Noninfective disorders of pinna

H8_PINNADIS

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H61.1
  • Hospital discharge: ICD-9 3803
  • Cause of death: ICD-10 H61.1
  • Cause of death: ICD-9 3803

2 out of 7 registries used, show all original rules.

91

4. Check minimum number of events

None

91

5. Include endpoints

None

91

6. Filter based on genotype QC (FinnGen only)

83

Control definitions (FinnGen only)

Control exclude
H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H61
Name in latin
Morbositates non infectiosae auriculae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 684 319 359
Only index persons 610 287 323
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 32.55 34.65 30.36
Only index persons 32.98 37.05 29.37

-FinnGen-

Key figures

All Female Male
Number of individuals 83 47 36
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 52.88 48.65 58.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
88
Matched controls
880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H61.1
ICD-10 Finland
Noninfective disorders of pinna
+∞
101.9
77
*
H29
ICPC
Ear symptom/complaint other
4.9
8.2
21
53
3803B
ICD-9 Finland
Disorders of external ear, Non-infectious disorders of pinna[DEFORMATIO AURICULARIS AQCUISITA]
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
84
4.19
8.07
1.9
1.5
—
—
—
0
0
30
173
2.11
2.62
2.3
1.3
1.95
2.44
g/l
1.10
22
102
13
52
2.76
2.49
1.1
1.2
202.69
955.97
u/ml
0.84
13
52
5
8
6.54
2.40
7.0
1.1
—
—
—
0
0
20
101
2.27
2.39
1.5
1.4
173.33
408.89
titre
—
6
27
5
10
5.22
2.10
2.2
1.1
—
—
—
0
0
8
26
3.28
2.07
1.1
1.2
5.59
5.37
u/l
—
8
18
7
25
2.95
1.69
1.0
1.2
—
—
—
0
0
41
297
1.71
1.66
2.0
1.9
1.26
1.39
mmol/l
0.40
36
253
50
383
1.71
1.64
6.2
6.4
0.54
0.57
e9/l
0.47
44
336
8
32
2.65
1.64
1.0
1.2
—
—
—
0
0
50
385
1.69
1.60
6.2
6.4
0.04
0.04
e9/l
0.01
44
337
51
397
1.68
1.55
6.0
6.4
0.19
0.19
e9/l
0.04
46
356
54
427
1.68
1.54
8.0
10.8
4.66
3.86
e9/l
0.99
49
384
9
38
2.52
1.51
4.1
9.1
24.19
24.77
mmol/l
—
9
38
29
196
1.72
1.48
1.4
1.3
6.82
1.52
u/ml
—
10
58
5
16
3.25
1.46
1.0
1.3
—
—
—
0
0
29
197
1.70
1.45
4.9
4.1
—
—
—
0
0
9
40
2.39
1.45
1.3
1.2
—
—
—
0
0
29
198
1.69
1.42
1.4
1.7
15.93
20.05
nmol/l
1.09
23
172
6
23
2.72
1.39
1.5
1.0
—
—
—
0
0
15
231
0.58
1.11
3.3
2.9
0.00
0.00
estimate
—
8
80
66
575
1.59
1.06
8.6
8.9
79.03
78.17
u/l
0.07
66
549
7
34
2.15
1.05
2.7
2.4
24.86
23.78
mmol/l
—
7
34
32
240
1.52
1.04
2.3
2.4
—
—
—
0
0
7
35
2.08
1.02
3.3
2.0
24.00
43.11
nmol/l
—
7
35
15
93
1.74
1.02
2.0
2.1
—
—
—
0
0
67
589
1.58
1.00
4.1
4.4
14.51
14.88
pmol/l
0.70
61
547
7
36
2.02
0.99
3.3
1.2
—
—
—
0
0
14
86
1.75
0.98
2.0
1.4
—
—
—
0
0
41
330
1.45
0.92
17.5
10.7
1.18
1.19
inr
0.07
35
270
44
360
1.44
0.90
11.7
10.7
0.00
0.01
e9/l
0.51
33
296
38
303
1.45
0.89
3.9
3.5
16.53
31.91
e6/l
0.67
27
214
31
241
1.44
0.82
6.9
5.5
—
—
—
0
0
0
24
0.00
0.80
0.0
2.7
—
3.60
—
0
16
38
308
1.41
0.80
2.4
2.0
96.68
100.21
pmol/l
0.20
18
164
0
27
0.00
0.79
0.0
1.3
—
—
—
0
0
18
245
0.67
0.76
8.1
3.7
3.98
9.93
mg/mmol
—
10
152
5
24
2.15
0.76
1.6
1.1
401.60
480.79
mg/l
—
5
24
39
323
1.37
0.71
2.5
3.3
5.96
6.18
ph
0.37
14
187
18
238
0.69
0.65
7.2
3.2
35.79
67.30
mg/l
0.51
12
157
35
290
1.34
0.62
2.7
2.1
—
—
—
0
0
27
327
0.75
0.56
3.7
2.9
—
—
—
0
0
32
267
1.31
0.53
3.6
2.9
14.30
29.52
e6/l
0.78
25
202
16
119
1.42
0.53
3.2
2.7
3.50
1.82
e6/l
—
10
59
7
50
1.43
0.46
4.0
9.5
1.16
1.51
mmol/l
—
7
50
14
105
1.40
0.44
1.9
1.9
—
—
—
0
0
8
57
1.44
0.43
3.6
9.1
—
—
—
0
0
5
33
1.55
0.42
5.2
2.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
4721.38
—
0
8
9
66
1.40
0.40
3.2
2.9
—
—
—
0
0
36
315
1.24
0.39
8.5
5.7
1.21
