Hypertension, portal

I9_HYPTENSPOR

portal hypertension: Increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K76.6
  • Hospital discharge: ICD-9 5723A
  • Cause of death: ICD-10 K76.6
  • Cause of death: ICD-9 5723A

2 out of 7 registries used, show all original rules.

116

4. Check minimum number of events

None

116

5. Include endpoints

None

116

6. Filter based on genotype QC (FinnGen only)

112

Control definitions (FinnGen only)

Control exclude
CIRRHOSIS_BROAD

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K76
Name in latin
Hypertensio venae portae

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 745 296 439
Only index persons 603 241 362
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 58.88 59.75 58.18
Only index persons 58.65 58.48 58.77

-FinnGen-

Key figures

All Female Male
Number of individuals 112 51 61
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 57.86 57.79 57.92

-FinRegistry-

Age distribution of first events

01020304050607080020406080100120140160180200AgeIndividuals

-FinnGen-

Age distribution of first events

0304050607002468101214161820222426AgeIndividuals

-FinRegistry-

Year distribution of first events

197019751980198519901995200020052010201520202022020406080100120140160180200220YearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519902000200520102015202020250510152025303540YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
116
Matched controls
1160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K76.6
ICD-10 Finland
Portal hypertension
+∞
164.3
115
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
22.6
67.7
74
84
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
64.8
56
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
31.9
61.8
101
202
C03DA01
ATC
spironolactone; oral
19.8
61.1
67
75
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
+∞
52.1
46
*
R18
ICD-10 Finland
Ascites
187.6
46.8
46
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
+∞
38.7
35
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
13.0
38.0
46
56
A06AD11
ATC
lactulose; oral
12.7
37.4
46
57
C03CA01
ATC
furosemide; systemic
9.5
33.0
78
206
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
145.6
31.5
32
*
C07AG02
ATC
carvedilol; oral
14.1
29.0
30
28
D64.9
ICD-10 Finland
Anaemia, unspecified
9.2
26.3
40
63
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
26.0
24
*
C07AA05
ATC
propranolol; systemic
6.3
22.1
59
163
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
253.7
21.3
21
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
41.3
21.3
26
8
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.9
20.0
26
33
A10AB05
ATC
insulin aspart; parenteral
8.3
20.0
31
49
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
9.3
19.1
26
35
ZX120
NOMESCO Finland
Intravenous
7.4
19.0
33
59
Z94.4
ICD-10 Finland
Liver transplant status
+∞
18.2
17
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
112.6
18.1
19
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
27.1
17.7
24
11
UJF32
NOMESCO Finland
Coloscopy
5.2
17.3
57
183
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.6
17.2
34
69
K70.4
ICD-10 Finland
Alcoholic hepatic failure
197.2
17.0
17
*
A10AE04
ATC
insulin glargine; parenteral
6.7
16.9
32
62
JN3AD
NOMESCO Finland
Abdominal CT examination
6.2
16.2
34
73
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
5.0
16.1
53
168
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.2
16.1
45
125
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.3
15.7
85
394
127
Kela drug reimbursment
Transplant complication
52.7
15.6
18
*
103
Kela drug reimbursment
Diabetes, insulin-treated
4.7
15.3
55
186
L04AA06
ATC
mycophenolic acid; systemic
65.7
15.2
17
*
I81
ICD-10 Finland
Portal vein thrombosis
92.1
15.0
16
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
170.6
14.8
15
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.8
14.7
48
150
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.6
14.5
52
174
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.8
14.2
22
34
K83.0
ICD-10 Finland
Cholangitis
85.1
13.9
15
*
A07AA11
ATC
rifaximin; oral
+∞
13.8
13
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
13.8
13
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
13.8
13
*
K70.1
ICD-10 Finland
Alcoholic hepatitis
+∞
13.8
13
*
UJF30
NOMESCO Finland
Ileoscopy through colon
6.2
13.7
27
54
WW500
NOMESCO Finland
Blood transfusion
12.8
13.5
24
23
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.8
13.5
