3.1
1.27
1.01
mmol/l
0.14
16
46
41
139
3.94
10.76
2.1
1.9
—
—
—
0
0
104
650
5.07
10.65
22.6
4.9
7.81
6.61
mmol/l
4.85
104
617
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
25
9.90
10.58
3.6
2.3
0.25
0.41
iu/ml
0.76
12
11
46
171
3.71
10.52
4.1
3.1
0.94
2.80
e6/l
1.17
34
86
41
145
3.75
10.05
2.1
1.8
—
—
—
0
0
56
254
3.23
9.12
1.4
1.3
10.73
1.58
u/ml
—
10
76
62
308
3.06
8.49
5.4
3.1
1.02
0.35
e6/l
0.72
55
229
20
32
7.26
8.45
2.2
2.2
—
—
—
0
0
45
188
3.21
8.30
4.3
3.0
1.35
0.76
e6/l
0.72
33
103
32
108
3.66
8.26
3.9
3.6
—
—
—
0
0
20
51
4.49
7.50
1.3
2.0
48.20
38.58
u/l
0.74
15
46
17
27
7.13
7.25
4.0
1.4
8.43
8.17
kpa
0.18
17
27
50
237
2.88
7.23
4.1
1.6
2.89
1.35
mg/l
1.42
43
190
17
39
4.90
7.22
4.5
1.7
22.64
24.27
mmol/l
1.26
17
39
68
380
2.78
7.15
6.4
3.3
—
—
—
0
0
77
463
2.80
6.95
5.4
2.6
71.35
76.64
nmol/l
0.96
72
407
18
35
5.85
6.64
1.2
2.1
1.34
3.80
ratio
0.54
11
16
28
100
3.34
6.53
4.8
3.1
65.63
65.56
ml/min/173m2
—
8
48
6
0
+∞
6.30
2.0
0.0
—
—
—
0
0
63
358
2.57
6.15
5.5
4.2
29.61
9.13
mg/mmol
1.52
50
233
8
5
16.97
5.49
1.1
3.0
—
—
—
0
0
8
5
16.97
5.49
1.1
3.0
—
—
—
0
0
14
29
5.31
4.99
1.4
1.9
—
—
—
0
0
0
112
0.00
4.67
0.0
2.2
—
3.47
—
0
87
8
9
9.41
4.35
3.8
1.3
—
—
—
0
0
10
17
6.30
4.22
1.4
1.5
—
—
—
0
0
10
17
6.30
4.22
1.3
1.7
—
—
—
0
0
13
31
4.57
4.16
1.4
2.2
—
—
—
0
0
13
31
4.57
4.16
1.5
1.3
252.13
309.63
ug/g
—
8
18
9
14
6.84
4.06
1.4
1.2
—
—
—
0
0
8
11
7.69
3.92
1.1
1.2
—
—
—
0
0
14
40
3.82
3.75
3.3
1.2
0.83
0.83
g/l
0.00
14
40
11
25
4.73
3.72
1.5
1.2
—
—
—
0
0
6
6
10.43
3.53
2.8
3.0
—
—
—
0
0
10
22
4.85
3.51
1.3
2.3
—
—
—
0
0
11
27
4.37
3.49
2.1
1.4
—
—
—
0
0
0
89
0.00
3.45
0.0
1.9
—
3.67
—
0
63
20
85
2.62
3.36
7.4
4.9
124.56
80.09
ng/l
0.82
20
77
14
49
3.10
3.31
1.6
1.3
—
—
—
0
0
78
573
2.00
3.30
5.8
3.8
0.00
0.00
estimate
-0.00
14
112
79
584
2.00
3.27
5.8
3.9
0.00
0.00
estimate
-0.00
13
104
11
31
3.79
3.08
3.8
4.3
2.33
2.00
index
—
6
17
7
12
6.11
3.06
1.0
1.3
—
—
—
0
0
12
37
3.48
3.03
2.2
2.3
—
—
—
0
0
12
37
3.48
3.03
1.8
2.0
—
—
—
0
0
12
37
3.48
3.03
1.6
2.8
—
—
—
0
0
77
581
1.88
2.81
5.9
3.9
0.00
0.00
estimate
-0.00
15
113
6
10
6.24
2.73
1.0
1.6
—
—
—
0
0
6
10
6.24
2.73
1.0
1.6
—
—
—
0
0
6
10
6.24
2.73
1.0
1.6
—
—
—
0
0
6
10
6.24
2.73
1.0
1.5
—
—
—
0
0
10
30
3.54
2.67
1.9
1.3
0.26
0.25
g/l
—
10
30
5
7
7.38
2.57
6.6
1.3
651.00
1234.57
u/ml
—
5
7
7
16
4.57
2.51
1.3
1.2
—
—
—
0
0
96
1077
0.49
2.43
7.6
5.2
1.24
1.44
mmol/l
3.96
88
996
6
12
5.20
2.43
1.0
1.5
—
—
—
0
0
8
22
3.81
2.41
1.0
1.5
—
—
—
0
0
8
22
3.81
2.41
1.0
1.5
—
—
—
0
0
97
1083
0.49
2.36
7.5
5.3
4.01
4.65
mmol/l
6.50
89
1008
15
67
2.41
2.28
5.9
2.7
0.53
0.63
%
0.81
15
67
15
67
2.41
2.28
5.9
2.7
1.10
1.30
%
0.48
15
67
5
9
5.74
2.23
2.2
1.3
—
—
—
0
0
9
30
3.16
2.20
1.1
1.2
—
—
—
0
0
9
30
3.16
2.20
1.3
1.7
—
—
—
0
0
6
14
4.45
2.18
1.0
1.4
—
—
—
0
0
9
31
3.05
2.12
2.2
1.4
1.12
1.22
g/l
—
9
31
5
10
5.16
2.09
1.4
5.8
1152.80
1183.00
mg
—
5
10
8
27
3.10
1.97
1.3
1.7
—
—
—
0
0
5
11
4.69
1.96
1.2
1.5
—
—
—
0
0
5
11
4.69
1.96
1.0
1.1
—
—
—
0
0
15
73
2.20
1.90
11.7
7.8
23.57
25.30
mmol/l
0.60
15
67
100
1095
0.52
1.87
8.0
5.9
2.14
2.73
mmol/l
10.56
92
1016
9
36
2.62