1.21
mmol/l
0.06
36
300
0
19
0.00
0.39
0.0
3.6
—
51.71
—
0
19
21
172
1.29
0.39
2.6
3.6
1.02
1.02
kg/l
—
8
117
10
72
1.44
0.39
1.4
2.0
—
—
—
0
0
20
241
0.78
0.38
1.4
1.5
—
—
—
0
0
79
755
1.45
0.38
18.6
14.9
26.62
21.79
mg/l
0.46
61
628
56
516
1.23
0.37
4.5
3.9
—
—
—
0
0
40
356
1.23
0.37
2.5
2.7
—
—
estimate
—
0
0
6
42
1.46
0.36
3.5
10.5
25.12
24.37
mmol/l
—
6
42
6
45
1.36
0.34
1.0
1.1
—
—
—
0
0
21
175
1.26
0.34
4.6
5.2
—
—
—
0
0
12
92
1.35
0.34
1.3
1.2
—
—
—
0
0
20
168
1.25
0.30
1.8
1.7
1.05
1.32
mg/l
0.32
14
138
22
187
1.24
0.30
2.1
2.1
—
—
—
0
0
9
116
0.75
0.29
1.2
1.4
—
—
—
0
0
25
218
1.21
0.27
6.6
3.9
7.42
7.40
ph
1.04
16
163
5
71
0.69
0.27
3.4
5.0
—
0.87
—
0
23
12
96
1.29
0.26
4.3
7.4
102.67
103.16
mmol/l
0.15
12
96
26
230
1.19
0.24
3.6
3.1
—
—
—
0
0
5
37
1.37
0.24
2.2
1.8
—
—
—
0
0
81
789
1.33
0.24
22.5
19.2
78.77
75.76
umol/l
0.22
81
778
26
231
1.18
0.23
3.5
2.7
0.44
0.28
e6/l
0.24
20
169
26
231
1.18
0.23
8.7
6.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
21.91
—
0
11
0
11
0.00
0.21
0.0
3.4
—
0.95
—
0
6
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
15
127
1.22
0.21
1.7
1.6
974.63
1258.07
nmol/l
—
10
100
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
5.3
—
—
—
0
0
0
13
0.00
0.21
0.0
3.3
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
5.92
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
28
308
0.87
0.20
3.1
3.5
0.00
0.00
estimate
—
9
82
6
52
1.16
0.19
1.0
1.3
—
—
—
0
0
5
65
0.76
0.17
21.0
4.0
1.19
1.23
mmol/l
—
5
60
6
75
0.79
0.16
2.7
4.8
—
1.23
—
0
26
28
300
0.90
0.12
4.7
3.6
20.99
30.35
ng/l
0.49
19
202
25
232
1.11
0.11
4.0
3.8
0.00
0.00
estimate
—
8
87
17
154
1.13
0.11
1.8
1.8
—
—
—
0
0
6
73
0.81
0.08
2.7
4.8
—
0.25
—
0
24
8
78
1.03
0.07
2.6
1.6
—
—
—
0
0
9
100
0.89
0.07
3.4
3.4
6.13
6.39
e9/l
—
9
92
12
109
1.12
0.06
1.7
1.9
—
—
—
0
0
23
223
1.04
0.01
2.6
2.7
—
—
—
0
0
41
416
0.97
0.00
3.6
3.6
0.00
0.00
estimate
—
9
89
41
409
1.00
0.00
3.5
3.6
0.00
0.00
estimate
—
9
96
78
775
1.06
0.00
15.1
13.0
—
—
—
0
0
10
96
1.05
0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
58.40
—
0
5
9
93
0.96
-0.00
1.0
1.5
—
—
—
0
0
7
76
0.91
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
41
410
1.00
-0.00
3.6
3.6
0.00
0.00
estimate
—
9
95
0
8
0.00
-0.00
0.0
3.3
—
1.20
—
0
8
0
5
0.00
-0.00
0.0
2.6
—
75.20
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
10.09
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
50.14
—
0
5
7
76
0.91
-0.00
2.7
5.4
—
0.00
—
0
22
0
6
0.00
-0.00
0.0
1.0
—
1650.17
—
0
6
0
8
0.00
-0.00
0.0
1.9
—
6.03
—
0
8
0
8
0.00
-0.00
0.0
3.3
—
106.63
—
0
8
8
80
1.00
-0.00
1.1
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.3
—
4.04
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
14.6
—
819.80
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
17.70
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
5.98
—
0
5
7
77
0.90
-0.00
4.4
1.9
—
0.20
estimate
—
0
15
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
1.17
—
0
6
17
170
1.00
-0.00
1.5
1.7
420.73
451.26
pmol/l
0.12
11
148
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
71
0.98
-0.00
1.7
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
18.6
—
1630.80
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
239.29
—
0
7
0
8
0.00
-0.00
0.0
1.3
—
38.63
—
0
8

Mortality – FinRegistry

Association

Association between endpoint H8_PINNADIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_PINNADIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H8_PINNADIS – Noninfective disorders of pinna

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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