29
63
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.9
13.4
28
59
K92.0
ICD-10 Finland
Haematemesis
32.8
13.4
17
6
K72.9
ICD-10 Finland
Hepatic failure, unspecified
+∞
12.7
12
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
145.0
12.7
13
*
L04AD02
ATC
tacrolimus; systemic
145.0
12.7
13
*
J01MA02
ATC
ciprofloxacin; systemic
4.0
12.3
70
319
N02AX02
ATC
tramadol; systemic, rectal
4.1
12.2
77
376
K92.1
ICD-10 Finland
Melaena
10.1
12.0
24
29
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
21.8
12.0
17
9
Z2446
NOMESCO Finland
Social worker
6.5
11.7
21
38
K76.9
ICD-10 Finland
Liver disease, unspecified
39.4
11.6
14
*
A10BH01
ATC
sitagliptin; oral
5.5
11.3
25
55
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
48.4
11.2
13
*
T90
ICPC
Diabetes non-insulin dependent
3.9
10.9
45
162
D97
ICPC
Liver disease NOS
+∞
10.6
10
*
K76.7
ICD-10 Finland
Hepatorenal syndrome
+∞
10.6
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
10.4
28
73
SPAT1262
SPAT
Handing over of treatment supplies
4.2
10.3
34
104
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
18.9
10.2
15
9
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.5
10.0
55
237
Z51.5
ICD-10 Finland
Palliative care
8.2
9.9
22
32
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.9
9.7
37
125
L04AD01
ATC
ciclosporin; systemic
24.1
9.6
13
6
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.4
9.6
59
272
L04AX01
ATC
azathioprine; systemic
12.2
9.1
16
15
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
12.2
9.1
16
15
A05AA02
ATC
ursodeoxycholic acid; oral
26.5
9.1
12
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
9.1
34
113
R4110
NOMESCO Finland
Physiotherapy
3.3
9.1
51
221
A10BA02
ATC
metformin; oral
3.3
9.0
49
208
J01MA12
ATC
levofloxacin; systemic
3.6
8.8
37
133
ZXD05
NOMESCO Finland
Urgent procedure
3.2
8.7
52
233
TPH07
NOMESCO Finland
Cathetrisation of artery
4.5
8.6
24
64
JN4AD
NOMESCO Finland
Body CT examination
4.5
8.6
24
64
WX002
NOMESCO Finland
Sedation and analgesia
3.6
8.6
36
129
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
+∞
8.4
8
*
I86.4
ICD-10 Finland
Gastric varices
+∞
8.4
8
*
JJ5AT, ,
NOMESCO Finland
+∞
8.4
8
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
16.1
8.4
13
9
UJD02
NOMESCO Finland
Gastroscopy
8.3
8.4
18
25
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
24.1
8.2
11
5
JN4BD
NOMESCO Finland
Extensive body CT
4.1
8.1
26
77
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.9
8.0
27
83
A10BB12
ATC
glimepiride; oral
5.1
8.0
18
40
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
16.5
7.9
12
8
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
7.8
40
162
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
20.0
7.8
11
6
A02BC02
ATC
pantoprazole; systemic
3.8
7.7
95
631
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.4
7.6
34
126
WX892
NOMESCO Finland
Monitored bed care
4.9
7.5
18
42
3AC01, ,
NOMESCO Finland
85.3
7.5
8
*
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
7.4
7
*
TKC20
NOMESCO Finland
Catheterisation of bladder
4.9
7.2
17
39
R50.9
ICD-10 Finland
Fever, unspecified
3.5
7.2
29
100
WX402
NOMESCO Finland
General anaesthesia
3.2
7.2
37
149
N02AA05
ATC
oxycodone; systemic
3.3
7.2
33
124
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
18.0
6.9
10
6
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.7
6.7
24
76
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
11.0
6.7
12
12
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.2
6.7
33
129
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
6.7
43
196
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.0
6.6
38
162
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.3
6.6
15
23
A10AC01
ATC
insulin (human); parenteral
4.3
6.5
18
47
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
73.7
6.5
7
*
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
73.7
6.5
7
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
12.0
6.4
11
10
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.3
6.4
18
48
L28
ICPC
Limited function/disability (L)
3.2
6.3
29
108
K70.2
ICD-10 Finland
Alcoholic fibrosis and sclerosis of liver
+∞
6.3
6
*
D73.1
ICD-10 Finland
Hypersplenism
+∞
6.3
6
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
10.9
6.2
11
11
TK800
NOMESCO Finland
Hemodialysis
10.9
6.2
11
11
A10AE05
ATC
insulin detemir; parenteral
6.5
6.1
15
26
N17.9
ICD-10 Finland
Acute renal failure, unspecified
8.8
6.0
12
15
A41.9
ICD-10 Finland
Sepsis, unspecified
8.8
6.0
12
15