1.78
1.2
1.4
—
265.77
—
0
18
8
30
2.78
1.76
1.4
1.5
—
—
—
0
0
8
30
2.78
1.76
1.1
1.2
—
—
—
0
0
6
22
2.81
1.45
1.2
1.7
—
—
—
0
0
5
16
3.21
1.45
1.2
1.3
—
—
—
0
0
6
24
2.57
1.32
1.0
1.0
—
—
—
0
0
6
25
2.47
1.26
1.2
1.8
—
—
—
0
0
7
31
2.33
1.12
1.3
1.3
—
—
—
0
0
95
1031
0.65
1.12
6.3
4.4
1.43
1.32
mmol/l
0.41
88
948
5
21
2.44
1.10
1.4
1.3
—
—
—
0
0
7
33
2.19
1.07
1.6
1.5
—
1.31
—
0
7
77
666
1.42
1.06
3.2
3.0
—
—
—
0
0
29
211
1.49
1.01
1.1
1.3
108.15
31.79
iu/ml
—
8
67
12
71
1.77
0.92
7.9
4.5
1.23
1.22
mmol/l
0.08
12
62
20
275
0.67
0.83
2.3
3.0
0.46
0.77
ug/l
2.24
11
162
6
33
1.86
0.80
1.0
1.5
—
—
—
0
0
15
101
1.55
0.74
1.6
1.4
—
—
—
0
0
88
805
1.33
0.69
4.5
4.3
14.77
14.80
pmol/l
0.03
80
739
8
49
1.68
0.63
2.0
2.0
—
—
—
0
0
8
52
1.58
0.61
1.1
1.4
—
—
—
0
0
6
39
1.57
0.54
1.2
1.3
—
—
—
0
0
24
197
1.27
0.42
1.2
1.3
48.60
9.81
u/ml
—
9
78
0
15
0.00
0.41
0.0
3.7
—
18.29
—
0
7
0
15
0.00
0.41
0.0
1.1
—
181.83
—
0
15
9
66
1.39
0.39
7.0
3.5
3.66
4.48
pmol/l
—
9
56
9
67
1.37
0.39
1.1
1.1
—
130.15
—
0
22
6
41
1.49
0.36
2.3
2.1
—
—
—
0
0
44
485
0.85
0.31
3.3
2.0
1.37
1.45
mmol/l
0.21
44
407
36
319
1.18
0.31
5.5
3.3
0.00
0.00
estimate
-0.00
13
89
8
107
0.73
0.30
2.1
2.0
—
—
—
0
0
29
255
1.18
0.27
6.9
4.0
1.02
1.02
kg/l
0.08
23
157
17
201
0.82
0.26
1.5
1.6
—
—
—
0
0
101
978
1.19
0.25
6.2
5.2
2.17
1.91
mu/l
1.07
94
897
5
41
1.23
0.22
2.4
1.7
—
—
—
0
0
5
42
1.20
0.21
1.8
1.5
4.28
24.32
iu/l
—
5
37
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
13.60
—
0
10
0
10
0.00
0.21
0.0
1.0
—
609.00
—
0
5
0
10
0.00
0.21
0.0
1.0
—
36.00
—
0
5
6
47
1.29
0.21
1.0
1.0
—
—
—
0
0
43
462
0.89
0.20
3.1
5.1
1.16
1.80
ug/l
1.06
38
412
12
138
0.86
0.14
20.5
8.7
—
—
—
0
0
46
436
1.09
0.13
7.0
3.7
0.00
0.00
estimate
-0.00
13
94
103
1047
0.90
0.11
7.5
5.1
6.62
5.97
mmol/l
3.28
95
969
113
1132
0.98
0.07
47.2
12.0
32.54
27.21
u/l
2.87
113
1110
13
136
0.95
0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
37.18
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
51.75
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
56.20
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
96
0.93
-0.00
1.8
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
32
320
1.00
-0.00
8.5
3.7
0.00
0.00
estimate
-0.00
11
108
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPTENSPOR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSPOR | 11.525 [6.2, 21.42] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.111 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 189 females with I9_HYPTENSPOR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSPOR | 8.06 [4.37, 14.86] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 292 males with I9_HYPTENSPOR died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPTENSPOR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.019% | 1.869% |
| 5 | 5.916% | 9.495% |
| 10 | 14.89% | 22.671% |
| 15 | 26.58% | 39.024% |
| 20 | 41.417% | 57.582% |
Relationships between endpoints
↥Index endpoint: I9_HYPTENSPOR – Hypertension, portal
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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