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
89
29.02
78.56
7.6
2.2
0.17
0.22
g/l
4.30
75
82
46
16
46.99
72.14
1.4
1.3
—
—
—
0
0
74
124
14.72
49.66
3.8
2.3
2.18
2.33
g/l
0.74
69
115
72
117
14.59
49.42
4.1
2.4
23.94
21.99
%
0.28
67
102
54
97
9.54
32.40
1.6
1.7
—
—
—
0
0
74
216
7.70
27.19
4.0
2.0
3.65
3.23
mg/l
0.50
67
192
54
117
7.76
26.70
1.7
1.6
—
—
—
0
0
53
119
7.36
25.12
1.6
1.4
257.14
510.77
titre
0.65
14
26
54
134
6.67
22.83
3.3
2.0
—
—
—
0
0
47
111
6.44
20.68
1.7
1.3
—
—
—
0
0
40
81
7.01
20.56
4.7
2.4
34.82
31.94
u/l
0.14
34
68
72
256
5.78
19.80
6.4
4.7
—
—
—
0
0
39
81
6.75
19.47
3.4
3.2
80.97
78.42
e9/l
0.17
31
61
88
376
6.55
19.34
5.8
2.6
178.97
114.07
ug/l
1.40
83
353
78
301
5.86
19.34
6.5
2.5
—
—
—
0
0
59
184
5.49
18.76
2.1
1.4
4.26
2.39
g/l
4.19
44
106
35
68
6.94
18.59
1.4
1.7
—
—
—
0
0
23
8
35.33
18.24
2.5
1.0
—
—
—
0
0
92
424
6.65
18.05
33.8
12.7
1.40
1.22
inr
1.14
28
116
32
65
6.42
16.11
1.4
1.8
—
—
—
0
0
27
24
14.29
15.81
1.9
1.1
—
—
—
0
0
65
254
4.55
14.85
7.8
4.4
7.38
7.40
ph
—
10
41
22
17
15.66
13.60
1.4
1.4
—
—
—
0
0
19
10
22.39
13.44
1.1
1.0
—
—
—
0
0
41
121
4.69
13.32
12.6
7.1
105.29
103.70
mmol/l
1.11
41
121
78
371
4.37
13.13
2.6
1.9
94.90
95.78
pmol/l
0.05
46
182
32
81
5.07
12.46
14.4
8.6
—
—
—
0
0
19
13
17.19
12.30
1.1
1.3
—
—
—
0
0
91
498
4.84
12.28
15.8
5.3
0.03
0.04
e9/l
2.96
84
429
91
498
4.84
12.28
15.7
5.3
0.51
0.58
e9/l
1.40
83
430
16
7
26.21
11.94
1.4
1.0
—
—
—
0
0
11
0
+∞
11.65
1.4
0.0
—
—
—
0
0
91
509
4.66
11.64
16.2
5.6
0.15
0.20
e9/l
2.48
84
448
87
472
4.37
11.60
16.9
6.0
—
—
—
0
0
16
8
22.89
11.50
1.0
1.3
—
—
—
0
0
25
55
5.52
11.35
3.8
3.2
7.43
7.43
ph
—
5
6
91
515
4.56
11.30
15.9
5.3
1.20
1.82
e9/l
13.35
83
457
96
568
5.00
11.13
17.3
4.0
7.69
6.61
mmol/l
4.03
96
531
16
10
18.30
10.70
2.0
2.3
—
—
—
0
0
10
0
+∞
10.57
1.0
0.0
—
—
—
0
0
10
0
+∞
10.57
1.0
0.0
—
—
—
0
0
41
143
3.89
10.36
3.1
2.8
1.00
3.01
e6/l
1.10
31
76
32
97
4.17
9.77
12.8
7.9
96.41
96.24
%
0.07
32
90
30
87
4.30
9.71
2.0
1.3
—
—
—
0
0
34
109
4.00
9.61
12.1
7.5
4.87
5.20
kpa
1.29
34
101
42
157
3.63
9.48
1.6
1.8
—
—
—
0
0
31
94
4.14
9.44
8.0
4.1
—
—
—
0
0
20
27
8.71
9.42
1.4
1.4
—
—
—
0
0
34
111
3.92
9.34
11.9
7.4
-0.20
1.26
mmol/l
1.12
29
91
46
184
3.49
9.33
3.9
2.4
7.71
4.89
e6/l
0.47
40
170
49
205
3.41
9.24
1.3
1.3
13.91
1.13
u/ml
—
7
64
15
12
14.14
9.16
1.1
1.0
—
—
—
0
0
56
256
3.30
9.11
4.3
2.9
1.06
0.42
e6/l
0.58
49
193
44
174
3.46
9.05
4.1
2.8
496.45
553.37
mosm/kgh2o
0.90
38
153
33
109
3.83
8.88
12.2
7.5
13.95
11.86
kpa
1.11
33
102
23
58
4.70
8.83
11.6
7.6
22.56
25.47
mmol/l
3.80
23
58
58
277
3.19
8.67
5.0
2.9
16.23
278.90
e6/l
0.60
52
216
29
89
4.01
8.64
8.5
4.2
0.44
1.87
mmol/l
1.55
22
69
21
52
4.71
8.21
13.5
8.3
—
—
—
0
0
53
248
3.09
8.09
4.2
2.8
—
—
—
0
0
28
90
3.78
7.76
13.9
8.4
105.18
122.35
g/l
2.95
28
85
15
18
9.39
7.59
3.4
1.5
8.56
8.18
kpa
0.25
15
18
61
319
2.92
7.49
5.8
3.4
41.37
59.26
e6/l
0.34
52
229
52
250
2.96
7.44
15.2
7.4
—
—
—
0
0
29
100
3.53
7.22
1.4
1.4
—
—
—
0
0
53
267
2.81
6.84
3.2
2.7
—
—
—
0
0
30
110
3.33
6.76
2.8
1.6
—
—
—
0
0
52
262
2.78
6.68
4.0
3.4
151.14
312.40
mg/l
0.27
38
174
12
14
9.41
6.23
3.9
1.6
—
—
—
0
0
53
280
2.64
6.08
4.8
3.9
28.83
8.23
mg/mmol
1.29
41
175
14
22
7.08
6.08
4.5
1.4
22.47
24.43
mmol/l
1.37
14
22
42
198
2.76
6.03
3.5
1.7
2.92
1.18
mg/l
1.40
35
155
22
71
3.59
5.99
1.0
1.3
—
—
—
0
0
11
13
9.21
5.70
1.5
1.8
—
—
—
0
0
10
10
10.81
5.65
2.6
1.7
34.71
35.35
%
—
10
10
12
17
7.73
5.60
1.3
3.1
—
—
—
0
0
29
116
3.00
5.59
2.7
1.5
—
—
—
0
0
11
15
7.97
5.28
4.6
2.2
—
—
—
0
0
15
42
3.95
4.95
3.5
3.4
—
—
—
0
0
8
7
12.15
4.86
3.0
1.6
—
—
—
0
0
88
635
2.60
4.73
5.9
4.0
—
—
—
0
0
9
12
8.02
4.44
1.2
1.3
—
—
—
0
0
11
20
5.96
4.41
1.2
1.1
—
—
—
0
0
22
89
2.82
4.09
5.0
5.1
—
—
—
0
0
12
27
4.83
4.07
1.3
1.3
240.86
272.39
ug/g
—
7
16
7
8
9.21
3.82
3.1
1.5
34.00
31.38
pg
—
7
8
7
9
8.19
3.61
2.1
3.0
89.67
90.26
%
—
7
9
7
9
8.19
3.61
1.1
1.4
—
—
—
0
0
63
431
2.01
3.36
25.6
9.1
0.00
0.00
e9/l
0.37
53
342
18
73
2.73
3.32
6.5
4.8
143.78
81.27
ng/l
0.89
18
66
14
50
3.05
3.21
1.1
1.3
—
—
—
0
0
11
30
3.94
3.18
3.6
3.8
—
—
—
0
0
23
109
2.38
3.10
1.9
1.2
—
—
—
0
0
5
5
10.36
3.00
1.0
1.2
—
—
—
0
0
6
9
6.96
2.90
1.0
1.0
—
—
—
0
0
6
9
6.96
2.90
1.0
1.4
—
—
—
0
0
65
468
1.88
2.81
5.0
3.4
0.00
0.00
estimate
-0.00
12
80
5
6
8.63
2.77
1.4
1.2
—
—
—
0
0
20
367
0.45
2.73
3.6
2.7
—
—
—
0
0
13
50
2.80
2.63
2.8
2.3
—
—
—
0
0
56
392
1.83
2.59
2.9
1.9
—
—
—
0
0
5
7
7.40
2.57
1.0
1.3
—
—
—
0
0
63
461
1.80
2.49
6.5
4.7
0.00
0.00
estimate
-0.00
12
83
36
222
1.90
2.46
3.8
3.3
—
—
—
0
0
8
22
3.82
2.41
2.3
2.7
—
—
—
0
0
5
8
6.47
2.39
1.0
1.0
—
—
—
0
0
63
465
1.78
2.38
5.0
3.4
0.00
0.00
estimate
-0.00
13
88
9
28
3.40
2.36
1.0
1.2
—
—
—
0
0
9
30
3.16
2.20
1.7
1.6
—
—
—
0
0
52
370
1.73
2.18
6.6
3.3
38.41
39.52
ng/l
0.03
47
253
8
25
3.36
2.14
1.1
1.2
—
—
—
0
0
6
15
4.16
2.06
2.7
4.2
—
—
—
0
0
46
322
1.71
2.02
5.6
3.3
2.26
2.35
mmol/l
3.63
41
279
38
253
1.75
1.98
2.1
1.3
—
—
—
0
0
8
27
3.10
1.97
1.1
1.5
—
278.19
—
0
15
14
65
2.31
1.97
9.1
4.1
—
—
—
0
0
11
46
2.54
1.91
5.1
2.5
0.06
0.07
e6/l
0.10
11
46
6
17
3.66
1.86
1.5
2.6
53.00
68.72
%
—
6
17
5
12
4.30
1.84
1.8
1.1
—
—
—
0
0
6
18
3.46
1.77
7.5
2.2
3.78
5.21
e9/l
—
6
18
6
18
3.46
1.77
9.3
3.1
59.67
59.89
%
—
6
18
7
25
2.91
1.68
2.3
1.3
0.25
0.25
g/l
—
7
25
11
50
2.33
1.62
6.2
2.5
0.52
0.67
%
1.07
11
50
11
51
2.28
1.56
6.2
2.5
1.15
1.36
%
0.36
11
51
9
38
2.48
1.49
2.9
1.5
—
—
—
0
0
12
62
2.04
1.33
13.6
7.5
23.49
25.24
mmol/l
0.48
12
56
11
55
2.10
1.32
3.3
2.1
—
—
—
0
0
14
77
1.93
1.32
1.1
1.4
—
—
—
0
0
10
48
2.19
1.32
1.3
1.3
—
—
—
0
0
11
59
1.95
1.11
7.3
4.7
1.21
1.23
mmol/l
0.38
11
54
5
21
2.44
1.10
3.6
1.5
—
—
—
0
0
80
700
1.46
1.06
3.9
3.8
14.64
14.73
pmol/l
0.11
69
639
0
30
0.00
0.99
0.0
1.5
—
—
—
0
0
6
27
2.29
0.95
2.8
1.3
0.99
1.24
g/l
—
6
27
91
980
0.67
0.92
6.4
4.4
1.27
1.45
mmol/l
3.42
83
895
6
29
2.13
0.91
1.2
1.2
—
—
—
0
0
8
43
1.92
0.89
5.1
3.5
—
—
—
0
0
92
987
0.67
0.88
6.3
4.5
4.11
4.69
mmol/l
3.97
84
909
94
871
1.42
0.72
5.2
4.5
2.15
1.91
mu/l
0.71
84
792
17
230
0.69
0.65
2.2
2.7
0.48
0.77
ug/l
—
10
138
95
1000
0.72
0.59
6.7
4.9
2.19
2.79
mmol/l
9.78
87
913
34
280
1.30
0.58
7.0
3.5
—
—
—
0
0
31
253
1.31
0.56
5.5
3.1
—
—
—
0
0
6
37
1.65
0.56
1.0
1.3
—
—
—
0
0
90
947
0.78
0.46
5.8
4.0
1.41
1.31
mmol/l
0.37
83
859
0
15
0.00
0.41
0.0
1.1
—
181.83
—
0
15
34
391
0.82
0.41
3.2
4.5
0.86
1.86
ug/l
4.72
29
346
10
74
1.38
0.33
7.0
3.6
—
—
—
0
0
7
52
1.37
0.32
7.1
3.2
3.46
4.44
pmol/l
—
7
42
71
666
1.17
0.31
4.8
3.8
—
—
—
0
0
108
1093
0.83
0.27
79.6
19.9
35.70
40.87
%
15.90
100
1041
7
92
0.75
0.23
1.6
1.6
—
—
—
0
0
28
250
1.16
0.22
7.4
3.5
0.00
0.00
estimate
—
9
84
105
1026
1.25
0.22
47.4
12.6
—
—
—
0
0
0
11
0.00
0.21
0.0
3.6
—
3.42
—
0
11
0
11
0.00
0.21
0.0
13.3
—
1391.64
—
0
11
0
11
0.00
0.21
0.0
9.7
—
845.64
—
0
11
0
10
0.00
0.21
0.0
1.0
—
262.50
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
107
1049
1.26
0.21
39.7
10.1
33.22
26.82
u/l
3.54
107
1019
107
1050
1.25
0.21
60.1
15.3
87.89
77.86
umol/l
1.43
107
1050
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
7
59
1.20
0.18
1.0
1.1
—
132.28
—
0
19
7
61
1.16
0.18
2.1
1.3
53.91
163.60
u/ml
—
7
53
5
43
1.17
0.10
14.6
4.0
—
—
—
0
0
18
167
1.09
0.07
1.1
1.2
122.74
36.32
iu/ml
—
7
54
11
99
1.12
0.06
1.4
1.3
—
—
—
0
0
28
268
1.06
0.05
2.4
1.7
1.24
1.40
mmol/l
0.78
28
226
17
165
1.04
0.00
1.2
1.2
84.82
10.70
u/ml
—
5
68
95
955
0.97
0.00
6.7
4.5
6.70
5.96
mmol/l
2.79
87
876
7
71
0.99
0.00
6.3
3.3
—
—
—
0
0
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
8.86
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
25.18
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.98
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
3.11
—
0
8
7
70
1.00
-0.00
1.6
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
190.00
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.2
—
0.61
—
0
9
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint I9_HYPTENSPOR and mortality.

Females

Parameter HR [95% CI] p-value
I9_HYPTENSPOR 11.525 [6.2, 21.42] < 0.001
Birth year 0.993 [0.98, 1.0] 0.111

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 189 females with I9_HYPTENSPOR died.

Males

Parameter HR [95% CI] p-value
I9_HYPTENSPOR 8.06 [4.37, 14.86] < 0.001
Birth year 0.99 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 292 males with I9_HYPTENSPOR died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPTENSPOR.

N-year risk Females Males
1 1.019% 1.869%
5 5.916% 9.495%
10 14.89% 22.671%
15 26.58% 39.024%
20 41.417% 57.582%

Relationships between endpoints

Index endpoint: I9_HYPTENSPOR – Hypertension, portal

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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